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Condition: Obesity
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Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research
Sodium salicylate induces browning of white adipocytes via M2 macrophage polarization by HO-1 upregulation
Eur J Pharmacol. 2022 Jun 6:175085. doi: 10.1016/j.ejphar.2022.175085. Online ahead of print.ABSTRACTBrowning, a white to brown-like (beige) adipocyte conversion, offers a promising therapeutic strategy for the treatment of human obesity. In the present study, the effects of sodium salicylate, a nonsteroidal anti-inflammatory drug, on adipocyte browning were investigated. We found sodium salicylate altered the macrophage phenotype to M2 in RAW264.7 cells, mediated by up-regulation of heme oxygenase-1 (HO-1), and sodium salicylate-treated conditioned medium from macrophages (Sal-M2 CM) induced browning of fully differentiat...
Source: European Journal of Pharmacology - June 9, 2022 Category: Drugs & Pharmacology Authors: Hye-Eun Choi Eun Jeong Jeon Dong Young Kim Mi Jin Choi Hana Yu Jea Il Kim Hyae Gyeong Cheon Source Type: research
Downregulation of peripheral lipopolysaccharide binding protein impacts on perigonadal adipose tissue only in female mice
CONCLUSION: LBP seems to exert a negative feedback on ERα-mediated estrogen action, impacting on genes involved in thermogenesis. The known decreased estrogen action and negative effects of metabolic endotoxemia may be targeted through LBP downregulation.PMID:35643066 | DOI:10.1016/j.biopha.2022.113156
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 1, 2022 Category: Drugs & Pharmacology Authors: Ferran Comas Ramon D íaz-Trelles Aleix Gavald à-Navarro Edward Milbank Nathalia Dragano Samantha Mor ón-Ros Rajesh Mukthavaram Jessica Latorre Francisco Ortega Maria Arnoriaga-Rodriguez N úria Oliveras-Cañellas Wifredo Ricart Priya P Karmali Kiyoshi Source Type: research
Adapalene induces adipose browning through the RAR β-p38 MAPK-ATF2 pathway
This study identifies new actions of AD as an adipose browning agent and demonstrates that RARβ activation followed by increased phosphorylation of p38 MAPK and ATF2 appears to be a key mechanism of AD action.PMID:35608792 | DOI:10.1007/s12272-022-01384-4
Source: Archives of Pharmacal Research - May 24, 2022 Category: Drugs & Pharmacology Authors: Na Hyun Lee Mi Jin Choi Hana Yu Jea Il Kim Hyae Gyeong Cheon Source Type: research
A fluorinated peptide with high serum- and lipid-tolerence for the delivery of siRNA drugs to treat obesity and metabolic dysfunction
Biomaterials. 2022 Apr 28;285:121541. doi: 10.1016/j.biomaterials.2022.121541. Online ahead of print.ABSTRACTObesity is the major risk factor for metabolic diseases such as fatty liver, hyperlipidemia and insulin resistance. Beige fat has been recognized as a therapeutic target considering its great potential to burn energy. Since the evolutionary discovery of RNA interference and its utilization for gene knockdown in mammalian cells, a remarkable progress has been achieved in siRNA-based therapeutics. However, efficient delivery of siRNA into adipose tissues or differentiated adipocytes is challenging due to high lipid co...
Source: Biomaterials - May 9, 2022 Category: Materials Science Authors: Jin Qiu Qianqian Fan Sainan Xu Dongmei Wang Juntong Chen Sainan Wang Tianhui Hu Xinran Ma Yiyun Cheng Lingyan Xu Source Type: research
Raspberry ketone promotes FNDC5 protein expression via HO-1 upregulation in 3T3-L1 adipocytes
In conclusion, RK can induce FNDC5 protein expression via the HO-1 signaling pathway, and this study provides new evidence for the potential use of RK in the treatment of obesity.PMID:35488673 | DOI:10.4103/cjp.cjp_95_21
Source: The Chinese Journal of Physiology - April 30, 2022 Category: Physiology Authors: Yung-Chieh Tsai Jung-Hua Chen Yen-Mei Lee Mao-Hsiung Yen Pao-Yun Cheng Source Type: research
