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Condition: Obesity
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Total 449 results found since Jan 2013.
Musclin Mitigates the Attachment of HUVECs to THP-1 Monocytes in Hyperlipidemic Conditions through PPAR α/HO-1-Mediated Attenuation of Inflammation
This study aimed to explore the impact of musclin on inflammatory responses and the interaction between endothelial cells and monocytes under hyperlipidemic conditions. The attachment levels of THP-1 monocytes on cultured HUVECs were examined. Inflammation and the expression of cell adhesion molecules were also evaluated. To explore the molecular mechanisms of musclin, PPAR α or heme oxygenase 1 (HO-1) siRNA transfection was performed in HUVECs. The results revealed that treatment with recombinant musclin effectively suppressed the attachment of palmitate-induced HUVECs to THP-1 cells and reduced the expression of cell ad...
Source: Inflammation - September 22, 2023 Category: Allergy & Immunology Source Type: research
Spexin role in human granulosa cells physiology and PCOS: expression and negative impact on steroidogenesis and proliferation
Biol Reprod. 2023 Sep 2:ioad108. doi: 10.1093/biolre/ioad108. Online ahead of print.ABSTRACTSpexin (SPX) is a novel neuropeptide and adipokine negatively correlated with obesity and insulin resistance. A recent study investigated expression and regulatory function of SPX in the hypothalamus and pituitary; however, the effect on ovarian function is still unknown. The aim of this study was to characterize the expression of SPX and its receptors, galanin receptors 2 and 3 (GALR2/3) in the human ovary and to study its in vitro effect on granulosa cells (GC) function. Follicular fluid (FF) and GC were obtained from normal weigh...
Source: Reproductive Biology - September 2, 2023 Category: Reproduction Medicine Authors: Patrycja Kurowska Monika Dawid Julia Oprocha Natalia Repekta Lo ïse Serra Anthony Estienne Piotr Pawlicki Ma łgorzata Kotula-Balak Fabrice Gu érif Joelle Dupont Agnieszka Rak Source Type: research
Higher gestational weight gain delays wound healing and reduces expression of long non-coding RNA KLRK1-AS1 in neonatal endothelial progenitor cells
J Physiol. 2023 Jul 20. doi: 10.1113/JP284871. Online ahead of print.ABSTRACTHigh gestational weight gain (GWG) is a cardiovascular risk factor and may disturb neonatal endothelial function. Long non-coding RNAs (lncRNAs) regulate gene expression epigenetically and can modulate endothelial function. Endothelial colony forming cells (ECFCs), circulating endothelial precursors, are a recruitable source of endothelial cells and sustain endothelial function, vascular growth and repair. We here investigated whether higher GWG affects neonatal ECFC function and elucidated the role of lncRNAs herein. Wound healing of umbilical co...
Source: The Journal of Physiology - July 20, 2023 Category: Physiology Authors: Elisa Weiss Anna Schr üfer Carolina Tocantins Mariana Simoes Diniz Boris Novakovic Anke S van Bergen Azra Kulovic-Sissawo Richard Saffery Reinier A Boon Ursula Hiden Source Type: research
Contribution of adipocyte Na/K-ATPase α1/CD36 signaling induced exosome secretion in response to oxidized LDL
DISCUSSION: In this work, we report that CD36, a scavenger receptor for oxidized LDL, formed a signaling complex with another membrane signal transducer Na/K-ATPase in adipocytes. The atherogenic oxidized LDL induced a pro-inflammatory response in in vitro differentiated mouse and human adipocytes and also stimulated the cells to secrete more exosomes. This was largely blocked by either CD36 knockdown using siRNA or pNaKtide, a peptide inhibitor of Na/K-ATPase signaling. These results showed a critical role of the CD36/Na/K-ATPase signaling complex in oxidized LDL-induced adipocyte exosome secretion. Moreover, by co-incuba...
Source: Atherosclerosis - May 14, 2023 Category: Cardiology Authors: Sneha S Pillai Duane G Pereira Jue Zhang Wenxin Huang Mirza Ahmar Beg Darcy A Knaack Bruno de Souza Goncalves Daisy Sahoo Roy L Silverstein Joseph I Shapiro Komal Sodhi Yiliang Chen Source Type: research
Islr regulates insulin sensitivity by interacting with Psma4 to control insulin receptor alpha levels in obese mice
Int J Biochem Cell Biol. 2023 Apr 26:106420. doi: 10.1016/j.biocel.2023.106420. Online ahead of print.ABSTRACTInsulin resistance is the leading cause of type 2 diabetes (T2D), and dysfunctional insulin receptor signaling is a major manifestation of this insulin resistance. In T2D, the corresponding insulin receptor levels are aberrantly down-regulated, which is one of the major factors underlying obesity-induced insulin resistance in adipose tissue. However, the precise mechanism of insulin receptor impairment in obese individuals remains unclear. In the current study, we established that immunoglobulin superfamily contain...
Source: The International Journal of Biochemistry and Cell Biology - April 28, 2023 Category: Biochemistry Authors: Yuying Zhang Miaomiao Lan Chang Liu Tongtong Wang Chuncheng Liu Sen Wu Qingyong Meng Source Type: research
Visfatin-induced upregulation of lipogenesis via EGFR/AKT/GSK3 β pathway promotes breast cancer cell growth
Cell Signal. 2023 Apr 19:110686. doi: 10.1016/j.cellsig.2023.110686. Online ahead of print.ABSTRACTBreast cancer (BC) incidence and associated mortality have increased in tandem with the growth in obesity among the females worldwide. An adipokine, visfatin, has been shown to potentially impact glucose, lipid, and protein metabolism, and promote cancer growth however, the mechanism underlying the effect of visfatin on lipid metabolism dysregulation contributing to BC cell survival, proliferation, and metastasis has not been elucidated. Herein, we have investigated the role of visfatin on the induction of Sterol regulatory e...
Source: Cellular Signalling - April 21, 2023 Category: Cytology Authors: Pradeep Kumar Rajput Johnna Francis Varghese Amit Kumar Srivastava Umesh Kumar Umesh C S Yadav Source Type: research
Chaperonin counteracts diet-induced non-alcoholic fatty liver disease by aiding sirtuin 3 in the control of fatty acid oxidation
Conclusion/interpretationMitochondrial HSP60 promotes fatty acid oxidation while repressing mitochondrial stress and inflammation to ameliorate the development of NAFLD by preserving SIRT3 signalling. This study reveals the hepatoprotective effects of HSP60 and indicates that HSP60 could play a fundamental role in the development of therapeutics for NAFLD or type 2 diabetes.Graphical abstract
Source: Diabetologia - March 24, 2023 Category: Endocrinology Source Type: research
STAT3 signaling promotes cardiac injury by upregulating NCOA4-mediated ferritinophagy and ferroptosis in high-fat-diet fed mice
In this study, we found that oleic acid/palmitic acid (OA/PA) increased the level of ferroptotic events including iron and ROS accumulation, upregulation of PTGS2 mRNA and protein levels, reduced SOD and GSH levels, and significant mitochondrial damage in H9C2 cells, which could be reversed by the ferroptosis inhibitor ferrostatin-1 (Fer-1). Intriguingly, we found that the autophagy inhibitor 3-methyladenine mitigated OA/PA-induced ferritin downregulation, iron overload and ferroptosis. OA/PA increased the protein level of NCOA4. Knockdown of NCOA4 by SiRNA partly reversed the reduction in ferritin, mitigated iron overload...
Source: Free Radical Biology and Medicine - March 20, 2023 Category: Biology Authors: Mengying Zhu Lulu Peng Shengqi Huo Dewei Peng Junyi Gou Wei Shi Jingwen Tao Tao Jiang Yue Jiang Qian Wang Bingyu Huang Lintong Men Sheng Li Jiagao Lv Li Lin Source Type: research
