Interleukin-27 decreases ghrelin production through signal transducer and activator of transcription 3—mechanistic target of rapamycin signaling

In conclusion, IL-27 suppresses ghrelin production through the STAT3-mTOR dependent mechanism.Graphical abstractIL-27 stimulates the activity of STAT3 and mTOR. IL-27 also enhances the interaction between STAT3 and mTOR, leading to the subsequent inhibition of ghrelin expression and appetite.
Source: Acta Pharmaceutica Sinica B - Category: Cancer & Oncology Source Type: research