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Cancer: Glioma

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Total 625 results found since Jan 2013.

microRNA cluster MC-let-7a-1~let-7d promotes autophagy and apoptosis of glioma cells by down-regulating STAT3.
CONCLUSION: Taken together, the miR cluster MC-let-7a-1 ~ let-7d promotes glioma cell autophagy and apoptosis by repressing STAT3. The current study highlights the potential of the miR cluster MC-let-7a-1 ~ let-7d as biomarkers and promising treatment strategies for glioma. PMID: 31868319 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - December 22, 2019 Category: Neuroscience Authors: Yang ZY, Wang Y, Liu Q, Wu M Tags: CNS Neurosci Ther Source Type: research

Adipocyte enhancer binding protein 1 (AEBP1) knockdown suppresses human glioma cell proliferation, invasion and induces early apoptosis
ConclusionElevated AEBP1 is positively associated with poor prognosis of glioma. AEBP1 downregulation suppressed cell proliferation and invasion, but promoted early cell apoptosis. AEBP1 downregulation suppressed the cell proliferation and invasion may by inhibiting the NF-κB signaling pathway.
Source: Pathology Research and Practice - December 18, 2019 Category: Pathology Source Type: research

Adipocyte enhancer binding protein 1 (AEBP1) knockdown suppresses human glioma cell proliferation, invasion and induces early apoptosis.
CONCLUSION: Elevated AEBP1 is positively associated with poor prognosis of glioma. AEBP1 downregulation suppressed cell proliferation and invasion, but promoted early cell apoptosis. AEBP1 downregulation suppressed the cell proliferation and invasion may by inhibiting the NF-κB signaling pathway. PMID: 31864713 [PubMed - as supplied by publisher]
Source: Pathology, Research and Practice - December 16, 2019 Category: Pathology Authors: Cheng L, Shao X, Wang Q, Jiang X, Dai Y, Chen S Tags: Pathol Res Pract Source Type: research

Long non ‑coding RNA Unigene56159 promotes glioblastoma multiforme cell proliferation and invasion through negatively regulating microRNA‑194‑5p.
Long non‑coding RNA Unigene56159 promotes glioblastoma multiforme cell proliferation and invasion through negatively regulating microRNA‑194‑5p. Mol Med Rep. 2019 Nov 26;: Authors: Jiang G, Dong H, Dong Y, Yang X Abstract Long non‑coding RNAs (lncRNA) serve a vital role in tumor progression. The present study identified a fundamental role for a novel lincRNA, Unigene56159, in the progression of glioblastoma (GBM). Unigene56159 gene expression was found to be significantly upregulated in tissue samples from patients with GBM as well as in GBM cell lines by reverse transcription‑quantitative PC...
Source: Molecular Medicine Reports - December 5, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Reduced expression of proteolipid protein 2 increases ER stress-induced apoptosis and autophagy in glioblastoma.
Abstract Proteolipid protein 2 (PLP2) is an integral ion channel membrane protein of the endoplasmic reticulum. The protein has been shown to be highly expressed in many cancer types, but its importance in glioma progression is poorly understood. Using publicly available datasets (Rembrandt, TCGA and CGGA), we found that the expression of PLP2 was significantly higher in high-grade gliomas than in low-grade gliomas. We confirmed these results at the protein level through IHC staining of high-grade (n = 56) and low-grade glioma biopsies (n = 16). Kaplan-Meier analysis demonstrated that increased PLP2 expression...
Source: J Cell Mol Med - November 27, 2019 Category: Molecular Biology Authors: Feng Z, Zhou W, Wang J, Qi Q, Han M, Kong Y, Hu Y, Zhang Y, Chen A, Huang B, Chen A, Zhang D, Li W, Zhang Q, Bjerkvig R, Wang J, Thorsen F, Li X Tags: J Cell Mol Med Source Type: research

TGF ‐β1 activates RSC96 Schwann cells migration and invasion through MMP‐2 and MMP‐9 activities
AbstractFollowing peripheral nerve injury, remnant Schwann cells adopt a migratory phenotype and remodel the extracellular matrix allowing axonal regrowth. Although much evidence has demonstrated that TGF ‐β1 promotes glioma cell motility and induces the expression of extracellular matrix proteins, the effects of TGF‐β1 on Schwann cell migration has not yet been studied. We therefore investigated the cellular effects and the signal transduction pathways evoked by TGF‐β1 inrattus norvegicus neuronal Schwann RSC96 cell. TGF ‐β1 significantly increased migration and invasion of Schwann cells assessed by wound‐he...
Source: Journal of Neurochemistry - November 14, 2019 Category: Neuroscience Authors: Antonella Muscella, Carla Vetrugno, Luca Giulio Cossa, Santo Marsigliante Tags: Original Article Source Type: research

miR-452 promotes the development of gastric cancer via targeting EPB41L3
In this study, we found that miR-452 was highly expressed in both tumor tissue and gastric cancer cells, and could directly target the cancer suppressor gene EPB41L3 3′-UTR. miR-452 significantly promoted the proliferation, migration and the S-phase arrest of gastric cancer cells, but EPB41L3 as a downstream target gene of miR-452 reversed such promoting effect. While down-regulation of miR-452 expression significantly inhibited the malignant biological behavior of gastric cancer cells, but this inhibitory effect was reversed by EPB41L3 siRNA. In addition, miR-452 in the gastric cancer xenograft model in nude mice could ...
Source: Pathology Research and Practice - November 1, 2019 Category: Pathology Source Type: research

Co-delivery of GOLPH3 siRNA and gefitinib by cationic lipid-PLGA nanoparticles improves EGFR-targeted therapy for glioma
AbstractGlioblastoma is one of the most aggressive types of brain tumor. Epidermal growth factor receptors (EGFRs) are overexpressed in glioma, and EGFR amplifications and mutations lead to rapid proliferation and invasion. EGFR-targeted therapy might be an effective treatment for glioma. Gefitinib (Ge) is an EGFR tyrosine kinase inhibitor (TKI), and Golgi phosphoprotein 3 (GOLPH3) expression is associated with worse glioma prognosis. Downregulation of GOLPH3 could promote EGFR degradation. Here, an angiopep-2 (A2)-modified cationic lipid-poly (lactic-co-glycolic acid) (PLGA) nanoparticle (A2-N) was developed that can rele...
Source: Journal of Molecular Medicine - October 29, 2019 Category: Molecular Biology Source Type: research

Ecotropic viral integration site 1 regulates EGFR transcription in glioblastoma cells
ConclusionThis is the first study reporting the regulation ofEGFR transcription by EVI1 in GBM cells.
Source: Journal of Neuro-Oncology - October 14, 2019 Category: Cancer & Oncology Source Type: research

43PXAF1 enhances temozolomide induced autophagic cell death through AMPK signaling pathway
ConclusionsEpigenetic inactivation of XAF1 contributes to the malignant progression of human glioma by rendering tumor cells a survival advantage via the attenuation of AMPK signaling.Legal entity responsible for the studyThe authors.FundingNational Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (No. 2018R1D1A1B07041512).DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - October 1, 2019 Category: Cancer & Oncology Source Type: research

CBX3 promotes glioma U87 cell proliferation and predicts an unfavorable prognosis
ConclusionsIn conclusion, results of the current research suggest that a high CBX3 expression level predicts the poor prognosis for glioma patients. CBX3 can stimulate the growth of glioma U87 cells through targeting CDKN1A and CBX3 may become a novel target in the clinical treatment for glioma.
Source: Journal of Neuro-Oncology - September 8, 2019 Category: Cancer & Oncology Source Type: research

RSL3 induced autophagic death in glioma cells via causing glycolysis dysfunction.
In this study, we found RSL3 inhibited the viabilities of glioma cells and induced glioma cell death in a dose-dependent manner. In vitro studies revealed that RSL3-induced cell death was accompanied with the changes of autophagy-associated protein levels and was alleviated by pretreatment of 3-Methyladenine, bafilomycin A1 and knockdown of ATG5 with siRNA. The ATP and pyruvate content as well as the protein levels of HKII, PFKP, PKM2 were decreased in cells treated by RSL3, indicating that RSL3 induced glycolysis dysfunction in glioma cells. Moreover, supplement of exterior sodium pyruvate, which was a final product of g...
Source: Biochemical and Biophysical Research communications - August 20, 2019 Category: Biochemistry Authors: Wang X, Lu S, He C, Wang C, Wang L, Piao M, Chi G, Luo Y, Ge P Tags: Biochem Biophys Res Commun Source Type: research

LINK-A lncRNA participates in the pathogenesis of glioma by interacting with survivin.
In conclusion, LINK-A lncRNA inhibited glioma cell apoptosis potentially by the upregulation of survivin. The present study revealed that LINK-A may serve as possible diagnostic marker for glioma. PMID: 31410112 [PubMed]
Source: Experimental and Therapeutic Medicine - August 16, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Tim-3 expression in glioma cells is associated with drug resistance
Conclusions: The presence of Tim-3 mRNA and protein in glioma cells was detected. Significantly, knocking down Tim-3 expression improved the potential of TMZ treatment.
Source: Journal of Cancer Research and Therapeutics - August 13, 2019 Category: Cancer & Oncology Authors: Ji Zhang Zheng Quan Zhu Yan Xia Li Qiu Feng Zhuang Yuanhong Lai Shao Fang Li Xiao Bing Xu Jian Min Liu Source Type: research

G3BP1 knockdown sensitizes U87 glioblastoma cell line to Bortezomib by inhibiting stress granules assembly and potentializing apoptosis
ConclusionOur data suggest G3BP1 knockdown diminishes SG formation and stimulates BZM-induced apoptosis of U87 cells in vitro, in addition to inhibiting glioblastoma-induced angiogenesis in vivo.
Source: Journal of Neuro-Oncology - August 6, 2019 Category: Cancer & Oncology Source Type: research