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Cancer: Glioma
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Total 625 results found since Jan 2013.
Insulin receptor substrate 1 gene expression is strongly up-regulated by HSPB8 silencing in U87 glioma cells
Conclusions. Results of this investigation demonstrated that silencing of HSPB8 mRNA affected the expression of IRS1 gene as well as many other genes encoding tumor growth related proteins. It is possible that the dysregulation of most of the studied genes in glioma cells after silencing of HSPB8 is reflected by a complex of intergenic interactions and that this polyfunctional chaperone is an important factor for the stability of genome function and regulatory mechanisms contributing to the tumorigenesis control.PMID:33885248 | DOI:10.2478/enr-2020-0026
Source: Endocrine Regulations - April 22, 2021 Category: Endocrinology Authors: Oksana S Hnatiuk Dariia O Tsymbal Dmytro O Minchenko Olena O Khita Yulia M Viletska Olha V Rundytska Halyna E Kozynkevych Hanna S Maslak Oleksandr H Minchenko Source Type: research
FOXO3a protects glioma cells against temozolomide-induced DNA double strand breaks via promotion of BNIP3-mediated mitophagy
In this study we investigated the role of FOXO3a in regulating the sensitivity of glioma cells to temozolomide (TMZ) and its relationship with BNIP3-mediated mitophagy. We showed that TMZ dosage-dependently inhibited the viability of human U87, U251, T98G, LN18 and rat C6 glioma cells with IC50 values of 135.75, 128.26, 142.65, 155.73 and 111.60 μM, respectively. In U87 and U251 cells, TMZ (200 μM) induced DNA double strand breaks (DSBs) and nuclear translocation of apoptosis inducing factor (AIF), which was accompanied by BNIP3-mediated mitophagy and FOXO3a accumulation in nucleus. TMZ treatment induced intracellular RO...
Source: Acta Pharmacologica Sinica - April 21, 2021 Category: Drugs & Pharmacology Authors: Chuan He Shan Lu Xuan-Zhong Wang Chong-Cheng Wang Lei Wang Shi-Peng Liang Tian-Fei Luo Zhen-Chuan Wang Mei-Hua Piao Guang-Fan Chi Peng-Fei Ge Source Type: research
Cancers, Vol. 13, Pages 1998: CD81 Enhances Radioresistance of Glioblastoma by Promoting Nuclear Translocation of Rad51
In conclusion, we demonstrated for the first time that CD81 not only played a vital role in DNA repair through regulating Rad51 nuclear transport, but also might serve as a potential target of GBM radiotherapy.
Source: Cancers - April 21, 2021 Category: Cancer & Oncology Authors: Wang Zheng Qianping Chen Hongxia Liu Songling Hu Yuchuan Zhou Yang Bai Jianghong Zhang Yan Pan Chunlin Shao Tags: Article Source Type: research
RNA Interference-Mediated Aurora Kinase A Gene Silencing Inhibits Human Glioma Cells Proliferation and Tumor Growth in Mice
Conclusion: Aurora A can be used as a candidate targeting gene and inhibition of Aurora A is a potentially promising therapy for glioblastoma.
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Ge Zhang, Guanghui Ren, Xin Zhao, Haibo Wang Tags: Research Paper Source Type: research
Lentivirus vector ‑mediated genetic manipulation of oncogenic pathways induces tumor formation in rabbit brain
Mol Med Rep. 2021 Jun;23(6):422. doi: 10.3892/mmr.2021.12061. Epub 2021 Apr 13.ABSTRACTTranslation of promising experimental therapies from rodent models to clinical success has been complicated as the novel therapies often fail in clinical trials. Existing rodent glioma models generally do not allow for preclinical evaluation of the efficiency of novel therapies in combination with surgical resection. Therefore, the aim of the present study was to develop a larger animal model utilizing lentivirus vector‑mediated oncogenic transformation in the rabbit brain. Lentiviruses carrying constitutively active AKT and H‑Ras on...
Source: Molecular Medicine - April 13, 2021 Category: Molecular Biology Authors: Farizan Ahmad Anna Hyv ärinen Agnieszka Pirinen Venla Olsson Jaana Rummukainen Arto Immonen Johanna N ärväinen Pasi Tuunanen Timo Liimatainen Virve K ärkkäinen Jari Koistinaho Seppo Yl ä-Ηerttuala Source Type: research
