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Cancer: Glioma

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Total 625 results found since Jan 2013.

Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells
CONCLUSION: Taken together, our findings indicate that temozolomide may suppress cell growth partly by inducing ferroptosis by targeting DMT1 expression in glioblastoma cells.PMID:34427071 | PMC:PMC8382730 | DOI:10.3349/ymj.2021.62.9.843
Source: Yonsei Medical Journal - August 24, 2021 Category: Universities & Medical Training Authors: Qingxin Song Shanxin Peng Zhiqing Sun Xueyuan Heng Xiaosong Zhu Source Type: research

Cancers, Vol. 13, Pages 4123: Photodynamic Therapy Combined with Bcl-2/Bcl-xL Inhibition Increases the Noxa/Mcl-1 Ratio Independent of Usp9X and Synergistically Enhances Apoptosis in Glioblastoma
tsch Georg Karpel-Massler The purpose of this study was to assess in vitro whether the biological effects of 5-aminolevulinic acid (5-ALA)-based photodynamic therapy are enhanced by inhibition of the anti-apoptotic Bcl-2 family proteins Bcl-2 and Bcl-xL in different glioblastoma models. Pre-clinical testing of a microcontroller-based device emitting light of 405 nm wavelength in combination with exposure to 5-ALA (PDT) and the Bcl-2/Bcl-xL inhibitor ABT-263 (navitoclax) was performed in human established and primary cultured glioblastoma cells as well as glioma stem-like cells. We applied cell count analyses to asses...
Source: Cancers - August 17, 2021 Category: Cancer & Oncology Authors: Carolin Golla Mayas Bilal Annika Dwucet Nicolas Bader Jenson Anthonymuthu Tim Heiland Maximilian Pruss Mike-Andrew Westhoff Markus David Siegelin Felix Capanni Christian Rainer Wirtz Richard Eric Kast Marc-Eric Halatsch Georg Karpel-Massler Tags: Article Source Type: research

TNIK influence the effects of antipsychotics on Wnt/ β-catenin signaling pathway
ConclusionsThe influence of TNIK on the effects of antipsychotics may be partly through Wnt/ β-catenin signaling pathway.
Source: Psychopharmacology - August 5, 2021 Category: Psychiatry Source Type: research

LY294002 and sorafenib as inhibitors of intracellular survival pathways in the elimination of human glioma cells by programmed cell death
Cell Tissue Res. 2021 Jul 8. doi: 10.1007/s00441-021-03481-0. Online ahead of print.ABSTRACTGliomas are aggressive brain tumors with very high resistance to chemotherapy throughout the overexpression of multiple intracellular survival pathways. Therefore, the aim of the present study was to investigate for the first time the anticancer activity of LY294002, phosphatidylinositol 3-kinase (PI3K) inhibitor and sorafenib, and rapidly accelerated fibrosarcoma kinase (Raf) inhibitor in the elimination of human glioma cells by programmed cell death. MOGGCCM (anaplastic astrocytoma, III) and T98G (glioblastoma multiforme, IV) cell...
Source: Cell Research - July 8, 2021 Category: Cytology Authors: Zaj ąc A Sumorek-Wiadro J Maciejczyk A Langner E Wertel I Rzeski W Jakubowicz-Gil J Source Type: research

TRIM66 Overexpression Promotes Glioma Progression and Regulates Glucose Uptake Through cMyc/GLUT3 Signaling
CONCLUSION: TRIM66 was upregulated in human gliomas, where it promoted cell growth and chemoresistance. Our data also identified novel roles of TRIM66 in glioma progression. TRIM66 upregulates glucose uptake and mitochondrial function through the cMyc/GLUT3 signaling, which makes it a potential therapeutic target.PMID:34234562 | PMC:PMC8256720 | DOI:10.2147/CMAR.S293728
Source: Cell Research - July 8, 2021 Category: Cytology Authors: Yuequn Song Lifang Meng Jian Yu Zhi Cao Jizhou Sun Hongyu Zhao Source Type: research

LY294002 and sorafenib as inhibitors of intracellular survival pathways in the elimination of human glioma cells by programmed cell death
AbstractGliomas are aggressive brain tumors with very high resistance to chemotherapy throughout the overexpression of multiple intracellular survival pathways. Therefore, the aim of the present study was to investigate for the first time the anticancer activity of LY294002, phosphatidylinositol 3-kinase (PI3K) inhibitor and sorafenib, and rapidly accelerated fibrosarcoma kinase (Raf) inhibitor in the elimination of human glioma cells by programmed cell death. MOGGCCM (anaplastic astrocytoma, III) and T98G (glioblastoma multiforme, IV) cell lines incubated with LY294002 and/or sorafenib were used in the experiments. Simult...
Source: Cell and Tissue Research - July 8, 2021 Category: Cytology Source Type: research

Rewiring of lactate-IL-1 β auto-regulatory loop with Clock-Bmal1: A feed-forward circuit in glioma
Mol Cell Biol. 2021 Jun 14:MCB0044920. doi: 10.1128/MCB.00449-20. Online ahead of print.ABSTRACTDe-synchronized circadian rhythm in tumors is coincident with aberrant inflammation and dysregulated metabolism. As their inter-relationship in cancer etiology is largely unknown, we investigated the link between the three in glioma. Tumor metabolite lactate- mediated increase in pro-inflammatory cytokine IL-1β was concomitant with elevated levels of core circadian regulators Clock and Bmal1. siRNA mediated knockdown of Bmal1 and Clock decreased (i) LDHA and IL-1β levels and (ii) release of lactate and pro-inflammatory cytokin...
Source: Mol Biol Cell - June 14, 2021 Category: Molecular Biology Authors: Pruthvi Gowda Kirti Lathoria Shalini Sharma Shruti Patrick Sonia B Umdor Ellora Sen Source Type: research

CDK-associated Cullin 1 promotes Cell Proliferation and inhibits Cell Apoptosis in Human Glioblastoma
CONCLUSION: CACUL1 can promote cell proliferation and suppress apoptosis of glioma cells and might serve as a potential oncogene for gliomas.PMID:34080964 | DOI:10.2174/1568009621666210602164225
Source: Current Cancer Drug Targets - June 3, 2021 Category: Cancer & Oncology Authors: Xiaohua Zhang Tianying Zhang Xiaojuan Han Zhongying Qiu Jianghong Cheng Xingchun Gao Xingchun Gou Source Type: research

The enzyme L-isoaspartyl (D-aspartyl) methyltransferase promotes migration and invasion in human U-87 MG and U-251 MG glioblastoma cell lines
Biomed Pharmacother. 2021 May 31;140:111766. doi: 10.1016/j.biopha.2021.111766. Online ahead of print.ABSTRACTThe protein L-isoaspartyl (D-aspartyl) methyltransferase (PIMT) recognizes abnormal L-isoaspartyl and D-aspartyl residues in proteins. Among examined tissues, PIMT shows the highest level in the brain. The U-87 MG cell line is a commonly used cellular model to study the most frequent brain tumor, glioblastoma. Previously, we reported that PIMT amount increased when U-87 MG cells were detached from the extracellular matrix. Recently, we also showed that PIMT possessed pro-angiogenic properties. Together, these PIMT ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 3, 2021 Category: Drugs & Pharmacology Authors: Fatima Belkourchia Richard R Desrosiers Source Type: research