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Cancer: Glioma
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Total 625 results found since Jan 2013.
Hemin protects against Zika virus infection by disrupting virus-endosome fusion
This study elaborated that hemin could play anti-ZIKV activity by disrupting the virus-endosome fusion process and shed new light on developing novel agents against ZIKV infection.PMID:35643150 | DOI:10.1016/j.antiviral.2022.105347
Source: Antiviral Research - June 1, 2022 Category: Virology Authors: Meng-Meng Xu Bing Wu Guan-Gen Huang Chun-Lan Feng Xiao-Han Wang Hao-Yu Wang Yan-Wei Wu Wei Tang Source Type: research
HOXC6 Regulates the Epithelial-Mesenchymal Transition through the TGF- < em > β < /em > /Smad Signaling Pathway and Predicts a Poor Prognosis in Glioblastoma
CONCLUSIONS: HOXC6 enhances the migration and proliferation of GBM by activating the EMT signaling pathway.PMID:35571491 | PMC:PMC9098331 | DOI:10.1155/2022/8016102
Source: Journal of Oncology - May 16, 2022 Category: Cancer & Oncology Authors: Sun Eryi Li Zheng Cai Honghua Zhao Su Xie Han Pan Donggang Zhou Zhou Zhan Liping Chen Bo Source Type: research
The Neurokinin-1 Receptor Is Essential for the Viability of Human Glioma Cells: A Possible Target for Treating Glioblastoma
CONCLUSIONS: Our results show for the first time that the expression of the TAC1R gene (NK-1R) is essential for the viability of GAMG and U-87 MG glioma cells. On the contrary, the TAC1R gene is not essential for the viability of normal cells, confirming that NK-1R could be a promising and specific therapeutic target for the treatment of glioma.PMID:35434136 | PMC:PMC9006081 | DOI:10.1155/2022/6291504
Source: Cell Research - April 18, 2022 Category: Cytology Authors: Mario F Mu ñoz Sandro Arg üelles Marisa Rosso Rafael Medina Rafael Cove ñas Antonio Ayala Miguel Mu ñoz Source Type: research
Sevoflurane Induces Ferroptosis of Glioma Cells Through Activating the ATF4-CHAC1 Pathway
ConclusionsIn summary, this study suggested that Sev exposure-induced ferroptosis by the ATF4-CHAC1 pathway in glioma cells.
Source: Frontiers in Oncology - March 17, 2022 Category: Cancer & Oncology Source Type: research
LncRNA HOTAIR sponges miR-301a-3p to promote glioblastoma proliferation and invasion through upregulating FOSL1
In this study, HOTAIR expression was found to be positively regulated by TRPM7, significantly upregulated in glioma tissues, and is a poor prognosis factor for glioma patients. Moreover, reduced HOTAIR expression impeded the proliferation and invasion of glioma cells. Mechanistically, HOTAIR directly interacted with miR-301a-3p, and downregulation of miR-301a-3p efficiently reversed FOSL1 suppression induced by siRNA HOTAIR, which implied that HOTAIR positively regulated FOSL1 level through sponging miR-301a-3p and played an oncogenic role in glioma progression. In contrast to HOTAIR's role, miR-301a-3p alone served as a t...
Source: Cellular Signalling - March 16, 2022 Category: Cytology Authors: Shanchun Guo Pendelton King Emily Liang Alyssa A Guo Mingli Liu Source Type: research
Targeting long non-coding RNA PVT1/TGF- β/Smad by p53 prevents glioma progression
This study discussed the impact of p53/lncRNA plasmacytoma variant translocation 1 (lncRNA PVT1)/transforming growth factor beta (TGF-β)/Smad axis on the biological characteristics of glioma. Glioma and normal tissues were collected, in which relative lncRNA PVT1 and p53 expression was assessed. Pearson's analysis was adopted for the correlation analysis between lncRNA PVT1 and p53. Short interfering RNA (siRNA) against lncRNA PVT1 (siRNA-PVT1), siRNA-p53 or both was transfected into the glioma cells to evaluate effects of lncRNA PVT1 and p53 on cell proliferation, migration, invasion, and apoptosis. Mouse xenograft model...
Source: Cancer Biology and Therapy - March 11, 2022 Category: Cancer & Oncology Authors: Zhang Li Ming Li Pengcheng Xia Lili Wang Zhiming Lu Source Type: research
