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Lactate-induced up-regulation of PLEKHA4 promotes proliferation and apoptosis of human glioma cells
CONCLUSION: PLEKHA4 knockdown inhibited the proliferation of glioma cells and promoted apoptosis by inhibiting the activation of the MAPK signaling pathway and expression of β-catenin. Lactic acid produced by glycolysis upregulates the expression of PLEKHA4 in glioma cells.PMID:37488789 | PMC:PMC10366507 | DOI:10.12122/j.issn.1673-4254.2023.07.03
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: J Ye W Xu B Xi N Wang T Chen Source Type: research
