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Cancer: Glioma
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Total 625 results found since Jan 2013.
Enhanced expression of Pentraxin-3 in glioblastoma cells correlates with increased invasion and IL8-VEGF signaling axis
In this study, we examined the role of PTX3 in GB growth, angiogenesis, and invasion using in vitro and in vivo GB models, proteomic profiling, molecular and biochemical approaches. Under in vitro conditions, PTX3 over-expression in U87 cells correlated with cell cycle progression, increased migratory potential, and proliferation under hypoxic conditions. Conditioned media containing PTX3 enhanced the angiogenic potential of endothelial cells. While silencing of PTX3 by siRNA decreased the proliferation, migration, and angiogenic potential of U87 cells in vitro. Importantly, PTX3 over-expression increased tumor growth, ang...
Source: Brain Research - December 15, 2021 Category: Neurology Authors: Umadevi V Wesley Ian Sutton Paul A Clark Katelin Cunningham Carolina Larrain John S Kuo Robert J Dempsey Source Type: research
BNIP3 contributes to silibinin-induced DNA double strand breaks in glioma cells via inhibition of mTOR
In this study, we find that silibinin triggers DNA DSBs, ROS accumulation and expressional upregulation of BNIP3 in glioma cells. Mitigation of ROS with antioxidant GSH significantly inhibits silibinin-induced DNA DSBs and glioma cell death. Then, we find knockdown of BNIP3 with SiRNA obviously prevents silibinin-induced DNA DSBs and ROS accumulation. Mechanistically, BNIP3 knockdown not only reverses silibinin-triggered depletion of cysteine and GSH via maintaining xCT level, but also abrogates catalase decrease. Notably, silibinin-induced dephosphorylation of mTOR is also prevented when BNIP3 is knocked down. Given that ...
Source: Biochemical and Biophysical Research communications - December 9, 2021 Category: Biochemistry Authors: Cong Hua Xuanzhong Wang Shipeng Liang Xi Chen Chen Li Guangqiang You Chongcheng Wang Tianfei Luo Zhenchuan Wang Pengfei Ge Source Type: research
Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway
This study demonstrates that autophagy inhibition induced by MCOLN1/TRPML1 suppresses cancer metastasis by evoking the ROS-mediated TP53/p53 pathway. First, we found that MCOLN1-mediated autophagy inhibition not only profoundly inhibits both migration and invasion in malignant melanoma and glioma cell lines in vitro, but also suppresses melanoma metastasis in vivo. Second, our study reveals that autophagy inhibition induced by MCOLN1 leads to damaged mitochondria accumulation followed by large quantities of ROS release. Third, we demonstrate that the elevated ROS resulting from autophagy inhibition subsequently triggers TP...
Source: Autophagy - December 8, 2021 Category: Cytology Authors: Yanhong Xing Xiangqing Wei Yucheng Liu Meng-Meng Wang Zhongheng Sui Xinyan Wang Wucheng Zhu Mengmei Wu Chen Lu Yuan-Hui Fei Yi Jiang Yang Zhang Yuqing Wang Feng Guo Jun-Li Cao Jiansong Qi Wuyang Wang Source Type: research
Cancers, Vol. 13, Pages 6160: Microglial Cytokines Induce Invasiveness and Proliferation of Human Glioblastoma through Pyk2 and FAK Activation
In this study, 20 human glioblastoma specimens were evaluated with the use of RT-PCR and western blotting. A Pierson correlation test demonstrated a correlation (0.6–1.0) between the gene expression levels for platelet-derived growth factor β(PDGFβ), stromal-derived factor 1α (SDF-1α), IL-6, IL-8, and epidermal growth factor (EGF) in tumor-purified microglia and levels of p-Pyk2 (Y579/Y580) and p-FAK(Y925) in glioma cells. siRNA knockdown against Pyk2 or FAK in three primary glioblastoma cell lines, developed from the investigated specimens, in combination...
Source: Cancers - December 7, 2021 Category: Cancer & Oncology Authors: Rebeca E. Nu ñez Miguel Mayol del Valle Kyle Ortiz Luis Almodovar Lilia Kucheryavykh Tags: Article Source Type: research
Cancers, Vol. 13, Pages 5943: MEOX2 Transcription Factor Is Involved in Survival and Adhesion of Glioma Stem-Like Cells
In this study, we unraveled, for the first time, MEOX2 contribution to cell viability and proliferation through AKT/ERK pathway and its potential involvement in phenotype and adhesion properties of GSC.
Source: Cancers - November 25, 2021 Category: Cancer & Oncology Authors: Ga ëlle Tachon Konstantin Masliantsev Pierre Rivet Amandine Desette Serge Milin Elise Gueret Michel Wager Lucie Karayan-Tapon Pierre-Olivier Guichet Tags: Article Source Type: research
Posttranscriptional inhibition of γ-adducin promotes the proliferation and migration of osteosarcoma cells
CONCLUSIONS: Our study found that ADD3 functioned as a tumor suppressor gene during osteosarcoma development. The abnormal upregulation of miR-23b-3p targeted the expression of ADD3 and resulted in accelerated osteosarcoma cell proliferation and migration. Thus, the miR-23b-3p/ADD3 axis contributes to the development of osteosarcoma and ADD3 is a key driver of malignancy.PMID:34632867 | DOI:10.1177/03008916211050687
Source: Tumori - October 11, 2021 Category: Cancer & Oncology Authors: Zhigang Suo Xiucai Ma Yueping Ding Yu Zhou Xiangguo Duan Le Fei Jianmin Song Huiqiang Ding Source Type: research
SOCS3 is Related to Cell Proliferation in Neuronal Tissue: An Integrated Analysis of Bioinformatics and Experiments
Glioma is the most common primary malignant tumor that occurs in the central nervous system. Gliomas are subdivided according to a combination of microscopic morphological, molecular, and genetic factors. Glioblastoma (GBM) is the most aggressive malignant tumor; however, efficient therapies or specific target molecules for GBM have not been developed. We accessed RNA-seq and clinical data from The Cancer Genome Atlas, the Chinese Glioma Genome Atlas, and the GSE16011 dataset, and identified differentially expressed genes (DEGs) that were common to both GBM and lower-grade glioma (LGG) in three independent cohorts. The bio...
Source: Frontiers in Genetics - September 27, 2021 Category: Genetics & Stem Cells Source Type: research
