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Cancer: Glioma

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Total 625 results found since Jan 2013.

Intelligent Nanoparticles With pH-Sensitive Co-Delivery of Temozolomide and siEGFR to Ameliorate Glioma Therapy
In this study, pH-sensitive and GBM-targeting nanovesicle (Tf-PEG-PAE(SS)) was fabricated. The chemotherapy drug (TMZ) and EGFR inhibitor (EGFR-siRNA) were co-encapsulated in the nanocarrier, and their anticancer outcomes were investigated in detail. In vitro experiments have shown that the nanocarrier transports TMZ and EGFR-siRNA efficiently into U87 cells, causing a vigorous apoptotic response by silencing the proliferative EGFR gene and increasing the drug concentration of TMZ simultaneously. An experimental study in mice bearing orthotropic glioma revealed that the accumulated nanocarriers in the tumor site could inhi...
Source: Frontiers in Genetics - July 12, 2022 Category: Genetics & Stem Cells Source Type: research

FMR1NB Involved in Glioma Tumorigenesis Is a Promising Target for Prognosis and Therapy
ConclusionOur findings suggest that FMR1NB contributes to the tumorigenesis of glioma cells and may represent a potential prognostic biomarker and an attractive therapeutic target in glioma.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - July 11, 2022 Category: Research Source Type: research

Centromere protein J is overexpressed in human glioblastoma and promotes cell proliferation and migration
AbstractGlioblastoma is the most common and malignant type of primary brain tumor. Previous studies have shown that alterations in centrosome amplification and its components are frequently found in treatment-resistant tumors and may be associated with tumor progression. A centrosome protein essential for centrosome biogenesis is the centromere protein J (CENPJ), known to control the proliferation of neural progenitors and hepatocarcinoma cells, and also neuronal migration. However, it remains unknown the role of CENPJ in glioblastoma. Here we show that CENPJ is overexpressed in human glioblastoma cell lines in comparison ...
Source: Journal of Neurochemistry - July 7, 2022 Category: Neuroscience Authors: Gabriella P. A. de Freitas, Luiz Henrique M. Geraldo, Bruna M. Faria, Soniza Vieira Alves ‐Leon, Jorge Marcondes de Souza, Vivaldo Moura‐Neto, Bruno Pontes, Luciana F. Romão, Patrícia P. Garcez Tags: ORIGINAL ARTICLE Source Type: research

GSE189462 LncRNA SPRY4-IT1 Facilitates Cell Proliferation and Angiogenesis of Glioma by the miR-101-3p/EZH2/VEGFA Signaling Axis
Contributors : Ji Wang ; Yanming Chen ; Qing LanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSPRY4-IT1 (SPRY4 intronic transcript 1) is a long non-coding RNA (lncRNA) that was identified as a novel oncogene in various human cancers, including glioma. However, its function and the further mechanism in glioma remain largely unclear. Here, we aimed to investigate the role of SPRY4-IT1 in the development of glioma and its underlying molecular mechanism. We identify that SPRY4-IT1 is overexpressed in patients with glioma from the TCGA database and own cohort, and correlated with poor pr...
Source: GEO: Gene Expression Omnibus - June 30, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Cancers, Vol. 14, Pages 3122: Cordycepin (3 & prime;-Deoxyadenosine) Suppresses Heat Shock Protein 90 Function and Targets Tumor Growth in an Adenosine Deaminase-Dependent Manner
Cancers, Vol. 14, Pages 3122: Cordycepin (3′-Deoxyadenosine) Suppresses Heat Shock Protein 90 Function and Targets Tumor Growth in an Adenosine Deaminase-Dependent Manner Cancers doi: 10.3390/cancers14133122 Authors: Su-Chan Lee Lujain Alaali HyukJean Kwon Mohammed Rigi Charles G. Eberhart Alterations in metabolism and energy production are increasingly being recognized as important drivers of neoplasia, raising the possibility that metabolic analogs could disrupt oncogenic pathways. 3′-deoxyadenosine, also known as cordycepin, is an adenosine analog that inhibits the growth of sever...
Source: Cancers - June 25, 2022 Category: Cancer & Oncology Authors: Su-Chan Lee Lujain Alaali HyukJean Kwon Mohammed Rigi Charles G. Eberhart Tags: Article Source Type: research

The role of A-kinase interacting protein 1 in regulating progression and stemness as well as indicating the prognosis in glioblastoma
CONCLUSIONS: AKIP1 regulates the malignant behaviors and stemness of GBM via regulating multiple carcinogenetic pathways.PMID:35691247 | DOI:10.1016/j.tranon.2022.101463
Source: Translational Oncology - June 12, 2022 Category: Cancer & Oncology Authors: Jingxia Tang Shirong Peng Haifeng Yan Ming Ni Xiaodan Hou Peizhi Ma Yuanlong Li Source Type: research

Interference of P2X4 receptor expression in tumor-associated macrophages suppresses migration and invasion of glioma cells
CONCLUSION: Interference of P2X4 receptor in the TAMs suppresses the migration and invasion of glioma cells possibly by lowering the expressions of IL-1β and IL-18.PMID:35673908 | PMC:PMC9178632 | DOI:10.12122/j.issn.1673-4254.2022.05.05
Source: Journal of Southern Medical University - June 8, 2022 Category: Universities & Medical Training Authors: X Yang H Shen Q Li Z Dai R Yang G Huang R Chen F Wang J Song H Hua Source Type: research