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Cancer: Glioma

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Total 625 results found since Jan 2013.

Identification of Immune-Related Genes Contributing to the Development of Glioblastoma Using Weighted Gene Co-expression Network Analysis
Conclusions: Our results demonstrated that TREM1 could be used as a novel immunotherapy target for glioma patients.
Source: Frontiers in Immunology - July 15, 2020 Category: Allergy & Immunology Source Type: research

Circ-ABCB10 acts as an oncogene in glioma cells via regulation of the miR-620/FABP5 axis.
CONCLUSIONS: These data suggest that circ-ABCB10 affects glioma progression by regulating the miR-620/FABP5 axis, and circ-ABCB10 might be used as a potential target for the treatment of glioma. PMID: 32633377 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 9, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Long Noncoding RNASBF2-AS1 Promotes Gastric Cancer Progression via Regulating miR-545/EMS1 Axis.
Conclusion: These findings elucidated a crucial role of SBF2-AS1 as a miR-545 sponge in GC cells, suggesting that SBF2-AS1 might be a potential target for GC. PMID: 32626753 [PubMed - in process]
Source: Biomed Res - July 8, 2020 Category: Research Authors: He M, Feng L, Qi L, Rao M, Zhu Y Tags: Biomed Res Int Source Type: research

Silica Perturbs Primary Cilia and Causes Myofibroblast Differentiation during Silicosis by Reduction of the KIF3A-Repressor GLI3 Complex
Conclusion: Our findings indicate that primary cilia are markedly altered during silicosis and the loss of KIF3A may promote myofibroblast differentiation induced by SiO2.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Shifeng Li, Zhongqiu Wei, Gengxu Li, Qiaodan Zhang, Siyu Niu, Dingjie Xu, Na Mao, Si Chen, Xuemin Gao, Wenchen Cai, Ying Zhu, Guizhen Zhang, Dan Li, Xue Yi, Fang Yang, Hong Xu Tags: Research Paper Source Type: research

Silencing of NAMPT leads to up-regulation of insulin receptor substrate 1 gene expression in U87 glioma cells.
CONCLUSIONS: Results of this investigation demonstrated that silencing of NAMPT mRNA with corresponding down-regulation of NAMPT protein and suppression of the glioma cell proliferation affected the expression of IRS1 gene as well as many other genes encoding the proliferation related proteins. It is possible that dysregulation of most of the studied genes in glioma cells after silencing of NAMPT is reflected by a complex of intergenic interactions and that NAMPT is an important factor for genome stability and regulatory mechanisms contributing to the control of glioma cell metabolism and proliferation. PMID: 32597148 ...
Source: Endocrine Regulations - July 2, 2020 Category: Endocrinology Tags: Endocr Regul Source Type: research

RGFP966, a Histone deacetylase 3 inhibitor, promotes glioma stem cell differentiation by blocking TGF- β signaling via SMAD7.
RGFP966, a Histone deacetylase 3 inhibitor, promotes glioma stem cell differentiation by blocking TGF-β signaling via SMAD7. Biochem Pharmacol. 2020 Jun 22;:114118 Authors: Liang H, Wang Q, Wang D, Zheng H, Kalvakolanu DV, Lu H, Wen N, Chen X, Xu L, Ren J, Guo B, Zhang L Abstract Glioma stem cells (GSC) play a major role in drug resistance and tumor recurrence. Using a genetic screen with a set of shRNAs that can target chromatin regulators in a GSC model, we have HDAC3 as a major negative regulator of GSC differentiation. Inhibition of HDAC3 using a pharmacological inhibitor or a siRNA led to the in...
Source: Biochemical Pharmacology - June 21, 2020 Category: Drugs & Pharmacology Authors: Liang H, Wang Q, Wang D, Zheng H, Kalvakolanu DV, Lu H, Wen N, Chen X, Xu L, Ren J, Guo B, Zhang L Tags: Biochem Pharmacol Source Type: research

KDELR2 is an unfavorable prognostic biomarker and regulates CCND1 to promote tumor progression in glioma.
CONCLUSIONS: KDELR2 is highly expressed in human glioma tissues and cell lines, a higher expression of KDELR2 is associated with a poor prognosis of glioma patients. Moreover, KDELR2 regulated the cellular functions of U87 cells by targeting CCND1. The KDELR2/CCND1 axis may provide a new therapeutic target for the treatment of glioma and deepen our understanding of glioma mechanisms. PMID: 32534703 [PubMed - as supplied by publisher]
Source: Pathology, Research and Practice - June 16, 2020 Category: Pathology Authors: Hui M, Nian J, Wang Z, Li X, Huang C Tags: Pathol Res Pract Source Type: research

Roles of circ-CSPP1 on the proliferation and metastasis of glioma cancer.
CONCLUSIONS: Circ-CSPP1 promoted the proliferation, invasion, and migration of GC cells. PMID: 32495924 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - June 5, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Knockdown of Tousled ‑like kinase 1 inhibits survival of glioblastoma multiforme cells.
Knockdown of Tousled‑like kinase 1 inhibits survival of glioblastoma multiforme cells. Int J Mol Med. 2020 May 28;: Authors: Ibrahim K, Abdul Murad NA, Harun R, Jamal R Abstract Glioblastoma multiforme (GBM) is an aggressive type of brain tumour that commonly exhibits resistance to treatment. The tumour is highly heterogenous and complex kinomic alterations have been reported leading to dysregulation of signalling pathways. The present study aimed to investigate the novel kinome pathways and to identify potential therapeutic targets in GBM. Meta‑analysis using Oncomine identified 113 upregulated k...
Source: International Journal of Molecular Medicine - May 27, 2020 Category: Molecular Biology Authors: Ibrahim K, Abdul Murad NA, Harun R, Jamal R Tags: Int J Mol Med Source Type: research

CD73 as a target to improve temozolomide chemotherapy effect in glioblastoma preclinical model
AbstractGlioblastoma is the most devastating primary brain tumor and effective therapies are not available. Treatment is based on surgery followed by radio and chemotherapy with temozolomide (TMZ), but TMZ increases patient survival only by 2  months. CD73, an enzyme responsible for adenosine production, emerges as a target for glioblastoma treatment. Indeed, adenosine causes tumor-promoting actions and CD73 inhibition increases sensitivity to TMZ in vitro. Here, a cationic nanoemulsion to nasal delivery of siRNA CD73 (NE-siRNA CD73) ai ming glioblastoma treatment was employed alone or in combination with TMZ. In vitro, t...
Source: Cancer Chemotherapy and Pharmacology - May 15, 2020 Category: Cancer & Oncology Source Type: research

siRNA and chemotherapeutic molecules entrapped into a redox-responsive platform for targeted synergistic combination therapy of glioma
Publication date: Available online 13 May 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Lijuan Wen, Changlong Wen, Fengtian Zhang, Kai Wang, Hong Yuan, Fuqiang Hu
Source: Nanomedicine: Nanotechnology, Biology and Medicine - May 14, 2020 Category: Nanotechnology Source Type: research

Downregulation of FHL1 protein in glioma inhibits tumor growth through PI3K/AKT signaling.
In conclusion, the results of the present study demonstrated that FHL1 suppressed glioma development through PI3K/AKT signaling. PMID: 32382330 [PubMed]
Source: Oncology Letters - May 10, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

MUC15 promotes growth and invasion of glioma cells by activating Raf/MEK/ERK pathway.
In this study, high MUC15 levels were detected in glioma tissues and cells. We found that transfection with MUC15 siRNA in U251 and T98G cells reduced MUC15 expression and decreased cell proliferation, invasion, and migration (p<0.05). After transfecting U251 and T98G cells with pcDNA3.1-myc-His-MUC15 plasmid to overexpress MUC15, MUC15 expression was significantly upregulated and cell proliferation, invasion, and migration were increased (p<0.05). MUC15 activated Raf/MEK/ERK signaling pathway and the ERK inhibitor PD98059 partly reversed MUC15-enhanced proliferation, invasion, and migration of glioma cells (p<0.0...
Source: Clinical and Experimental Pharmacology and Physiology - February 6, 2020 Category: Drugs & Pharmacology Authors: Cheng M, Liu L Tags: Clin Exp Pharmacol Physiol Source Type: research

Knockdown of MCM10 Gene Impairs Glioblastoma Cell Proliferation, Migration and Invasion and the Implications for the Regulation of Tumorigenesis
AbstractMinichromosome maintenance 10 (MCM10) plays an important role in DNA replication and is expressed in a variety of tumors, including glioma. However, its role and mechanism in glioma remain elusive. The purpose of this study was to examine the molecular function of MCM10 in glioblastoma cell lines in vitro and to further investigate the molecular mechanisms in the network mediated by MCM10. Cell proliferation, invasion, and migration were investigated in the absence of MCM10 mediated by RNA interference (RNAi) in U87 and U251 cell lines. Microarray data were obtained from U87 cells infected with a lentivirus express...
Source: Journal of Molecular Neuroscience - February 5, 2020 Category: Neuroscience Source Type: research

Correction to: Co-delivery of GOLPH3 siRNA and gefitinib by cationic lipid-PLGA nanoparticles improves EGFR-targeted therapy for glioma
The correct affiliation no 2 is presented in this paper.
Source: Journal of Molecular Medicine - January 2, 2020 Category: Molecular Biology Source Type: research