Selected 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors. A look into their use and potential in pre-diabetes and type 2 diabetes
Conclusions. Selected statins, FLC, CAs and HMGA can manage or have a potential to manage at least three features of the cluster of seven. Most of the literature-stated concerns are with select statins but there are concerns (one actual and two potential) with HMGA.PMID:34523296 | DOI:10.2478/enr-2021-0020 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Douglas Edward Barre Kazimiera Amelia Mizier-Barre Source Type: research

Tumor-induced osteomalacia - a mystery illness beyond aches, pains, and depression
Conclusion. The present case demonstrated the need to extensively investigate causes of generalized bone pain in patients with hypophosphatemia, as TIO is highly curable. Importantly, 68Ga-DOTATATE PET/CT imaging successfully identified the FGF23 producing tumor, which was undetectable by conventional imaging, favoring its early use in suspected TIO presentation. The present report highlights the importance of timely diagnosis of this complex medical condition, aiming to improve general awareness and enable better clinical outcomes for this rare disorder.PMID:34523297 | DOI:10.2478/enr-2021-0017 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Huajing Jing Ni Roderick Clifton-Bligh Malgorzata Monika Brzozowska Source Type: research

Graves' disease with spontaneous resolution following ocrelizumab in primary progressive multiple sclerosis
Conclusions. This is the first case of GD reported after ocrelizumab administration. The timing, onset and course of this case is similar to alemtuzumab-induced GD, usually interpreted as an "immune reconstitution syndrome"; however, ocrelizumab cell count depletion is inferior in severity, cell population affected and duration of depletion. This case highlights the importance of pre-screening and follow-up with thyroid function tests in patients treated with ocrelizumab. As a novel therapeutic antibody, further investigation is required to unravel the causes of thyroid autoimmunity.PMID:34523298 | DOI:10.2478/en...
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Diana Borges Duarte Ana Martins da Silva Claudia Freitas Helena Cardoso Source Type: research

Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
Conclusion. The present data indicate that HAL and ARI in the doses 1 mg/kg or 10 mg/kg, respectively, does not modify the effect of the CMS preconditioning on the BDNF and GR mRNA levels in the PFC or the HIP. However, HAL seems to modify the CMS effect on the HIP activation.PMID:34523299 | DOI:10.2478/enr-2021-0016 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Jana Osacka Romana Koprdova Andrej Tillinger Zdenko Pirnik Alexander Kiss Source Type: research

Does thyroid dysfunction influence inflammatory mediators in experimental periodontitis?
Endocr Regul. 2021 Sep 13;55(3):131-141. doi: 10.2478/enr-2021-0014.ABSTRACTObjective. The aim of the present study was to investigate the presence of inflammatory mediators in rats with only periodontitis and periodontitis in a setting of hyper- and hypo-thyroidism and to analyze the correlative linkages between inflammatory mediators and thyroid hormones. Methods. White male 12-14 weeks old inbred rats (n=48) weighing 180-200 g were employed in the experiment. They were randomly divided into the following groups: Group I - control group, Group II - group with a model of periodontitis, Group III - group with a periodontit...
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Vitaliy Shcherba Inna Krynytska Mariya Marushchak Mykhaylo Korda Source Type: research

Quercetin improves myocardial redox status in rats with type 2 diabetes
Conclusions. The findings demonstrate that Q in both doses 10 mg/kg and 50 mg/kg can protect from the development of oxidative stress in cardiomyocytes in the diabetic rats. The present data indicate that the use of Q may contribute to the amelioration of cardiovascular risk in patients with T2DM.PMID:34523301 | DOI:10.2478/enr-2021-0015 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Nataliia I Gorbenko Oleksii Yu Borikov Tetiana V Kiprych Olha V Ivanova Kateryna V Taran Tetiana S Litvinova Source Type: research

Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?
Endocr Regul. 2021 Sep 13;55(3):174-181. doi: 10.2478/enr-2021-0019.ABSTRACTThe pathophysiology of COVID comprises an exaggerated pro-inflammatory response. Hypothalamic-pituitary-adrenal (HPA) axis has a crucial role in various inflammatory conditions and modulated immunological response. Limited evidence is available regarding the incidence and the effect of HPA dysfunction in COVID-19. Although the cortisol levels have only been estimated in a few studies, the dehydroepiandrosterone sulfate (DHEAS) release from the adrenal gland has not been explored yet. In this mini review, the authors discuss the role of dehydroepian...
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Sojit Tomo Mithu Banerjee Praveen Sharma Mahendra Garg Source Type: research

Selected 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors. A look into their use and potential in pre-diabetes and type 2 diabetes
Conclusions. Selected statins, FLC, CAs and HMGA can manage or have a potential to manage at least three features of the cluster of seven. Most of the literature-stated concerns are with select statins but there are concerns (one actual and two potential) with HMGA.PMID:34523296 | DOI:10.2478/enr-2021-0020 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Douglas Edward Barre Kazimiera Amelia Mizier-Barre Source Type: research

Tumor-induced osteomalacia - a mystery illness beyond aches, pains, and depression
Conclusion. The present case demonstrated the need to extensively investigate causes of generalized bone pain in patients with hypophosphatemia, as TIO is highly curable. Importantly, 68Ga-DOTATATE PET/CT imaging successfully identified the FGF23 producing tumor, which was undetectable by conventional imaging, favoring its early use in suspected TIO presentation. The present report highlights the importance of timely diagnosis of this complex medical condition, aiming to improve general awareness and enable better clinical outcomes for this rare disorder.PMID:34523297 | DOI:10.2478/enr-2021-0017 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Huajing Jing Ni Roderick Clifton-Bligh Malgorzata Monika Brzozowska Source Type: research

Graves' disease with spontaneous resolution following ocrelizumab in primary progressive multiple sclerosis
Conclusions. This is the first case of GD reported after ocrelizumab administration. The timing, onset and course of this case is similar to alemtuzumab-induced GD, usually interpreted as an "immune reconstitution syndrome"; however, ocrelizumab cell count depletion is inferior in severity, cell population affected and duration of depletion. This case highlights the importance of pre-screening and follow-up with thyroid function tests in patients treated with ocrelizumab. As a novel therapeutic antibody, further investigation is required to unravel the causes of thyroid autoimmunity.PMID:34523298 | DOI:10.2478/en...
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Diana Borges Duarte Ana Martins da Silva Claudia Freitas Helena Cardoso Source Type: research

Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
Conclusion. The present data indicate that HAL and ARI in the doses 1 mg/kg or 10 mg/kg, respectively, does not modify the effect of the CMS preconditioning on the BDNF and GR mRNA levels in the PFC or the HIP. However, HAL seems to modify the CMS effect on the HIP activation.PMID:34523299 | DOI:10.2478/enr-2021-0016 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Jana Osacka Romana Koprdova Andrej Tillinger Zdenko Pirnik Alexander Kiss Source Type: research

Does thyroid dysfunction influence inflammatory mediators in experimental periodontitis?
Endocr Regul. 2021 Sep 13;55(3):131-141. doi: 10.2478/enr-2021-0014.ABSTRACTObjective. The aim of the present study was to investigate the presence of inflammatory mediators in rats with only periodontitis and periodontitis in a setting of hyper- and hypo-thyroidism and to analyze the correlative linkages between inflammatory mediators and thyroid hormones. Methods. White male 12-14 weeks old inbred rats (n=48) weighing 180-200 g were employed in the experiment. They were randomly divided into the following groups: Group I - control group, Group II - group with a model of periodontitis, Group III - group with a periodontit...
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Vitaliy Shcherba Inna Krynytska Mariya Marushchak Mykhaylo Korda Source Type: research

Quercetin improves myocardial redox status in rats with type 2 diabetes
Conclusions. The findings demonstrate that Q in both doses 10 mg/kg and 50 mg/kg can protect from the development of oxidative stress in cardiomyocytes in the diabetic rats. The present data indicate that the use of Q may contribute to the amelioration of cardiovascular risk in patients with T2DM.PMID:34523301 | DOI:10.2478/enr-2021-0015 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Nataliia I Gorbenko Oleksii Yu Borikov Tetiana V Kiprych Olha V Ivanova Kateryna V Taran Tetiana S Litvinova Source Type: research

Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?
Endocr Regul. 2021 Sep 13;55(3):174-181. doi: 10.2478/enr-2021-0019.ABSTRACTThe pathophysiology of COVID comprises an exaggerated pro-inflammatory response. Hypothalamic-pituitary-adrenal (HPA) axis has a crucial role in various inflammatory conditions and modulated immunological response. Limited evidence is available regarding the incidence and the effect of HPA dysfunction in COVID-19. Although the cortisol levels have only been estimated in a few studies, the dehydroepiandrosterone sulfate (DHEAS) release from the adrenal gland has not been explored yet. In this mini review, the authors discuss the role of dehydroepian...
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Sojit Tomo Mithu Banerjee Praveen Sharma Mahendra Garg Source Type: research

Selected 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors. A look into their use and potential in pre-diabetes and type 2 diabetes
Conclusions. Selected statins, FLC, CAs and HMGA can manage or have a potential to manage at least three features of the cluster of seven. Most of the literature-stated concerns are with select statins but there are concerns (one actual and two potential) with HMGA.PMID:34523296 | DOI:10.2478/enr-2021-0020 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Douglas Edward Barre Kazimiera Amelia Mizier-Barre Source Type: research

Tumor-induced osteomalacia - a mystery illness beyond aches, pains, and depression
Conclusion. The present case demonstrated the need to extensively investigate causes of generalized bone pain in patients with hypophosphatemia, as TIO is highly curable. Importantly, 68Ga-DOTATATE PET/CT imaging successfully identified the FGF23 producing tumor, which was undetectable by conventional imaging, favoring its early use in suspected TIO presentation. The present report highlights the importance of timely diagnosis of this complex medical condition, aiming to improve general awareness and enable better clinical outcomes for this rare disorder.PMID:34523297 | DOI:10.2478/enr-2021-0017 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Huajing Jing Ni Roderick Clifton-Bligh Malgorzata Monika Brzozowska Source Type: research

Graves' disease with spontaneous resolution following ocrelizumab in primary progressive multiple sclerosis
Conclusions. This is the first case of GD reported after ocrelizumab administration. The timing, onset and course of this case is similar to alemtuzumab-induced GD, usually interpreted as an "immune reconstitution syndrome"; however, ocrelizumab cell count depletion is inferior in severity, cell population affected and duration of depletion. This case highlights the importance of pre-screening and follow-up with thyroid function tests in patients treated with ocrelizumab. As a novel therapeutic antibody, further investigation is required to unravel the causes of thyroid autoimmunity.PMID:34523298 | DOI:10.2478/en...
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Diana Borges Duarte Ana Martins da Silva Claudia Freitas Helena Cardoso Source Type: research

Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
Conclusion. The present data indicate that HAL and ARI in the doses 1 mg/kg or 10 mg/kg, respectively, does not modify the effect of the CMS preconditioning on the BDNF and GR mRNA levels in the PFC or the HIP. However, HAL seems to modify the CMS effect on the HIP activation.PMID:34523299 | DOI:10.2478/enr-2021-0016 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Jana Osacka Romana Koprdova Andrej Tillinger Zdenko Pirnik Alexander Kiss Source Type: research

Does thyroid dysfunction influence inflammatory mediators in experimental periodontitis?
Endocr Regul. 2021 Sep 13;55(3):131-141. doi: 10.2478/enr-2021-0014.ABSTRACTObjective. The aim of the present study was to investigate the presence of inflammatory mediators in rats with only periodontitis and periodontitis in a setting of hyper- and hypo-thyroidism and to analyze the correlative linkages between inflammatory mediators and thyroid hormones. Methods. White male 12-14 weeks old inbred rats (n=48) weighing 180-200 g were employed in the experiment. They were randomly divided into the following groups: Group I - control group, Group II - group with a model of periodontitis, Group III - group with a periodontit...
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Vitaliy Shcherba Inna Krynytska Mariya Marushchak Mykhaylo Korda Source Type: research

Quercetin improves myocardial redox status in rats with type 2 diabetes
Conclusions. The findings demonstrate that Q in both doses 10 mg/kg and 50 mg/kg can protect from the development of oxidative stress in cardiomyocytes in the diabetic rats. The present data indicate that the use of Q may contribute to the amelioration of cardiovascular risk in patients with T2DM.PMID:34523301 | DOI:10.2478/enr-2021-0015 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Nataliia I Gorbenko Oleksii Yu Borikov Tetiana V Kiprych Olha V Ivanova Kateryna V Taran Tetiana S Litvinova Source Type: research

Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?
Endocr Regul. 2021 Sep 13;55(3):174-181. doi: 10.2478/enr-2021-0019.ABSTRACTThe pathophysiology of COVID comprises an exaggerated pro-inflammatory response. Hypothalamic-pituitary-adrenal (HPA) axis has a crucial role in various inflammatory conditions and modulated immunological response. Limited evidence is available regarding the incidence and the effect of HPA dysfunction in COVID-19. Although the cortisol levels have only been estimated in a few studies, the dehydroepiandrosterone sulfate (DHEAS) release from the adrenal gland has not been explored yet. In this mini review, the authors discuss the role of dehydroepian...
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Sojit Tomo Mithu Banerjee Praveen Sharma Mahendra Garg Source Type: research

Selected 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors. A look into their use and potential in pre-diabetes and type 2 diabetes
Conclusions. Selected statins, FLC, CAs and HMGA can manage or have a potential to manage at least three features of the cluster of seven. Most of the literature-stated concerns are with select statins but there are concerns (one actual and two potential) with HMGA.PMID:34523296 | DOI:10.2478/enr-2021-0020 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Douglas Edward Barre Kazimiera Amelia Mizier-Barre Source Type: research

Tumor-induced osteomalacia - a mystery illness beyond aches, pains, and depression
Conclusion. The present case demonstrated the need to extensively investigate causes of generalized bone pain in patients with hypophosphatemia, as TIO is highly curable. Importantly, 68Ga-DOTATATE PET/CT imaging successfully identified the FGF23 producing tumor, which was undetectable by conventional imaging, favoring its early use in suspected TIO presentation. The present report highlights the importance of timely diagnosis of this complex medical condition, aiming to improve general awareness and enable better clinical outcomes for this rare disorder.PMID:34523297 | DOI:10.2478/enr-2021-0017 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Huajing Jing Ni Roderick Clifton-Bligh Malgorzata Monika Brzozowska Source Type: research

Graves' disease with spontaneous resolution following ocrelizumab in primary progressive multiple sclerosis
Conclusions. This is the first case of GD reported after ocrelizumab administration. The timing, onset and course of this case is similar to alemtuzumab-induced GD, usually interpreted as an "immune reconstitution syndrome"; however, ocrelizumab cell count depletion is inferior in severity, cell population affected and duration of depletion. This case highlights the importance of pre-screening and follow-up with thyroid function tests in patients treated with ocrelizumab. As a novel therapeutic antibody, further investigation is required to unravel the causes of thyroid autoimmunity.PMID:34523298 | DOI:10.2478/en...
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Diana Borges Duarte Ana Martins da Silva Claudia Freitas Helena Cardoso Source Type: research

Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
Conclusion. The present data indicate that HAL and ARI in the doses 1 mg/kg or 10 mg/kg, respectively, does not modify the effect of the CMS preconditioning on the BDNF and GR mRNA levels in the PFC or the HIP. However, HAL seems to modify the CMS effect on the HIP activation.PMID:34523299 | DOI:10.2478/enr-2021-0016 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Jana Osacka Romana Koprdova Andrej Tillinger Zdenko Pirnik Alexander Kiss Source Type: research

Does thyroid dysfunction influence inflammatory mediators in experimental periodontitis?
Endocr Regul. 2021 Sep 13;55(3):131-141. doi: 10.2478/enr-2021-0014.ABSTRACTObjective. The aim of the present study was to investigate the presence of inflammatory mediators in rats with only periodontitis and periodontitis in a setting of hyper- and hypo-thyroidism and to analyze the correlative linkages between inflammatory mediators and thyroid hormones. Methods. White male 12-14 weeks old inbred rats (n=48) weighing 180-200 g were employed in the experiment. They were randomly divided into the following groups: Group I - control group, Group II - group with a model of periodontitis, Group III - group with a periodontit...
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Vitaliy Shcherba Inna Krynytska Mariya Marushchak Mykhaylo Korda Source Type: research

Quercetin improves myocardial redox status in rats with type 2 diabetes
Conclusions. The findings demonstrate that Q in both doses 10 mg/kg and 50 mg/kg can protect from the development of oxidative stress in cardiomyocytes in the diabetic rats. The present data indicate that the use of Q may contribute to the amelioration of cardiovascular risk in patients with T2DM.PMID:34523301 | DOI:10.2478/enr-2021-0015 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Nataliia I Gorbenko Oleksii Yu Borikov Tetiana V Kiprych Olha V Ivanova Kateryna V Taran Tetiana S Litvinova Source Type: research

Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?
Endocr Regul. 2021 Sep 13;55(3):174-181. doi: 10.2478/enr-2021-0019.ABSTRACTThe pathophysiology of COVID comprises an exaggerated pro-inflammatory response. Hypothalamic-pituitary-adrenal (HPA) axis has a crucial role in various inflammatory conditions and modulated immunological response. Limited evidence is available regarding the incidence and the effect of HPA dysfunction in COVID-19. Although the cortisol levels have only been estimated in a few studies, the dehydroepiandrosterone sulfate (DHEAS) release from the adrenal gland has not been explored yet. In this mini review, the authors discuss the role of dehydroepian...
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Sojit Tomo Mithu Banerjee Praveen Sharma Mahendra Garg Source Type: research

Selected 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors. A look into their use and potential in pre-diabetes and type 2 diabetes
Conclusions. Selected statins, FLC, CAs and HMGA can manage or have a potential to manage at least three features of the cluster of seven. Most of the literature-stated concerns are with select statins but there are concerns (one actual and two potential) with HMGA.PMID:34523296 | DOI:10.2478/enr-2021-0020 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Douglas Edward Barre Kazimiera Amelia Mizier-Barre Source Type: research

Tumor-induced osteomalacia - a mystery illness beyond aches, pains, and depression
Conclusion. The present case demonstrated the need to extensively investigate causes of generalized bone pain in patients with hypophosphatemia, as TIO is highly curable. Importantly, 68Ga-DOTATATE PET/CT imaging successfully identified the FGF23 producing tumor, which was undetectable by conventional imaging, favoring its early use in suspected TIO presentation. The present report highlights the importance of timely diagnosis of this complex medical condition, aiming to improve general awareness and enable better clinical outcomes for this rare disorder.PMID:34523297 | DOI:10.2478/enr-2021-0017 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Huajing Jing Ni Roderick Clifton-Bligh Malgorzata Monika Brzozowska Source Type: research

Graves' disease with spontaneous resolution following ocrelizumab in primary progressive multiple sclerosis
Conclusions. This is the first case of GD reported after ocrelizumab administration. The timing, onset and course of this case is similar to alemtuzumab-induced GD, usually interpreted as an "immune reconstitution syndrome"; however, ocrelizumab cell count depletion is inferior in severity, cell population affected and duration of depletion. This case highlights the importance of pre-screening and follow-up with thyroid function tests in patients treated with ocrelizumab. As a novel therapeutic antibody, further investigation is required to unravel the causes of thyroid autoimmunity.PMID:34523298 | DOI:10.2478/en...
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Diana Borges Duarte Ana Martins da Silva Claudia Freitas Helena Cardoso Source Type: research

Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
Conclusion. The present data indicate that HAL and ARI in the doses 1 mg/kg or 10 mg/kg, respectively, does not modify the effect of the CMS preconditioning on the BDNF and GR mRNA levels in the PFC or the HIP. However, HAL seems to modify the CMS effect on the HIP activation.PMID:34523299 | DOI:10.2478/enr-2021-0016 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Jana Osacka Romana Koprdova Andrej Tillinger Zdenko Pirnik Alexander Kiss Source Type: research

Does thyroid dysfunction influence inflammatory mediators in experimental periodontitis?
Endocr Regul. 2021 Sep 13;55(3):131-141. doi: 10.2478/enr-2021-0014.ABSTRACTObjective. The aim of the present study was to investigate the presence of inflammatory mediators in rats with only periodontitis and periodontitis in a setting of hyper- and hypo-thyroidism and to analyze the correlative linkages between inflammatory mediators and thyroid hormones. Methods. White male 12-14 weeks old inbred rats (n=48) weighing 180-200 g were employed in the experiment. They were randomly divided into the following groups: Group I - control group, Group II - group with a model of periodontitis, Group III - group with a periodontit...
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Vitaliy Shcherba Inna Krynytska Mariya Marushchak Mykhaylo Korda Source Type: research

Quercetin improves myocardial redox status in rats with type 2 diabetes
Conclusions. The findings demonstrate that Q in both doses 10 mg/kg and 50 mg/kg can protect from the development of oxidative stress in cardiomyocytes in the diabetic rats. The present data indicate that the use of Q may contribute to the amelioration of cardiovascular risk in patients with T2DM.PMID:34523301 | DOI:10.2478/enr-2021-0015 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Nataliia I Gorbenko Oleksii Yu Borikov Tetiana V Kiprych Olha V Ivanova Kateryna V Taran Tetiana S Litvinova Source Type: research

Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?
Endocr Regul. 2021 Sep 13;55(3):174-181. doi: 10.2478/enr-2021-0019.ABSTRACTThe pathophysiology of COVID comprises an exaggerated pro-inflammatory response. Hypothalamic-pituitary-adrenal (HPA) axis has a crucial role in various inflammatory conditions and modulated immunological response. Limited evidence is available regarding the incidence and the effect of HPA dysfunction in COVID-19. Although the cortisol levels have only been estimated in a few studies, the dehydroepiandrosterone sulfate (DHEAS) release from the adrenal gland has not been explored yet. In this mini review, the authors discuss the role of dehydroepian...
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Sojit Tomo Mithu Banerjee Praveen Sharma Mahendra Garg Source Type: research

Selected 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors. A look into their use and potential in pre-diabetes and type 2 diabetes
Conclusions. Selected statins, FLC, CAs and HMGA can manage or have a potential to manage at least three features of the cluster of seven. Most of the literature-stated concerns are with select statins but there are concerns (one actual and two potential) with HMGA.PMID:34523296 | DOI:10.2478/enr-2021-0020 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Douglas Edward Barre Kazimiera Amelia Mizier-Barre Source Type: research

Tumor-induced osteomalacia - a mystery illness beyond aches, pains, and depression
Conclusion. The present case demonstrated the need to extensively investigate causes of generalized bone pain in patients with hypophosphatemia, as TIO is highly curable. Importantly, 68Ga-DOTATATE PET/CT imaging successfully identified the FGF23 producing tumor, which was undetectable by conventional imaging, favoring its early use in suspected TIO presentation. The present report highlights the importance of timely diagnosis of this complex medical condition, aiming to improve general awareness and enable better clinical outcomes for this rare disorder.PMID:34523297 | DOI:10.2478/enr-2021-0017 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Huajing Jing Ni Roderick Clifton-Bligh Malgorzata Monika Brzozowska Source Type: research

Graves' disease with spontaneous resolution following ocrelizumab in primary progressive multiple sclerosis
Conclusions. This is the first case of GD reported after ocrelizumab administration. The timing, onset and course of this case is similar to alemtuzumab-induced GD, usually interpreted as an "immune reconstitution syndrome"; however, ocrelizumab cell count depletion is inferior in severity, cell population affected and duration of depletion. This case highlights the importance of pre-screening and follow-up with thyroid function tests in patients treated with ocrelizumab. As a novel therapeutic antibody, further investigation is required to unravel the causes of thyroid autoimmunity.PMID:34523298 | DOI:10.2478/en...
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Diana Borges Duarte Ana Martins da Silva Claudia Freitas Helena Cardoso Source Type: research

Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
Conclusion. The present data indicate that HAL and ARI in the doses 1 mg/kg or 10 mg/kg, respectively, does not modify the effect of the CMS preconditioning on the BDNF and GR mRNA levels in the PFC or the HIP. However, HAL seems to modify the CMS effect on the HIP activation.PMID:34523299 | DOI:10.2478/enr-2021-0016 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Jana Osacka Romana Koprdova Andrej Tillinger Zdenko Pirnik Alexander Kiss Source Type: research

Does thyroid dysfunction influence inflammatory mediators in experimental periodontitis?
Endocr Regul. 2021 Sep 13;55(3):131-141. doi: 10.2478/enr-2021-0014.ABSTRACTObjective. The aim of the present study was to investigate the presence of inflammatory mediators in rats with only periodontitis and periodontitis in a setting of hyper- and hypo-thyroidism and to analyze the correlative linkages between inflammatory mediators and thyroid hormones. Methods. White male 12-14 weeks old inbred rats (n=48) weighing 180-200 g were employed in the experiment. They were randomly divided into the following groups: Group I - control group, Group II - group with a model of periodontitis, Group III - group with a periodontit...
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Vitaliy Shcherba Inna Krynytska Mariya Marushchak Mykhaylo Korda Source Type: research

Quercetin improves myocardial redox status in rats with type 2 diabetes
Conclusions. The findings demonstrate that Q in both doses 10 mg/kg and 50 mg/kg can protect from the development of oxidative stress in cardiomyocytes in the diabetic rats. The present data indicate that the use of Q may contribute to the amelioration of cardiovascular risk in patients with T2DM.PMID:34523301 | DOI:10.2478/enr-2021-0015 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Nataliia I Gorbenko Oleksii Yu Borikov Tetiana V Kiprych Olha V Ivanova Kateryna V Taran Tetiana S Litvinova Source Type: research

Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?
Endocr Regul. 2021 Sep 13;55(3):174-181. doi: 10.2478/enr-2021-0019.ABSTRACTThe pathophysiology of COVID comprises an exaggerated pro-inflammatory response. Hypothalamic-pituitary-adrenal (HPA) axis has a crucial role in various inflammatory conditions and modulated immunological response. Limited evidence is available regarding the incidence and the effect of HPA dysfunction in COVID-19. Although the cortisol levels have only been estimated in a few studies, the dehydroepiandrosterone sulfate (DHEAS) release from the adrenal gland has not been explored yet. In this mini review, the authors discuss the role of dehydroepian...
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Sojit Tomo Mithu Banerjee Praveen Sharma Mahendra Garg Source Type: research

Selected 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors. A look into their use and potential in pre-diabetes and type 2 diabetes
Conclusions. Selected statins, FLC, CAs and HMGA can manage or have a potential to manage at least three features of the cluster of seven. Most of the literature-stated concerns are with select statins but there are concerns (one actual and two potential) with HMGA.PMID:34523296 | DOI:10.2478/enr-2021-0020 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Douglas Edward Barre Kazimiera Amelia Mizier-Barre Source Type: research

Tumor-induced osteomalacia - a mystery illness beyond aches, pains, and depression
Conclusion. The present case demonstrated the need to extensively investigate causes of generalized bone pain in patients with hypophosphatemia, as TIO is highly curable. Importantly, 68Ga-DOTATATE PET/CT imaging successfully identified the FGF23 producing tumor, which was undetectable by conventional imaging, favoring its early use in suspected TIO presentation. The present report highlights the importance of timely diagnosis of this complex medical condition, aiming to improve general awareness and enable better clinical outcomes for this rare disorder.PMID:34523297 | DOI:10.2478/enr-2021-0017 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Huajing Jing Ni Roderick Clifton-Bligh Malgorzata Monika Brzozowska Source Type: research

Graves' disease with spontaneous resolution following ocrelizumab in primary progressive multiple sclerosis
Conclusions. This is the first case of GD reported after ocrelizumab administration. The timing, onset and course of this case is similar to alemtuzumab-induced GD, usually interpreted as an "immune reconstitution syndrome"; however, ocrelizumab cell count depletion is inferior in severity, cell population affected and duration of depletion. This case highlights the importance of pre-screening and follow-up with thyroid function tests in patients treated with ocrelizumab. As a novel therapeutic antibody, further investigation is required to unravel the causes of thyroid autoimmunity.PMID:34523298 | DOI:10.2478/en...
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Diana Borges Duarte Ana Martins da Silva Claudia Freitas Helena Cardoso Source Type: research

Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
Conclusion. The present data indicate that HAL and ARI in the doses 1 mg/kg or 10 mg/kg, respectively, does not modify the effect of the CMS preconditioning on the BDNF and GR mRNA levels in the PFC or the HIP. However, HAL seems to modify the CMS effect on the HIP activation.PMID:34523299 | DOI:10.2478/enr-2021-0016 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Jana Osacka Romana Koprdova Andrej Tillinger Zdenko Pirnik Alexander Kiss Source Type: research

Does thyroid dysfunction influence inflammatory mediators in experimental periodontitis?
Endocr Regul. 2021 Sep 13;55(3):131-141. doi: 10.2478/enr-2021-0014.ABSTRACTObjective. The aim of the present study was to investigate the presence of inflammatory mediators in rats with only periodontitis and periodontitis in a setting of hyper- and hypo-thyroidism and to analyze the correlative linkages between inflammatory mediators and thyroid hormones. Methods. White male 12-14 weeks old inbred rats (n=48) weighing 180-200 g were employed in the experiment. They were randomly divided into the following groups: Group I - control group, Group II - group with a model of periodontitis, Group III - group with a periodontit...
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Vitaliy Shcherba Inna Krynytska Mariya Marushchak Mykhaylo Korda Source Type: research

Quercetin improves myocardial redox status in rats with type 2 diabetes
Conclusions. The findings demonstrate that Q in both doses 10 mg/kg and 50 mg/kg can protect from the development of oxidative stress in cardiomyocytes in the diabetic rats. The present data indicate that the use of Q may contribute to the amelioration of cardiovascular risk in patients with T2DM.PMID:34523301 | DOI:10.2478/enr-2021-0015 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Nataliia I Gorbenko Oleksii Yu Borikov Tetiana V Kiprych Olha V Ivanova Kateryna V Taran Tetiana S Litvinova Source Type: research

Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?
Endocr Regul. 2021 Sep 13;55(3):174-181. doi: 10.2478/enr-2021-0019.ABSTRACTThe pathophysiology of COVID comprises an exaggerated pro-inflammatory response. Hypothalamic-pituitary-adrenal (HPA) axis has a crucial role in various inflammatory conditions and modulated immunological response. Limited evidence is available regarding the incidence and the effect of HPA dysfunction in COVID-19. Although the cortisol levels have only been estimated in a few studies, the dehydroepiandrosterone sulfate (DHEAS) release from the adrenal gland has not been explored yet. In this mini review, the authors discuss the role of dehydroepian...
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Sojit Tomo Mithu Banerjee Praveen Sharma Mahendra Garg Source Type: research

Selected 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors. A look into their use and potential in pre-diabetes and type 2 diabetes
Conclusions. Selected statins, FLC, CAs and HMGA can manage or have a potential to manage at least three features of the cluster of seven. Most of the literature-stated concerns are with select statins but there are concerns (one actual and two potential) with HMGA.PMID:34523296 | DOI:10.2478/enr-2021-0020 (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 15, 2021 Category: Endocrinology Authors: Douglas Edward Barre Kazimiera Amelia Mizier-Barre Source Type: research