c-Fos expression in the hypothalamic paraventricular nucleus after a single treatment with a typical haloperidol and nine atypical antipsychotics: a pilot study.
CONCLUSIONS: The present pilot study revealed c-Fos expression increase predominantly in the PVN medial parvocellular subdivision neurons by action of only several sorts of antipsychotics tested indicating that this structure of the brain does not represent a common extra-striatal target area for all antipsychotics. PMID: 29715183 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - May 3, 2018 Category: Endocrinology Tags: Endocr Regul Source Type: research

Mutations in SURF1 are important genetic causes of Leigh syndrome in Slovak patients.
CONCLUSIONS: We identified disease-causing mutations in all three probands, which points to the important role of SURF1 gene in etiology of Leigh syndrome in Slovakia. Our data showed that patients with atypical Leigh syndrome phenotype without lesions in basal ganglia may benefit from the whole exome sequencing method. In the case of probands presenting the typical phenotype, Sanger sequencing of the SURF1 gene seems to be an effective method of DNA analysis. PMID: 29715184 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - May 3, 2018 Category: Endocrinology Tags: Endocr Regul Source Type: research

Darapladib inhibits atherosclerosis development in type 2 diabetes mellitus Sprague-Dawley rat model.
Authors: Wihastuti TA, Heriansyah T, Hanifa H, Andarini S, Sholichah Z, Sulfia YH, Adam AA, Refialdinata J, Lutfiana NC Abstract OBJECTIVE: Increase in the low-density lipoprotein (LDL) level in diabetes mellitus and atherosclerosis is related to lipoprotein associated phospholipase A2 (Lp-PLA2). Lp-PLA2 is an enzyme that produces lysophosphatidylcholine (LysoPC) and oxidized nonesterified fatty acids (oxNEFA). LysoPC regulates inflammation mediators, including intra-cellular adhesion molecule-1 (ICAM-1). Darapladib is known as a Lp-PLA2 specific inhibitor. The aim of this study was to reveal the effect of daraplad...
Source: Endocrine Regulations - May 3, 2018 Category: Endocrinology Tags: Endocr Regul Source Type: research

Glucometabolic effects of single and repeated exposure to forced-swimming stressor in Sprague-Dawley rats.
CONCLUSIONS: In conclusion, repeated exposure to forced-swimming stressor induced glucose intolerance and insulin resistance in rats by disrupting the insulin sensitivity as well as heightening the glycogenolysis in the liver and skeletal muscle. Acute stressor was unable to cause glucose intolerance and insulin resistance but it appears that may have a positive effect on the lipid metabolism. PMID: 29715186 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - May 3, 2018 Category: Endocrinology Tags: Endocr Regul Source Type: research

Possible association of ghrelin/obestatin balance with cardiometabolic risk in obese subjects with Helicobacter pylori.
CONCLUSIONS: It can be concluded that ghrelin, obestatin, and leptin are affected by presence of H. pylori seropositivity in obese subjects. The higher ghrelin levels and ghrelin/obestatin ratio with lowered obestatin could be considered as a gastro-protective effect against inflammation induced by H. pylori. PMID: 29715187 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - May 3, 2018 Category: Endocrinology Tags: Endocr Regul Source Type: research

Possible protective effect of curcumin on the thyroid gland changes induced by sodium fluoride in albino rats: light and electron microscopic study.
CONCLUSIONS: Sodium fluoride affected both the function and structure of the thyroid gland while curcumin was protective against these toxic effects. PMID: 29715188 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - May 3, 2018 Category: Endocrinology Tags: Endocr Regul Source Type: research

Co-exposure to endocrine disruptors: effect of bisphenol A and soy extract on glucose homeostasis and related metabolic disorders in male mice.
CONCLUSION: Soy extract may protect against some adverse effects of BPA. These findings represent the first report suggesting a potential effect between soy extract and BPA in low doses, however, further studies are needed to confirm these results. PMID: 29715189 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - May 3, 2018 Category: Endocrinology Tags: Endocr Regul Source Type: research

High dose of histone deacetylase inhibitors affects insulin secretory mechanism of pancreatic beta cell line.
CONCLUSIONS: Our results showed that HDACis caused failure to suppress insulin secretion at low glucose concentrations and enhance insulin secretion at high glucose concentrations. In other words, when these HDACis are used clinically, high doses of HDACis may cause hypoglycemia in the fasting state and hyperglycemia in the fed state. When using HDACis, physicians should, therefore, be aware of the capacity of these drugs to modulate the insulin secretory capacity of pancreatic beta cells. PMID: 29453918 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - February 19, 2018 Category: Endocrinology Tags: Endocr Regul Source Type: research

Genetic and epigenetic differences of benign and malignant pheochromocytomas and paragangliomas (PPGLs).
Authors: Khatami F, Mohammadamoli M, Tavangar SM Abstract Pheochromocytomas and paragangliomas (PPGLs) are tumors arising from the adrenal medulla and sympathetic/parasympathetic paraganglia, respectively. According to Th e Cancer Genome Atlas (TCGA), approximately 40% of PPGLs are due to germ line mutations in one of 16 susceptibility genes, and a further 30% are due to somatic alterations in at least seven main genes (VHL, EPAS1, CSDE1, MAX, HRAS, NF1, RET, and possibly KIF1B). Th e diagnosis of malignant PPGL was straight forward in most cases as it was defined as presence of PPGL in non-chromaffin tissues. Acco...
Source: Endocrine Regulations - February 19, 2018 Category: Endocrinology Tags: Endocr Regul Source Type: research

Effect of trans-chalcone on hepatic IL-8 through the regulation of miR-451 in male rats.
CONCLUSION: Based on the results of present study, miR-451/IL-8 pathway is a possible mechanism for hepatoprotective action of trans-chalcone in long-term. PMID: 29453920 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - February 19, 2018 Category: Endocrinology Tags: Endocr Regul Source Type: research

Changes in erythrocyte deformability during day and possible role of melatonin.
Authors: Vazan R, Plauterova K, Porubska G, Radosinska J Abstract OBJECTIVES: The deformability of erythrocytes is their ability to change shape in order to pass through the capillaries. Th is is necessary for quality of microcirculation and sufficient delivery of oxygen to the tissues. Th e aim of our study was to investigate the possible spontaneous changes in the erythrocyte deformability during day and evaluation of the possible direct effects of melatonin (hormone involved in regulation of biorhythms) on the erythrocyte deformability. METHODS: Samples of capillary blood were taken from 12 healthy volunteer...
Source: Endocrine Regulations - February 19, 2018 Category: Endocrinology Tags: Endocr Regul Source Type: research

A short review of primary aldosteronism in a question and answer fashion.
Conclusions. We present our results in a question and answer fashion in order to make reading more interesting. RESULTS: PA should be searched in all high-risk populations. The gold standard for diagnosis PA is the plasma aldosterone/plasma renin ratio (ARR). If this test is positive, then we proceed with one of the four confirmatory tests. If positive, then we proceed with a localizing technique like adrenal vein sampling (AVS) and CT scan. If the lesion is unilateral, after proper preoperative preparation, we proceed, in adrenalectomy. If the lesion is bilateral or the patient refuses or is not fit for surgery, we tr...
Source: Endocrine Regulations - February 19, 2018 Category: Endocrinology Tags: Endocr Regul Source Type: research

Magnesium upregulates insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide-induced type-2 diabetic rats.
CONCLUSION: These findings demonstrate that magnesium may mediate effective metabolic control by stimulating the antioxidant defense, and increased levels of INSR and GLUT4 in diabetic rats. PMID: 29453923 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - February 19, 2018 Category: Endocrinology Tags: Endocr Regul Source Type: research

Cerebral germinoma revealed through a polydipsic polyuric syndrome in a 10-year-old girl: case report.
We report the case of a 10-year-old girl with diabetes insipidus evolving for 12 months associated with a decrease in visual acuity. Brain MRI (Magnetic Resonance Imaging) revealed a tumor process in the suprasellar region. The stereotaxic biopsy of the tumor confirmed the diagnosis of the hypothalamic germinoma, which allowed the patient to be treated by radiotherapy and chemotherapy. The incidence of cerebral germinoma, its clinical (principally diabetes insipidus) and radiological features as well as therapeutic strategies are discussed hereby. PMID: 29232188 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - December 14, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

A rare cause of hypophysitis: tuberculosis.
CONCLUSION: The tubercular hypophysitis, as a result of performed tests, is discussed hereby, in the case report. PMID: 29232189 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - December 14, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

The effects of Curcuma longa and curcumin on reproductive systems.
CONCLUSION: C. longa and curcumin might decrease the risk of cancer and other malignant diseases in the reproductive system. C. longa and curcumin have a protective effect on the reproductive organs activity such as, anti-inflammatory, anti-apoptotic, and antioxidant effects in normal cells but showed pro-apoptotic effects in the malignant cells. Therefore, different effects of C. longa and curcumin are dependent on the doses and the type of cells used in various models studied. PMID: 29232190 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - December 14, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

Salivary adiponectin concentration in healthy adult males in relation to anthropometric measures and fat distribution.
Authors: Abdalla MMI, Soon SC Abstract OBJECTIVES: Body fat content, fat distribution, and adiponectin level are important variables in the development of obesity related complications. Anthropometric indices may provide an economic and faster method in measuring the risk for complications through their predictive effect of fat distribution and adiponectin concentration. We aimed to determine, which of the waist circumference (WC), waist-to-hip ratio (WHR), and body mass index (BMI) may be the best predictor for the total fat percentage (WF), visceral fat level (VF), and subcutaneous whole-body fat (SCWBF). We aime...
Source: Endocrine Regulations - December 14, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

Vitamin E improved redox homeostasis in heart and aorta of hypothyroid rats.
The objective of this study was to evaluate the effect of vitamin E on the oxidative stress parameters and antioxidant defense enzymes in the heart and aorta of 6-n-propylthiouracil (PTU)-induced hypothyroid rats. METHODS: The animals were divided into 4 experimental groups: Group 1 (Euthyroid) received tap water, Group 2 (Hypothyroid) received 0.05 % of PTU in dissolved in their drinking water, Group 3 (PTU+Vit E) hypothyroid rats treated with vitamin E, and Group 4 (Euthyroid+Vit E). Vitamin E was injected daily (20 mg/kg) to groups 3 and 4 via daily gavage for 6 weeks. Malondialdehyde (MDA) levels, total thiol level...
Source: Endocrine Regulations - December 14, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

Testosterone regulates granzyme K expression in rat testes.
CONCLUSIONS: GZMK expression in testes is testosterone dependent. GZMK is located adjacent to germ cells in seminiferous tubules and the presence of apoptotic round spermatids in the epididymis suggest its role in the degradation of microtubules in ectoplasmic specializations. Thus, overexpression of GZMK may indirectly regulate germ cell apoptosis by premature release of round spermatids from seminiferous tubule lumen. PMID: 29232193 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - December 14, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

Using plasma exchange to successfully manage thyrotoxicosis in a patient with possible antithyroid drug-related thrombotic thrombocytopenic purpura.
CONCLUSIONS: The present report is the first in the literature to demonstrate the co-existence of these two diseases and the use of plasma exchange as a modality to treat both conditions. PMID: 28858843 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 1, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

Can regular moderate exercise lead to changes in miRNA-146a and its adapter proteins in the kidney of streptozotocin-induced diabetic male rats?
CONCLUSION: The present data indicate that exercise might be able to help in the prevention in the diabetic nephropathy development. PMID: 28858844 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 1, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

Bidirectional asymmetry in the neurovisceral communication for the cardiovascular control: New insights.
In conclusion, there are numerous evidences supporting the existence of a neurovisceral connection with multiorgan involvement that controls, among others, the cardiovascular function. This connection is asymmetrically organized. PMID: 28858845 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 1, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

TLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuum.
CONCLUSION: Our study demonstrates that Asp299Gly and Thr399Ile polymorphisms seem not to be associated with the type 2 diabetes and prediabetes but Asp299Gly may contribute to diabetic retinopathy predisposition. PMID: 28858846 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 1, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

Pheochromocytoma, diagnosis and treatment: Review of the literature.
CONCLUSIONS: The biggest problem for pheochromocytoma is to suspect it in the first place. Elevated metanephrines establish the diagnosis. With the proper preoperative preparation the risks during operation and the postoperative period are minimal. If there is a risk of the hereditable mutation, it is strongly suggested that all the patients with pheochromocytoma need clinical genetic testing. PMID: 28858847 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 1, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) may be superior to C-reactive protein (CRP) for predicting the occurrence of differentiated thyroid cancer.
CONCLUSION: In our study, we found out that higher NLR and PLR was associated with higher levels of thyroglobulin which indicates worse survival. CRP levels were also associated with poorer tumor profile but the determining rate was lower according to ROC analysis. PMID: 28858848 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - September 1, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

Premature ovarian failure could be an alarming sign of polyglandular autoimmune dysfunction.
Authors: Saif A, Assem M Abstract A 31-year-old lady, diagnosed to have premature ovarian failure in the gynecology clinic, was referred for endocrine assessment because of an abnormal thyroid function test. Clinical examination revealed hypotension, and fungal skin infection under her atrophic breasts. Thyroid stimulating hormone (TSH) level was very high. Assessment of the suprarenal function revealed evidence of Addison's disease. Polyglandular autoimmune dysfunction was diagnosed. She was treated with prednisone, fludrocortisone, and levothyroxine with significant improvement of her general condition and blood ...
Source: Endocrine Regulations - June 14, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

Expression of genes encoding IGFBPs, SNARK, CD36, and PECAM1 in the liver of mice treated with chromium disilicide and titanium nitride nanoparticles.
CONCLUSIONS: The results of this study demonstrate that chromium disilicide and titanium nitride nanoparticles have variable effects on the expression of IGFBP2, IGFBP3, IGFBP4, IGFBP5, SNARK, CD36, and PECAM1 genes in mouse liver, which may reflect the genotoxic activities of the studied nanoparticles. PMID: 28609285 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - June 14, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

Th e eff ects of Nigella Sativa extract on renal tissue oxidative damage during neonatal and juvenile growth in propylthiouracil-induced hypothyroid rats.
CONCLUSION: The results of this study demonstrate that the hydroalcoholic extract of NS has a protective effect on the renal tissue oxidative damage associated with PTU-induced hypothyroidism during neonatal and juvenile growth in rats. PMID: 28609286 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - June 14, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

The role of thyrostimulin and its potential clinical significance.
Authors: Karponis D, Ananth S Abstract Thyrostimulin is a glycoprotein heterodimer of GPA2 and GPB5, first described in 2002. It is involved in the physiological function of several tissues. Moreover, evidence points towards the ability of thyrostimulin's individual monomers to induce a biological effect, which could denote the circulatory/systemic effects of the molecule when found in higher concentrations. From the evolutionary point of view, thyrostimulin shares a binding epitope with the thyroid-stimulating hormone for the thyroid stimulating hormone receptor, whilst possessing affinity for another unique bindi...
Source: Endocrine Regulations - June 14, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

Eff ect of a single asenapine treatment on Fos expression in the brain catecholamine-synthesizing neurons: impact of a chronic mild stress preconditioning.
CONCLUSIONS: Th e present study provides an anatomical/functional knowledge about the nature of the acute ASE treatment on the catecholamine-synthesizing neurons activity in certain brain structures and their missing interplay with the CMS preconditioning. PMID: 28609288 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - June 14, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

Adverse eff ects of polymeric nanoparticle poly(ethylene glycol)- block-polylactide methyl ether (PEG-b-PLA) on steroid hormone secretion by porcine granulosa cells.
CONCLUSIONS: The obtained results indicate that polymeric NPs PEG-b-PLA might induce alterations in steroid hormone production by ovarian GCs and thereby could modify reproductive functions. PMID: 28609289 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - June 14, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

Intense blue light therapy during the night-time does not suppress the rhythmic melatonin biosynthesis in a young boy.
CONCLUSIONS: We conclude that the whole night treatment of hyperbilirubinemia with intense blue light has negligible side effect on the rhythmic melatonin production, when the eyes are sufficiently protected by the sleep mask. PMID: 28222021 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - February 22, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

Central and peripheral control of food intake.
In conclusion, the present review summarizes the current knowledge about the complex system of the peripheral and central regulatory mechanisms of food intake and their potential therapeutic implications in the treatment of obesity. PMID: 28222022 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - February 22, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

Factors associated with increased irisin levels in the type 1 diabetes mellitus.
This study included 35 cases diagnosed with T1DM and 36 healthy volunteers. Antiglutamic acid decarboxylase (anti-GAD), islet cell antibody (ICA), and insulin autoantibody levels were measured in patients at the time when they were included into the study and recorded from the patient files. Serum irisin levels were measured by ELISA kit. RESULTS: The median irisin levels were determined higher in T1DM group compared to the control one (6.8 ng/ml vs. 4.8 ng/ml, p=0.022; respectively). Median irisin levels were higher in anti-GAD (p=0.022) and ICA (p=0.044) positive groups compared to negative groups. In T1DM group, iri...
Source: Endocrine Regulations - February 22, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

Eff ects of hemin, a heme oxygenase-1 inducer in L-arginine-induced acute pancreatitis and associated lung injury in adult male albino rats.
CONCLUSIONS: The current study indicates that the induction of HO-1 by hemin pre-treatment significantly ameliorated the L-arginine-induced pancreatitis and associated pulmonary complications may be due to its anti-inflammatory and antioxidant properties. PMID: 28222024 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - February 22, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

Radiology of the adrenal incidentalomas. Review of the literature.
Authors: Farrugia FA, Martikos G, Surgeon C, Tzanetis P, Misiakos E, Zavras N, Charalampopoulos A Abstract The term "adrenal incidentaloma" is a radiological term. Adrenal incidentalomas are adrenal tumors discovered in an imaging study that has been obtained for indications exclusive to adrenal conditions (Udelsman 2001; Linos 2003; Bulow et al. 2006; Anagnostis et al. 2009). This definition excludes patients undergoing imaging testing as part of staging and work-up for cancer (Grumbach et al. 2003; Anagnostis et al. 2009). Papierska et al. (2013) have added the prerequisite that the size of a tumor must...
Source: Endocrine Regulations - February 22, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

Hypoxic regulation of the expression of genes encoded estrogen related proteins in U87 glioma cells: eff ect of IRE1 inhibition.
CONCLUSIONS: Results of this investigation demonstrate that inhibition of IRE1 signaling enzyme function affects the expression of NRIP1, EBBP, ESRRA, E2IG5, PGRMC2, and SLC39A6 genes in U87 glioma cells in gene specific manner and these changes possibly contribute to the suppression of the cell proliferation. Most of these genes are regulated by hypoxia and preferentially through IRE1 signaling pathway of endoplasmic reticulum stress. PMID: 28222026 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - February 22, 2017 Category: Endocrinology Tags: Endocr Regul Source Type: research

A case of hypercalcaemic crisis secondary to coexistence of primary hyperparathyroidism and Graves' disease.
Authors: Baldane S, Ipekci SH, Evcen R, Gedik GK, Guler I, Kebapcilar L Abstract A 46 year-old female patient presented to the hospital with ongoing and progressively increasing fatigue, severe nausea and vomiting, loss of appetite, constipation, palpitations and somnolence. Laboratory evaluation revealed a severe hypercalcaemia and overt hyperthyroidism. She was diagnosed with primary hyperparathyroidism accompanied by Graves' disease. The patient underwent total thyroidectomy and right inferior parathyroid gland adenoma excision on the 24th day of her admission to the hospital after calcium levels and free thyroi...
Source: Endocrine Regulations - December 14, 2016 Category: Endocrinology Tags: Endocr Regul Source Type: research

Protective effects of boron and vitamin E on ethylene glycol-induced renal crystal calcium deposition in rat.
CONCLUSIONS: Efficient effect of boron and Vit E supplements, separately and in combination, has a complimentary effect in protection against the formation of kidney stones, probably by decreasing oxidative stress. PMID: 27941176 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - December 14, 2016 Category: Endocrinology Tags: Endocr Regul Source Type: research

Effect of the autonomic nervous system on cancer progression depends on the type of tumor: solid are more affected then ascitic tumors.
CONCLUSIONS: Based on the obtained data, it seems that the solid types of tumors are suitable substrate for the direct action of neurotransmitters released especially from the sympathetic nerves. In contrast, it appears that the malignant ascites are not under the direct autonomic nerves control; however, an indirect action via the immune functions modulation cannot be excluded. PMID: 27941177 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - December 14, 2016 Category: Endocrinology Tags: Endocr Regul Source Type: research

Alternative renin-angiotensin system pathways in adipose tissue and their role in the pathogenesis of obesity.
Authors: Slamkova M, Zorad S, Krskova K Abstract Adipose tissue expresses all the renin-angiotensin system (RAS) components that play an important role in the adipogenesis, lipid and glucose metabolism regulation in an auto/paracrine manner. The classical RAS has been found to be over-activated during the adipose tissue enlargement, thus elevated generation of angiotensin II (Ang II) may contribute to the obesity pathogenesis. The contemporary view on the RAS has become more complex with the discovery of alternative pathways, including angiotensin-converting enzyme 2 (ACE2)/angiotensin (Ang)-(1-7)/Mas receptor, (pr...
Source: Endocrine Regulations - December 14, 2016 Category: Endocrinology Tags: Endocr Regul Source Type: research

Flaxseed oil supplementation manipulates correlations between serum individual mol % free fatty acid levels and insulin resistance in type 2 diabetics. Insulin resistance and percent remaining pancreatic β-cell function are unaffected.
CONCLUSIONS: The obtained data indicate that high doses of flaxseed oil have no statistically significant effect on HOMA-IR or HOMA-%β in T2Ds, probably due to the additive effects of negative and positive correlations. PMID: 27941179 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - December 14, 2016 Category: Endocrinology Tags: Endocr Regul Source Type: research

Sympathectomized tumor-bearing mice survive longer but develop bigger melanomas.
CONCLUSIONS: The data of the present study showed that effect of the chemical sympathectomy, performed before the tumor growth induction, persisted even at the time when sympathetic nerves started to regenerate that resulted in a prolonged survival of the mice with melanoma. However, comparing to our previous study, in which we have shown a reduced tumor mass in earlier stages of the tumor growth, specifically 20 days after melanoma cells injection, now we indicate that in later stages of the melanoma progression, the tumor mass was significantly increased in sympathectomized animals. These contra-intuitive findings may in...
Source: Endocrine Regulations - December 14, 2016 Category: Endocrinology Tags: Endocr Regul Source Type: research

Current status of iodine deficiency-related disorders prophylaxis in Slovakia - the life's work of Julian Podoba remained unfinished.
CONCLUSIONS: 1/ Iodine nutrition in Slovakia is generally sufficient, even oversteps the requirement, with the exception of pregnant women. Iodine intake in pregnant women should be fortified by iodine containing multivitamin preparations. 2/ We recommend to include the examination of urinary iodine into the screening of thyropathies in early pregnancy. 3/ It is not enough to implement the iodine deficiency-related disorders prevention programs, it is also necessary to stabilize such programs over time and balance the benefits with possible side effects of this program. PMID: 27560630 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - August 27, 2016 Category: Endocrinology Tags: Endocr Regul Source Type: research

Handedness and gender influence blood pressure in young healthy men and women: A pilot study.
CONCLUSIONS: These results may reflect an asymmetrical modulatory influence of sex hormones in BP control. PMID: 27560631 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - August 27, 2016 Category: Endocrinology Tags: Endocr Regul Source Type: research

The prepulse inhibition deficit appearance is largely independent on the circadian cycle, body weight, and the gender of vasopressin deficient Brattleboro rat.
CONCLUSIONS: The present data confirmed and extended our previous studies that vasopressin-deficient rat is a good model of schizophrenia. It seems that female as well as lactating Brattleboro rats are useful tools for testing putative novel antipsychotics in line with special attention required for schizophrenic women. PMID: 27560632 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - August 27, 2016 Category: Endocrinology Tags: Endocr Regul Source Type: research

Newly diagnosed primary hypothyroidism applicant with massive pericardial effusion and acute renal failure.
CONCLUSION: Massive PE and acute renal failure due to primary hypothyroidism is a rare clinical condition. Primary hypothyroidism should be kept in mind in patients with symptoms like shortness of breath, chest pain, and generalized edema; moreover, when acute renal failure and PE were detected. It should be considered that patient's biochemical parameters can improve starting from the two weeks after levothyroxine treatment started with pericardiocentesis in severe symptomatic patients. PMID: 27560633 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - August 27, 2016 Category: Endocrinology Tags: Endocr Regul Source Type: research

Pancrelipase treatment in a patient with the history of Roux-en-Y gastric bypass operation that developed resistant hypocalcemia secondary to total thyroidectomy.
CONCLUSION: This report presents a case history of RYGB and resistant hypocalcaemia, which developed after thyroid surgery and positively responded to pancrelipase treatment. PMID: 27560634 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - August 27, 2016 Category: Endocrinology Tags: Endocr Regul Source Type: research

Comparison of clinical and biochemical variables in type 2 diabetes mellitus patients and their first-degree relatives with metabolic syndrome in Benin City, Nigeria: A cross sectional case controlled study.
Authors: Ogedengbe S, Ezeani IU, Aihanuwa E Abstract OBJECTIVE: Type 2 diabetes mellitus (T2DM) is characterized by a relative insulin deficiency or insulin resistance. It is also associated with a cluster of metabolic abnormalities, including hyper-tension and dyslipidemia. Although there are many studies that have studied the metabolic abnormalities in T2DM patients with metabolic syndrome (MetS), only few of them have assessed the metabolic abnormalities in their first-degree relatives (FDRs) who had MetS. The aim of this study is to compare the clinical and biochemical variables in T2DM subjects and their FDRs ...
Source: Endocrine Regulations - August 27, 2016 Category: Endocrinology Tags: Endocr Regul Source Type: research

Effect of hypoxia on the expression of genes encoding insulin-like growth factors and some related proteins in U87 glioma cells without IRE1 function.
CONCLUSIONS: Results of this study demonstrate that the expression of IGF1 and IGF1R genes is resistant to hypoxic condition both in control U87 glioma cells and cells without IRE1 signaling enzyme function. However, hypoxia significantly up-regulates the expression of IGFBP4 gene independently on the inhibition of IRE1 enzyme. These data show that proteins encoded by these genes are resistant to hypoxia except IGFBP4 and participate in the regulation of metabolic and proliferative processes through IRE1 signaling. PMID: 27560636 [PubMed - in process] (Source: Endocrine Regulations)
Source: Endocrine Regulations - August 27, 2016 Category: Endocrinology Tags: Endocr Regul Source Type: research