Advanced glycation end products of dietary origin and their association with inflammation in diabetes - A minireview
Endocr Regul. 2024 Apr 2;58(1):57-67. doi: 10.2478/enr-2024-0007. Print 2024 Jan 1.ABSTRACTAdvanced glycation end products (AGEs) are a diverse group of compounds that are formed as a result of the non-enzymatic reaction between a reducing sugar such as glucose and the free NH2 groups of an amino acid in a protein or other biomolecule. The chemical reaction, by which these products are generated, is known as the Maillard reaction and occurs as a part of the body's normal metabolism. Such a reaction is enhanced during diabetes due to hyperglycemia, but it can also occur during the preparation, processing, and preservation o...
Source: Endocrine Regulations - April 2, 2024 Category: Endocrinology Authors: Adriana Pedreanez Jorge Robalino Diego Tene Patricio Salazar Source Type: research
Relationships of apolipoprotein E genotypes with a cluster of seven in persons with type 2 diabetes
CONCLUSION.: We can conclude that those with at least one 4 allele in the presence of another allele being 2, 3 or 4 is potentially (in the case of trends) deleterious or is deleterious in terms of hyperglycemia, hypertension (systolic and diastolic blood pressure), dyslipidemia, LDL conjugated dienes and CRP levels.PMID:38563295 | DOI:10.2478/enr-2024-0005 (Source: Endocrine Regulations)
Source: Endocrine Regulations - April 2, 2024 Category: Endocrinology Authors: Douglas E Barre Kazimiera A Mizier-Barre Odette Griscti Kevin Hafez Source Type: research
The relationship between the tumor and its innervation: historical, methodical, morphological, and functional assessments - A minireview
Endocr Regul. 2024 Apr 2;58(1):68-82. doi: 10.2478/enr-2024-0008. Print 2024 Jan 1.ABSTRACTThe acceptance of the tumor as a non-isolated structure within the organism has opened a space for the study of a wide spectrum of potential direct and indirect interactions, not only between the tumor tissue and its vicinity, but also between the tumor and its macroenvironment, including the nervous system. Although several lines of evidence have implicated the nervous system in tumor growth and progression, for many years, researchers believed that tumors lacked innervation and the notion of indirect neuro-neoplastic interactions v...
Source: Endocrine Regulations - April 2, 2024 Category: Endocrinology Authors: Filip Blasko Lubica Horvathova Source Type: research
Cortisol controls endoplasmic reticulum stress and hypoxia dependent regulation of insulin receptor and related genes expression in HEK293 cells
Conclusion. Taken together, the present study indicates that cortisol may interact with ER stress and hypoxia in the regulation of ER stress dependent XBP1 and DNAJB9 mRNA expression as well as INSR and its signaling and that this corticosteroid hormone modified the impact of hypoxia and especially tunicamycin on the expression of most studied genes in HEK293 cells. These data demonstrate molecular mechanisms of glucocorticoids interaction with ER stress and insulin signaling at the cellular level.PMID:38345493 | DOI:10.2478/enr-2024-0001 (Source: Endocrine Regulations)
Source: Endocrine Regulations - February 12, 2024 Category: Endocrinology Authors: Dmytro O Minchenko Olena O Khita Yuliia M Viletska Myroslava Y Sliusar Olha V Rudnytska Halyna E Kozynkevych Borys H Bezrodnyi Yevgen P Khikhlo Oleksandr H Minchenko Source Type: research
One-week sorghum ( < em > Sorghum bicolor < /em > L.) grain consumption is insufficient to increase adiponectin levels in prediabetic adults
Conclusion. Sorghum grain consumption for a week is insufficient to increase adiponectin levels in the prediabetic patients. Insulin resistance, central obesity, and dyslipidemia may be the confounding variables that alter the favorable effect of sorghum on adiponectin. Longer sorghum consumption or other interventions may be needed to increase the adiponectin levels in people under these conditions.PMID:38345494 | DOI:10.2478/enr-2024-0002 (Source: Endocrine Regulations)
Source: Endocrine Regulations - February 12, 2024 Category: Endocrinology Authors: Sony Wibisono Mudjanarko Teguh Rahardjo Soebagijo Adi Soelistijo Siti Rahmawati Source Type: research
Risk of malignancy in Thy3 thyroid nodules
Conclusion. Our rates of malignancy in Thy3 cytology are similar to the literature. These rates should be explained clearly to the patient during the preoperative counselling. Future advances in biomarkers technology may help to improve the preoperative diagnostic accuracy and reduce the rate of unnecessary thyroid surgery.PMID:38345495 | DOI:10.2478/enr-2024-0003 (Source: Endocrine Regulations)
Source: Endocrine Regulations - February 12, 2024 Category: Endocrinology Authors: Emad Mofid Nassif Rezkallah Ragai Sobhi Hanna Wael Magdy Elsaify Source Type: research
Potential of medicinal plants to ameliorate neovascularization activities in diabetes: A systematic review
Endocr Regul. 2024 Feb 12;58(1):26-39. doi: 10.2478/enr-2024-0004. Print 2023 Jan 1.ABSTRACTHyperglycemia in diabetes mediates the release of angiogenic factors, oxidative stress, hypoxia, and inflammation, which in turn stimulate angiogenesis. Excessive angiogenesis can cause diabetic retinopathy, diabetic neuropathy, and diabetic nephropathy. All of these complications are debilitating, which may lead to an increased susceptibility to lower-limb amputations due to ulcerations and infections. In addition, microvascular alterations, segmental demyelination, and endoneurial microangiopathy may cause progressive deterioratio...
Source: Endocrine Regulations - February 12, 2024 Category: Endocrinology Authors: Phaik Har Yong Shin Yee New Meram Azzani Yuan Seng Wu Vi Vien Chia Zhi Xiang Ng Source Type: research
Cortisol controls endoplasmic reticulum stress and hypoxia dependent regulation of insulin receptor and related genes expression in HEK293 cells
Conclusion. Taken together, the present study indicates that cortisol may interact with ER stress and hypoxia in the regulation of ER stress dependent XBP1 and DNAJB9 mRNA expression as well as INSR and its signaling and that this corticosteroid hormone modified the impact of hypoxia and especially tunicamycin on the expression of most studied genes in HEK293 cells. These data demonstrate molecular mechanisms of glucocorticoids interaction with ER stress and insulin signaling at the cellular level.PMID:38345493 | DOI:10.2478/enr-2024-0001 (Source: Endocrine Regulations)
Source: Endocrine Regulations - February 12, 2024 Category: Endocrinology Authors: Dmytro O Minchenko Olena O Khita Yuliia M Viletska Myroslava Y Sliusar Olha V Rudnytska Halyna E Kozynkevych Borys H Bezrodnyi Yevgen P Khikhlo Oleksandr H Minchenko Source Type: research
One-week sorghum ( < em > Sorghum bicolor < /em > L.) grain consumption is insufficient to increase adiponectin levels in prediabetic adults
Conclusion. Sorghum grain consumption for a week is insufficient to increase adiponectin levels in the prediabetic patients. Insulin resistance, central obesity, and dyslipidemia may be the confounding variables that alter the favorable effect of sorghum on adiponectin. Longer sorghum consumption or other interventions may be needed to increase the adiponectin levels in people under these conditions.PMID:38345494 | DOI:10.2478/enr-2024-0002 (Source: Endocrine Regulations)
Source: Endocrine Regulations - February 12, 2024 Category: Endocrinology Authors: Sony Wibisono Mudjanarko Teguh Rahardjo Soebagijo Adi Soelistijo Siti Rahmawati Source Type: research
Risk of malignancy in Thy3 thyroid nodules
Conclusion. Our rates of malignancy in Thy3 cytology are similar to the literature. These rates should be explained clearly to the patient during the preoperative counselling. Future advances in biomarkers technology may help to improve the preoperative diagnostic accuracy and reduce the rate of unnecessary thyroid surgery.PMID:38345495 | DOI:10.2478/enr-2024-0003 (Source: Endocrine Regulations)
Source: Endocrine Regulations - February 12, 2024 Category: Endocrinology Authors: Emad Mofid Nassif Rezkallah Ragai Sobhi Hanna Wael Magdy Elsaify Source Type: research
Potential of medicinal plants to ameliorate neovascularization activities in diabetes: A systematic review
Endocr Regul. 2024 Feb 12;58(1):26-39. doi: 10.2478/enr-2024-0004. Print 2023 Jan 1.ABSTRACTHyperglycemia in diabetes mediates the release of angiogenic factors, oxidative stress, hypoxia, and inflammation, which in turn stimulate angiogenesis. Excessive angiogenesis can cause diabetic retinopathy, diabetic neuropathy, and diabetic nephropathy. All of these complications are debilitating, which may lead to an increased susceptibility to lower-limb amputations due to ulcerations and infections. In addition, microvascular alterations, segmental demyelination, and endoneurial microangiopathy may cause progressive deterioratio...
Source: Endocrine Regulations - February 12, 2024 Category: Endocrinology Authors: Phaik Har Yong Shin Yee New Meram Azzani Yuan Seng Wu Vi Vien Chia Zhi Xiang Ng Source Type: research
Cortisol controls endoplasmic reticulum stress and hypoxia dependent regulation of insulin receptor and related genes expression in HEK293 cells
Conclusion. Taken together, the present study indicates that cortisol may interact with ER stress and hypoxia in the regulation of ER stress dependent XBP1 and DNAJB9 mRNA expression as well as INSR and its signaling and that this corticosteroid hormone modified the impact of hypoxia and especially tunicamycin on the expression of most studied genes in HEK293 cells. These data demonstrate molecular mechanisms of glucocorticoids interaction with ER stress and insulin signaling at the cellular level.PMID:38345493 | DOI:10.2478/enr-2024-0001 (Source: Endocrine Regulations)
Source: Endocrine Regulations - February 12, 2024 Category: Endocrinology Authors: Dmytro O Minchenko Olena O Khita Yuliia M Viletska Myroslava Y Sliusar Olha V Rudnytska Halyna E Kozynkevych Borys H Bezrodnyi Yevgen P Khikhlo Oleksandr H Minchenko Source Type: research
One-week sorghum ( < em > Sorghum bicolor < /em > L.) grain consumption is insufficient to increase adiponectin levels in prediabetic adults
Conclusion. Sorghum grain consumption for a week is insufficient to increase adiponectin levels in the prediabetic patients. Insulin resistance, central obesity, and dyslipidemia may be the confounding variables that alter the favorable effect of sorghum on adiponectin. Longer sorghum consumption or other interventions may be needed to increase the adiponectin levels in people under these conditions.PMID:38345494 | DOI:10.2478/enr-2024-0002 (Source: Endocrine Regulations)
Source: Endocrine Regulations - February 12, 2024 Category: Endocrinology Authors: Sony Wibisono Mudjanarko Teguh Rahardjo Soebagijo Adi Soelistijo Siti Rahmawati Source Type: research
Risk of malignancy in Thy3 thyroid nodules
Conclusion. Our rates of malignancy in Thy3 cytology are similar to the literature. These rates should be explained clearly to the patient during the preoperative counselling. Future advances in biomarkers technology may help to improve the preoperative diagnostic accuracy and reduce the rate of unnecessary thyroid surgery.PMID:38345495 | DOI:10.2478/enr-2024-0003 (Source: Endocrine Regulations)
Source: Endocrine Regulations - February 12, 2024 Category: Endocrinology Authors: Emad Mofid Nassif Rezkallah Ragai Sobhi Hanna Wael Magdy Elsaify Source Type: research
Potential of medicinal plants to ameliorate neovascularization activities in diabetes: A systematic review
Endocr Regul. 2024 Feb 12;58(1):26-39. doi: 10.2478/enr-2024-0004. Print 2023 Jan 1.ABSTRACTHyperglycemia in diabetes mediates the release of angiogenic factors, oxidative stress, hypoxia, and inflammation, which in turn stimulate angiogenesis. Excessive angiogenesis can cause diabetic retinopathy, diabetic neuropathy, and diabetic nephropathy. All of these complications are debilitating, which may lead to an increased susceptibility to lower-limb amputations due to ulcerations and infections. In addition, microvascular alterations, segmental demyelination, and endoneurial microangiopathy may cause progressive deterioratio...
Source: Endocrine Regulations - February 12, 2024 Category: Endocrinology Authors: Phaik Har Yong Shin Yee New Meram Azzani Yuan Seng Wu Vi Vien Chia Zhi Xiang Ng Source Type: research
