The relationship between the tumor and its innervation: historical, methodical, morphological, and functional assessments - A minireview
Endocr Regul. 2024 Apr 2;58(1):68-82. doi: 10.2478/enr-2024-0008. Print 2024 Jan 1.ABSTRACTThe acceptance of the tumor as a non-isolated structure within the organism has opened a space for the study of a wide spectrum of potential direct and indirect interactions, not only between the tumor tissue and its vicinity, but also between the tumor and its macroenvironment, including the nervous system. Although several lines of evidence have implicated the nervous system in tumor growth and progression, for many years, researchers believed that tumors lacked innervation and the notion of indirect neuro-neoplastic interactions v...
Source: Endocrine Regulations - April 2, 2024 Category: Endocrinology Authors: Filip Blasko Lubica Horvathova Source Type: research
ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells
CONCLUSION.: The results of the present study demonstrate that hypoxia affected the expression of homeobox genes MEIS1, MEIS2, MEIS3, LHX1, LHX2, LHX6, SPAG4, and NKX3-1 in U87MG glioblastoma cells in gene-specific manner and that the sensitivity of all studied genes to hypoxia condition is mediated by ERN1, the major pathway of the endoplasmic reticulum stress signaling, and possibly contributed to the control of glioblastoma growth. A fundamentally new results of this work is the establishment of the fact regarding the dependence of hypoxic regulation of SPAG4 gene expression on ER stress, in particular ERN1, which is as...
Source: Endocrine Regulations - April 2, 2024 Category: Endocrinology Authors: Daria A Krasnytska Olena O Khita Yuliia M Viletska Dmytro O Minchenko Oleh V Halkin Olha V Rudnytska Sofiia L Hoian Oleksandr H Minchenko Source Type: research
Advanced glycation end products of dietary origin and their association with inflammation in diabetes - A minireview
Endocr Regul. 2024 Apr 2;58(1):57-67. doi: 10.2478/enr-2024-0007. Print 2024 Jan 1.ABSTRACTAdvanced glycation end products (AGEs) are a diverse group of compounds that are formed as a result of the non-enzymatic reaction between a reducing sugar such as glucose and the free NH2 groups of an amino acid in a protein or other biomolecule. The chemical reaction, by which these products are generated, is known as the Maillard reaction and occurs as a part of the body's normal metabolism. Such a reaction is enhanced during diabetes due to hyperglycemia, but it can also occur during the preparation, processing, and preservation o...
Source: Endocrine Regulations - April 2, 2024 Category: Endocrinology Authors: Adriana Pedreanez Jorge Robalino Diego Tene Patricio Salazar Source Type: research
Relationships of apolipoprotein E genotypes with a cluster of seven in persons with type 2 diabetes
CONCLUSION.: We can conclude that those with at least one 4 allele in the presence of another allele being 2, 3 or 4 is potentially (in the case of trends) deleterious or is deleterious in terms of hyperglycemia, hypertension (systolic and diastolic blood pressure), dyslipidemia, LDL conjugated dienes and CRP levels.PMID:38563295 | DOI:10.2478/enr-2024-0005 (Source: Endocrine Regulations)
Source: Endocrine Regulations - April 2, 2024 Category: Endocrinology Authors: Douglas E Barre Kazimiera A Mizier-Barre Odette Griscti Kevin Hafez Source Type: research
The relationship between the tumor and its innervation: historical, methodical, morphological, and functional assessments - A minireview
Endocr Regul. 2024 Apr 2;58(1):68-82. doi: 10.2478/enr-2024-0008. Print 2024 Jan 1.ABSTRACTThe acceptance of the tumor as a non-isolated structure within the organism has opened a space for the study of a wide spectrum of potential direct and indirect interactions, not only between the tumor tissue and its vicinity, but also between the tumor and its macroenvironment, including the nervous system. Although several lines of evidence have implicated the nervous system in tumor growth and progression, for many years, researchers believed that tumors lacked innervation and the notion of indirect neuro-neoplastic interactions v...
Source: Endocrine Regulations - April 2, 2024 Category: Endocrinology Authors: Filip Blasko Lubica Horvathova Source Type: research
ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells
CONCLUSION.: The results of the present study demonstrate that hypoxia affected the expression of homeobox genes MEIS1, MEIS2, MEIS3, LHX1, LHX2, LHX6, SPAG4, and NKX3-1 in U87MG glioblastoma cells in gene-specific manner and that the sensitivity of all studied genes to hypoxia condition is mediated by ERN1, the major pathway of the endoplasmic reticulum stress signaling, and possibly contributed to the control of glioblastoma growth. A fundamentally new results of this work is the establishment of the fact regarding the dependence of hypoxic regulation of SPAG4 gene expression on ER stress, in particular ERN1, which is as...
Source: Endocrine Regulations - April 2, 2024 Category: Endocrinology Authors: Daria A Krasnytska Olena O Khita Yuliia M Viletska Dmytro O Minchenko Oleh V Halkin Olha V Rudnytska Sofiia L Hoian Oleksandr H Minchenko Source Type: research
Advanced glycation end products of dietary origin and their association with inflammation in diabetes - A minireview
Endocr Regul. 2024 Apr 2;58(1):57-67. doi: 10.2478/enr-2024-0007. Print 2024 Jan 1.ABSTRACTAdvanced glycation end products (AGEs) are a diverse group of compounds that are formed as a result of the non-enzymatic reaction between a reducing sugar such as glucose and the free NH2 groups of an amino acid in a protein or other biomolecule. The chemical reaction, by which these products are generated, is known as the Maillard reaction and occurs as a part of the body's normal metabolism. Such a reaction is enhanced during diabetes due to hyperglycemia, but it can also occur during the preparation, processing, and preservation o...
Source: Endocrine Regulations - April 2, 2024 Category: Endocrinology Authors: Adriana Pedreanez Jorge Robalino Diego Tene Patricio Salazar Source Type: research
Relationships of apolipoprotein E genotypes with a cluster of seven in persons with type 2 diabetes
CONCLUSION.: We can conclude that those with at least one 4 allele in the presence of another allele being 2, 3 or 4 is potentially (in the case of trends) deleterious or is deleterious in terms of hyperglycemia, hypertension (systolic and diastolic blood pressure), dyslipidemia, LDL conjugated dienes and CRP levels.PMID:38563295 | DOI:10.2478/enr-2024-0005 (Source: Endocrine Regulations)
Source: Endocrine Regulations - April 2, 2024 Category: Endocrinology Authors: Douglas E Barre Kazimiera A Mizier-Barre Odette Griscti Kevin Hafez Source Type: research
The relationship between the tumor and its innervation: historical, methodical, morphological, and functional assessments - A minireview
Endocr Regul. 2024 Apr 2;58(1):68-82. doi: 10.2478/enr-2024-0008. Print 2024 Jan 1.ABSTRACTThe acceptance of the tumor as a non-isolated structure within the organism has opened a space for the study of a wide spectrum of potential direct and indirect interactions, not only between the tumor tissue and its vicinity, but also between the tumor and its macroenvironment, including the nervous system. Although several lines of evidence have implicated the nervous system in tumor growth and progression, for many years, researchers believed that tumors lacked innervation and the notion of indirect neuro-neoplastic interactions v...
Source: Endocrine Regulations - April 2, 2024 Category: Endocrinology Authors: Filip Blasko Lubica Horvathova Source Type: research
ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells
CONCLUSION.: The results of the present study demonstrate that hypoxia affected the expression of homeobox genes MEIS1, MEIS2, MEIS3, LHX1, LHX2, LHX6, SPAG4, and NKX3-1 in U87MG glioblastoma cells in gene-specific manner and that the sensitivity of all studied genes to hypoxia condition is mediated by ERN1, the major pathway of the endoplasmic reticulum stress signaling, and possibly contributed to the control of glioblastoma growth. A fundamentally new results of this work is the establishment of the fact regarding the dependence of hypoxic regulation of SPAG4 gene expression on ER stress, in particular ERN1, which is as...
Source: Endocrine Regulations - April 2, 2024 Category: Endocrinology Authors: Daria A Krasnytska Olena O Khita Yuliia M Viletska Dmytro O Minchenko Oleh V Halkin Olha V Rudnytska Sofiia L Hoian Oleksandr H Minchenko Source Type: research
Advanced glycation end products of dietary origin and their association with inflammation in diabetes - A minireview
Endocr Regul. 2024 Apr 2;58(1):57-67. doi: 10.2478/enr-2024-0007. Print 2024 Jan 1.ABSTRACTAdvanced glycation end products (AGEs) are a diverse group of compounds that are formed as a result of the non-enzymatic reaction between a reducing sugar such as glucose and the free NH2 groups of an amino acid in a protein or other biomolecule. The chemical reaction, by which these products are generated, is known as the Maillard reaction and occurs as a part of the body's normal metabolism. Such a reaction is enhanced during diabetes due to hyperglycemia, but it can also occur during the preparation, processing, and preservation o...
Source: Endocrine Regulations - April 2, 2024 Category: Endocrinology Authors: Adriana Pedreanez Jorge Robalino Diego Tene Patricio Salazar Source Type: research
Relationships of apolipoprotein E genotypes with a cluster of seven in persons with type 2 diabetes
CONCLUSION.: We can conclude that those with at least one 4 allele in the presence of another allele being 2, 3 or 4 is potentially (in the case of trends) deleterious or is deleterious in terms of hyperglycemia, hypertension (systolic and diastolic blood pressure), dyslipidemia, LDL conjugated dienes and CRP levels.PMID:38563295 | DOI:10.2478/enr-2024-0005 (Source: Endocrine Regulations)
Source: Endocrine Regulations - April 2, 2024 Category: Endocrinology Authors: Douglas E Barre Kazimiera A Mizier-Barre Odette Griscti Kevin Hafez Source Type: research
The relationship between the tumor and its innervation: historical, methodical, morphological, and functional assessments - A minireview
Endocr Regul. 2024 Apr 2;58(1):68-82. doi: 10.2478/enr-2024-0008. Print 2024 Jan 1.ABSTRACTThe acceptance of the tumor as a non-isolated structure within the organism has opened a space for the study of a wide spectrum of potential direct and indirect interactions, not only between the tumor tissue and its vicinity, but also between the tumor and its macroenvironment, including the nervous system. Although several lines of evidence have implicated the nervous system in tumor growth and progression, for many years, researchers believed that tumors lacked innervation and the notion of indirect neuro-neoplastic interactions v...
Source: Endocrine Regulations - April 2, 2024 Category: Endocrinology Authors: Filip Blasko Lubica Horvathova Source Type: research
ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells
CONCLUSION.: The results of the present study demonstrate that hypoxia affected the expression of homeobox genes MEIS1, MEIS2, MEIS3, LHX1, LHX2, LHX6, SPAG4, and NKX3-1 in U87MG glioblastoma cells in gene-specific manner and that the sensitivity of all studied genes to hypoxia condition is mediated by ERN1, the major pathway of the endoplasmic reticulum stress signaling, and possibly contributed to the control of glioblastoma growth. A fundamentally new results of this work is the establishment of the fact regarding the dependence of hypoxic regulation of SPAG4 gene expression on ER stress, in particular ERN1, which is as...
Source: Endocrine Regulations - April 2, 2024 Category: Endocrinology Authors: Daria A Krasnytska Olena O Khita Yuliia M Viletska Dmytro O Minchenko Oleh V Halkin Olha V Rudnytska Sofiia L Hoian Oleksandr H Minchenko Source Type: research
Advanced glycation end products of dietary origin and their association with inflammation in diabetes - A minireview
Endocr Regul. 2024 Apr 2;58(1):57-67. doi: 10.2478/enr-2024-0007. Print 2024 Jan 1.ABSTRACTAdvanced glycation end products (AGEs) are a diverse group of compounds that are formed as a result of the non-enzymatic reaction between a reducing sugar such as glucose and the free NH2 groups of an amino acid in a protein or other biomolecule. The chemical reaction, by which these products are generated, is known as the Maillard reaction and occurs as a part of the body's normal metabolism. Such a reaction is enhanced during diabetes due to hyperglycemia, but it can also occur during the preparation, processing, and preservation o...
Source: Endocrine Regulations - April 2, 2024 Category: Endocrinology Authors: Adriana Pedreanez Jorge Robalino Diego Tene Patricio Salazar Source Type: research
