miR-452 promotes the development of gastric cancer via targeting EPB41L3

In this study, we found that miR-452 was highly expressed in both tumor tissue and gastric cancer cells, and could directly target the cancer suppressor gene EPB41L3 3′-UTR. miR-452 significantly promoted the proliferation, migration and the S-phase arrest of gastric cancer cells, but EPB41L3 as a downstream target gene of miR-452 reversed such promoting effect. While down-regulation of miR-452 expression significantly inhibited the malignant biological behavior of gastric cancer cells, but this inhibitory effect was reversed by EPB41L3 siRNA. In addition, miR-452 in the gastric cancer xenograft model in nude mice could down-regulated the expression level of EPB41L3 and promote the growth of transplanted tumor in nude mice. Taken together, this study reveals the role of miR-452 in gastric cancer via inhibiting the target gene EPB41L3, suggesting that miR-452 has the potential to become a new target for the diagnosis and treatment of gastric cancer.
Source: Pathology Research and Practice - Category: Pathology Source Type: research

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Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research
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Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - Category: ENT & OMF Source Type: research
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Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - Category: ENT & OMF Source Type: research
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Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
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Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
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Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
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Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
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Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
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