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Construction, evaluation, and AOP framework-based application of the EpPRS as a genetic surrogate for assessing environmental pollutants
CONCLUSIONS: EpPRSs can serve as a proxy for assessing pollutant internal exposure. The application of the EpPRS to disease risk assessment can reveal the toxic pathway and mode of action linking exposure and disease in detail, providing a basis for the development of environmental pollutant control strategies.PMID:37734146 | DOI:10.1016/j.envint.2023.108202
Source: Environment International - September 21, 2023 Category: Environmental Health Authors: Silu Chen Junyi Xin Zhutao Ding Lingyan Zhao Shuai Ben Rui Zheng Shuwei Li Huiqin Li Wei Shao Yifei Cheng Zhengdong Zhang Mulong Du Meilin Wang Source Type: research
Pulse rate variability predicted cardiovascular disease in sleep disordered breathing: The Guangdong sleep health study
CONCLUSIONS: PRV parameters may be specific predictors for CVD in SDB. PNN50 was a potent biomarker for CVD risk in the elderly with SDB, event without traditional CVD risk factors.PMID:37734671 | DOI:10.1016/j.rmed.2023.107408
Source: Respiratory Care - September 21, 2023 Category: Respiratory Medicine Authors: Miaochan Lao Qiong Ou Guangliang Shan Murui Zheng Guo Pei Yanxia Xu Longlong Wang Jiaoying Tan Bin Lu Source Type: research
Defective insulin-stimulated equilibrative nucleoside transporter-2 activity and altered subcellular transporter distribution drive the loss of adenosine homeostasis in diabetic kidney disease progression
CONCLUSION: Deficient insulin regulation of ENT2 activity contributes to chronically high adenosine levels and glomerular alterations that underline diabetic kidney disease progression.PMID:37734469 | DOI:10.1016/j.bbadis.2023.166890
Source: Biochimica et Biophysica Acta - September 21, 2023 Category: Biochemistry Authors: Raibel Suarez Carolina Villarreal Yessica Nahuelp án Claudia Jara Carlos Oyarz ún Sebasti án Alarcón Montserrat M D íaz-Encarnación Elena Guill én-Gómez Claudia Quezada Rody San Mart ín Source Type: research
Polyazine nanoparticles as anchors of PQQ glucose dehydrogenase for its most efficient bioelectrocatalysis
We report on the drop-cast production of glucose biosensors based on the most efficient bioelectrocatalysis by pyrroloquinoline quinone dependent glucose dehydrogenase (PQQ GDH). To orient the enzyme upon immobilization we suggest using poly(Methylene Green) (p(MG)) nanoparticles acting as anchors. Synthesis of polymeric anchors has been carried out in course of Methylene Green electropolymerization, which allowed to tune polymer-to-monomer ratio in the drop-cast mixtures varying the monomer concentration and applying different number of potential sweep cycles. Except for elimination of electrochemical step for the electro...
Source: Talanta - September 21, 2023 Category: Chemistry Authors: Maria A Komkova Anna S Alexandrovich Arkady A Karyakin Source Type: research
Predicting Prosthetic Mobility at Discharge From Rehabilitation Following Major Amputation in Vascular Surgery < sup > † < /sup >
CONCLUSION: An internally validated decision aid for estimating the likelihood of independence with a prosthesis after major amputation was constructed. A strong association between female sex and poorer prosthetic mobility was observed. Prosthetic function was shown to be a surrogate marker of long term survival. Future research will involve external validation studies to confirm the generalisability of the decision aid in clinical practice.PMID:37734438 | DOI:10.1016/j.ejvs.2023.09.034
Source: PubMed: Eur J Vasc Endovasc ... - September 21, 2023 Category: Surgery Authors: Arsalan Wafi Luis Ribeiro Vijay Kolli Bilal Azhar James Budge Ian M Loftus Peter J E Holt Source Type: research
Efficacy and Safety of Esaxerenone in Hypertensive Patients with Diabetes Mellitus Undergoing Treatment with Sodium-Glucose Cotransporter 2 Inhibitors (EAGLE-DH)
CONCLUSION: Esaxerenone effectively lowered BP, was safe, and showed renoprotective effects in hypertensive patients with diabetes mellitus receiving treatment with SGLT2 inhibitors. Esaxerenone and SGLT2 inhibitors did not interfere with either drug's efficacy and may reduce the frequency of serum potassium elevations, suggesting they are a compatible combination.CLINICAL TRIAL REGISTRATION: jRCTs031200273.PMID:37733211 | DOI:10.1007/s12325-023-02633-8
Source: Adv Data - September 21, 2023 Category: Epidemiology Authors: Hirohiko Motoki Yoshito Inobe Toshiki Fukui Arata Iwasaki Shinya Hiramitsu Sekiya Koyama Izuru Masuda Noriyuki Sekimura Kazuya Yamamoto Ai Sato Mitsuhisa Komatsu Takashi Taguchi Kazuhito Shiosakai Kotaro Sugimoto Koichiro Kuwahara Source Type: research
Network pharmacology and molecular docking to scientifically validate the potential mechanism of Lonicerae japonicae flos in the clinical treatment of COVID-19
Nat Prod Res. 2023 Sep 21:1-8. doi: 10.1080/14786419.2023.2260070. Online ahead of print.ABSTRACTUsing network pharmacology and molecular docking, we predicted the potential mechanisms of Lonicerae japonicae flos (LJF) therapy for COVID-19. A total of 493 component-related targets and 6,233 COVID-19-related genes were identified, and 267 core genes with overlapping of the two types of genes were identified. The target AKT1, CASP3, IL1B, IL6, PTGS2, TNF and JUN were the hub genes in PPI network according to MCODE score. Component-Target analysis showed the close relationship between targets and components. The results of fu...
Source: Natural Product Research - September 21, 2023 Category: Biochemistry Authors: Yisheng Huang Yan Fang Huanhuan Jie Hongbiao Yang Wen Zhou Yijian Chen Baolin Zhong Source Type: research
Effect of cycloastragenol and punicalagin on Prp(106-126) and A β(25-35) oligomerization and fibrillizaton
In this study, we have examined the effect of two NPs, cycloastragenol (CAG) and punicalagin (PCG), on the metal-induced oligomerization and aggregation of Aβ25-35 and PrP106-126 peptides. The peptide aggregation and inhibitory properties of both NPs were examined by the thioflavin-T (ThT) assay, MALDI-TOF, circular dichroism (CD) spectroscopy, and transmission electron microscopy (TEM). Among the two NPs, PCG significantly binds to the peptides, chelates metal ions (Cu2+ and Zn2+), inhibits peptide aggregation, substantially reduces oxidative stress, and controls the production of reactive oxygen species (ROS). Both NPs ...
Source: Biophysical Chemistry - September 21, 2023 Category: Chemistry Authors: Govinda R Navale Rahul Chauhan Saakshi Saini Partha Roy Kaushik Ghosh Source Type: research
Assisted reproductive technology outcomes and management considerations for people with epilepsy
Curr Opin Endocrinol Diabetes Obes. 2023 Sep 22. doi: 10.1097/MED.0000000000000838. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Epilepsy is a common neurologic condition amongst people with reproductive capacity, and assisted reproductive technology (ART) is being increasingly utilized. A recent population-based study described favorable outcomes of ART in this population, but other work shows how fluctuating sex hormones may influence medication concentrations and seizures.RECENT FINDINGS: This review discusses hormonal influences on epilepsy and catamenial epilepsy, considerations regarding fertility in women with e...
Source: Epilepsy Curr - September 21, 2023 Category: Neurology Authors: Regan J Lemley Paula Emanuela Voinescu Source Type: research
Relationship Between Standardized Measures of Chronic Kidney Disease-associated Pruritus Intensity and Health-related Quality of Life Measured with the EQ-5D Questionnaire: A Mapping Study
Acta Derm Venereol. 2023 Sep 20;103:adv11604. doi: 10.2340/actadv.v103.11604.ABSTRACTChronic kidney disease-associated pruritus is linked with decreased health-related quality of life assessed using disease-specific instruments. The extent to which worsening pruritus reduces generic quality of life assessed using the EQ-5D instrument is unknown. Prevalent kidney failure patients receiving in-centre haemodialysis from 5 centres completed the EQ-5D-5L quality of life measure, worst Itching Intensity Numerical Rating Scale and 5-D itch pruritus instruments. Latent class models were used to identify clusters of patients with s...
Source: Acta Derm Venereol A... - September 21, 2023 Category: Dermatology Authors: Monica Hernandez Alava Alessandro Sasso Pann Ei Hnynn Si Matthew Gittus Richard Powell Louese Dunn Praveen Thokala James Fotheringham Source Type: research
Effect of 23 % low-sodium salt applied to Chinese modified DASH diet on cerebrovascular function in patients with hypertension and type 2 diabetes: a pilot study
CONCLUSIONS: based on the study, 23 % low-sodium formula combined with CM-DASH diet pattern can improve cerebrovascular function in community patients with hypertension complicated with diabetes and has a good short-term benefit of blood pressure and glucose control.PMID:37732352 | DOI:10.20960/nh.04648
Source: Nutricion Hospitalaria - September 21, 2023 Category: Nutrition Authors: Yi Wu Jie Tang Dan Chen Yujia Zou Pingping Yu Huini Xu Shuwen Cai Yanni Ren Ying Mei Lihong Mu Source Type: research
< em > Glucocorticoids, Their Uses, Sexual Dimorphisms, and Diseases: New Concepts, Mechanisms, and Discoveries < /em >
Physiol Rev. 2023 Sep 21. doi: 10.1152/physrev.00021.2023. Online ahead of print.ABSTRACTThe normal stress response in humans is governed by the hypothalamic-pituitary-adrenal (HPA) axis through heightened mechanisms during stress, raising blood levels of the glucocorticoid hormone cortisol. Glucocorticoids are quintessential compounds that balance the proper functioning of numerous systems in the mammalian body. They are also generated synthetically and are the preeminent therapy for inflammatory diseases. They act by binding to the nuclear receptor transcription factor, the glucocorticoid receptor (GR), which has two mai...
Source: Physiological Reviews - September 21, 2023 Category: Physiology Authors: Genesee J Martinez Malik Appleton Zachary A Kipp Analia S Loria Booki Min Terry D Hinds Source Type: research
Diabetes exacerbates inflammatory bowel disease in mice with diet-induced obesity
CONCLUSION: In obese mice, diabetes worsened clinical and pathologic outcomes of colitis via mechanisms that are reversible with treatment of hyperglycemia. Hyperglycemia-induced intestinal barrier dysfunction offers a plausible mechanism linking diabetes to increased colitis severity. These findings suggest that effective diabetes management may decrease the clinical severity of IBD.PMID:37731997 | PMC:PMC10507503 | DOI:10.3748/wjg.v29.i33.4991
Source: World Journal of Gastroenterology : WJG - September 21, 2023 Category: Gastroenterology Authors: Kendra L Francis Kimberly M Alonge Maria Cristina Pacheco Shannon J Hu Cody A Krutzsch Gregory J Morton Michael W Schwartz Jarrad M Scarlett Source Type: research
The effect of type 2 diabetes and diabetic peripheral neuropathy on predictive grip force control
This study investigated the impact of type 2 diabetes and diabetic peripheral neuropathy on grip force control during object manipulation. The study included three age-matched groups: type 2 diabetes alone (n = 11), type 2 diabetes with neuropathy (n = 13), and healthy controls (n = 12). Grip force control variables derived from lifting and holding an experimental cup were the ratio between grip force and load forces during lifting (GFR), latency 1 and latency 2, which represented the time between the object's grip and its lift-off from the table, and the period between object's lift-off and the grip force peak, respective...
Source: Brain Research - September 21, 2023 Category: Neurology Authors: Marcio Dos Santos Abdalghani Yahya Patricia Kluding Mamatha Pasnoor Jo Wick Wen Liu Source Type: research
Diabetes exacerbates inflammatory bowel disease in mice with diet-induced obesity
CONCLUSION: In obese mice, diabetes worsened clinical and pathologic outcomes of colitis via mechanisms that are reversible with treatment of hyperglycemia. Hyperglycemia-induced intestinal barrier dysfunction offers a plausible mechanism linking diabetes to increased colitis severity. These findings suggest that effective diabetes management may decrease the clinical severity of IBD.PMID:37731997 | PMC:PMC10507503 | DOI:10.3748/wjg.v29.i33.4991
Source: World Journal of Gastroenterology - September 21, 2023 Category: Gastroenterology Authors: Kendra L Francis Kimberly M Alonge Maria Cristina Pacheco Shannon J Hu Cody A Krutzsch Gregory J Morton Michael W Schwartz Jarrad M Scarlett Source Type: research
