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Condition: Diabetes
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Association of participants who screened positive for night eating syndrome with physical health, sleep problems, and weight status in an Australian adult population
CONCLUSIONS: Several physical health problems were found to be significantly associated with the spNES group including sleep problems, increased BMI, increased levels of pain and lower self-reported physical health-related quality of life. Consequently, future research exploring the complex interaction between NES and these medical conditions may provide further insight into the diagnosis, screening tools and management of NES. Additionally, this study highlights the need for future studies which use larger population-based samples.LEVEL OF EVIDENCE: Level III. Evidence obtained from well-designed cohort or case-control an...
Source: Eating and weight disorders : EWD - September 20, 2023 Category: Eating Disorders & Weight Management Authors: Sai Janani Sakthivel Phillipa Hay Stephen Touyz David Currow Haider Mannan Source Type: research
Microbiome-targeted interventions for the control of oral-gut dysbiosis and chronic systemic inflammation
Trends Mol Med. 2023 Sep 18:S1471-4914(23)00191-0. doi: 10.1016/j.molmed.2023.08.006. Online ahead of print.ABSTRACTRecent research has confirmed the strong connection between imbalances in the oral and gut microbiome (oral-gut dysbiosis), periodontitis, and inflammatory conditions such as diabetes, Alzheimer's disease, and cardiovascular diseases. Microbiome modulation is crucial for preventing and treating several autoimmune and inflammatory diseases, including periodontitis. However, the causal relationships between the microbiome and its derived metabolites that mediate periodontitis and chronic inflammation constitute...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Juan Pacheco-Yanes Eric Reynolds Jian Li Eliana Mari ño Source Type: research
Cerium oxide nanoparticles in diabetic foot ulcer management: Advances, limitations, and future directions
Colloids Surf B Biointerfaces. 2023 Sep 9;231:113535. doi: 10.1016/j.colsurfb.2023.113535. Online ahead of print.ABSTRACTDiabetic foot ulcer (DFU) is one of the most serious complications of diabetes, potentially resulting in wound infection and amputation under severe circumstances. Oxidative stress and dysbiosis are the primary factors that delay wound healing, posing challenges to effective treatment. Unfortunately, conventional approaches in these aspects have proven satisfactory in achieving curative outcomes. Recent research has increasingly focused on using nanoparticles, leveraging their potential in wound dressing...
Source: Colloids and Surfaces - September 20, 2023 Category: Biotechnology Authors: Haotian Xu Shiqi Li Xiaoxuan Ma Tingting Xue Fang Shen Yi Ru Jingsi Jiang Le Kuai Bin Li Hang Zhao Xin Ma Source Type: research
Effect of Zuo's warming Yang acupuncture therapy combined with lifestyle interventions on prediabetes: A randomized controlled trial
CONCLUSIONS: Zuo's warming Yang acupuncture therapy conjunction with lifestyle interventions was more effective than lifestyle interventions alone in reducing FPG, 2hPG and HbA1c levels in prediabetic patients. These results suggest that Zuo's warming Yang acupuncture therapy may be a safe and effective treatment option for prediabetes.PMID:37730092 | DOI:10.1016/j.ctim.2023.102985
Source: Complementary Therapies in Medicine - September 20, 2023 Category: Complementary Medicine Authors: Yang Li Kehang Xie Xuanli Zeng Lu Ding Yuting Wang Liming Lu Changbo Zuo Source Type: research
24-year-old woman • large joint arthralgias • history of type 1 diabetes, seizures, migraines • Dx?
J Fam Pract. 2023 Sep;72(7):E30-E32. doi: 10.12788/jfp.0651.ABSTRACT► large joint arthralgias ► history of type 1 diabetes, seizures, migraines.PMID:37729147 | DOI:10.12788/jfp.0651
Source: The Journal of Family Practice - September 20, 2023 Category: Practice Management Authors: Asher George Stephen Rayborn Peyton Herrington Svenja Albrecht Adrian Billings Source Type: research
Is low-dose naltrexone effective in chronic pain management?
J Fam Pract. 2023 Sep;72(7):320-321. doi: 10.12788/jfp.0654.ABSTRACTYES. Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a superior safety profile (strength of recommendation [SOR], B; single randomized controlled trial [RCT]). Low-dose naltrexone significantly reduced pain by 32% in inflammatory conditions and 44% in neuropathic conditions (SOR, B; single retrospective cohort study). Doses as low as 5.4 mg were found to reduce pain in 95% of patients with fibromyalgia (SOR, B; single prospective dose-response study).PMID:37729143 | DOI:10.12788/jfp.0654
Source: The Journal of Family Practice - September 20, 2023 Category: Practice Management Authors: Roxanne Radi Harriet Huang Jason Rivera Corey Lyon Kristen DeSanto Source Type: research
Acetylation in pathogenesis: Revealing emerging mechanisms and therapeutic prospects
Biomed Pharmacother. 2023 Sep 18;167:115519. doi: 10.1016/j.biopha.2023.115519. Online ahead of print.ABSTRACTProtein acetylation modifications play a central and pivotal role in a myriad of biological processes, spanning cellular metabolism, proliferation, differentiation, apoptosis, and beyond, by effectively reshaping protein structure and function. The metabolic state of cells is intricately connected to epigenetic modifications, which in turn influence chromatin status and gene expression patterns. Notably, pathological alterations in protein acetylation modifications are frequently observed in diseases such as metabo...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Nan Jiang Wenyong Li Shuanglin Jiang Ming Xie Ran Liu Source Type: research
Mechanisms of action of incretin receptor based dual- and tri-agonists in pancreatic islets
Am J Physiol Endocrinol Metab. 2023 Sep 20. doi: 10.1152/ajpendo.00236.2023. Online ahead of print.ABSTRACTSimultaneous activation of the incretin G protein coupled receptors via unimolecular dual-receptor agonists (UDRA) has emerged as a new therapeutic approach for type 2 diabetes. Recent studies also advocate triple agonism with molecules also capable of binding the glucagon receptor. In this scoping review we discuss the cellular mechanisms of action (MOA) underlying the actions of these novel and therapeutically important classes of peptide receptor agonists. Clinical efficacy studies of several UDRAs have demonstrate...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 20, 2023 Category: Physiology Authors: Franco Folli Giovanna Finzi Roberto Manfrini Alessandra Galli Francesca Casiraghi Lucia Centofanti Cesare Berra Paolo Fiorina Alberto Davalli Stefano La Rosa Carla Perego Paul B Higgins Source Type: research
Endoplasmic Reticulum Stress in Pancreatic β-Cells Induces Incretin Desensitization and β-Cell Dysfunction via ATF4-Mediated PDE4D Expression
Am J Physiol Endocrinol Metab. 2023 Sep 20. doi: 10.1152/ajpendo.00156.2023. Online ahead of print.ABSTRACTPancreatic β-cell dysfunction and eventual loss are key steps in the progression of type 2 diabetes (T2D). Endoplasmic reticulum (ER) stress responses, especially those mediated by the PERK-ATF4 pathway, have been implicated in promoting these β-cell pathologies. However, the exact molecular events surrounding the role of the PERK-ATF4 pathway in β-cell dysfunction remain unknown. Here, we report our discovery that ATF4 promotes the expression of PDE4D, which disrupts β-cell function via a downregulation of cAMP s...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 20, 2023 Category: Physiology Authors: Ji-Hye Lee Hanguk Ryu Hyejin Lee Hye Ram Yu Yurong Gao Kyeong-Min Lee Young-Joon Kim Jaemin Lee Source Type: research
The role of miR-433-3p in vascular calcification in type 2 diabetic patients: targeting WNT/ β-Catenin and RANKL/RANK/OPG signaling pathways
CONCLUSION: Collectively, the study documented that down-regulation of miR-433-3p may contribute to the development of VC through activating WNT/β-Catenin and RANKL/RANK/OPG signaling pathways.PMID:37728820 | DOI:10.1007/s11033-023-08792-9
Source: Molecular Biology Reports - September 20, 2023 Category: Molecular Biology Authors: Amira M Elshamy Yasser Mostafa Hafez Mohamed A E Safa Hoda A Ibrahim Mohamed Khalfallah Fatma H Rizk Eman F Eltabaa Muhammad T Abdel Ghafar Marwa Mohamed Atef Source Type: research
Diabetes Mellitus Drug Discovery: Insights into Targeting Feline and Human Amylin with Small Molecules
Vet Q. 2023 Sep 20:1-20. doi: 10.1080/01652176.2023.2260442. Online ahead of print.ABSTRACTType 2 diabetes (T2D) is a health concern for both humans and cats, with cases rising over the past decade. Around 70% of patients from either species exhibit pancreatic aggregates of islet amyloid polypeptide (IAPP), a protein that proves toxic upon misfolding. These misfolded protein aggregates congregate in the islets of Langerhans of the pancreas, diminishing the capability of β-cells to produce insulin and further perpetuating disease. Our team's drug discovery program is investigating newly synthesized compounds that could dim...
Source: Veterinary Quarterly - September 20, 2023 Category: Veterinary Research Authors: Kendall B E Moore Natalie G Horgan Brooke Lenters Jessica S Fortin Source Type: research
Islet-on-Chip: Promotion of Islet Health and Function via Encapsulation within a Polymerizable Fibrillar Collagen Scaffold
Lab Chip, 2023, Accepted Manuscript DOI: 10.1039/D3LC00371J, PaperEmma L. Vanderlaan, Joshua Sexton, Carmella Evans-Molina, Adrian Buganza Tepole, Sherry L. Voytik-Harbin The protection and interrogation of pancreatic β-cell health and functionex vivo is a fundamental aspect of diabetes research, including mechanistic studies, evaluation of β-cell health modulators, and development and... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Lab Chip latest articles - September 19, 2023 Category: Chemistry Authors: Emma L. Vanderlaan Source Type: research
Osteopontin-driven T-cell accumulation and function in adipose tissue and liver promoted insulin resistance and MAFLD
CONCLUSIONS: Current findings highlight a critical role of SPP1 in the initiation of obesity-driven chronic inflammation by regulating accumulation and/or polarization of T cells. Early targeting of SPP1 could be beneficial for IR and MAFLD treatment.PMID:37724058 | DOI:10.1002/oby.23868
Source: Obesity - September 19, 2023 Category: Eating Disorders & Weight Management Authors: Fr édéric Soysouvanh D éborah Rousseau St éphanie Bonnafous Manon Bourinet Axelle Strazzulla St éphanie Patouraux Jean Machowiak Marwin A Farrugia Antonio Iannelli Albert Tran Rodolphe Anty Carmelo Luci Philippe Gual Source Type: research
Associations and predictive performance of 11 anthropometric measures with incident type 2 diabetes: A prospective cohort study from the UK Biobank
CONCLUSIONS: Although most adiposity markers were associated with type 2 diabetes, the magnitude of the associations differed. WHtR had the strongest associations and predictive ability for type 2 diabetes and thus could be a more suitable marker for clinical use.PMID:37724055 | DOI:10.1002/oby.23849
Source: Obesity - September 19, 2023 Category: Eating Disorders & Weight Management Authors: Jirapitcha Boonpor Solange Parra-Soto Atefeh Talebi Ziyi Zhou Fernanda Carrasco-Marin Fanny Petermann-Rocha Paul Welsh Jill P Pell Naveed Sattar Jason M R Gill Stuart R Gray Carlos Celis-Morales Frederick K Ho Source Type: research
