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Condition: Diabetes

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Prevalence and Management of Obesity in U.S. Adults With Type 1 Diabetes
Ann Intern Med. 2023 Sep;176(9):eL230227. doi: 10.7326/L23-0227.NO ABSTRACTPMID:37722122 | DOI:10.7326/L23-0227
Source: Annals of Internal Medicine - September 18, 2023 Category: Internal Medicine Authors: Djordje Popovic Dimitrios Patoulias Nikolaos Papanas Source Type: research

ARL15 and its multiple disease associations: Emerging functions and potential therapeutic applications
Curr Protein Pept Sci. 2023 Sep 15. doi: 10.2174/1389203724666230915123217. Online ahead of print.ABSTRACTARL15 is a member of the RAS superfamily of small GTPases and is associated with several metabolic traits, including increased risk of diabetes, rheumatoid arthritis and lipid metabolism disorders. The ARL15 gene encodes for an uncharacterized small GTP binding protein. Its precise role in human physiology remains unknown, but several genetic association studies have recognized different variants in this gene to be statistically associated with numerous traits and complex diseases. Here, we provided the unique features...
Source: Current Protein and Peptide Science - September 18, 2023 Category: Biochemistry Authors: Manisha Saini Varnita Anand Aditya Sharma Anuj Pandey B K Thelma Suman Kundu Source Type: research

Integration of palliative care in the management of oral squamous cell carcinoma
Bioinformation. 2023 Jan 31;19(1):1-4. doi: 10.6026/97320630019001. eCollection 2023.ABSTRACTOral Squamous cell Cancers (OSCC) is strongly associated with tobacco consumption. We here in present a case study of a OSCC patient who refused standard oncological care (SOC), to highlight the importance of integrating palliative care (PC) for improved patient outcomes. A 61 years male patient, with history of chewing tobacco for more than 20 years and diagnosed to have OSCC for 1.5 years presented with severe anaemia and a cauliflower-like growth (12 x 10 cm) in the left oral cavity and cheek with greenish-yellow discharge. Pus ...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Republica Sridhar Huwait Etimad Peter Natesan Pushparaj Gauthaman Kalamegam Source Type: research

Diabetes linked oral complications in south Indian cohorts
Bioinformation. 2023 Jan 31;19(1):85-87. doi: 10.6026/97320630019085. eCollection 2023.ABSTRACTDiabetes is characterized by elevated blood sugar and insulin resistance. In poorly controlled or uncontrolled diabetes, persistent hyperglycemia causes oral and systemic problems. Therefore, it is of interest to evaluate biochemical indicators for oral health and diabetes using a fully automatic biochemistry analyzer which separates patient serum from blood samples. Data shows that diabetic oral complex patients showed high RBS, HbA1c, FBS, and PBSS. Thus, dental condition is linked to diabetes.PMID:37720287 | PMC:PMC10504521 | ...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Manisha K Vishnu Priya Veeraraghavan Kaviyarasi Renu Kavitha Sankaran Gayathri Rengasamy Source Type: research

Ethnicity and risk factors among Indian coronary artery disease patients
In this study, an attempt was made to investigate the distribution of coronary risk factors in male patients with coronary artery disease (CAD)(n=50 each) belonging to Jaat and Vaishya castes. A Significantly higher average height, waist and hip circumferences, glucose, and waist-height ratio were observed in Jaats compared to the Vaishyas (p=0.000). Mean BMI, total cholesterol (total-C) and non-high density lipoprotein cholesterol (HDL-C), and lean body mass index (LBMI) were significantly higher in Vaishyas against Jaats (p=0.00). A significantly higher percentage of type 2 diabetes(T2DM) (p=0.03) and isolated hypertrigl...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Monika Sah Latheef Saa Venkataramana P Source Type: research

Molecular docking analysis of calcium channel blockers with ALR2 and RAGE
We report that 1, 4-dihydropyridine compounds, particularly Benidipine, bind to the active sites with good efficiency. Thus, 1,4 dihydropyridine derivatives can be considered for further confirmation in drug discovery.PMID:37720280 | PMC:PMC10504517 | DOI:10.6026/97320630019028
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Samreen Kazmi Surekha Challa Malini Devi Alaparthi Indira Devi M Swetha Sudha Nagamalla Priya Ej Source Type: research

Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The three-dimensional structure of insulin and its receptor
Vitam Horm. 2023;123:151-185. doi: 10.1016/bs.vh.2022.12.001. Epub 2023 Jun 5.ABSTRACTInsulin is a peptide hormone essential for maintaining normal blood glucose levels. Individuals unable to secrete sufficient insulin or not able to respond properly to insulin develop diabetes. Since the discovery of insulin its structure and function has been intensively studied with the aim to develop effective diabetes treatments. The three-dimensional crystal structure of this 51 amino acid peptide paved the way for discoveries, outlined in this review, of determinants important for receptor binding and hormone stability that have bee...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Briony E Forbes Source Type: research

Signaling mechanism of growth hormone-releasing hormone receptor
Vitam Horm. 2023;123:1-26. doi: 10.1016/bs.vh.2023.06.004. Epub 2023 Jul 7.ABSTRACTThe hypothalamic peptide growth hormone-releasing hormone (GHRH) stimulates the secretion of growth hormone (GH) from the pituitary through binding and activation of the pituitary type of GHRH receptor (GHRH-R), which belongs to the family of G protein-coupled receptors with seven potential membrane-spanning domains. Splice variants of GHRH-Rs (SV) in human tumors and other extra pituitary tissues were identified and their cDNA was sequenced. Among the SVs, splice variant 1 (SV1) possesses the greatest similarity to the full-length GHRH-R an...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Gabor Halmos Zsuzsanna Szabo Eva Juhasz Andrew V Schally Source Type: research

Impact of diet modification on body mass and kidney function in patients with diabetic nephropathy: a pilot study
CONCLUSIONS: The study shows that obesity is a common comorbid disease in patients with DN and that dietary intervention is associated with a significant reduction in body mass and stabilization of eGFR in these patients.PMID:37717272 | DOI:10.18388/abp.2020_6889
Source: Acta Biochim Pol - September 17, 2023 Category: Biochemistry Authors: Ma łgorzata Kaczkan Sylwia Czaja-Stolc Ma łgorzata Sikorska-Wiśniewska Micha ł Chmielewski Alicja D ębska-Ślizień Sylwia Ma łgorzewicz Source Type: research

Bioderived cellulose fibre-guar gum grafted poly (N, N'-dimethylacrylamide) polymer network for controlled release of metformin hydrochloride
Int J Biol Macromol. 2023 Sep 15:126882. doi: 10.1016/j.ijbiomac.2023.126882. Online ahead of print.ABSTRACTAn interpenetrating polymer network (IPN) of areca cellulose and guar gum grafted with poly (N, N'-dimethylacrylamide) was made by microwave irradiation technique. N, N-methylenebisacrylamide (MBA) was used as the crosslinking agent. The network polymer was characterised using Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), Powder X-ray Diffraction (XRD) and Field Emission Scanning Electron Microscopy (FESEM). The chemical interaction between the drug and the polymer was studied usin...
Source: International Journal of Biological Macromolecules - September 17, 2023 Category: Biochemistry Authors: Smitha Rai Ruchira Raychaudhuri Ritu Kudarha Srinivas Mutalik B Vishalakshi K M Usha Source Type: research

Carboxymethyl chitosan-TK resistant starch complex ameliorates type 2 diabetes by regulating the gut microbiota
Int J Biol Macromol. 2023 Sep 15:126930. doi: 10.1016/j.ijbiomac.2023.126930. Online ahead of print.ABSTRACTCarboxymethyl chitosan and resistant starch exhibit good performance in diabetes regulation. We prepared carboxymethyl chitosan - resistant starch complex. Test the properties of composite resistant starch by using X-ray diffraction, water contact angle, infrared spectroscopy, and scanning electron microscopy, interactions with intestinal microbiota and mouse experiments were also conducted. The results indicated that the composite resistant starch had a good effect on promoting the proliferation of probiotics on Bif...
Source: International Journal of Biological Macromolecules - September 17, 2023 Category: Biochemistry Authors: Xin Pan Pei Liu Ye-Jun Zhang Hao-Kuang Zhang Hao Wei Jing-Yi Jiang None Hui-Yan Er-Xin Shang Wei-Wen Li Yiwei Wang Jin-Ao Duan Source Type: research

Opening a window to skin biomarkers for diabetes stage with optoacoustic mesoscopy
Light Sci Appl. 2023 Sep 18;12(1):231. doi: 10.1038/s41377-023-01275-3.ABSTRACTBeing the largest and most accessible organ of the human body, the skin could offer a window to diabetes-related complications on the microvasculature. However, skin microvasculature is typically assessed by histological analysis, which is not suited for applications to large populations or longitudinal studies. We introduce ultra-wideband raster-scan optoacoustic mesoscopy (RSOM) for precise, non-invasive assessment of diabetes-related changes in the dermal microvasculature and skin micro-anatomy, resolved with unprecedented sensitivity and det...
Source: Appl Human Sci - September 17, 2023 Category: Physiology Authors: Hailong He Nikolina-Alexia Fasoula Angelos Karlas Murad Omar Juan Aguirre Jessica Lutz Michael Kallmayer Martin F üchtenbusch Hans-Henning Eckstein Annette Ziegler Vasilis Ntziachristos Source Type: research

Circulating organochlorine pesticide levels, genetic predisposition and the risk of incident type 2 diabetes
In conclusion, higher circulating OCP levels were independently associated with an increased risk of T2D, with β-BHC possibly being the major contributor. Genetic predisposition to T2D-related morbidity, such as visceral adiposity, should be considered when assessing the risk of T2D conferred by OCPs.PMID:37717893 | DOI:10.1016/j.envpol.2023.122541
Source: Environmental Pollution - September 17, 2023 Category: Environmental Health Authors: Chengyong Jia Shiyang Zhang Xu Cheng Peiwen Li Jun An Xin Zhang Wending Li Yali Xu Handong Yang Tao Jing Huan Guo Meian He Source Type: research