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Feasibility and acceptability of miracle fruit application prior to the consumption of sour-tasting foods as a weight-loss strategy in adults with diabetes or prediabetes: A randomized crossover trial
Appetite. 2023 Sep 17:107046. doi: 10.1016/j.appet.2023.107046. Online ahead of print.ABSTRACTMiracle fruit (MF) has emerged as a promising option for healthy noncaloric sweeteners due to its sour-to-sweet taste-modifying effects and high antioxidant activity. We aimed to examine the feasibility and acceptability of using MF as a weight-loss strategy for individuals with diabetes or prediabetes. Fifty Korean-American men and women (25 participants each) aged 45-75 years with diabetes or prediabetes were recruited in this study. They participated in a randomized placebo-controlled crossover trial where they took the assigne...
Source: Appetite - September 19, 2023 Category: Nutrition Authors: Sung Eun Choi Taehwan Park Source Type: research
Harnessing role of sesamol and its nanoformulations against neurodegenerative diseases
Biomed Pharmacother. 2023 Sep 17;167:115512. doi: 10.1016/j.biopha.2023.115512. Online ahead of print.ABSTRACTSesamol is a lignan of sesame seeds and a natural phenolic molecule that has emerged as a useful medical agent. Sesamol is a non-toxic phytoconstituent, which exerts certain valuable effects in the management of cancer, diabetes, cardiovascular diseases, neurodegenerative diseases (NDs), etc. Sesamol is known to depict its neuroprotective role by various mechanisms, such as metabolic regulators, action on oxidative stress, neuroinflammation, etc. However, its poor oral bioavailability, rapid excretion (as conjugate...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 19, 2023 Category: Drugs & Pharmacology Authors: Navneet Singh Sukriti Vishwas Amandeep Kaur Harmanpreet Kaur Violina Kakoty Rubiya Khursheed M V N L Chaitanya Molakpogu Ravindra Babu Ankit Awasthi Leander Corrie Vancha Harish Palakurthi Yanadaiah Saurabh Gupta Amany A Sayed Amr El-Sayed Iftikhar Ali Os Source Type: research
The Intersocietal IWGDF, ESVS, SVS Guidelines on Peripheral Artery Disease in People With Diabetes Mellitus and a Foot Ulcer
Eur J Vasc Endovasc Surg. 2023 Sep 6:S1078-5884(23)00586-5. doi: 10.1016/j.ejvs.2023.07.020. Online ahead of print.ABSTRACTDiabetes related foot complications have become a major cause of morbidity and are implicated in most major and minor amputations globally. Approximately 50% of people with diabetes and a foot ulcer have peripheral artery disease (PAD) and the presence of PAD significantly increases the risk of adverse limb and cardiovascular events. The International Working Group on the Diabetic Foot (IWGDF) has published evidence based guidelines on the management and prevention of diabetes related foot complication...
Source: PubMed: Eur J Vasc Endovasc ... - September 19, 2023 Category: Surgery Authors: Robert Fitridge Vivienne Chuter Joseph Mills Robert Hinchliffe Nobuyoshi Azuma Christian-Alexander Behrendt Edward J Boyko Michael S Conte Misty Humphries Lee Kirksey Katharine C McGinigle Sigrid Nikol Joakim Nordanstig Vincent Rowe David Russell Jos C va Source Type: research
Control of diabetes mellitus and the risk of neointimal hyperplasia after percutaneous coronary intervention: Post-hoc analysis from the BLADE-PCI trial
CONCLUSIONS: Uncontrolled DM at the time of PCI performed with contemporary drug-eluting stents was not associated with an increased risk of NIH development.PMID:37726192 | DOI:10.1016/j.atherosclerosis.2023.117264
Source: Atherosclerosis - September 19, 2023 Category: Cardiology Authors: Michael Jonas Philippe Genereux Akiko Maehara Ori Ben-Yehuda Gregg W Stone Gil Chernin Source Type: research
Is COMPLETE Revascularization Beneficial in Diabetic Patients With Multivessel CAD Undergoing Primary PCI for STEMI?
Circ Cardiovasc Interv. 2023 Sep;16(9):e013462. doi: 10.1161/CIRCINTERVENTIONS.123.013462. Epub 2023 Sep 19.NO ABSTRACTPMID:37725678 | DOI:10.1161/CIRCINTERVENTIONS.123.013462
Source: Atherosclerosis - September 19, 2023 Category: Cardiology Authors: Nicola Ryan William F Fearon Source Type: research
Transient left bundle branch block associated with very high coronary artery calcium: a case report
We present a case of very high CAC in a 64-year-old woman with hypertension, type 2 diabetes, and hyperlipidemia presenting with dyspnea. Initial electrocardiogram (ECG) demonstrated normal conduction with a heart rate of 76 beats/min, but new T-wave inversions in V1-V4 and a high-sensitivity troponin-I (hsTnI) value of 6 ng/L (normal < 6 ng/L). Repeat ECG in the emergency department showed normal sinus rhythm (heart rate of 80 beats/min); however, it subsequently demonstrated a left bundle branch block (LBBB) with a repeat hsTnI of 7 ng/L. Stress testing with pharmacologic single-photon emission computerized tomography...
Source: Atherosclerosis - September 19, 2023 Category: Cardiology Authors: Alexander C Razavi Sindhu Prabakaran Mariem Sawan Lakshmi Tummala Ifeoma Onuorah Sagar B Amin Marly van Assen Carlo N De Cecco Arshed A Quyyumi Seamus P Whelton Laurence S Sperling Francois G Rollin Source Type: research
Maintaining renin-angiotensin-aldosterone system inhibitor treatment with patiromer in hyperkalaemic chronic kidney disease patients: comparison of a propensity-matched real-world population with AMETHYST-DN
CONCLUSIONS: These results demonstrate the benefit of patiromer for sK+ management to enable RAASi use, while revealing beneficial effects on BP.PMID:37725919 | DOI:10.1159/000533753
Source: American Journal of Nephrology - September 19, 2023 Category: Urology & Nephrology Authors: Rajkumar Chinnadurai Sharmilee Rengarajan Jeffrey J Budden Carol Moreno Quinn Philip A Kalra Source Type: research
Aging adipose tissue, insulin resistance, and type 2 diabetes
Biogerontology. 2023 Sep 19. doi: 10.1007/s10522-023-10067-6. Online ahead of print.ABSTRACTWith the increase of population aging, the prevalence of type 2 diabetes (T2D) is also rising. Aging affects the tissues and organs of the whole body, which is the result of various physiological and pathological processes. Adipose tissue has a high degree of plasticity and changes with aging. Aging changes the distribution of adipose tissue, affects adipogenesis, browning characteristics, inflammatory status and adipokine secretion, and increases lipotoxicity. These age-dependent changes in adipose tissue are an important cause of ...
Source: Biogerontology - September 19, 2023 Category: Geriatrics Authors: Yixuan Zhao Rensong Yue Source Type: research
Error traps in the perioperative management of children with type 1 diabetes
This article reviews common errors of associated with the perioperative management of patients with T1D, including failure to assess and coordinate patient care preoperatively; failure to understand diabetes management and technology; failure to monitor blood glucose and recognize dysglycemia; and failure to appropriately administer basal insulin.PMID:37724489 | DOI:10.1111/pan.14763
Source: Paediatric Anaesthesia - September 19, 2023 Category: Anesthesiology Authors: M Hoagland B Duggar J Hamrick G Todd Alonso L Martin Source Type: research
Prediction of large-for-gestational age at 36 weeks' gestation: two-dimensional vs three-Dimensional vs magnetic resonance imaging
CONCLUSION: At 36 WG, MRI performs better than 2D-US and 3D-US in predicting birthweight > 95th percentile at birth, especially in patients at high-risk for macrosomia, while 2D-US and 3D-US are comparable. For low-risk patients, the three modalities perform similarly. This article is protected by copyright. All rights reserved.PMID:37725758 | DOI:10.1002/uog.27485
Source: The Ultrasound Review of Obstetrics and Gynecology - September 19, 2023 Category: Radiology Authors: E Mazzone C Kadji M M Cannie D A Badr J C Jani Source Type: research
Effects of hypoxia in cardiac metabolic remodeling and heart failure
Exp Cell Res. 2023 Sep 17:113763. doi: 10.1016/j.yexcr.2023.113763. Online ahead of print.ABSTRACTAerobic cellular respiration requires oxygen, which is an essential part of cardiomyocyte metabolism. Thus, oxygen is required for the physiologic metabolic activities and development of adult hearts. However, the activities of metabolic pathways associated with hypoxia in cardiomyocytes (CMs) have not been conclusively described. In this review, we discuss the role of hypoxia in the development of the hearts metabolic system, and the metabolic remodeling associated with the hypoxic adult heart. Hypoxia-inducible factors (HIFs...
Source: Experimental Cell Research - September 19, 2023 Category: Cytology Authors: Mingzhou Jiang Xi Fan Yiqing Wang Xiaotian Sun Source Type: research
Angiopoietin-like protein 3 deficiency combined with valsartan administration protects better against podocyte damage in streptozotocin-induced diabetic nephropathy mice
Int Immunopharmacol. 2023 Feb;115:109715. doi: 10.1016/j.intimp.2023.109715. Epub 2023 Jan 25.ABSTRACTDiabetic nephropathy (DN) is a common leading cause of end-stage renal disease (ESRD). Podocyte injury is a major pathogenesis of DN. Pharmacological inhibition of the renin-angiotensin-aldosterone system (RAAS) is insufficient to fully prevent the development of ESRD. The present investigation aims to evaluate the protective function of valsartan, an angiotensin receptor blocker, alone and in combination with angiopoietin-like protein 3 (Angptl3) knockout against renal damage and podocyte injury in streptozotocin (STZ)-in...
Source: International Immunopharmacology - September 19, 2023 Category: Allergy & Immunology Authors: Yanli Ma Di Xie Junchao Liu Xinli Han Hong Xu Yu Chen Source Type: research
A 30-year retrospective cohort outcome study of periodontal treatment of stages III and IV patients in a private practice
CONCLUSION: The majority of patients with stages III and IV periodontitis could be successfully treated with conventional periodontal treatment over a period of 30 years. The findings suggest that retrospective studies with shorter observation times cannot automatically be projected onto the outcome of a lifetime of periodontal treatment.PMID:37726161 | DOI:10.1111/jcpe.13877
Source: Journal of Clinical Periodontology - September 19, 2023 Category: Dentistry Authors: Øystein Fardal Irene Skau Jostein Grytten Source Type: research
Osteopontin-driven T-cell accumulation and function in adipose tissue and liver promoted insulin resistance and MAFLD
CONCLUSIONS: Current findings highlight a critical role of SPP1 in the initiation of obesity-driven chronic inflammation by regulating accumulation and/or polarization of T cells. Early targeting of SPP1 could be beneficial for IR and MAFLD treatment.PMID:37724058 | DOI:10.1002/oby.23868
Source: Obesity - September 19, 2023 Category: Eating Disorders & Weight Management Authors: Fr édéric Soysouvanh D éborah Rousseau St éphanie Bonnafous Manon Bourinet Axelle Strazzulla St éphanie Patouraux Jean Machowiak Marwin A Farrugia Antonio Iannelli Albert Tran Rodolphe Anty Carmelo Luci Philippe Gual Source Type: research
Associations and predictive performance of 11 anthropometric measures with incident type 2 diabetes: A prospective cohort study from the UK Biobank
CONCLUSIONS: Although most adiposity markers were associated with type 2 diabetes, the magnitude of the associations differed. WHtR had the strongest associations and predictive ability for type 2 diabetes and thus could be a more suitable marker for clinical use.PMID:37724055 | DOI:10.1002/oby.23849
Source: Obesity - September 19, 2023 Category: Eating Disorders & Weight Management Authors: Jirapitcha Boonpor Solange Parra-Soto Atefeh Talebi Ziyi Zhou Fernanda Carrasco-Marin Fanny Petermann-Rocha Paul Welsh Jill P Pell Naveed Sattar Jason M R Gill Stuart R Gray Carlos Celis-Morales Frederick K Ho Source Type: research
