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Development and Characterization of Guinea Pig Anti-Insulin Polyclonal Antibody
Appl Biochem Biotechnol. 2023 Sep 15. doi: 10.1007/s12010-023-04670-z. Online ahead of print.ABSTRACTDevelopment and characterization of guinea pig anti-insulin polyclonal antibody against a target-specific insulin antigen. In India, an insulin immunogenicity kit for detecting insulin antibodies (neutralizing Nab) is an unmet medical need for diabetic patient's routine diagnosis. Type 1 diabetics rely on insulin injections daily basis for survival; if the body develops anti-insulin antibodies and neutralizes the exogenous recombinant insulin, glucose control is lost, and the patient eventually dies. Antibodies are excellen...
Source: Applied Biochemistry and Biotechnology - September 15, 2023 Category: Biochemistry Authors: Sathiya Varadarajan Arumugam Muruganandam V Ramesh Kumar Source Type: research
Cumulative BMI and incident prediabetes over 30 years of follow-up: The CARDIA study
CONCLUSIONS: The cumulative burden of higher weight and longer duration was associated with incident prediabetes, but this association was statistically significant only after a higher threshold was reached. Strategies for prevention of prediabetes in middle age may focus on avoiding overweight in young adulthood to limit duration.PMID:37712179 | DOI:10.1002/oby.23866
Source: Obesity - September 15, 2023 Category: Eating Disorders & Weight Management Authors: Pamela J Schreiner Sejong Bae Norrina Allen Kiang Liu Jared P Reis Colin Wu Katherine H Ingram Donald Lloyd-Jones Cora E Lewis Jamal S Rana Source Type: research
Dapagliflozin alleviates renal podocyte pyroptosis via regulation of the HO ‑1/NLRP3 axis
In this study, a model of lipid metabolism disturbance was established through palmitic acid (PA) induction in a mouse podocyte clone 5 (MPC5) cell line. MPC5 PA‑induced pyroptosis was measured by ELISA, western blotting, quantitative PCR and Hoechst 33342/propidium iodide double‑fluorescence staining. The protective role of HO‑1 was measured using knockdown and overexpression experiments. It was found that dapagliflozin attenuated the expression of pyroptosis‑related proteins, including nucleotide oligomerization domain‑like receptor thermal protein domain associated protein 3, apoptosis‑associated speck‑lik...
Source: Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Zhenwang Zhang Ping Ni Mingqiu Tang Yi Song Chao Liu Baoqing Zhao Source Type: research
Type 1 diabetes mellitus is likely to increase the risk of thyrotoxicdsis: a two-sample Mendelian randomization study
CONCLUSION: T1DM is likely to increase the risk of thyrotoxicosis.PMID:37712277 | DOI:10.12122/j.issn.1673-4254.2023.08.17
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: W Zhan L Zhao Source Type: research
The role of neutrophils in diabetic ulcers and targeting therapeutic strategies
Int Immunopharmacol. 2023 Sep 13;124(Pt A):110861. doi: 10.1016/j.intimp.2023.110861. Online ahead of print.ABSTRACTDiabetic ulcers (DUs) are a common complication of diabetes with high morbidity, poor prognosis, and a high socio-economic burden. The main pathological manifestations of DUs are chronic inflammation, impaired re-epithelialization, and impaired angiogenesis. During the inflammatory phase, neutrophils are one of the main DU cell types and act by releasing neutrophil extracellular traps (NETs), leading to poor healing in DUs. This review summarizes the role of neutrophils in the pathology and treatment of DUs, ...
Source: International Immunopharmacology - September 15, 2023 Category: Allergy & Immunology Authors: Xiao-Xuan Ma Qing-Kai Liu Le Kuai Xin Ma Yue Luo Ying Luo Jian-Kun Song Xiao-Ya Fei Jing-Si Jiang Ming-Xia Wang Fang Shen Yi Ru Bin Li Source Type: research
The clinical predictive value and regulation mechanism of microRNA-188-5p in contrast-induced acute kidney injury
Biochem Biophys Res Commun. 2023 Sep 10;679:215-223. doi: 10.1016/j.bbrc.2023.09.019. Online ahead of print.ABSTRACTContrast-induced acute kidney injury (CI-AKI), also known as contrast-induced nephropathy (CIN), has become the third leading cause of iatrogenic AKI. Serum creatinine (Scr) is currently used in CIN clinical diagnosis. Patients with increased Scr have developed severe kidney injury, so there is an urgent need to find a bio-marker for CIN early diagnosis. To investigate the changes in circulating microRNA-188-5p (miR-188-5p) after coronary angiography and its predictive value for the CIN occurrence, miR-188-5p...
Source: Biochemical and Biophysical Research communications - September 15, 2023 Category: Biochemistry Authors: Ran Yu Caixia Wu Yao Xiao Qingju Li Jiajia Chen Jian Song Haoyu Chen Zhengqian Wang Wanpeng Wang Source Type: research
Hypoxic Mesenchymal Stem Cells Promote Diabetic Wound Healing in Rats by Increasing VEGF Secretion
Biomed Environ Sci. 2023 Aug 20;36(8):756-759. doi: 10.3967/bes2023.100.NO ABSTRACTPMID:37711087 | DOI:10.3967/bes2023.100
Source: Biomedical and Environmental Sciences : BES - September 15, 2023 Category: Biomedical Science Authors: Su Jing Zhuang Xu Yan Sun Meng Luo Zhong Wang Xue Juan Zhang Zong Sheng Gao Jian Liu Xin Ran Liu Shi Ze Liu Xiao Peng Jia Source Type: research
Performance of multi-biomarker panels based on urinary N-terminal osteopontin for prediction of diabetic kidney disease in patients with diabetes mellitus
Eur J Intern Med. 2023 Sep 13:S0953-6205(23)00325-4. doi: 10.1016/j.ejim.2023.09.004. Online ahead of print.NO ABSTRACTPMID:37714773 | DOI:10.1016/j.ejim.2023.09.004
Source: European Journal of Internal Medicine - September 15, 2023 Category: Internal Medicine Authors: Ling Sun Yu Wu Satyesh K Sinha Susanne B Nicholas Lu-Xi Zou Source Type: research
Analysis of the mechanism of action of Euphorbia fischeriana Steud on cirrhosis based on network pharmacology
This study aimed to employ network pharmacology to elucidate the mechanism by which Euphorbia fischeriana Steud (EFS) exhibits the efficacy on cirrhosis. The compounds and targets of EFS were retrieved from Traditional Chinese Medicine Integrated Database and Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Next, these compounds and targets were analyzed based on protein-protein interaction (PPI) network. Furthermore, Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling network was established based on KEGG database. We constructed a compound-compound target-intersection target-...
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Lu Liu Yinliang Xu Liu Yang Zhenzhong Jiang Xiaoyan Li Source Type: research
Short Versus Long Duration of Dual Antiplatelet Therapy After Second-Generation Drug-Eluting Stents Implantation in Patients with Diabetes
CONCLUSION: This meta-analysis showed no statistically significant benefit of longer DAPT over shorter DAPT therapy in patients undergoing PCI with drug-eluting stent in patients with diabetes.PMID:37713685 | DOI:10.1097/MJT.0000000000001519
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Manesh Kumar Gangwani Muhammad Aziz Paul Chacko Asif Mahmood Muhammad Ali Fnu Priyanka Siraj Munir Abeer Aziz Shazib Sagheer Wade Lee-Smith Om Parkash Devesh Rai Bipul Baibhav Wilbert S Aronow Source Type: research
Cardiac Insulin Resistance in Subjects With Metabolic Syndrome Traits and Early Subclinical Atherosclerosis
CONCLUSIONS: Apparently healthy individuals without cardiac 18F-FDG uptake have higher HOMA-IR and higher prevalence of MetS traits, cardiovascular risk factors, and early atherosclerosis. An improvement in cardiometabolic profile is associated with the recovery of myocardial 18F-FDG uptake at follow-up.PMID:37713581 | DOI:10.2337/dc23-0871
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Ana Devesa Valentin Fuster Ravi Vazirani In és García-Lunar Bel én Oliva Samuel Espa ña Andrea Moreno-Arciniegas Javier Sanz Cristina Perez-Herreras H éctor Bueno Enrique Lara-Pezzi Ana Garc ía-Alvarez Vicente Mart ínez de Vega Leticia Fern ández- Source Type: research
Role of LncRNA MIAT in Diabetic Complications
Curr Med Chem. 2023 Sep 14. doi: 10.2174/0929867331666230914091944. Online ahead of print.ABSTRACTLong non-coding RNA (LncRNA) refers to a large class of RNAs with over 200 nucleotides that do not have the function of encoding proteins. In recent years, more and more literature has revealed that lncRNA is involved in manipulating genes related to human health and disease, playing outstanding biological functions, which has attracted widespread attention from researchers. The newly discovered long-stranded non-coding RNA myocardial infarction-related transcript (LncRNA MIAT) is abnormally expressed in a variety of diseases,...
Source: Current Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Lijun Wang Hailin Wang Yiyang Luo Wei Wu Yibei Gui Jiale Zhao Ruisi Xiong Xueqin Li Ding Yuan Chengfu Yuan Source Type: research
Medicinal Aspects of PTP 1B Inhibitors as Anti-Breast Cancer Agents: An Overview
This study will provide significant information to the researchers developing PTP1B inhibitors for breast cancer treatment.PMID:37711015 | DOI:10.2174/0929867331666230914103645
Source: Current Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Rakesh Khator Avadh Biharee Neha Bhatia Swanand Kulkarni Yogesh Singh Chandrabose Karthikeyan Akhlesh Kumar Jain Suresh Thareja Source Type: research
Discovery of novel 4,5-diphenyl-imidazol- α-aminophosphonate hybrids as promising anti-diabetic agents: Design, synthesis, in vitro, and in silico enzymatic studies
Bioorg Chem. 2023 Sep 9;141:106846. doi: 10.1016/j.bioorg.2023.106846. Online ahead of print.ABSTRACTHerein, a novel series of 4,5-diphenyl-imidazol-α-aminophosphonate hybrids 4a-m was designed, synthesized, and evaluated as new anti-diabetic agents. These compounds were evaluated against two important target enzymes in the diabetes treatment: α-glucosidase and α-amylase. These new compounds were synthesized in three steps and characterized by different spectroscopic techniques. The in vitro evaluations demonstrated that all the synthesized compounds 4a-m were more potent that standard inhibitor acarbose against studied...
Source: Bioorganic Chemistry - September 15, 2023 Category: Chemistry Authors: Samira Zareei Sara Ranjbar Mohammad Mohammadi Younes Ghasemi Sahand Golestanian Laya Avizheh Ali Moazzam Bagher Larijani Maryam Mohammadi-Khanaposhtani Mohammad Majid Tarahomi Mohammad Mahdavi Nastaran Sadeghian Parham Taslimi Source Type: research
Secretome Derived from Mesenchymal Stem/Stromal Cells: A Promising Strategy for Diabetes and its Complications
Curr Stem Cell Res Ther. 2023 Sep 13. doi: 10.2174/1574888X19666230913154544. Online ahead of print.ABSTRACTDiabetes is a complex metabolic disease with a high global prevalence. The health and quality of life of patients with diabetes are threatened by many complications, including diabetic foot ulcers, diabetic kidney diseases, diabetic retinopathy, and diabetic peripheral neuropathy. The application of mesenchymal stem/stromal cells (MSCs) in cell therapies has been recognized as a potential treatment for diabetes and its complications. MSCs were originally thought to exert biological effects exclusively by differentiat...
Source: Current Stem Cell Research and Therapy - September 15, 2023 Category: Stem Cells Authors: Ling Li Siyu Hua Lianghui You Tianying Zhong Source Type: research
