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Condition: Diabetes
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Skin substitutes as treatment for chronic wounds: current and future directions
Front Med (Lausanne). 2023 Aug 29;10:1154567. doi: 10.3389/fmed.2023.1154567. eCollection 2023.ABSTRACTChronic wounds such as diabetic foot ulcers and venous leg ulcers place a significant burden on the healthcare system and in some cases, have 5-year mortality rates comparable to cancer. They negatively impact patients' quality of life due to pain, odor, decreased mobility, and social isolation. Skin substitutes are an advanced therapy recommended for wounds that fail to show decrease in size with standard care. The choice of substitute used should be based on evidence, which often differs based on wound etiology. There a...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Nicole M Vecin Robert S Kirsner Source Type: research
A narrative review of exercise participation among adults with prediabetes or type 2 diabetes: barriers and solutions
Front Clin Diabetes Healthc. 2023 Aug 30;4:1218692. doi: 10.3389/fcdhc.2023.1218692. eCollection 2023.ABSTRACTType 2 diabetes (T2D) has been rising in prevalence over the past few decades in the US and worldwide. T2D contributes to significant morbidity and premature mortality, primarily due to cardiovascular disease (CVD). Exercise is a major cornerstone of therapy for T2D as a result of its positive effects on glycemic control, blood pressure, weight loss and cardiovascular risk as well as other measures of health. However, studies show that a majority of people with T2D do not exercise regularly. The reasons given as to...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Samantha C Thielen Jane E B Reusch Judith G Regensteiner Source Type: research
Secretome Derived from Mesenchymal Stem/Stromal Cells: A Promising Strategy for Diabetes and its Complications
Curr Stem Cell Res Ther. 2023 Sep 13. doi: 10.2174/1574888X19666230913154544. Online ahead of print.ABSTRACTDiabetes is a complex metabolic disease with a high global prevalence. The health and quality of life of patients with diabetes are threatened by many complications, including diabetic foot ulcers, diabetic kidney diseases, diabetic retinopathy, and diabetic peripheral neuropathy. The application of mesenchymal stem/stromal cells (MSCs) in cell therapies has been recognized as a potential treatment for diabetes and its complications. MSCs were originally thought to exert biological effects exclusively by differentiat...
Source: Current Stem Cell Research and Therapy - September 15, 2023 Category: Stem Cells Authors: Ling Li Siyu Hua Lianghui You Tianying Zhong Source Type: research
Characteristics and Predictors of Apparent Treatment Resistant Hypertension in Real-World Populations Using Electronic Health Record-Based Data
CONCLUSIONS: In two large, diverse real-world populations, we observed similar comorbidities and predictors of aTRH as prior studies. In the future, these results may be used to improve healthcare professionals' understanding of aTRH predictors and associated comorbidities.PMID:37712350 | DOI:10.1093/ajh/hpad084
Source: American Journal of Hypertension - September 15, 2023 Category: Cardiology Authors: Eissa Jafari Rhonda M Cooper-DeHoff Mark B Effron William R Hogan Caitrin W McDonough Source Type: research
Secretome Derived from Mesenchymal Stem/Stromal Cells: A Promising Strategy for Diabetes and its Complications
Curr Stem Cell Res Ther. 2023 Sep 13. doi: 10.2174/1574888X19666230913154544. Online ahead of print.ABSTRACTDiabetes is a complex metabolic disease with a high global prevalence. The health and quality of life of patients with diabetes are threatened by many complications, including diabetic foot ulcers, diabetic kidney diseases, diabetic retinopathy, and diabetic peripheral neuropathy. The application of mesenchymal stem/stromal cells (MSCs) in cell therapies has been recognized as a potential treatment for diabetes and its complications. MSCs were originally thought to exert biological effects exclusively by differentiat...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Ling Li Siyu Hua Lianghui You Tianying Zhong Source Type: research
Cumulative BMI and incident prediabetes over 30 years of follow-up: The CARDIA study
CONCLUSIONS: The cumulative burden of higher weight and longer duration was associated with incident prediabetes, but this association was statistically significant only after a higher threshold was reached. Strategies for prevention of prediabetes in middle age may focus on avoiding overweight in young adulthood to limit duration.PMID:37712179 | DOI:10.1002/oby.23866
Source: Obesity - September 15, 2023 Category: Eating Disorders & Weight Management Authors: Pamela J Schreiner Sejong Bae Norrina Allen Kiang Liu Jared P Reis Colin Wu Katherine H Ingram Donald Lloyd-Jones Cora E Lewis Jamal S Rana Source Type: research
Dapagliflozin alleviates renal podocyte pyroptosis via regulation of the HO ‑1/NLRP3 axis
In this study, a model of lipid metabolism disturbance was established through palmitic acid (PA) induction in a mouse podocyte clone 5 (MPC5) cell line. MPC5 PA‑induced pyroptosis was measured by ELISA, western blotting, quantitative PCR and Hoechst 33342/propidium iodide double‑fluorescence staining. The protective role of HO‑1 was measured using knockdown and overexpression experiments. It was found that dapagliflozin attenuated the expression of pyroptosis‑related proteins, including nucleotide oligomerization domain‑like receptor thermal protein domain associated protein 3, apoptosis‑associated speck‑lik...
Source: Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Zhenwang Zhang Ping Ni Mingqiu Tang Yi Song Chao Liu Baoqing Zhao Source Type: research
Experiences and expectations of physician communication: A focus group discussion with Indian patients with type 2 diabetes mellitus
CONCLUSIONS: The medical encounter with the physician elicited a range of negative experiences and clear expectations from the patients with type 2 diabetes mellitus. This pilot points to the need for (a) a mixed methods approach to comprehensively examine the communication needs of patients with type 2 diabetes mellitus from their physician, (b) understand physicians' communication practices, and (c) using these findings, culturally adapt and test the Relationship: Establishment, Development, and Engagement to improve physicians' communication skills in India.PMID:37710965 | DOI:10.1177/17423953231200683
Source: Chronic Illness - September 15, 2023 Category: General Medicine Authors: Tejal Lathia Mahati Chittem Shweta Chawak Praneeta Katdare Shreya Jayaram Chitra Selvan Source Type: research
Vitamin E and diabetic foot ulcers
Curr Diabetes Rev. 2023 Sep 14. doi: 10.2174/1573399820666230914155232. Online ahead of print.ABSTRACTThis narrative mini-review discusses vitamin E levels in subjects with diabetic foot ulcers (DFUs). Vitamin E may be reduced in subjects with DFUs, but this finding is inconsistent. Its administration appears to benefit patients with DM, delaying the onset of complications, including DFU. There is also evidence that it may promote DFU healing. Nonetheless, further studies are required to confirm these promising results and estimate vitamin E administration's cost-effectiveness.PMID:37711108 | DOI:10.2174/1573399820666230914155232
Source: Current Diabetes Reviews - September 15, 2023 Category: Endocrinology Authors: Nikolaos D Karakousis Elisavet E Pyrgioti Petros N Georgakopoulos Dimitrios S Karagiannakis Nikolaos Papanas Source Type: research
Potential Use of Acrocomia aculeata Pulp Oil in the Modulation of Chronic Non-communicable Diseases, Especially in Diabetes: A Systematic Review
CONCLUSION: The Acrocomia aculeate pulp oil exhibited promising results in experimental studies for glycemic control and reduction of a specific tumor, indicating a good potential to be explored for chronic NCDs treatment.PMID:37710998 | DOI:10.2174/1573399820666230913105935
Source: Current Diabetes Reviews - September 15, 2023 Category: Endocrinology Authors: Maur ílio de Souza Cazarim Davi Trombini Aleixo Estael Luzia Coelho da Cruz-Cazarim Mohamed A Abd El-Salam Frederico Pittella Source Type: research
Short Versus Long Duration of Dual Antiplatelet Therapy After Second-Generation Drug-Eluting Stents Implantation in Patients with Diabetes
CONCLUSION: This meta-analysis showed no statistically significant benefit of longer DAPT over shorter DAPT therapy in patients undergoing PCI with drug-eluting stent in patients with diabetes.PMID:37713685 | DOI:10.1097/MJT.0000000000001519
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Manesh Kumar Gangwani Muhammad Aziz Paul Chacko Asif Mahmood Muhammad Ali Fnu Priyanka Siraj Munir Abeer Aziz Shazib Sagheer Wade Lee-Smith Om Parkash Devesh Rai Bipul Baibhav Wilbert S Aronow Source Type: research
Cardiac Insulin Resistance in Subjects With Metabolic Syndrome Traits and Early Subclinical Atherosclerosis
CONCLUSIONS: Apparently healthy individuals without cardiac 18F-FDG uptake have higher HOMA-IR and higher prevalence of MetS traits, cardiovascular risk factors, and early atherosclerosis. An improvement in cardiometabolic profile is associated with the recovery of myocardial 18F-FDG uptake at follow-up.PMID:37713581 | DOI:10.2337/dc23-0871
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Ana Devesa Valentin Fuster Ravi Vazirani In és García-Lunar Bel én Oliva Samuel Espa ña Andrea Moreno-Arciniegas Javier Sanz Cristina Perez-Herreras H éctor Bueno Enrique Lara-Pezzi Ana Garc ía-Alvarez Vicente Mart ínez de Vega Leticia Fern ández- Source Type: research
Correlation between High Incidence of Colorectal Neoplastic Polyps and High-risk Adenomas in Patients with Diabetes Mellitus: A Retrospective Study
CONCLUSION: This study demonstrated that patients with DM, age ≥ 50 years, male gender, alcohol consumption, and a first-degree relative with a history of CRC should undergo regular endoscopic screening and colonic polypectomy.PMID:37711116 | DOI:10.2174/1871530323666230913105743
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 15, 2023 Category: Endocrinology Authors: Chuan-Yu Zheng Wa Zhong Ji-Hao Xu Yu-Hong Yuan Nai-Zhao Chen Wei-Ling Liang Qi-Kui Chen Yu Lai Source Type: research
Mentha pulegium: A Plant With Several Medicinal Properties
Endocr Metab Immune Disord Drug Targets. 2023 Sep 14. doi: 10.2174/1871530323666230914103731. Online ahead of print.ABSTRACTThe species Mentha pulegium L. (M. pulegium L.) belongs to the family Lamiaceae, native to Europe, North Africa, and the Middle East, and the genus Mentha. It has been traditionally used in food, cosmetics, and medicines. It is a perennial, fragrant, well-liked, herbaceous plant that can grow up to half a meter tall. It is extensively used as a food flavoring, particularly for Moroccan traditional drinks. Chewing mint and M. pulegium, a relaxing and refreshing plant, can be used to treat hiccups and a...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 15, 2023 Category: Endocrinology Authors: Smail Amtaghri Miloudia Slaoui Mohamed Eddouks Source Type: research
Steady solution and its stability of a mathematical model of diabetic atherosclerosis
J Biol Dyn. 2023 Dec;17(1):2257734. doi: 10.1080/17513758.2023.2257734.ABSTRACTAtherosclerosis is a leading cause of death worldwide. Making matters worse, nearly 463 million people have diabetes, which increases atherosclerosis-related inflammation. Diabetic patients are twice as likely to have a heart attack or stroke. In this paper, we consider a simplified mathematical model for diabetic atherosclerosis involving LDL, HDL, glucose, insulin, free radicals (ROS), β cells, macrophages and foam cells, which satisfy a system of partial differential equations with a free boundary, the interface between the blood flow and th...
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Xuming Xie Source Type: research
