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Exudative vascular anomalous complex-like lesion of the peripapillary area
CONCLUSION: Exudative intraretinal aneurysmal lesions can occur in areas other than perifoveal area. OCT is an useful investigation for knowing their characteristics and the response to treatment. These aneurysmal lesions irrespective of their location can be called by the name eVAC-like or more aptly retinal capillary macro aneurysms (RCM).PMID:37715627 | DOI:10.1177/11206721231202895
Source: European Journal of Ophthalmology - September 16, 2023 Category: Opthalmology Authors: Shreyas Temkar Kaviyapriya Natarajan Amit Kumar Deb Pradeep Sagar Source Type: research
Anti-oxidant, diabetic and inflammatory activities of alpinia calcarata roscoe extract
CONCLUSION: Our findings demonstrated that leaf oil was slightly more promising results than rhizome oil of AC extract,which was ultimately showed medicinal potential of secondary metabolites with antioxidant, diabetic/inflammatory activities. Further, Eoils of AC have a wide range of pharmacological potential and promising anti-diabetic effects.PMID:37715949 | DOI:10.1002/cbdv.202300970
Source: Chemistry and Biodiversity - September 16, 2023 Category: Biochemistry Authors: Naorem Manglembi Devi Sankaranarayanan Nagarajan Chingakham Brajakishor Singh Mohammad Mujahid Ali Khan Anish Khan Nisha Khan Mohamed H Mahmoud Hassan Fouad AbuZar Ansari Source Type: research
Mikania micrantha Kunth: An Ethnopharmacological Treasure Trove of Therapeutic Potential
This study aimed at summarizing the traditional uses, phytochemical profile, and biological activities of M. micrantha based on obtainable information screened from different databases. The results suggest that fresh leaves and whole plant are frequently used in folk medicine. The plant contains more than 150 different phytochemicals under the following groups: essential oils, phenolics and flavonoids, terpenes, terpene lactones, glycosides, and sulfated flavonoids. It contains carbohydrates and micronutrients including vitamins and major and trace minerals. M. micrantha possesses antioxidant, anti-inflammatory, anti-micro...
Source: Chemistry and Biodiversity - September 16, 2023 Category: Biochemistry Authors: Muahmmad Ali Khan Dina M El-Kersh Md Shafiqul Islam Shams Ara Khan Hossam Kamli Chandan Sarkar Md Shimul Bhuia Tawhida Islam Manik Chandra Shill Glenda C Gobe Eda S önmez Gürer William N Setzer Javad Sharifi-Rad Muhammad Torequl Islam Source Type: research
Bioinformatics-based analysis of core genes and pathway enrichment in early diabetic nephropathy
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):51-56. doi: 10.14715/cmb/2023.69.7.9.ABSTRACTDiabetic nephropathy (DN) is the main cause of end-stage renal disease (ESRD). Bioinformatics technology was adopted to screen and analyze the core genes of early DN to explore its pathogenesis. GSE30528, GSE96804, and GSE30122 chip data were obtained from Gene Expression Omnibus (GEO) database to screen DN and healthy controls for differentially expressed genes. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) for functional annotation and signaling pathway enrichment; String and Cytoscape were used for protein...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Yangwenxuan Han Xiaoyan Liu Jing Shang Na Li Chunjian Zhang Ying Li Jiaxin Zheng Source Type: research
MiRNA a New Insight in Metabolic and Human Diseases: A Review
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):102-110. doi: 10.14715/cmb/2023.69.8.16.ABSTRACTThe purpose of this research is to examine existing studies on the association between microRNAs (miRNA) and age-related disorders. The miRNAs are small, noncoding RNA molecules with the ability to regulate gene expression. These are well-established in extracellular circulation, including various types of diseases such as cancer, cardiovascular diseases, and diabetes. Similarly, several miRNAs are associated with certain age-related conditions, such as increased miR-21 expression in cancer patients. Besides that, the miR-122 ...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Ibrahim Jafri Source Type: research
Multifunctional and theranostic hydrogels for wound healing acceleration: An emphasis on diabetic-related chronic wounds
Environ Res. 2023 Sep 14:117087. doi: 10.1016/j.envres.2023.117087. Online ahead of print.ABSTRACTHydrogels represent intricate three-dimensional polymeric structures, renowned for their compatibility with living systems and their ability to naturally degrade. These networks stand as promising and viable foundations for a range of biomedical uses. The practical feasibility of employing hydrogels in clinical trials has been well-demonstrated. Among the prevalent biomedical uses of hydrogels, a significant application arises in the context of wound healing. This intricate progression involves distinct phases of inflammation,...
Source: Environmental Research - September 16, 2023 Category: Environmental Health Authors: Pooya M Tehrany Parham Rahmanian Aryan Rezaee Golnaz Ranjbarpazuki Farima Sohrabi Fard Yasaman Asadollah Salmanpour Mohammad Arad Zandieh Ali Ranjbarpazuki Sajedeh Asghari Nazanin Javani Noushin Nabavi Amir Reza Aref Mehrdad Hashemi Mohsen Rashidi Afshin Source Type: research
Emergency department visits associated with wildfire smoke events in California, 2016-2019
We examined associations between smoke events and emergency department visits (EDVs) for respiratory, cardiovascular, diabetes, and mental health outcomes in California during the wildfire season June-December 2016-2019. Daily, zip code tabulation area-level wildfire-specific fine particulate matter (PM2.5) concentrations were aggregated to air basins. A "smoke event" was defined as an air basin-day with a wildfire-specific PM2.5 concentration at or above the 98th percentile across all air basin-days (threshold = 13.5 μg/m3). We conducted a two-stage time-series analysis using quasi-Poisson regression considering lag effe...
Source: Environmental Research - September 16, 2023 Category: Environmental Health Authors: Annie I Chen Keita Ebisu Tarik Benmarhnia Rupa Basu Source Type: research
Comparison of various prediction models in the effect of Roux-en-Y gastric bypass on type 2 diabetes in the Chinese population 5 years after surgery
CONCLUSIONS: T2D was relieved to varying degrees 5 years after RYGB in patients with obesity. The prediction models in ABCD and the Panuzi et al. [34] studies showed the best prediction effects. ABCD was recommended for clinical use because of excellent predictive performance, good statistical test results, and simple and practical design features.PMID:37716844 | DOI:10.1016/j.soard.2023.05.012
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - September 16, 2023 Category: Surgery Authors: Chengyuan Yu Zheng Wang Qiqige Wuyun Weijian Chen Zhehong Li Mingyue Shang Nengwei Zhang Source Type: research
Effects of in vitro fermentation of Atractylodes chinensis (DC.) Koidz. polysaccharide on fecal microbiota and metabolites in patients with type 2 diabetes mellitus
This study has laid a theoretical foundation for AKP application in functional foods.PMID:37716665 | DOI:10.1016/j.ijbiomac.2023.126860
Source: International Journal of Biological Macromolecules - September 16, 2023 Category: Biochemistry Authors: Xin Zhang Qian Ma Lina Jia Hongpeng He Tongcun Zhang Weiguo Jia Liying Zhu Wei Qi Nan Wang Source Type: research
Chrysin attenuates paclitaxel-induced hepatorenal toxicity in rats by suppressing oxidative damage, inflammation, and apoptosis
Life Sci. 2023 Sep 14:122096. doi: 10.1016/j.lfs.2023.122096. Online ahead of print.ABSTRACTAIMS: Paclitaxel (Pax) is a chemotherapeutic drug from the taxane family that is used in the treatment of human cancer, including ovarian, breast, and non-small cell lung carcinoma. Chrysin (CR) has antioxidant, anti-inflammatory, anti-apoptotic, anti-diabetic, and anti-carcinogenic properties, as well as hepatoprotective and renoprotective activities. In the present study, we evaluated the protective effect of CR against Pax-induced hepatorenal toxicity on inflammation, apoptosis, antioxidant levels, oxidative DNA damage, and histo...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Selim Çomaklı Sel çuk Özdemir Meryem G üloğlu Source Type: research
Multifunctional and theranostic hydrogels for wound healing acceleration: An emphasis on diabetic-related chronic wounds
Environ Res. 2023 Sep 14:117087. doi: 10.1016/j.envres.2023.117087. Online ahead of print.ABSTRACTHydrogels represent intricate three-dimensional polymeric structures, renowned for their compatibility with living systems and their ability to naturally degrade. These networks stand as promising and viable foundations for a range of biomedical uses. The practical feasibility of employing hydrogels in clinical trials has been well-demonstrated. Among the prevalent biomedical uses of hydrogels, a significant application arises in the context of wound healing. This intricate progression involves distinct phases of inflammation,...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Pooya M Tehrany Parham Rahmanian Aryan Rezaee Golnaz Ranjbarpazuki Farima Sohrabi Fard Yasaman Asadollah Salmanpour Mohammad Arad Zandieh Ali Ranjbarpazuki Sajedeh Asghari Nazanin Javani Noushin Nabavi Amir Reza Aref Mehrdad Hashemi Mohsen Rashidi Afshin Source Type: research
MiRNA a New Insight in Metabolic and Human Diseases: A Review
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):102-110. doi: 10.14715/cmb/2023.69.8.16.ABSTRACTThe purpose of this research is to examine existing studies on the association between microRNAs (miRNA) and age-related disorders. The miRNAs are small, noncoding RNA molecules with the ability to regulate gene expression. These are well-established in extracellular circulation, including various types of diseases such as cancer, cardiovascular diseases, and diabetes. Similarly, several miRNAs are associated with certain age-related conditions, such as increased miR-21 expression in cancer patients. Besides that, the miR-122 ...
Source: Atherosclerosis - September 16, 2023 Category: Cardiology Authors: Ibrahim Jafri Source Type: research
Immediate post-mastectomy prepectoral breast reconstruction with animal derived acellular dermal matrices: A systematic review
CONCLUSION: The complications associated with different animal-derived ADMs are generally comparable. The profile of patients required for eligibility for this type of reconstruction appears to have been identified and is in line with current recommendations.PMID:37716255 | DOI:10.1016/j.bjps.2023.08.020
Source: Hand Surgery - September 16, 2023 Category: Surgery Authors: Annachiara Tellarini Leonardo Garutti Martina Corno Federico Tamborini Ferruccio Paganini Veronica Fasoli Danilo Di Giovanna Luigi Valdatta Source Type: research
Plant-derived cell-penetrating microprotein α-astratide aM1 targets Akt signaling and alleviates insulin resistance
Cell Mol Life Sci. 2023 Sep 16;80(10):293. doi: 10.1007/s00018-023-04937-y.ABSTRACTInsulin-resistant diabetes is a common metabolic disease with serious complications. Treatments directly addressing the underlying molecular mechanisms involving insulin resistance would be desirable. Our laboratory recently identified a proteolytic-resistant cystine-dense microprotein from huáng qí (Astragalus membranaceus) called α-astratide aM1, which shares high sequence homology to leginsulins. Here we show that aM1 is a cell-penetrating insulin mimetic, enters cells by endocytosis, and activates the PI3K/Akt signaling pathway indepe...
Source: Cellular and Molecular Life Sciences : CMLS - September 16, 2023 Category: Cytology Authors: Bamaprasad Dutta Shining Loo Antony Kam James P Tam Source Type: research
