Lactoferrin as a potent natural supplement exhibiting a synergistic effect with drugs in antimicrobial and anticancer therapies
Curr Protein Pept Sci. 2021 Oct 11. doi: 10.2174/1389203722666211011113932. Online ahead of print.ABSTRACTFor many years, natural products have played a crucial role in drug discovery and drug design as a source of active agents or as inspiration. Lactoferrin (Lf), a glycoprotein found in milk and mammalian secretions, has been extensively studied in recent years, and numerous antimicrobial, anti-inflammatory, and anticancer properties of Lf have been demonstrated in the literature. The use of lactoferrin as a co-agent or supplement to enhance the beneficial effect of drugs, or to reduce their side effects, arouses the int...
Source: Current Protein and Peptide Science - October 12, 2021 Category: Biochemistry Authors: Przemys ław Gajda-Morszewski Ma łgorzata Brindell Source Type: research

Lactoferrin as a potent natural supplement exhibiting a synergistic effect with drugs in antimicrobial and anticancer therapies
Curr Protein Pept Sci. 2021 Oct 11. doi: 10.2174/1389203722666211011113932. Online ahead of print.ABSTRACTFor many years, natural products have played a crucial role in drug discovery and drug design as a source of active agents or as inspiration. Lactoferrin (Lf), a glycoprotein found in milk and mammalian secretions, has been extensively studied in recent years, and numerous antimicrobial, anti-inflammatory, and anticancer properties of Lf have been demonstrated in the literature. The use of lactoferrin as a co-agent or supplement to enhance the beneficial effect of drugs, or to reduce their side effects, arouses the int...
Source: Current Protein and Peptide Science - October 12, 2021 Category: Biochemistry Authors: Przemys ław Gajda-Morszewski Ma łgorzata Brindell Source Type: research

Lactoferrin as a potent natural supplement exhibiting a synergistic effect with drugs in antimicrobial and anticancer therapies
Curr Protein Pept Sci. 2021 Oct 11. doi: 10.2174/1389203722666211011113932. Online ahead of print.ABSTRACTFor many years, natural products have played a crucial role in drug discovery and drug design as a source of active agents or as inspiration. Lactoferrin (Lf), a glycoprotein found in milk and mammalian secretions, has been extensively studied in recent years, and numerous antimicrobial, anti-inflammatory, and anticancer properties of Lf have been demonstrated in the literature. The use of lactoferrin as a co-agent or supplement to enhance the beneficial effect of drugs, or to reduce their side effects, arouses the int...
Source: Current Protein and Peptide Science - October 12, 2021 Category: Biochemistry Authors: Przemys ław Gajda-Morszewski Ma łgorzata Brindell Source Type: research

Lactoferrin as a potent natural supplement exhibiting a synergistic effect with drugs in antimicrobial and anticancer therapies
Curr Protein Pept Sci. 2021 Oct 11. doi: 10.2174/1389203722666211011113932. Online ahead of print.ABSTRACTFor many years, natural products have played a crucial role in drug discovery and drug design as a source of active agents or as inspiration. Lactoferrin (Lf), a glycoprotein found in milk and mammalian secretions, has been extensively studied in recent years, and numerous antimicrobial, anti-inflammatory, and anticancer properties of Lf have been demonstrated in the literature. The use of lactoferrin as a co-agent or supplement to enhance the beneficial effect of drugs, or to reduce their side effects, arouses the int...
Source: Current Protein and Peptide Science - October 12, 2021 Category: Biochemistry Authors: Przemys ław Gajda-Morszewski Ma łgorzata Brindell Source Type: research

Difference of MreBCD Complex Interactome in Salmonella Typhimurium ST19 and ST213 Genotypes on Pathogenesis and Stress Response Pathways
In this study, 106 interactions among MreBCD and 15 proteins from S. Typhimurium Pathogenicity Islands 1 (SP-I) and 2 (SP-2) involved in both bacterial virulence and stress response were predicted in ST213 and ST19 genotypes, of which 12 interactions were confirmed in vitro. In addition, gene cluster analysis in 100 S. Typhimurium genomes was performed for these genes. The in silico and in vitro results showed a novel MreBCD interactome involved in the regulation of pathogenesis and stress response through interactions with virulence factors located at SPI-1 and SPI-2. Furthermore, both pseudogene presence and sequence var...
Source: Current Protein and Peptide Science - September 22, 2021 Category: Biochemistry Authors: Reyna Cristina Zepeda-Gurrola Gerardo V ázquez-Marrufo Xianwu Guo Isabel Cristina Rodr íguez-Luna Alejandro S ánchez-Varela Ma Soledad V ázquez-Garcidueñas Source Type: research

Difference of MreBCD Complex Interactome in Salmonella Typhimurium ST19 and ST213 Genotypes on Pathogenesis and Stress Response Pathways
In this study, 106 interactions among MreBCD and 15 proteins from S. Typhimurium Pathogenicity Islands 1 (SP-I) and 2 (SP-2) involved in both bacterial virulence and stress response were predicted in ST213 and ST19 genotypes, of which 12 interactions were confirmed in vitro. In addition, gene cluster analysis in 100 S. Typhimurium genomes was performed for these genes. The in silico and in vitro results showed a novel MreBCD interactome involved in the regulation of pathogenesis and stress response through interactions with virulence factors located at SPI-1 and SPI-2. Furthermore, both pseudogene presence and sequence var...
Source: Current Protein and Peptide Science - September 22, 2021 Category: Biochemistry Authors: Reyna Cristina Zepeda-Gurrola Gerardo V ázquez-Marrufo Xianwu Guo Isabel Cristina Rodr íguez-Luna Alejandro S ánchez-Varela Ma Soledad V ázquez-Garcidueñas Source Type: research

Difference of MreBCD Complex Interactome in Salmonella Typhimurium ST19 and ST213 Genotypes on Pathogenesis and Stress Response Pathways
In this study, 106 interactions among MreBCD and 15 proteins from S. Typhimurium Pathogenicity Islands 1 (SP-I) and 2 (SP-2) involved in both bacterial virulence and stress response were predicted in ST213 and ST19 genotypes, of which 12 interactions were confirmed in vitro. In addition, gene cluster analysis in 100 S. Typhimurium genomes was performed for these genes. The in silico and in vitro results showed a novel MreBCD interactome involved in the regulation of pathogenesis and stress response through interactions with virulence factors located at SPI-1 and SPI-2. Furthermore, both pseudogene presence and sequence var...
Source: Current Protein and Peptide Science - September 22, 2021 Category: Biochemistry Authors: Reyna Cristina Zepeda-Gurrola Gerardo V ázquez-Marrufo Xianwu Guo Isabel Cristina Rodr íguez-Luna Alejandro S ánchez-Varela Ma Soledad V ázquez-Garcidueñas Source Type: research

Difference of MreBCD Complex Interactome in Salmonella Typhimurium ST19 and ST213 Genotypes on Pathogenesis and Stress Response Pathways
In this study, 106 interactions among MreBCD and 15 proteins from S. Typhimurium Pathogenicity Islands 1 (SP-I) and 2 (SP-2) involved in both bacterial virulence and stress response were predicted in ST213 and ST19 genotypes, of which 12 interactions were confirmed in vitro. In addition, gene cluster analysis in 100 S. Typhimurium genomes was performed for these genes. The in silico and in vitro results showed a novel MreBCD interactome involved in the regulation of pathogenesis and stress response through interactions with virulence factors located at SPI-1 and SPI-2. Furthermore, both pseudogene presence and sequence var...
Source: Current Protein and Peptide Science - September 22, 2021 Category: Biochemistry Authors: Reyna Cristina Zepeda-Gurrola Gerardo V ázquez-Marrufo Xianwu Guo Isabel Cristina Rodr íguez-Luna Alejandro S ánchez-Varela Ma Soledad V ázquez-Garcidueñas Source Type: research

Difference of MreBCD Complex Interactome in Salmonella Typhimurium ST19 and ST213 Genotypes on Pathogenesis and Stress Response Pathways
In this study, 106 interactions among MreBCD and 15 proteins from S. Typhimurium Pathogenicity Islands 1 (SP-I) and 2 (SP-2) involved in both bacterial virulence and stress response were predicted in ST213 and ST19 genotypes, of which 12 interactions were confirmed in vitro. In addition, gene cluster analysis in 100 S. Typhimurium genomes was performed for these genes. The in silico and in vitro results showed a novel MreBCD interactome involved in the regulation of pathogenesis and stress response through interactions with virulence factors located at SPI-1 and SPI-2. Furthermore, both pseudogene presence and sequence var...
Source: Current Protein and Peptide Science - September 22, 2021 Category: Biochemistry Authors: Reyna Cristina Zepeda-Gurrola Gerardo V ázquez-Marrufo Xianwu Guo Isabel Cristina Rodr íguez-Luna Alejandro S ánchez-Varela Ma Soledad V ázquez-Garcidueñas Source Type: research

Difference of MreBCD Complex Interactome in Salmonella Typhimurium ST19 and ST213 Genotypes on Pathogenesis and Stress Response Pathways
In this study, 106 interactions among MreBCD and 15 proteins from S. Typhimurium Pathogenicity Islands 1 (SP-I) and 2 (SP-2) involved in both bacterial virulence and stress response were predicted in ST213 and ST19 genotypes, of which 12 interactions were confirmed in vitro. In addition, gene cluster analysis in 100 S. Typhimurium genomes was performed for these genes. The in silico and in vitro results showed a novel MreBCD interactome involved in the regulation of pathogenesis and stress response through interactions with virulence factors located at SPI-1 and SPI-2. Furthermore, both pseudogene presence and sequence var...
Source: Current Protein and Peptide Science - September 22, 2021 Category: Biochemistry Authors: Reyna Cristina Zepeda-Gurrola Gerardo V ázquez-Marrufo Xianwu Guo Isabel Cristina Rodr íguez-Luna Alejandro S ánchez-Varela Ma Soledad V ázquez-Garcidueñas Source Type: research

Difference of MreBCD Complex Interactome in Salmonella Typhimurium ST19 and ST213 Genotypes on Pathogenesis and Stress Response Pathways
In this study, 106 interactions among MreBCD and 15 proteins from S. Typhimurium Pathogenicity Islands 1 (SP-I) and 2 (SP-2) involved in both bacterial virulence and stress response were predicted in ST213 and ST19 genotypes, of which 12 interactions were confirmed in vitro. In addition, gene cluster analysis in 100 S. Typhimurium genomes was performed for these genes. The in silico and in vitro results showed a novel MreBCD interactome involved in the regulation of pathogenesis and stress response through interactions with virulence factors located at SPI-1 and SPI-2. Furthermore, both pseudogene presence and sequence var...
Source: Current Protein and Peptide Science - September 22, 2021 Category: Biochemistry Authors: Reyna Cristina Zepeda-Gurrola Gerardo V ázquez-Marrufo Xianwu Guo Isabel Cristina Rodr íguez-Luna Alejandro S ánchez-Varela Ma Soledad V ázquez-Garcidueñas Source Type: research

Difference of MreBCD Complex Interactome in Salmonella Typhimurium ST19 and ST213 Genotypes on Pathogenesis and Stress Response Pathways
In this study, 106 interactions among MreBCD and 15 proteins from S. Typhimurium Pathogenicity Islands 1 (SP-I) and 2 (SP-2) involved in both bacterial virulence and stress response were predicted in ST213 and ST19 genotypes, of which 12 interactions were confirmed in vitro. In addition, gene cluster analysis in 100 S. Typhimurium genomes was performed for these genes. The in silico and in vitro results showed a novel MreBCD interactome involved in the regulation of pathogenesis and stress response through interactions with virulence factors located at SPI-1 and SPI-2. Furthermore, both pseudogene presence and sequence var...
Source: Current Protein and Peptide Science - September 22, 2021 Category: Biochemistry Authors: Reyna Cristina Zepeda-Gurrola Gerardo V ázquez-Marrufo Xianwu Guo Isabel Cristina Rodr íguez-Luna Alejandro S ánchez-Varela Ma Soledad V ázquez-Garcidueñas Source Type: research

Difference of MreBCD Complex Interactome in Salmonella Typhimurium ST19 and ST213 Genotypes on Pathogenesis and Stress Response Pathways
In this study, 106 interactions among MreBCD and 15 proteins from S. Typhimurium Pathogenicity Islands 1 (SP-I) and 2 (SP-2) involved in both bacterial virulence and stress response were predicted in ST213 and ST19 genotypes, of which 12 interactions were confirmed in vitro. In addition, gene cluster analysis in 100 S. Typhimurium genomes was performed for these genes. The in silico and in vitro results showed a novel MreBCD interactome involved in the regulation of pathogenesis and stress response through interactions with virulence factors located at SPI-1 and SPI-2. Furthermore, both pseudogene presence and sequence var...
Source: Current Protein and Peptide Science - September 22, 2021 Category: Biochemistry Authors: Reyna Cristina Zepeda-Gurrola Gerardo V ázquez-Marrufo Xianwu Guo Isabel Cristina Rodr íguez-Luna Alejandro S ánchez-Varela Ma Soledad V ázquez-Garcidueñas Source Type: research

Difference of MreBCD Complex Interactome in Salmonella Typhimurium ST19 and ST213 Genotypes on Pathogenesis and Stress Response Pathways
In this study, 106 interactions among MreBCD and 15 proteins from S. Typhimurium Pathogenicity Islands 1 (SP-I) and 2 (SP-2) involved in both bacterial virulence and stress response were predicted in ST213 and ST19 genotypes, of which 12 interactions were confirmed in vitro. In addition, gene cluster analysis in 100 S. Typhimurium genomes was performed for these genes. The in silico and in vitro results showed a novel MreBCD interactome involved in the regulation of pathogenesis and stress response through interactions with virulence factors located at SPI-1 and SPI-2. Furthermore, both pseudogene presence and sequence var...
Source: Current Protein and Peptide Science - September 22, 2021 Category: Biochemistry Authors: Reyna Cristina Zepeda-Gurrola Gerardo V ázquez-Marrufo Xianwu Guo Isabel Cristina Rodr íguez-Luna Alejandro S ánchez-Varela Ma Soledad V ázquez-Garcidueñas Source Type: research

Difference of MreBCD Complex Interactome in Salmonella Typhimurium ST19 and ST213 Genotypes on Pathogenesis and Stress Response Pathways
In this study, 106 interactions among MreBCD and 15 proteins from S. Typhimurium Pathogenicity Islands 1 (SP-I) and 2 (SP-2) involved in both bacterial virulence and stress response were predicted in ST213 and ST19 genotypes, of which 12 interactions were confirmed in vitro. In addition, gene cluster analysis in 100 S. Typhimurium genomes was performed for these genes. The in silico and in vitro results showed a novel MreBCD interactome involved in the regulation of pathogenesis and stress response through interactions with virulence factors located at SPI-1 and SPI-2. Furthermore, both pseudogene presence and sequence var...
Source: Current Protein and Peptide Science - September 22, 2021 Category: Biochemistry Authors: Reyna Cristina Zepeda-Gurrola Gerardo V ázquez-Marrufo Xianwu Guo Isabel Cristina Rodr íguez-Luna Alejandro S ánchez-Varela Ma Soledad V ázquez-Garcidueñas Source Type: research

Difference of MreBCD Complex Interactome in Salmonella Typhimurium ST19 and ST213 Genotypes on Pathogenesis and Stress Response Pathways
In this study, 106 interactions among MreBCD and 15 proteins from S. Typhimurium Pathogenicity Islands 1 (SP-I) and 2 (SP-2) involved in both bacterial virulence and stress response were predicted in ST213 and ST19 genotypes, of which 12 interactions were confirmed in vitro. In addition, gene cluster analysis in 100 S. Typhimurium genomes was performed for these genes. The in silico and in vitro results showed a novel MreBCD interactome involved in the regulation of pathogenesis and stress response through interactions with virulence factors located at SPI-1 and SPI-2. Furthermore, both pseudogene presence and sequence var...
Source: Current Protein and Peptide Science - September 22, 2021 Category: Biochemistry Authors: Reyna Cristina Zepeda-Gurrola Gerardo V ázquez-Marrufo Xianwu Guo Isabel Cristina Rodr íguez-Luna Alejandro S ánchez-Varela Ma Soledad V ázquez-Garcidueñas Source Type: research

Difference of MreBCD Complex Interactome in Salmonella Typhimurium ST19 and ST213 Genotypes on Pathogenesis and Stress Response Pathways
In this study, 106 interactions among MreBCD and 15 proteins from S. Typhimurium Pathogenicity Islands 1 (SP-I) and 2 (SP-2) involved in both bacterial virulence and stress response were predicted in ST213 and ST19 genotypes, of which 12 interactions were confirmed in vitro. In addition, gene cluster analysis in 100 S. Typhimurium genomes was performed for these genes. The in silico and in vitro results showed a novel MreBCD interactome involved in the regulation of pathogenesis and stress response through interactions with virulence factors located at SPI-1 and SPI-2. Furthermore, both pseudogene presence and sequence var...
Source: Current Protein and Peptide Science - September 22, 2021 Category: Biochemistry Authors: Reyna Cristina Zepeda-Gurrola Gerardo V ázquez-Marrufo Xianwu Guo Isabel Cristina Rodr íguez-Luna Alejandro S ánchez-Varela Ma Soledad V ázquez-Garcidueñas Source Type: research

Difference of MreBCD Complex Interactome in Salmonella Typhimurium ST19 and ST213 Genotypes on Pathogenesis and Stress Response Pathways
In this study, 106 interactions among MreBCD and 15 proteins from S. Typhimurium Pathogenicity Islands 1 (SP-I) and 2 (SP-2) involved in both bacterial virulence and stress response were predicted in ST213 and ST19 genotypes, of which 12 interactions were confirmed in vitro. In addition, gene cluster analysis in 100 S. Typhimurium genomes was performed for these genes. The in silico and in vitro results showed a novel MreBCD interactome involved in the regulation of pathogenesis and stress response through interactions with virulence factors located at SPI-1 and SPI-2. Furthermore, both pseudogene presence and sequence var...
Source: Current Protein and Peptide Science - September 22, 2021 Category: Biochemistry Authors: Reyna Cristina Zepeda-Gurrola Gerardo V ázquez-Marrufo Xianwu Guo Isabel Cristina Rodr íguez-Luna Alejandro S ánchez-Varela Ma Soledad V ázquez-Garcidueñas Source Type: research

Difference of MreBCD Complex Interactome in Salmonella Typhimurium ST19 and ST213 Genotypes on Pathogenesis and Stress Response Pathways
In this study, 106 interactions among MreBCD and 15 proteins from S. Typhimurium Pathogenicity Islands 1 (SP-I) and 2 (SP-2) involved in both bacterial virulence and stress response were predicted in ST213 and ST19 genotypes, of which 12 interactions were confirmed in vitro. In addition, gene cluster analysis in 100 S. Typhimurium genomes was performed for these genes. The in silico and in vitro results showed a novel MreBCD interactome involved in the regulation of pathogenesis and stress response through interactions with virulence factors located at SPI-1 and SPI-2. Furthermore, both pseudogene presence and sequence var...
Source: Current Protein and Peptide Science - September 22, 2021 Category: Biochemistry Authors: Reyna Cristina Zepeda-Gurrola Gerardo V ázquez-Marrufo Xianwu Guo Isabel Cristina Rodr íguez-Luna Alejandro S ánchez-Varela Ma Soledad V ázquez-Garcidueñas Source Type: research

Peptide based therapy for neurological disorders
Curr Protein Pept Sci. 2021 Sep 20. doi: 10.2174/1389203722666210920151810. Online ahead of print.ABSTRACTPeptides are small molecules composed of amino acids linked together by peptide bonds. The targeted action of these peptides along with their magnificent ability to reach locations in body that are complicated to access, is being considered of tremendous potential in disease modifying therapies. Synthetic as well as natural peptides like Carnosine are currently under research for treatment of neurodegenerative disorders (NDDs). Peptide based vaccines are currently under immense research for diseases like dementia. Toxi...
Source: Current Protein and Peptide Science - September 21, 2021 Category: Biochemistry Authors: Asmita Yadav Damini Pandey Ghulam Md Ashraf None Rachana Source Type: research

Neuroinflammation in Alzheimer's disease: focus on NLRP1 and NLRP3 inflammasomes
Curr Protein Pept Sci. 2021 Sep 16. doi: 10.2174/1389203722666210916141436. Online ahead of print.ABSTRACTBACKGROUND: Alzheimer's disease (AD) is the main cause of dementia worldwide. The definitive diagnosis of AD is clinicopathological and based on the identification of cerebral deposition of amyloid β (Aβ) plaques and neurofibrillary tangles. However, the link between amyloid cascade and depositions of phosphorylated tau (p-tau) is still missing. In this scenario, inflammasomes might play a relevant role. Experimental models of AD have suggested that Aβ accumulation induces, through microglia, activation ...
Source: Current Protein and Peptide Science - September 17, 2021 Category: Biochemistry Authors: Eliana Cristina de Brito Toscano Natalia Pessoa Rocha Beatriz Noele Azevedo Lopes Claudia Kimie Suemoto Antonio Lucio Teixeira Source Type: research

Interactions between ACE2 and SARS-CoV-2 S protein: peptide inhibitors for potential drug developments against COVID-19
Curr Protein Pept Sci. 2021 Sep 16. doi: 10.2174/1389203722666210916141924. Online ahead of print.ABSTRACTAngiotensin-converting enzyme (ACE) shares some homologies with ACE2. However, they are not inhibited by the same inhibitors, but both are associated primarily with the hypertensive disorder through the renin-angiotensin system (RAS). The principal activity of ACE2 is to metabolize Ang II into the vasodilatory Ang-(1-7). The ongoing COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has brought the ACE2 to the center of attention. This coronavirus uses the host cell ACE2 protei...
Source: Current Protein and Peptide Science - September 17, 2021 Category: Biochemistry Authors: Miribane D ërmaku-Sopjani Mentor Sopjani Source Type: research

Exploring the potential of molecular spectroscopy for the detection of post-translational modifications of a stressed biopharmaceutical protein
CONCLUSION: This work required some novel computational approaches to pre-process Raman and IR spectra and a review of the band assignments for proteins existing in the literature.PMID:34530707 | DOI:10.2174/1389203722666210916143020 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - September 17, 2021 Category: Biochemistry Authors: Marco Pinto Corujo Vivian Lindo Nikola Chmel Alison Rodger Source Type: research

Neuroinflammation in Alzheimer's disease: focus on NLRP1 and NLRP3 inflammasomes
Curr Protein Pept Sci. 2021 Sep 16. doi: 10.2174/1389203722666210916141436. Online ahead of print.ABSTRACTBACKGROUND: Alzheimer's disease (AD) is the main cause of dementia worldwide. The definitive diagnosis of AD is clinicopathological and based on the identification of cerebral deposition of amyloid β (Aβ) plaques and neurofibrillary tangles. However, the link between amyloid cascade and depositions of phosphorylated tau (p-tau) is still missing. In this scenario, inflammasomes might play a relevant role. Experimental models of AD have suggested that Aβ accumulation induces, through microglia, activation ...
Source: Current Protein and Peptide Science - September 17, 2021 Category: Biochemistry Authors: Eliana Cristina de Brito Toscano Natalia Pessoa Rocha Beatriz Noele Azevedo Lopes Claudia Kimie Suemoto Antonio Lucio Teixeira Source Type: research

Interactions between ACE2 and SARS-CoV-2 S protein: peptide inhibitors for potential drug developments against COVID-19
Curr Protein Pept Sci. 2021 Sep 16. doi: 10.2174/1389203722666210916141924. Online ahead of print.ABSTRACTAngiotensin-converting enzyme (ACE) shares some homologies with ACE2. However, they are not inhibited by the same inhibitors, but both are associated primarily with the hypertensive disorder through the renin-angiotensin system (RAS). The principal activity of ACE2 is to metabolize Ang II into the vasodilatory Ang-(1-7). The ongoing COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has brought the ACE2 to the center of attention. This coronavirus uses the host cell ACE2 protei...
Source: Current Protein and Peptide Science - September 17, 2021 Category: Biochemistry Authors: Miribane D ërmaku-Sopjani Mentor Sopjani Source Type: research

Exploring the potential of molecular spectroscopy for the detection of post-translational modifications of a stressed biopharmaceutical protein
CONCLUSION: This work required some novel computational approaches to pre-process Raman and IR spectra and a review of the band assignments for proteins existing in the literature.PMID:34530707 | DOI:10.2174/1389203722666210916143020 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - September 17, 2021 Category: Biochemistry Authors: Marco Pinto Corujo Vivian Lindo Nikola Chmel Alison Rodger Source Type: research

Role of Adenosine Receptors in Rare Neurodegenerative Diseases with Motor Symptoms
Curr Protein Pept Sci. 2021 Sep 9. doi: 10.2174/1389203722666210910110126. Online ahead of print.ABSTRACTThe approval of istradefylline, an adenosine 2A receptor (A2AR) antagonist, as an add-on treatment in adult patients with Parkinson's disease by the Food and Drug Administration (FDA) and European Medicines Agency (EMA), is the latest proof of the importance of the adenosinergic system in the nervous system. Adenosine is an endogenous purine nucleoside with a role as a modulator of both neurotransmission and the inflammatory response. As such, the expression pattern of the 4 adenosine receptors (A1R, A2AR, A2BR and A3R)...
Source: Current Protein and Peptide Science - September 13, 2021 Category: Biochemistry Authors: Vicent Beltran-Beltran Noelia Benet ó Tamara Lape ña-Luzón Laura R Rodr íguez Federico V Pallard ó Pilar Gonzalez-Cabo Source Type: research

Diversity in the Accessory Proteins of SARS-CoV-2, SARS-CoV, and MERS-CoV Betacoronaviruses
Curr Protein Pept Sci. 2021 Sep 9. doi: 10.2174/1389203722666210910111055. Online ahead of print.ABSTRACTAlong with structural and non-structural proteins, SARS-CoV-2, SARS-CoV, and MERS-CoV can also express accessory proteins. During the past few years, there have been only a few studies focusing on this set of proteins. Despite available data on these proteins, there are still a lot of questions on the functions of these proteins during infection that must be answered. With these three betacoronaviruses causing outbreaks in humans during the past few years, the need for a thorough understanding of the roles of these prot...
Source: Current Protein and Peptide Science - September 13, 2021 Category: Biochemistry Authors: Christian Alfredo K Cruz Paul Mark B Medina Source Type: research

Role of Adenosine Receptors in Rare Neurodegenerative Diseases with Motor Symptoms
Curr Protein Pept Sci. 2021 Sep 9. doi: 10.2174/1389203722666210910110126. Online ahead of print.ABSTRACTThe approval of istradefylline, an adenosine 2A receptor (A2AR) antagonist, as an add-on treatment in adult patients with Parkinson's disease by the Food and Drug Administration (FDA) and European Medicines Agency (EMA), is the latest proof of the importance of the adenosinergic system in the nervous system. Adenosine is an endogenous purine nucleoside with a role as a modulator of both neurotransmission and the inflammatory response. As such, the expression pattern of the 4 adenosine receptors (A1R, A2AR, A2BR and A3R)...
Source: Current Protein and Peptide Science - September 13, 2021 Category: Biochemistry Authors: Vicent Beltran-Beltran Noelia Benet ó Tamara Lape ña-Luzón Laura R Rodr íguez Federico V Pallard ó Pilar Gonzalez-Cabo Source Type: research

Diversity in the Accessory Proteins of SARS-CoV-2, SARS-CoV, and MERS-CoV Betacoronaviruses
Curr Protein Pept Sci. 2021 Sep 9. doi: 10.2174/1389203722666210910111055. Online ahead of print.ABSTRACTAlong with structural and non-structural proteins, SARS-CoV-2, SARS-CoV, and MERS-CoV can also express accessory proteins. During the past few years, there have been only a few studies focusing on this set of proteins. Despite available data on these proteins, there are still a lot of questions on the functions of these proteins during infection that must be answered. With these three betacoronaviruses causing outbreaks in humans during the past few years, the need for a thorough understanding of the roles of these prot...
Source: Current Protein and Peptide Science - September 13, 2021 Category: Biochemistry Authors: Christian Alfredo K Cruz Paul Mark B Medina Source Type: research

Role of Adenosine Receptors in Rare Neurodegenerative Diseases with Motor Symptoms
Curr Protein Pept Sci. 2021 Sep 9. doi: 10.2174/1389203722666210910110126. Online ahead of print.ABSTRACTThe approval of istradefylline, an adenosine 2A receptor (A2AR) antagonist, as an add-on treatment in adult patients with Parkinson's disease by the Food and Drug Administration (FDA) and European Medicines Agency (EMA), is the latest proof of the importance of the adenosinergic system in the nervous system. Adenosine is an endogenous purine nucleoside with a role as a modulator of both neurotransmission and the inflammatory response. As such, the expression pattern of the 4 adenosine receptors (A1R, A2AR, A2BR and A3R)...
Source: Current Protein and Peptide Science - September 13, 2021 Category: Biochemistry Authors: Vicent Beltran-Beltran Noelia Benet ó Tamara Lape ña-Luzón Laura R Rodr íguez Federico V Pallard ó Pilar Gonzalez-Cabo Source Type: research

Diversity in the Accessory Proteins of SARS-CoV-2, SARS-CoV, and MERS-CoV Betacoronaviruses
Curr Protein Pept Sci. 2021 Sep 9. doi: 10.2174/1389203722666210910111055. Online ahead of print.ABSTRACTAlong with structural and non-structural proteins, SARS-CoV-2, SARS-CoV, and MERS-CoV can also express accessory proteins. During the past few years, there have been only a few studies focusing on this set of proteins. Despite available data on these proteins, there are still a lot of questions on the functions of these proteins during infection that must be answered. With these three betacoronaviruses causing outbreaks in humans during the past few years, the need for a thorough understanding of the roles of these prot...
Source: Current Protein and Peptide Science - September 13, 2021 Category: Biochemistry Authors: Christian Alfredo K Cruz Paul Mark B Medina Source Type: research

Role of Adenosine Receptors in Rare Neurodegenerative Diseases with Motor Symptoms
Curr Protein Pept Sci. 2021 Sep 9. doi: 10.2174/1389203722666210910110126. Online ahead of print.ABSTRACTThe approval of istradefylline, an adenosine 2A receptor (A2AR) antagonist, as an add-on treatment in adult patients with Parkinson's disease by the Food and Drug Administration (FDA) and European Medicines Agency (EMA), is the latest proof of the importance of the adenosinergic system in the nervous system. Adenosine is an endogenous purine nucleoside with a role as a modulator of both neurotransmission and the inflammatory response. As such, the expression pattern of the 4 adenosine receptors (A1R, A2AR, A2BR and A3R)...
Source: Current Protein and Peptide Science - September 13, 2021 Category: Biochemistry Authors: Vicent Beltran-Beltran Noelia Benet ó Tamara Lape ña-Luzón Laura R Rodr íguez Federico V Pallard ó Pilar Gonzalez-Cabo Source Type: research

Diversity in the Accessory Proteins of SARS-CoV-2, SARS-CoV, and MERS-CoV Betacoronaviruses
Curr Protein Pept Sci. 2021 Sep 9. doi: 10.2174/1389203722666210910111055. Online ahead of print.ABSTRACTAlong with structural and non-structural proteins, SARS-CoV-2, SARS-CoV, and MERS-CoV can also express accessory proteins. During the past few years, there have been only a few studies focusing on this set of proteins. Despite available data on these proteins, there are still a lot of questions on the functions of these proteins during infection that must be answered. With these three betacoronaviruses causing outbreaks in humans during the past few years, the need for a thorough understanding of the roles of these prot...
Source: Current Protein and Peptide Science - September 13, 2021 Category: Biochemistry Authors: Christian Alfredo K Cruz Paul Mark B Medina Source Type: research

Role of Adenosine Receptors in Rare Neurodegenerative Diseases with Motor Symptoms
Curr Protein Pept Sci. 2021 Sep 9. doi: 10.2174/1389203722666210910110126. Online ahead of print.ABSTRACTThe approval of istradefylline, an adenosine 2A receptor (A2AR) antagonist, as an add-on treatment in adult patients with Parkinson's disease by the Food and Drug Administration (FDA) and European Medicines Agency (EMA), is the latest proof of the importance of the adenosinergic system in the nervous system. Adenosine is an endogenous purine nucleoside with a role as a modulator of both neurotransmission and the inflammatory response. As such, the expression pattern of the 4 adenosine receptors (A1R, A2AR, A2BR and A3R)...
Source: Current Protein and Peptide Science - September 13, 2021 Category: Biochemistry Authors: Vicent Beltran-Beltran Noelia Benet ó Tamara Lape ña-Luzón Laura R Rodr íguez Federico V Pallard ó Pilar Gonzalez-Cabo Source Type: research

Diversity in the Accessory Proteins of SARS-CoV-2, SARS-CoV, and MERS-CoV Betacoronaviruses
Curr Protein Pept Sci. 2021 Sep 9. doi: 10.2174/1389203722666210910111055. Online ahead of print.ABSTRACTAlong with structural and non-structural proteins, SARS-CoV-2, SARS-CoV, and MERS-CoV can also express accessory proteins. During the past few years, there have been only a few studies focusing on this set of proteins. Despite available data on these proteins, there are still a lot of questions on the functions of these proteins during infection that must be answered. With these three betacoronaviruses causing outbreaks in humans during the past few years, the need for a thorough understanding of the roles of these prot...
Source: Current Protein and Peptide Science - September 13, 2021 Category: Biochemistry Authors: Christian Alfredo K Cruz Paul Mark B Medina Source Type: research

Role of Adenosine Receptors in Rare Neurodegenerative Diseases with Motor Symptoms
Curr Protein Pept Sci. 2021 Sep 9. doi: 10.2174/1389203722666210910110126. Online ahead of print.ABSTRACTThe approval of istradefylline, an adenosine 2A receptor (A2AR) antagonist, as an add-on treatment in adult patients with Parkinson's disease by the Food and Drug Administration (FDA) and European Medicines Agency (EMA), is the latest proof of the importance of the adenosinergic system in the nervous system. Adenosine is an endogenous purine nucleoside with a role as a modulator of both neurotransmission and the inflammatory response. As such, the expression pattern of the 4 adenosine receptors (A1R, A2AR, A2BR and A3R)...
Source: Current Protein and Peptide Science - September 13, 2021 Category: Biochemistry Authors: Vicent Beltran-Beltran Noelia Benet ó Tamara Lape ña-Luzón Laura R Rodr íguez Federico V Pallard ó Pilar Gonzalez-Cabo Source Type: research

Diversity in the Accessory Proteins of SARS-CoV-2, SARS-CoV, and MERS-CoV Betacoronaviruses
Curr Protein Pept Sci. 2021 Sep 9. doi: 10.2174/1389203722666210910111055. Online ahead of print.ABSTRACTAlong with structural and non-structural proteins, SARS-CoV-2, SARS-CoV, and MERS-CoV can also express accessory proteins. During the past few years, there have been only a few studies focusing on this set of proteins. Despite available data on these proteins, there are still a lot of questions on the functions of these proteins during infection that must be answered. With these three betacoronaviruses causing outbreaks in humans during the past few years, the need for a thorough understanding of the roles of these prot...
Source: Current Protein and Peptide Science - September 13, 2021 Category: Biochemistry Authors: Christian Alfredo K Cruz Paul Mark B Medina Source Type: research

Structure and function of the important internalins of Listeria monocytogenes
Curr Protein Pept Sci. 2021 Sep 2. doi: 10.2174/1389203722666210902163300. Online ahead of print.ABSTRACTListeria monocytogenes, a facultative intracellular gram-positive pathogen, is the causative agent of the disease listeriosis. The virulence of this intracellular bacterium is dependent on the coordinated activity of various bacterial factors, which are in turn tightly controlled by a specific set of regulators. The arsenal of virulence factors employed by L. monocytogenes for its infection cycle is available in the literature. Although the internalins of L. monocytogenes have been studied in detail their structural det...
Source: Current Protein and Peptide Science - September 2, 2021 Category: Biochemistry Authors: Shabir Ahmad Mir Source Type: research

Structure and function of the important internalins of Listeria monocytogenes
Curr Protein Pept Sci. 2021 Sep 2. doi: 10.2174/1389203722666210902163300. Online ahead of print.ABSTRACTListeria monocytogenes, a facultative intracellular gram-positive pathogen, is the causative agent of the disease listeriosis. The virulence of this intracellular bacterium is dependent on the coordinated activity of various bacterial factors, which are in turn tightly controlled by a specific set of regulators. The arsenal of virulence factors employed by L. monocytogenes for its infection cycle is available in the literature. Although the internalins of L. monocytogenes have been studied in detail their structural det...
Source: Current Protein and Peptide Science - September 2, 2021 Category: Biochemistry Authors: Shabir Ahmad Mir Source Type: research

Structure and function of the important internalins of Listeria monocytogenes
Curr Protein Pept Sci. 2021 Sep 2. doi: 10.2174/1389203722666210902163300. Online ahead of print.ABSTRACTListeria monocytogenes, a facultative intracellular gram-positive pathogen, is the causative agent of the disease listeriosis. The virulence of this intracellular bacterium is dependent on the coordinated activity of various bacterial factors, which are in turn tightly controlled by a specific set of regulators. The arsenal of virulence factors employed by L. monocytogenes for its infection cycle is available in the literature. Although the internalins of L. monocytogenes have been studied in detail their structural det...
Source: Current Protein and Peptide Science - September 2, 2021 Category: Biochemistry Authors: Shabir Ahmad Mir Source Type: research

Structure and function of the important internalins of Listeria monocytogenes
Curr Protein Pept Sci. 2021 Sep 2. doi: 10.2174/1389203722666210902163300. Online ahead of print.ABSTRACTListeria monocytogenes, a facultative intracellular gram-positive pathogen, is the causative agent of the disease listeriosis. The virulence of this intracellular bacterium is dependent on the coordinated activity of various bacterial factors, which are in turn tightly controlled by a specific set of regulators. The arsenal of virulence factors employed by L. monocytogenes for its infection cycle is available in the literature. Although the internalins of L. monocytogenes have been studied in detail their structural det...
Source: Current Protein and Peptide Science - September 2, 2021 Category: Biochemistry Authors: Shabir Ahmad Mir Source Type: research

A Bird's-Eye View of Proteomics
Curr Protein Pept Sci. 2021 Aug 12. doi: 10.2174/1389203722666210812120751. Online ahead of print.ABSTRACTModern protein science is broadening horizons by moving toward the systemic description of proteins in their natural habitats. This implies a transition from a classical reductionist approach associated with consideration of the unique structure and specific biological activity of an individual protein in a purified form to studying entire proteomes and their functions. This mini-review provides a brief description of structural, functional, and expression proteomics, the dark proteome (or unfoldome), and some of the t...
Source: Current Protein and Peptide Science - August 12, 2021 Category: Biochemistry Authors: Vladimir N Uversky Mohammed F Alghamdi Elrashdy M Redwan Source Type: research

Signal peptides - promising ingredients in cosmetics
Curr Protein Pept Sci. 2021 Aug 12. doi: 10.2174/1389203722666210812121129. Online ahead of print.ABSTRACTNaturally occurring peptides found in the human skin can serve particular biological activities and play roles as signaling molecules of various physiological processes such as homeostasis, growth, defense or immunity. Their great biological activity resulted in a growing interest in the pharmaceutical industry. Researchers consider peptides either promising compounds with potential application for human diagnosis, therapy or cosmetics. Peptides are becoming interesting cosmetic ingredients with the functions to reduce...
Source: Current Protein and Peptide Science - August 12, 2021 Category: Biochemistry Authors: Agnieszka Skibska Renata Perlikowska Source Type: research

A Bird's-Eye View of Proteomics
Curr Protein Pept Sci. 2021 Aug 12. doi: 10.2174/1389203722666210812120751. Online ahead of print.ABSTRACTModern protein science is broadening horizons by moving toward the systemic description of proteins in their natural habitats. This implies a transition from a classical reductionist approach associated with consideration of the unique structure and specific biological activity of an individual protein in a purified form to studying entire proteomes and their functions. This mini-review provides a brief description of structural, functional, and expression proteomics, the dark proteome (or unfoldome), and some of the t...
Source: Current Protein and Peptide Science - August 12, 2021 Category: Biochemistry Authors: Vladimir N Uversky Mohammed F Alghamdi Elrashdy M Redwan Source Type: research

Signal peptides - promising ingredients in cosmetics
Curr Protein Pept Sci. 2021 Aug 12. doi: 10.2174/1389203722666210812121129. Online ahead of print.ABSTRACTNaturally occurring peptides found in the human skin can serve particular biological activities and play roles as signaling molecules of various physiological processes such as homeostasis, growth, defense or immunity. Their great biological activity resulted in a growing interest in the pharmaceutical industry. Researchers consider peptides either promising compounds with potential application for human diagnosis, therapy or cosmetics. Peptides are becoming interesting cosmetic ingredients with the functions to reduce...
Source: Current Protein and Peptide Science - August 12, 2021 Category: Biochemistry Authors: Agnieszka Skibska Renata Perlikowska Source Type: research

A Bird's-Eye View of Proteomics
Curr Protein Pept Sci. 2021 Aug 12. doi: 10.2174/1389203722666210812120751. Online ahead of print.ABSTRACTModern protein science is broadening horizons by moving toward the systemic description of proteins in their natural habitats. This implies a transition from a classical reductionist approach associated with consideration of the unique structure and specific biological activity of an individual protein in a purified form to studying entire proteomes and their functions. This mini-review provides a brief description of structural, functional, and expression proteomics, the dark proteome (or unfoldome), and some of the t...
Source: Current Protein and Peptide Science - August 12, 2021 Category: Biochemistry Authors: Vladimir N Uversky Mohammed F Alghamdi Elrashdy M Redwan Source Type: research

Signal peptides - promising ingredients in cosmetics
Curr Protein Pept Sci. 2021 Aug 12. doi: 10.2174/1389203722666210812121129. Online ahead of print.ABSTRACTNaturally occurring peptides found in the human skin can serve particular biological activities and play roles as signaling molecules of various physiological processes such as homeostasis, growth, defense or immunity. Their great biological activity resulted in a growing interest in the pharmaceutical industry. Researchers consider peptides either promising compounds with potential application for human diagnosis, therapy or cosmetics. Peptides are becoming interesting cosmetic ingredients with the functions to reduce...
Source: Current Protein and Peptide Science - August 12, 2021 Category: Biochemistry Authors: Agnieszka Skibska Renata Perlikowska Source Type: research

A Bird's-Eye View of Proteomics
Curr Protein Pept Sci. 2021 Aug 12. doi: 10.2174/1389203722666210812120751. Online ahead of print.ABSTRACTModern protein science is broadening horizons by moving toward the systemic description of proteins in their natural habitats. This implies a transition from a classical reductionist approach associated with consideration of the unique structure and specific biological activity of an individual protein in a purified form to studying entire proteomes and their functions. This mini-review provides a brief description of structural, functional, and expression proteomics, the dark proteome (or unfoldome), and some of the t...
Source: Current Protein and Peptide Science - August 12, 2021 Category: Biochemistry Authors: Vladimir N Uversky Mohammed F Alghamdi Elrashdy M Redwan Source Type: research

Signal peptides - promising ingredients in cosmetics
Curr Protein Pept Sci. 2021 Aug 12. doi: 10.2174/1389203722666210812121129. Online ahead of print.ABSTRACTNaturally occurring peptides found in the human skin can serve particular biological activities and play roles as signaling molecules of various physiological processes such as homeostasis, growth, defense or immunity. Their great biological activity resulted in a growing interest in the pharmaceutical industry. Researchers consider peptides either promising compounds with potential application for human diagnosis, therapy or cosmetics. Peptides are becoming interesting cosmetic ingredients with the functions to reduce...
Source: Current Protein and Peptide Science - August 12, 2021 Category: Biochemistry Authors: Agnieszka Skibska Renata Perlikowska Source Type: research