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A Review on Anaplastic Lymphoma Kinase (ALK) Rearrangements and Mutations: Implications for Gastric Carcinogenesis and Target Therapy
Curr Protein Pept Sci. 2024 Feb 28. doi: 10.2174/0113892037291318240130103348. Online ahead of print.ABSTRACTGastric adenocarcinoma is a complex disease with diverse genetic modifications, including Anaplastic Lymphoma Kinase (ALK) gene changes. The ALK gene is located on chromosome 2p23 and encodes a receptor tyrosine kinase that plays a crucial role in embryonic development and cellular differentiation. ALK alterations can result from gene fusion, mutation, amplification, or overexpression in gastric adenocarcinoma. Fusion occurs when the ALK gene fuses with another gene, resulting in a chimeric protein with constitutive...
Source: Current Protein and Peptide Science - February 29, 2024 Category: Biochemistry Authors: Felipe Pantoja Mesquita Luina Benevides Lima Emerson Lucena da Silva Pedro Filho Noronha Souza Maria Elisabete Amaral de Moraes Rommel Mario Rodrigues Burbano Raquel Carvalho Montenegro Source Type: research
A Review on Anaplastic Lymphoma Kinase (ALK) Rearrangements and Mutations: Implications for Gastric Carcinogenesis and Target Therapy
Curr Protein Pept Sci. 2024 Feb 28. doi: 10.2174/0113892037291318240130103348. Online ahead of print.ABSTRACTGastric adenocarcinoma is a complex disease with diverse genetic modifications, including Anaplastic Lymphoma Kinase (ALK) gene changes. The ALK gene is located on chromosome 2p23 and encodes a receptor tyrosine kinase that plays a crucial role in embryonic development and cellular differentiation. ALK alterations can result from gene fusion, mutation, amplification, or overexpression in gastric adenocarcinoma. Fusion occurs when the ALK gene fuses with another gene, resulting in a chimeric protein with constitutive...
Source: Current Protein and Peptide Science - February 29, 2024 Category: Biochemistry Authors: Felipe Pantoja Mesquita Luina Benevides Lima Emerson Lucena da Silva Pedro Filho Noronha Souza Maria Elisabete Amaral de Moraes Rommel Mario Rodrigues Burbano Raquel Carvalho Montenegro Source Type: research
A Review on Anaplastic Lymphoma Kinase (ALK) Rearrangements and Mutations: Implications for Gastric Carcinogenesis and Target Therapy
Curr Protein Pept Sci. 2024 Feb 28. doi: 10.2174/0113892037291318240130103348. Online ahead of print.ABSTRACTGastric adenocarcinoma is a complex disease with diverse genetic modifications, including Anaplastic Lymphoma Kinase (ALK) gene changes. The ALK gene is located on chromosome 2p23 and encodes a receptor tyrosine kinase that plays a crucial role in embryonic development and cellular differentiation. ALK alterations can result from gene fusion, mutation, amplification, or overexpression in gastric adenocarcinoma. Fusion occurs when the ALK gene fuses with another gene, resulting in a chimeric protein with constitutive...
Source: Current Protein and Peptide Science - February 29, 2024 Category: Biochemistry Authors: Felipe Pantoja Mesquita Luina Benevides Lima Emerson Lucena da Silva Pedro Filho Noronha Souza Maria Elisabete Amaral de Moraes Rommel Mario Rodrigues Burbano Raquel Carvalho Montenegro Source Type: research
A Review on Anaplastic Lymphoma Kinase (ALK) Rearrangements and Mutations: Implications for Gastric Carcinogenesis and Target Therapy
Curr Protein Pept Sci. 2024 Feb 28. doi: 10.2174/0113892037291318240130103348. Online ahead of print.ABSTRACTGastric adenocarcinoma is a complex disease with diverse genetic modifications, including Anaplastic Lymphoma Kinase (ALK) gene changes. The ALK gene is located on chromosome 2p23 and encodes a receptor tyrosine kinase that plays a crucial role in embryonic development and cellular differentiation. ALK alterations can result from gene fusion, mutation, amplification, or overexpression in gastric adenocarcinoma. Fusion occurs when the ALK gene fuses with another gene, resulting in a chimeric protein with constitutive...
Source: Current Protein and Peptide Science - February 29, 2024 Category: Biochemistry Authors: Felipe Pantoja Mesquita Luina Benevides Lima Emerson Lucena da Silva Pedro Filho Noronha Souza Maria Elisabete Amaral de Moraes Rommel Mario Rodrigues Burbano Raquel Carvalho Montenegro Source Type: research
A Review on Anaplastic Lymphoma Kinase (ALK) Rearrangements and Mutations: Implications for Gastric Carcinogenesis and Target Therapy
Curr Protein Pept Sci. 2024 Feb 28. doi: 10.2174/0113892037291318240130103348. Online ahead of print.ABSTRACTGastric adenocarcinoma is a complex disease with diverse genetic modifications, including Anaplastic Lymphoma Kinase (ALK) gene changes. The ALK gene is located on chromosome 2p23 and encodes a receptor tyrosine kinase that plays a crucial role in embryonic development and cellular differentiation. ALK alterations can result from gene fusion, mutation, amplification, or overexpression in gastric adenocarcinoma. Fusion occurs when the ALK gene fuses with another gene, resulting in a chimeric protein with constitutive...
Source: Current Protein and Peptide Science - February 29, 2024 Category: Biochemistry Authors: Felipe Pantoja Mesquita Luina Benevides Lima Emerson Lucena da Silva Pedro Filho Noronha Souza Maria Elisabete Amaral de Moraes Rommel Mario Rodrigues Burbano Raquel Carvalho Montenegro Source Type: research
A Review on Anaplastic Lymphoma Kinase (ALK) Rearrangements and Mutations: Implications for Gastric Carcinogenesis and Target Therapy
Curr Protein Pept Sci. 2024 Feb 28. doi: 10.2174/0113892037291318240130103348. Online ahead of print.ABSTRACTGastric adenocarcinoma is a complex disease with diverse genetic modifications, including Anaplastic Lymphoma Kinase (ALK) gene changes. The ALK gene is located on chromosome 2p23 and encodes a receptor tyrosine kinase that plays a crucial role in embryonic development and cellular differentiation. ALK alterations can result from gene fusion, mutation, amplification, or overexpression in gastric adenocarcinoma. Fusion occurs when the ALK gene fuses with another gene, resulting in a chimeric protein with constitutive...
Source: Current Protein and Peptide Science - February 29, 2024 Category: Biochemistry Authors: Felipe Pantoja Mesquita Luina Benevides Lima Emerson Lucena da Silva Pedro Filho Noronha Souza Maria Elisabete Amaral de Moraes Rommel Mario Rodrigues Burbano Raquel Carvalho Montenegro Source Type: research
A Review on Anaplastic Lymphoma Kinase (ALK) Rearrangements and Mutations: Implications for Gastric Carcinogenesis and Target Therapy
Curr Protein Pept Sci. 2024 Feb 28. doi: 10.2174/0113892037291318240130103348. Online ahead of print.ABSTRACTGastric adenocarcinoma is a complex disease with diverse genetic modifications, including Anaplastic Lymphoma Kinase (ALK) gene changes. The ALK gene is located on chromosome 2p23 and encodes a receptor tyrosine kinase that plays a crucial role in embryonic development and cellular differentiation. ALK alterations can result from gene fusion, mutation, amplification, or overexpression in gastric adenocarcinoma. Fusion occurs when the ALK gene fuses with another gene, resulting in a chimeric protein with constitutive...
Source: Current Protein and Peptide Science - February 29, 2024 Category: Biochemistry Authors: Felipe Pantoja Mesquita Luina Benevides Lima Emerson Lucena da Silva Pedro Filho Noronha Souza Maria Elisabete Amaral de Moraes Rommel Mario Rodrigues Burbano Raquel Carvalho Montenegro Source Type: research
A Review on Anaplastic Lymphoma Kinase (ALK) Rearrangements and Mutations: Implications for Gastric Carcinogenesis and Target Therapy
Curr Protein Pept Sci. 2024 Feb 28. doi: 10.2174/0113892037291318240130103348. Online ahead of print.ABSTRACTGastric adenocarcinoma is a complex disease with diverse genetic modifications, including Anaplastic Lymphoma Kinase (ALK) gene changes. The ALK gene is located on chromosome 2p23 and encodes a receptor tyrosine kinase that plays a crucial role in embryonic development and cellular differentiation. ALK alterations can result from gene fusion, mutation, amplification, or overexpression in gastric adenocarcinoma. Fusion occurs when the ALK gene fuses with another gene, resulting in a chimeric protein with constitutive...
Source: Current Protein and Peptide Science - February 29, 2024 Category: Biochemistry Authors: Felipe Pantoja Mesquita Luina Benevides Lima Emerson Lucena da Silva Pedro Filho Noronha Souza Maria Elisabete Amaral de Moraes Rommel Mario Rodrigues Burbano Raquel Carvalho Montenegro Source Type: research
A Review on Anaplastic Lymphoma Kinase (ALK) Rearrangements and Mutations: Implications for Gastric Carcinogenesis and Target Therapy
Curr Protein Pept Sci. 2024 Feb 28. doi: 10.2174/0113892037291318240130103348. Online ahead of print.ABSTRACTGastric adenocarcinoma is a complex disease with diverse genetic modifications, including Anaplastic Lymphoma Kinase (ALK) gene changes. The ALK gene is located on chromosome 2p23 and encodes a receptor tyrosine kinase that plays a crucial role in embryonic development and cellular differentiation. ALK alterations can result from gene fusion, mutation, amplification, or overexpression in gastric adenocarcinoma. Fusion occurs when the ALK gene fuses with another gene, resulting in a chimeric protein with constitutive...
Source: Current Protein and Peptide Science - February 29, 2024 Category: Biochemistry Authors: Felipe Pantoja Mesquita Luina Benevides Lima Emerson Lucena da Silva Pedro Filho Noronha Souza Maria Elisabete Amaral de Moraes Rommel Mario Rodrigues Burbano Raquel Carvalho Montenegro Source Type: research
A Review on Anaplastic Lymphoma Kinase (ALK) Rearrangements and Mutations: Implications for Gastric Carcinogenesis and Target Therapy
Curr Protein Pept Sci. 2024 Feb 28. doi: 10.2174/0113892037291318240130103348. Online ahead of print.ABSTRACTGastric adenocarcinoma is a complex disease with diverse genetic modifications, including Anaplastic Lymphoma Kinase (ALK) gene changes. The ALK gene is located on chromosome 2p23 and encodes a receptor tyrosine kinase that plays a crucial role in embryonic development and cellular differentiation. ALK alterations can result from gene fusion, mutation, amplification, or overexpression in gastric adenocarcinoma. Fusion occurs when the ALK gene fuses with another gene, resulting in a chimeric protein with constitutive...
Source: Current Protein and Peptide Science - February 29, 2024 Category: Biochemistry Authors: Felipe Pantoja Mesquita Luina Benevides Lima Emerson Lucena da Silva Pedro Filho Noronha Souza Maria Elisabete Amaral de Moraes Rommel Mario Rodrigues Burbano Raquel Carvalho Montenegro Source Type: research
A Review on Anaplastic Lymphoma Kinase (ALK) Rearrangements and Mutations: Implications for Gastric Carcinogenesis and Target Therapy
Curr Protein Pept Sci. 2024 Feb 28. doi: 10.2174/0113892037291318240130103348. Online ahead of print.ABSTRACTGastric adenocarcinoma is a complex disease with diverse genetic modifications, including Anaplastic Lymphoma Kinase (ALK) gene changes. The ALK gene is located on chromosome 2p23 and encodes a receptor tyrosine kinase that plays a crucial role in embryonic development and cellular differentiation. ALK alterations can result from gene fusion, mutation, amplification, or overexpression in gastric adenocarcinoma. Fusion occurs when the ALK gene fuses with another gene, resulting in a chimeric protein with constitutive...
Source: Current Protein and Peptide Science - February 29, 2024 Category: Biochemistry Authors: Felipe Pantoja Mesquita Luina Benevides Lima Emerson Lucena da Silva Pedro Filho Noronha Souza Maria Elisabete Amaral de Moraes Rommel Mario Rodrigues Burbano Raquel Carvalho Montenegro Source Type: research
Molecular Players at the Sorting Stations of Malaria Parasite 'Plasmodium falciparum'
Curr Protein Pept Sci. 2024 Feb 23. doi: 10.2174/0113892037282522240130090156. Online ahead of print.ABSTRACTThe apicomplexan pathogenic parasite 'Plasmodium falciparum' (Pf) is responsible for most of the malaria related mortality. It resides in and refurbishes the infected red blood cells (iRBCs) for its own survival and to suffice its metabolic needs. Remodeling of host erythrocytes involves alteration of physical and biochemical properties of the membrane and genesis of new parasite induced structures within the iRBCs. The generated structures include knobs and solute ion channels on the erythrocyte surface and special...
Source: Current Protein and Peptide Science - February 27, 2024 Category: Biochemistry Authors: Jasweer Kaur Prakash Chandra Mishra Rachna Hora Source Type: research
Molecular Players at the Sorting Stations of Malaria Parasite 'Plasmodium falciparum'
Curr Protein Pept Sci. 2024 Feb 23. doi: 10.2174/0113892037282522240130090156. Online ahead of print.ABSTRACTThe apicomplexan pathogenic parasite 'Plasmodium falciparum' (Pf) is responsible for most of the malaria related mortality. It resides in and refurbishes the infected red blood cells (iRBCs) for its own survival and to suffice its metabolic needs. Remodeling of host erythrocytes involves alteration of physical and biochemical properties of the membrane and genesis of new parasite induced structures within the iRBCs. The generated structures include knobs and solute ion channels on the erythrocyte surface and special...
Source: Current Protein and Peptide Science - February 27, 2024 Category: Biochemistry Authors: Jasweer Kaur Prakash Chandra Mishra Rachna Hora Source Type: research
Molecular Players at the Sorting Stations of Malaria Parasite 'Plasmodium falciparum'
Curr Protein Pept Sci. 2024 Feb 23. doi: 10.2174/0113892037282522240130090156. Online ahead of print.ABSTRACTThe apicomplexan pathogenic parasite 'Plasmodium falciparum' (Pf) is responsible for most of the malaria related mortality. It resides in and refurbishes the infected red blood cells (iRBCs) for its own survival and to suffice its metabolic needs. Remodeling of host erythrocytes involves alteration of physical and biochemical properties of the membrane and genesis of new parasite induced structures within the iRBCs. The generated structures include knobs and solute ion channels on the erythrocyte surface and special...
Source: Current Protein and Peptide Science - February 27, 2024 Category: Biochemistry Authors: Jasweer Kaur Prakash Chandra Mishra Rachna Hora Source Type: research
Spectroscopic Analysis of the Effect of Ibuprofen Degradation Products on the Interaction between Ibuprofen and Human Serum Albumin
CONCLUSION: The conducted research allowed us to conclude that the presence of ibuprofen degradation products and the increase in their concentration significantly affect the formation of the IBU-albumin complex and thus, the value of the association constant of the drug, changing the concentration of its free fraction in the blood plasma. It was also found that the presence of an ibuprofen degradation product in a complex with albumin affects its secondary structure.PMID:38351694 | DOI:10.2174/0113892037284277240126094716 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - February 14, 2024 Category: Biochemistry Authors: Anna Ploch-Jankowska Source Type: research