Non-Histone Protein Methylation: Molecular Mechanisms and Physiopathological Relevance.
PMID: 32571200 [PubMed - as supplied by publisher] (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - June 20, 2020 Category: Biochemistry Authors: Salvi M Tags: Curr Protein Pept Sci Source Type: research

An Overview on Stroke: Mechanism, in vivo Experimental Models Thereof and Neuroprotective Agents.
CONCLUSION: The injury mechanism, available encouraging medicaments thereof, and outcomes of natural and modern medicines for ischemia have been summarised. In spite of available therapeutic agents (thrombolytics, calcium channel blockers, NMDA receptor antagonists and antioxidants), there is a need of an ideal drug for stroke. PMID: 32552641 [PubMed - as supplied by publisher] (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - June 17, 2020 Category: Biochemistry Authors: Khan MM, Badruddeen, Mujahid M, Akhtar J, Khan MI, Ahmad U Tags: Curr Protein Pept Sci Source Type: research

Gut barrier proteins mediate liver regulation by the effects of serotonin on the non-alcoholic fatty liver disease.
Abstract Serotonin (5-hydroxytryptamine, 5-HT) has been recognized as a potent pro-inflammatory mediator. Increasing the bioavailability and preventing the formation of 5-HT can reduce the inflammatory response in the body. Moreover, 5-HT is considered as an important central physiologic mediator of intestinal function by regulating intestinal motility, permeability and other functions. The dysfunction of intestinal serotonergic system causes intestinal barrier damage and it further leads to the increase of bacterial endotoxin (LPS) translocation into the liver which contributes to the development of non-alcoholic...
Source: Current Protein and Peptide Science - June 15, 2020 Category: Biochemistry Authors: Zhang K, Li X, Wang X, Zheng H, Tang S, Lu L, Ma X Tags: Curr Protein Pept Sci Source Type: research

Advent of Proteomic Tools For Diagnostic Biomarker Analysis in Alzheimer's Disease.
Abstract Locating remedies for Alzheimer's disease (AD) is been majorly restricted by inefficiency to establish a definitive detection model for early stage diagnosis of pathological events. This current lapse in AD diagnosis also limits the therapeutic efficiency of the drugs, which might have been effective if given at the earlier stages of the disease. The indicated situation directs towards the burgeoned need for an effective biomarker technique that will help in early detection of AD and would be imminently useful to facilitate improved diagnosis and stimulate therapeutic trials. Till date the major biomarker...
Source: Current Protein and Peptide Science - June 15, 2020 Category: Biochemistry Authors: Singh M, Singh SP, Dubey PK, Rachana R, Mani S, Yadav D, Agarwal M, Agarwal S, Agarwal V, Kaur H Tags: Curr Protein Pept Sci Source Type: research

Affinity tags for protein purification.
Abstract The affinity tags are unique proteins/peptides that are attached at the N- or C-terminus of the recombinant proteins. These tags help in protein purification. Additionally, some affinity tags also serve a dual purpose as solubility enhancers for challenging protein targets. By applying a combinatorial approach, carefully chosen affinity tags designed in tandem have proven to be very successful in the purification of single proteins or multi-protein complexes. In this minireview, I discuss the key features of the most commonly used affinity tags. I have classified the affinity tags into two significant cat...
Source: Current Protein and Peptide Science - June 6, 2020 Category: Biochemistry Authors: Mishra V Tags: Curr Protein Pept Sci Source Type: research

Vitamin D-RAAS connection: An Integrative Standpoint into Cardiovascular and Neuroinflammatory Disorders.
, Manucha W Abstract BACKGROUND: The neuroinflammatory process is associated with the pathogenesis of many cardiovascular disorders, particularly with hypertension. In this regard, the deficiency of vitamin D seems to increase the risk of cardiovascular pathologies related to neuroinflammation. Long-term vitamin D lack leads to over-activation of the reninangiotensin-aldosterone system (RAAS), one of the essential mechanisms of blood pressure regulation. PURPOSE OF REVIEW: This review summarizes the latest studies carried out to evaluate the primary mechanisms underlying the neuroprotective effect of vitamin ...
Source: Current Protein and Peptide Science - June 6, 2020 Category: Biochemistry Authors: Giménez VMM, Sanz RL, Marón FJM, Ferder L, Manucha W Tags: Curr Protein Pept Sci Source Type: research

The TRPM7 channel in the nervous and cardiovascular systems.
Abstract Transient receptor potential melastatin 7 (TRPM7), along with the closely related TRPM6, are unique channels that have dual operations: cation permeability and kinase activity. In contrast to the limited tissue distribution of TRPM6, TRPM7 is widely expressed among tissues and is therefore implicated in a variety of cellular functions physiologically and pathophysiologically. The discovery of TRPM7's unique structure imparting dual ion channel and kinase activities shed light onto novel and peculiar biological functions, such as Mg2+ homeostasis, cellular Ca2+ flickering, and even intranuclear transcripti...
Source: Current Protein and Peptide Science - June 5, 2020 Category: Biochemistry Authors: Inoue K, Xiong ZG, Ueki T Tags: Curr Protein Pept Sci Source Type: research

The Advances of the Structure and Function of Indoleamine 2, 3-dioxygenase 1 and Its Inhibitors.
Abstract Indoleamine 2, 3-dioxygenase 1 (IDO1) is the only rate-limiting enzyme outside the liver that catalyzes the oxidation and cracking of indole rings in the tryptophan along the kynurenine pathway (KP). The overactivation of IDO1 is closely related to the pathogenesis of various human immune and neurological diseases. As an important target for the treatment of many human serious diseases including malignant tumors, the development of IDO1 inhibitors is of great practical significance. In this work, the structure and function of IDO1 both are summarized from the aspects of signal pathway, catalytic mechanism...
Source: Current Protein and Peptide Science - May 26, 2020 Category: Biochemistry Authors: Duan HC, Peng LX, Luo Q, Hu YC, Liu XY, Sun X, Liang L, Gan Y, Liu W, Wan H, Shi HB, Zhao G, Hu JP Tags: Curr Protein Pept Sci Source Type: research

Nanotechnologies to Improve the Pharmacological Profile of Therapeutic Peptides.
PMID: 32400322 [PubMed - in process] (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - May 15, 2020 Category: Biochemistry Authors: Casciaro B, Mangoni ML Tags: Curr Protein Pept Sci Source Type: research

Melatonin modulates lactation by regulating prolactin secretion via tuberoinfundibular dopaminergic neurons in Hypothalamus-Pituitary system.
Abstract In-depth studies have identified many hormones important for controlling mammary growth and maintaining lactation. One of these is melatonin, which is synthesized and secreted by the pineal gland to regulate circadian rhythms, improve antioxidant capacity, and enhance immunity. Prolactin is secreted by the pituitary gland and is associated with growth and development of mammary glands as well as initiation and maintenance of lactation. The hypothalamus-pituitary system, the most important endocrine system in the body, regulates prolactin secretion mainly through dopamine released from tuberoinfundibular d...
Source: Current Protein and Peptide Science - May 10, 2020 Category: Biochemistry Authors: Li H, Wei J, Ma F, Shan Q, Gao D, Jin Y, Sun P Tags: Curr Protein Pept Sci Source Type: research

Proteomics in Neurodegenerative Disease.
Abstract Changes in protein structure and function, alteration in protein-protein interaction, and significant difference in protein concentration inside the body could play an important role in indicating the pathological evidence of abnormalities before the development of clinical symptoms and act as a critical detection and diagnostic tool commonly known as biomarkers. Biomarkers play important roles in the diagnosis of various chronic diseases including cancer. Neurodegenerative disorders including Parkinson's, Alzheimer's, Huntington's, prion, and multiple sclerosis are well characterized by neuronal deterior...
Source: Current Protein and Peptide Science - May 10, 2020 Category: Biochemistry Authors: Puranik N, Yadav D, Yadav SK, Chavda VK, Jin JO Tags: Curr Protein Pept Sci Source Type: research

Protein and antibody engineering - suppressing degranulation of the mast cells and type I hypersensitivity reaction.
Abstract With an increase in atopic cases and owing to a significant role of mast cells in type I hypersensitivity, a therapeutic need to inhibit degranulation of mast cells has risen . Mast cells are notorious for IgE-mediated allergic response. Advancements have allowed researchers to move to improve the clinical outcomes of already available therapies. Engineered peptides and antibodies can be easily manipulated to attain desired characteristics as per the biological environment. A number of these molecules are designed to target mast cells, in order to regulate the release of histamine and other mediators, the...
Source: Current Protein and Peptide Science - May 10, 2020 Category: Biochemistry Authors: Rajani HF, Shahidi S, Gomari MM Tags: Curr Protein Pept Sci Source Type: research

Non-Histone Arginine Methylation by Protein Arginine Methyltransferases.
Abstract Protein arginine methyltransferase (PRMT) enzymes play a crucial role in RNA splicing, DNA damage repair, cell signaling, and differentiation. Arginine methylation is a prominent post-transitional modification of histones and various non-histone proteins that can either activate or repress gene expression. The aberrant expression of PRMTs has been linked to multiple abnormalities, notably cancer. Herein, we review a number of non-histone protein substrates for all nine members of human PRMTs and how PRMT-mediated non-histone arginine methylation modulates various diseases. Additionally, we highlight the m...
Source: Current Protein and Peptide Science - May 6, 2020 Category: Biochemistry Authors: Al-Hamashi AA, Diaz K, Huang R Tags: Curr Protein Pept Sci Source Type: research

The role of Glyoxalase in Glycation and Carbonyl Stress Induced Metabolic Disorders.
Abstract Glycation refers to the covalent binding of sugar molecules to macromolecules, such as DNA, proteins, and lipids in a non-enzymatic reaction, resulting in the formation of irreversibly bound products known as advanced glycation end products (AGEs). AGEs are synthesized in high amounts both in pathological conditions, such as diabetes and under physiological conditions resulting in aging. The body's anti-glycation defense mechanisms play a critical role in removing glycated products. However, if this defense system fails, AGEs start accumulating, which results in pathological conditions. Studies have shown...
Source: Current Protein and Peptide Science - May 4, 2020 Category: Biochemistry Authors: Saeed M, Kausar MA, Singh R, Siddiqui AJ, Akhter A Tags: Curr Protein Pept Sci Source Type: research

Biochemical and Computational Approaches for the Large-Scale Analysis of Protein Arginine Methylation by Mass Spectrometry.
Abstract The absence of efficient mass spectrometry-based approaches for the large-scale analysis of protein arginine methylation has hindered the understanding of its biological role, beyond the transcriptional regulation occurring through histone modification. In the last decade, however, several technological advances of both the biochemical methods for methylated polypeptide enrichment and the computational pipelines for MS data analysis have considerably boosted this research field, generating novel insights about the extent and role of this post translational modification. Here, we offer an overview on state...
Source: Current Protein and Peptide Science - April 26, 2020 Category: Biochemistry Authors: Musiani D, Massignani E, Cuomo A, Yadav A, Bonaldi T Tags: Curr Protein Pept Sci Source Type: research

Analysis of inter-chromosomal distribution of disease-related genes in human genome.
In this study, we explored these issues using the available genomic data of both human and model organisms. Moreover, we also analyzed the distribution pattern of protein-coding genes that have been associated with 14 common diseases and the insert/deletion mutations and single nucleotide polymorphisms detected by whole genome sequencing in an acute promyelocyte leukemia patient. We obtained the following novel findings. Firstly, inter-chromosomal distribution of genes displays a non-stochastic pattern and the gene densities in different chromosomes are heterogeneous. This kind of heterogeneity is observed in genomes of bo...
Source: Current Protein and Peptide Science - April 26, 2020 Category: Biochemistry Authors: Sun X, Yang B, Zhang Q Tags: Curr Protein Pept Sci Source Type: research

D-Amino Acids in Peptides from Animals, Including Human: Occurrence, Structure, Bioactivity and Pharmacology..
This article is a review of their occurrence, structure and bioactivity. It further explores the pharmacology and potential medical applications of some of the peptides. PMID: 32338216 [PubMed - as supplied by publisher] (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - April 26, 2020 Category: Biochemistry Authors: Jimenez EC Tags: Curr Protein Pept Sci Source Type: research

Proteins as Virulence Factors and Immune Modulators During the Host-Fungus Interaction.
PMID: 32228414 [PubMed - in process] (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - April 3, 2020 Category: Biochemistry Authors: Mora-Montes HM Tags: Curr Protein Pept Sci Source Type: research

Protein histidine methylation.
Abstract Protein histidine methylation is rarely studied posttranslational modification in eukaryotes. Although the presence of N-methylhistidine residue in actin has been demonstrated in early 1960s, only a very limited number of methylhistidine-containing proteins including S100A9, myosin, myosin kinase and ribosomal protein RPL3 have been reported to date. The role of histidine methylation in protein function and in cell physiology also remain largely uncharted mostly due to a shortage of studies focusing on these issues. Recently, however, molecular identities of first two distinct histidine-specific protein m...
Source: Current Protein and Peptide Science - March 18, 2020 Category: Biochemistry Authors: Kwiatkowski S, Drozak J Tags: Curr Protein Pept Sci Source Type: research

Allergens at Asian Homes.
PMID: 32167036 [PubMed - in process] (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - March 14, 2020 Category: Biochemistry Authors: Jeong KY, Tungtrongchitr A Tags: Curr Protein Pept Sci Source Type: research

Anti-amyloid aggregating gold nanoparticles: Can they really be translated from bench to bedside for Alzheimer's disease treatment?
Abstract Alzheimer's disease (AD) is characterized by deposition of amyloid-β protein aggregates and an appropriate treatment strategy is urgently needed, as the number of diagnosed cases continues to increase. The management of AD and of the other brain-associated diseases are limited by the blood brain barrier and its selective control of drug passage. In fact, most of the promising drugs have restricted curative effects on AD owing to their lower bioavailability. Gold nanoparticles (AuNPs) have emerged as attractive therapeutic agents and have distinctive properties that could contribute to the development...
Source: Current Protein and Peptide Science - February 25, 2020 Category: Biochemistry Authors: Shaikh S, Nazam N, Danish Rizvi SM, Hussain T, Farhana A, Choi I Tags: Curr Protein Pept Sci Source Type: research

Amino Acids Regulate Glycolipid Metabolism and Alter Intestinal Microbial Composition..
Abstract Amino acids (AAs) and their metabolites regulate key metabolic pathways that are necessary for growth, reproduction, and immunity, metabolism of the body. It has been convinced that metabolic diseases are closely related to disorders of glycolipid metabolism. A growing number of studies have shown that AAs are closely related to energy metabolism. This review focuses on the effects of amino acids (arginine, branched-chain amino acids, glutamine) and their metabolites (short chain fatty acids) on glycolipid metabolism by regulating PI3K/AKT/mTOR and AMPK signaling pathways and GPCRs receptors, reducing int...
Source: Current Protein and Peptide Science - February 18, 2020 Category: Biochemistry Authors: Xie F, Liu Z, Liu M, Chen L, Ding W, Zhang H Tags: Curr Protein Pept Sci Source Type: research

GRASP55: A Multifunctional Protein.
Abstract GRASP55 was first found as a Golgi cisternae stacking protein. Due to the crucial role of Golgi in vesicular trafficking and protein modification, GRASP55 was found to function in these two aspects. Further investigation showed that GRASP55 also participates in unconventional secretory pathway under stress. Far more than that, GRASP55 is involved in autophagy initiation and autophagosome maturation, as well as cell activity. PMID: 32067616 [PubMed - as supplied by publisher] (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - February 17, 2020 Category: Biochemistry Authors: Wu H, Li T, Zhao J Tags: Curr Protein Pept Sci Source Type: research

Oxidative Stress in Autoimmune Diseases: An under dealt malice.
Abstract Oxidative stress is the off-balance of antioxidants and free radicals. All kinds of disease and disorders give rise to oxidative damage including autoimmune diseases. An autoimmune disorder is a pathological condition characterized by the breakdown of self-tolerance of the immune system in the body. Immunological processes against tissues and organs leading to enhanced oxidative stress and in turn, misbalance of oxidative stress aggravates the pathobiology of the disease. Highly reactive nature of free radicals, for example, hydroxyl, superoxide ions, alter DNA, protein, and lipids in the body which augme...
Source: Current Protein and Peptide Science - February 13, 2020 Category: Biochemistry Authors: Ramani S, Pathak A, Dalal V, Paul A, Biswas S Tags: Curr Protein Pept Sci Source Type: research

Detecting protein-protein interaction based on protein fragment complementation assay.
Abstract Proteins are the most critical executive molecules by responding to the instructions stored in the genetic materials in any form of life. More frequently, proteins do their jobs by acting as a roleplayer that interacts with other protein(s), which is more evident when the function of a protein is examined in the real context of a cell. Identifying the interactions between (or amongst) proteins is very crucial for the biochemistry investigation of an individual protein and for the attempts aiming to draw a holo-picture for the interacting members at the scale of proteomics ( or protein-protein interactions...
Source: Current Protein and Peptide Science - February 12, 2020 Category: Biochemistry Authors: Wang T, Yang N, Liang C, Xu H, An Y, Xiao S, Zheng M, Liu L, Wang G, Nie L Tags: Curr Protein Pept Sci Source Type: research

Overview of Gene Regulatory Network Inference Based on Differential Equation Models.
Abstract Reconstruction of gene regulatory networks (GRN) plays an important role in understanding the complexity, functionality and pathways of biological systems, which could support the design of new drugs for diseases. Because differential equation models are flexible and strong, these models have been utilized to identify biochemical reactions and gene regulatory networks. This paper investigates the differential equation models for reverse engineering gene regulatory networks. We introduce three kinds of differential equation models, including ordinary differential equation (ODE), time-delayed differential e...
Source: Current Protein and Peptide Science - February 12, 2020 Category: Biochemistry Authors: Yang B, Chen Y Tags: Curr Protein Pept Sci Source Type: research

2'-Deoxyribose mediated glycation leads to alterations in BSA structure via generation of carbonyl species.
In this study, Bovine Serum Albumin (BSA) was glycated with 50 and 100 mM 2'-Deoxyribose followed by examining secondary and tertiary structural modifications in BSA as compared to its native (unmodified) form by using various physicochemical techniques. We evident a significant modification in 2'-Deoxyribose-glycated BSA which was confirmed through increased hyperchromicity, keto amine moieties, carbonyl and hydroxymethyl furfural content, fluorescent AGEs, altered secondary structure conformers (α helix and β sheets), band shift in the amide-I region and diminished free lysine and free arginine content. These ...
Source: Current Protein and Peptide Science - February 12, 2020 Category: Biochemistry Authors: Rafi Z, Alouffi S, Khan MS, Ahmad S Tags: Curr Protein Pept Sci Source Type: research

Plant Virus Nanoparticles for Vaccine Applications.
Abstract In the rapidly evolving field of nanotechnology, plant virus nanoparticles (pVNPs) are emerging as powerful tools in diverse applications ranging from biomedicine to materials science. The proteinaceous structure of plant viruses allows the capsid structure to be modified by genetic engineering and/or chemical conjugation with nanoscale precision. This means that pVNPs can be engineered to display peptides and proteins on their external surface, including immunodominant peptides derived from pathogens allowing pVNPs to be used for active immunization. In this context, pVNPs are safer than VNPs derived fro...
Source: Current Protein and Peptide Science - February 11, 2020 Category: Biochemistry Authors: Santoni M, Zampieri R, Avesani L Tags: Curr Protein Pept Sci Source Type: research

Gastrointestinal Interaction between Dietary Amino Acids and Gut Microbiota: with Special Emphasis on Host Nutrition.
Abstract The gastro intestinal tract (GIT) of humans and animals is host to a complex community of different microorganisms whose activities significantly influence host nutrition and health through enhanced metabolic capabilities, protection against pathogens, and regulation of the gastrointestinal development and immune system. New molecular technologies and concepts have revealed distinct interactions between the gut microbiota and dietary amino acids (AAs) especially in relation to AA metabolism and utilization in resident bacteria in the digestive tract, and these interactions may play significant roles in ho...
Source: Current Protein and Peptide Science - February 11, 2020 Category: Biochemistry Authors: Abdallah A, Elemba E, Zhong Q, Sun Z Tags: Curr Protein Pept Sci Source Type: research

Fermentation and Metabolism of Dietary Protein by Intestinal Microorganisms.
Abstract Dietary protein is linked to the intestinal microorganisms. The decomposition of dietary protein can provide nutrients for microbial growth, which in turn can ferment protein to produce some metabolites. This review elaborates that the effects of different protein levels and types on intestinal microorganisms and its metabolites fermented by intestinal microorganisms, as well as the effects of these metabolites on organisms. It is well known that intestinal microbial imbalance can cause some diseases. Dietary protein supplementation can alter the composition of intestinal microorganisms and thus regulates...
Source: Current Protein and Peptide Science - February 11, 2020 Category: Biochemistry Authors: Zhang K, Ma X Tags: Curr Protein Pept Sci Source Type: research

Review of MiRNA-Disease Association prediction.
Abstract Accumulating evidence demonstrates that miRNAs serve as critical biomarkers in various complex human diseases. Thus, identifying potential miRNA-disease associations have become a hot research topic for providing better understanding of disease pathology, including cell carcinoma, cell proliferation and mevalonate pathway. Recently, based on various biological datasets, more and more computational prediction methods have been designed to uncover disease-related miRNAs for further experimental validation. Due to the fact that different limitations exist in previous computational methods, we proposed the mo...
Source: Current Protein and Peptide Science - February 9, 2020 Category: Biochemistry Authors: Jiang L, Zhu J Tags: Curr Protein Pept Sci Source Type: research

Glycation and Antioxidants: Hand in glove of antiglycation and natural antioxidants.
Abstract The non-enzymatic interaction of sugar and protein resulting in the formation of advanced glycation end products responsible for cell signaling alterations ultimately lead to the human chronic disorders such as diabetes mellitus, cardiovascular diseases, cancer, etc. Studies suggest that AGEs upon interaction with receptors for advanced glycation end products (RAGE) result in the production of pro-inflammatory molecules and free radicals that exert altered gene expression effect. Till date many studies unveiled the potent role of synthetic and natural agents in inhibiting the glycation reaction at lesser ...
Source: Current Protein and Peptide Science - February 9, 2020 Category: Biochemistry Authors: Khanam A, Ahmad S, Husain A, Rehman S, Farooqui A, Yusuf MA Tags: Curr Protein Pept Sci Source Type: research

The Brief Analysis of Peptide-combined Nanoparticle: Nanomedicine's Unique Value.
Abstract Therapeutic peptides (TPs) are biological macromolecules which can act as neurotransmitters, hormones, ion channel ligands and growth factors. Undoubtedly, TPs are crucial in the modern medicine. But low bio-stability and some special adverse reactions reduce their places to the application. With the development of nanotechnology, nanoparticles (NPs) in pharmaceutical science gained much attention. They can encapsulate the TPs into their membrane or shell. Therefore, they can protect the TPs against degradation and then increase the bioavailability, which was thought to be the biggest advantage of them. A...
Source: Current Protein and Peptide Science - February 9, 2020 Category: Biochemistry Authors: Wang J, Wu J, Li Y, Wen J, Cai J, Tang T, Hu X, Xiang D Tags: Curr Protein Pept Sci Source Type: research

The interplay between depression and Parkinson ´s disease: learning the link through Ca2+/cAMP signalling.
CONCLUSION: Thus, this article discussed the role of Ca2+ signaling in the interplay between depression and PD, including the implications for the pharmacotherapy involving CCBs. PMID: 32026774 [PubMed - as supplied by publisher] (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - February 6, 2020 Category: Biochemistry Authors: Bergantin LB Tags: Curr Protein Pept Sci Source Type: research

Process, outcomes and possible elimination of aggregation with special reference to heme proteins; Likely remediation of proteinopathies.
Abstract Protein folding is a natural phenomenon through which a linear polypeptide possessing necessary information attains three dimension functionally active conformation. This is a complex and multistep process and therefore, the presence of several intermediary structures could be speculated as a result of protein folding. In in vivo this folding process is governed by assistance of other proteins called molecular chaperons and heat shock proteins. Mechanism of protein folding and the nature these intermediary structures remains major challenge for modern biology. Mutation in gene encoding amino acid, adverse...
Source: Current Protein and Peptide Science - February 4, 2020 Category: Biochemistry Authors: Furkan M, Khan RH Tags: Curr Protein Pept Sci Source Type: research

Cellular Retinoic-Acid Binding Protein 2 in solid tumor.
Abstract The retinoic acid (RA) signaling pathway is crucial for many biological processes. The RA transporter, Cellular Retinoic-Acid Binding Protein 2 (CRABP2), abnormally expressed in various tumor types. CRABP2 presents significant effects on tumorous behaviors and functions, including cell proliferation, apoptosis, invasion, migration, metastasis, and angiogenesis. The tumorigenesis mechanism of CRABP2 as both suppressor and promotor is complicated, which remains ample space for further investigation. Elucidating the regulating mechanisms in a specific stage of the tumor could facilitate CRABP2 to be one biom...
Source: Current Protein and Peptide Science - February 3, 2020 Category: Biochemistry Authors: Jiao X, Liu R, Huang J, Lu L, Li Z, Xu L, Li E Tags: Curr Protein Pept Sci Source Type: research

CONTROL OF OXYGEN AFFINITY IN MAMMALIAM HEMOGLOBINS: implications for a system biology description of the respiratory properties of the red blood cell.
Abstract Hemoglobin and myoglobin have been considered for a long time the paradigmatic model systems for protein function, to the point of being defined the "hydrogen atom[s] of biology" [Frauenfelder et al. Proc. Natl. Acad. Sci. USA, 2003; 100, 8615-8617]. Given this privileged position and the huge amount of quantitative information available on these proteins, the red blood cell might appear as the model system and"hydrogen atom" of system biology. Indeed, since the red cell's main function is O2 transport by hemoglobin, the gap between the protein and the may appear quite small. Yet, a su...
Source: Current Protein and Peptide Science - February 3, 2020 Category: Biochemistry Authors: Bellelli A, Brunori M Tags: Curr Protein Pept Sci Source Type: research

Impacts of dietary protein from fermented cottonseed meal on lipid metabolism and metabolomic profiling in serum of broilers.
Abstract Dietary protein from fermented cottonseed meal (FCSM), widely used in poultry diets in China, had regulating effects on lipid metabolism. To understand the effects of FCSM on the lipid metabolism in broilers, we analyzed the biochemical indexes, enzyme activity, hormone level and metabolites in serum responses to FCSM intake. One hundred and eighty 21-d-old Chinese yellow feathered broilers (536.07±4.43 g) were randomly divided into 3 groups with 6 replicates and 3 diets with 6 % supplementation of unfermented CSM (control group), FCSM by C. Tropicalis (Ct CSM) or C. tropicalis plus S. Cerevisae (C...
Source: Current Protein and Peptide Science - February 3, 2020 Category: Biochemistry Authors: Nie C, Wang Y, Liu Y, Liu J, Ge W, Ma X, Zhang W Tags: Curr Protein Pept Sci Source Type: research

Self-Assembly in Peptides containing beta-and gamma-amino acids.
Abstract The peptides containing β-and γ-amino acids as building blocks display well-defined secondary structures with unique morphologies. The ability of such peptides to self-assemble into complex structures of controlled geometries has been exploited in biomedical applications. The ability of these peptides to self-assemble into complex structures of controlled geometries has been explored in biomaterials applications. Heirein, we have provided an updated overview about the peptides containing β-and γ-amino acids considering the significance and advancement in the area of development of pe...
Source: Current Protein and Peptide Science - January 26, 2020 Category: Biochemistry Authors: Shankar S, Junaid Ur Rahim, Rai R Tags: Curr Protein Pept Sci Source Type: research

Toward understanding molecular recognition between protein arginine methyltransferases (PRMTs) and their substrates.
Abstract Protein arginine methylation is a widespread eukaryotic posttranslational modification that occurs with as much frequency as ubiquitinylation. Yet how the nine different human protein arginine methyltransferases (PRMTs) recognize their respective protein targets is not well understood. This review summarizes the progress that has been made over the last decade or more to resolve this significant biochemical question. A multipronged approach involving structural biology, substrate profiling, bioorthogonal chemistry and proteomics is discussed. PMID: 31976831 [PubMed - as supplied by publisher] (Source...
Source: Current Protein and Peptide Science - January 24, 2020 Category: Biochemistry Authors: Price OM, Hevel JM Tags: Curr Protein Pept Sci Source Type: research

An Overview on Predicting Protein Subchloroplast Localization by using Machine Learning Methods.
Abstract The chloroplast is a type of subcellular organelle of green plants and eukaryotic algae, which plays an important role in the photosynthesis process. Since the function of a protein correlates with its location, knowing its subchloroplast localization is helpful for elucidating its functions. However, due to the large number of chloroplast proteins, it is costly and time-consuming to design biological experiments to recognize subchloroplast localizations of these proteins. To address this problem, during the past ten years, twelve computational prediction methods have been developed to predict protein sub...
Source: Current Protein and Peptide Science - January 17, 2020 Category: Biochemistry Authors: Liu ML, Su W, Guan ZX, Zhang D, Chen W, Liu L, Ding H Tags: Curr Protein Pept Sci Source Type: research

Comprehensive Review and Comparison for Anticancer Peptides Identification Models.
Abstract Anticancer peptides (ACPs) eliminate pathogenic bacteria and kill tumor cells, showing no hemolysis and no damages to normal human cells. This unique ability explores the possibility of ACPs as therapeutic delivery and its potential applications in clinical therapy. Identifying ACPs is one of the most fundamental and central problems in new antitumor drug research. During the past decades, a number of machine learning-based prediction tools have been developed to solve this important task. However, the predictions produced by various tools are difficult to quantify and compare. Therefore, in this article,...
Source: Current Protein and Peptide Science - January 17, 2020 Category: Biochemistry Authors: Song X, Zhuang Y, Lan Y, Lin Y, Min X Tags: Curr Protein Pept Sci Source Type: research

Progress in the development of antimicrobial peptide prediction tools.
Abstract Antimicrobial peptides (AMPs) are natural polypeptides with antimicrobial activities and are found in most organisms. AMPs are evolutionarily conservative components that belong to the innate immune system and show potent activity against bacteria, fungi, viruses and in some cases display antitumor activity. Thus, AMPs are major candidates in the development of new antibacterial reagents. In the last few decades, AMPs have attracted significant attention from the research community. During the early stages of the development of this research field, AMPs were experimentally identified, which is an expensiv...
Source: Current Protein and Peptide Science - January 17, 2020 Category: Biochemistry Authors: Ao C, Zhang Y, Li D, Zhao Y, Zou Q Tags: Curr Protein Pept Sci Source Type: research

Evolution of Machine Learning Algorithms in the Prediction and Design of Anticancer Peptides.
Abstract Peptides act as promising anticancer agents due to their ease of synthesis and modifications, enhanced tumor penetration, and less systemic toxicity. However, only limited success has been achieved so far, as experimental design and synthesis of anticancer peptides (ACPs) are prohibitively costly and time-consuming. Furthermore, sequential increase in the protein sequence data via high-throughput sequencing makes it difficult to identify ACPs only through experimentation, that often involves months or years of speculation and failure. All these limitations could be conquered by applying machine learning (...
Source: Current Protein and Peptide Science - January 17, 2020 Category: Biochemistry Authors: Basith Mail S, Manavalan B, Shin TH, Lee D, Lee G Tags: Curr Protein Pept Sci Source Type: research

Antimicrobial Peptides From Lycosidae (Sundevall, 1833) Spiders.
ma ME Abstract Antimicrobial peptides (AMPs) have been found in all organism taxa and may play an essential role as a host defense system. AMPs are organized in various conformations, such as linear peptides, disulfide bond-linked peptides, backbone-linked peptides and circular peptides. AMPs apparently act primarily on the plasma membrane, although an increasing number of works have shown that they may also target various intracellular sites. Spider venoms are rich sources of biomolecules that show several activities, including modulation or blockage of ion channels, anti-insect, anti-cancer, antihypertensive and...
Source: Current Protein and Peptide Science - January 15, 2020 Category: Biochemistry Authors: Melo-Braga MN, Almeida FM, Dos Santos DM, de Avelar Júnior JT, Dos Reis PVM, de Lima ME Tags: Curr Protein Pept Sci Source Type: research

Virulence factors in the entomopathogen genus Metarhizium.
ez A, Torres-Guzmán JC Abstract The fungal genus Metarhizium has been used as an entomopathogen worldwide for approximately 140 years, and its mechanism of infection and its virulence factors have been studied. The present review is a compilation of virulence factors described in the literature to date and their participation in specific stages of the infection process. PMID: 31951168 [PubMed - as supplied by publisher] (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - January 15, 2020 Category: Biochemistry Authors: González-Hernández GA, Padilla-Guerrero IE, Martínez-Vázquez A, Torres-Guzmán JC Tags: Curr Protein Pept Sci Source Type: research

Lysine Methyltransferases Signaling: Histones are Just the Tip of the Iceberg.
Abstract Protein lysine methylation is a functionally diverse post-translational modification involved in various major cellular processes. Lysine methylation can modulate proteins activity, stability, localization and/or interaction, resulting in specific downstream signaling and biological outcomes. Lysine methylation is a dynamic and fine-tuned process, deregulation of which often leads to human pathologies. In particular, the lysine methylome and its associated signaling network can be linked to carcinogenesis and cancer progression. Histone modifications and chromatin regulation is a major aspect of lysine me...
Source: Current Protein and Peptide Science - January 1, 2020 Category: Biochemistry Authors: Lukinović V, Casanova AG, Roth GS, Chuffart F, Reynoird N Tags: Curr Protein Pept Sci Source Type: research

Peptide nanomaterials for drug delivery applications.
Abstract Self-assembled peptides have been shown to form well-defined nanostructures which display outstanding characteristics for many biomedical applications and especially in controlled drug delivery. Such biomaterials are becoming increasingly popular due to routine, standardized methods of synthesis, high biocompatibility, biodegradability and ease of upscale. Moreover, one can modify the structure at the molecular level to form various nanostructures with a wide range of applications in the field of medicine. Through environmental modifications such as changes in pH and ionic strength and the introduction of...
Source: Current Protein and Peptide Science - December 31, 2019 Category: Biochemistry Authors: Pentlavalli S, Coulter S, Laverty G Tags: Curr Protein Pept Sci Source Type: research

Effects of Medium Chain Fatty Acids in Monogastric Animals' Intestinal Health.
Abstract Medium chain fatty acids (MCFAs) are the main forms of Medium Chain Triglycerides (MCTs) utilized by monogastric animals. MCFAs can be directly absorbed and supply rapid energy to promote the renewal and repair of intestinal epithelial cells, maintain the integrity of intestinal mucosal barrier function, and reduce inflammation and stress. In our review, we pay more attention on the role of MCFAs on intestinal microbiota and mucosa immunity to explore MCFA positive effect. It was found that MCFAs and their esterified forms can decrease pathogens while increasing probiotics. In addition, by being recognize...
Source: Current Protein and Peptide Science - December 31, 2019 Category: Biochemistry Authors: Jia M, Zhang Y, Gao Y, Ma X Tags: Curr Protein Pept Sci Source Type: research

Insights into The Function and Regulation of Jumonji C Lysine Demethylases as Hypoxic Responsive Enzymes.
Abstract Cellular responses to hypoxia (low oxygen) are governed by oxygen sensitive signalling pathways. Such pathways, in part, are controlled by enzymes with oxygen-dependent catalytic activity, of which the role of prolyl 4-hydroxylases has been widely reviewed. These enzymes inhibit hypoxic response by inducing the oxygen-dependent degradation of hypoxia-inducible factor 1α, the master regulator of transcriptional hypoxic response. Jumonji C domain-containing lysine demethylases are similar enzymes which share the same oxygen-dependent catalytic mechanism as prolyl 4-hydroxylases. Traditionally, the rol...
Source: Current Protein and Peptide Science - December 30, 2019 Category: Biochemistry Authors: Chopra A, Adhikary H, Willmore WG, Biggar KK Tags: Curr Protein Pept Sci Source Type: research