Melatonin against environmental plant stressors: a review.
uiz J Abstract Harsh or extreme environmental conditions largely determine the vegetative and reproductive development of plants. In the case of cultivated plants, their growth and yield are clearly diminished if they are exposed to severe conditions such as drought, waterlogging, extreme heat or cold, UV radiation, or toxic substances in the soil such as salts, heavy metals and pesticides. Melatonin has been studied for decades as a molecule capable of reducing the negative effects of abiotic stressors by increasing tolerance to these adverse growth conditions. This work presents a review of the most outstanding ...
Source: Current Protein and Peptide Science - January 1, 2021 Category: Biochemistry Authors: Arnao MB, Hernández-Ruiz J Tags: Curr Protein Pept Sci Source Type: research

Pathogenesis Related Proteins (PRs): From Cellular Mechanisms to Plant Defense.
Abstract Many unfavorable stress conditions, such as wounding, drought, extreme temperatures, salinity and pathogen attacks control growth, development and plant yield. To survive under such environments, plants have developed many strategies. They are able to induce the expression of a large number of genes that encodes effectors, receptors, as well as signaling proteins and protective molecules. Among all, we find pathogenesis-related proteins (PRs) which were found to be activated in response to a large number of biotic and abiotic threats. Those proteins have a wide range of functions; acting as chitinases, pe...
Source: Current Protein and Peptide Science - December 31, 2020 Category: Biochemistry Authors: Zribi I, Ghorbel M, Brini F Tags: Curr Protein Pept Sci Source Type: research

Impact of Reactive Dicarbonyls on Biological Macromolecules- Role in Metabolic Disorders.
PMID: 33323095 [PubMed - in process] (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - December 18, 2020 Category: Biochemistry Authors: Ahmad S, Rehman S Tags: Curr Protein Pept Sci Source Type: research

Deciphering the Neuroprotective Role of Glucagon-like peptide-1 Agonists in Diabetic Neuropathy: Current Perspective and Future Directions.
Abstract Diabetic neuropathy is referred as subsequential and debilitating complication belonging to type 1 and type 2 diabetes mellitus. It is a heterogeneous group of disorder with particularly complex pathophysiology and also includes multiple forms, ranging from normal discomfort to death. The evaluation of diabetic neuropathy is associated with hyperglycemic responses, resulting in alteration in various metabolic pathways including protein kinase C pathway, polyol pathway and hexosamine pathway in sachwann and glial cells of neurons. The essential source of neuronal destruction is analogous to these respectiv...
Source: Current Protein and Peptide Science - December 8, 2020 Category: Biochemistry Authors: Mehta K, Behl T, Kumar A, Uddin MS, Zengin G, Arora S Tags: Curr Protein Pept Sci Source Type: research

Understanding the role of Inflammasome in Angina Pectoris.
Abstract Angina pectoris, associated with coronary artery disease, a cardiovascular disease where, pain is caused by adverse oxygen supply in myocardium, resulting in contractility and discomfort in chest. Inflammasomes, triggered by stimuli due to infection and cellular stress have identified to play a vital role in the progression of cardiovascular disorders and thus, causing various symptoms like angina pectoris. Nlrp3 inflammasome, a key contributor in the pathogenesis of angina pectoris, requires activation and primary signaling for the commencement of inflammation. Nlrp3 inflammasome elicit out an inflammato...
Source: Current Protein and Peptide Science - December 8, 2020 Category: Biochemistry Authors: Sharma I, Behl T, Bungau S, Sachdeva M, Kumar A, Zengin G, Arora S Tags: Curr Protein Pept Sci Source Type: research

Purines and Pyrimidines: Metabolism, Function and Potential as therapeutic options in neurodegenerative diseases.
Abstract Various neurodegenerative disorders have molecular origin but some common molecular mechanisms. In the current scenario, there are very few treatment regimens present for advanced neurodegenerative diseases. In this context, there is an urgent need for alternate options in the form of natural compounds with an ameliorating effect on patients. There have been individual scattered experiments trying to identify potential values of various intracellular metabolites. Purines and Pyrimidines, which are vital molecules governing various aspects of cellular biochemical reactions, have been long sought as crucial...
Source: Current Protein and Peptide Science - December 8, 2020 Category: Biochemistry Authors: Kundu D, Dubey VK Tags: Curr Protein Pept Sci Source Type: research

Molecular pathways of Interferon-Stimulated Gene 15: Implications in cancer.
Abstract Human interferon-stimulated gene 15 (ISG15) is a 15-kDa ubiquitin-like protein that can be detected as either free ISG15 or covalently associated with its target proteins through a process termed ISGylation. Interestingly, extracellular free ISG15 has been proposed as a cytokine-like protein, whereas ISGylation is a posttranslational modification. ISG15 is a small protein with implications in some biological processes and pathologies that include cancer. This review highlights the findings of both free ISG15 and protein ISGylation involved in several molecular pathways, emerging as central elements in som...
Source: Current Protein and Peptide Science - December 8, 2020 Category: Biochemistry Authors: Tecalco-Cruz AC Tags: Curr Protein Pept Sci Source Type: research

Microbial enzymes used in prodrug activation for cancer therapy: Insights and future perspectives.
Abstract Enzyme prodrug therapy has gained momentum in the recent years due to their ability to improve therapeutic index (benefits versus toxic side-effects) and efficacy of chemotherapy in cancer treatment. Inactive prodrugs used in this system are converted into active anti-cancerous drugs by enzymes, specifically within the tumor cells. This therapy involves three components namely prodrug, enzyme and gene delivery vector. Past reports have clearly indicated that the choice of enzyme used, is the major determinant for the success of this therapy. Generally, enzymes from non-human sources are employed to avoid ...
Source: Current Protein and Peptide Science - December 7, 2020 Category: Biochemistry Authors: Dhankhar R, Kawatra A, Mohanty A, Gulati P Tags: Curr Protein Pept Sci Source Type: research

Characterization of Phosphorylated Proteins Using Mass Spectrometry.
Abstract Phosphorylation is arguably the most important post-translational modification that occurs within proteins. Phosphorylation is used as a signal to control numerous physiological activities ranging from gene expression to metabo-lism. Identifying phosphorylation sites within proteins was historically a challenge as it required either radioisotope label-ing or the use of phospho-specific antibodies. The advent of mass spectrometry (MS) has had a major impact on the abil-ity to qualitatively and quantitatively characterize phosphorylated proteins. In this article we describe MS methods for characterizing pho...
Source: Current Protein and Peptide Science - November 23, 2020 Category: Biochemistry Authors: Yu LR, Veenstra TD Tags: Curr Protein Pept Sci Source Type: research

Protein Metabolism in Host Gastrointestinal Tract.
PMID: 33210583 [PubMed - in process] (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - November 21, 2020 Category: Biochemistry Authors: Ma X Tags: Curr Protein Pept Sci Source Type: research

Recent Advances on Therapeutic Peptides for Breast Cancer Treatment.
Abstract Breast cancer is a heterogeneous malignancy which is the second cause of mortality among women in the world. Increasing the resistance to anti-cancer drugs in breast cancer cells persuades researchers to search the novel therapies approaches for the treatment of the malignancy. Among the novel methods, therapeutic peptides which target and disrupt tumor cells have been of great interest. Therapeutic peptides are short amino acids monomer chains with high specificity to bind and modulate a protein interaction of interest. Several advantages of peptides such as specific binding on tumor cells surface, low m...
Source: Current Protein and Peptide Science - November 17, 2020 Category: Biochemistry Authors: Beheshtirouy S, Mirzaei F, Eyvazi S, Tarhriz V Tags: Curr Protein Pept Sci Source Type: research

Regulation of Runx2 and its signaling pathways by microRNAs in breast cancer metastasis.
Abstract Posing as a major threat among women globally, breast cancer (BC) emerges as a primary research focus for several researchers. Although various therapeutic regimens are available, there is an increased chance of metastasis of BC cells, which raises the severity of this malignancy. Of multiple preferred secondary targets, metastasis to bone is extensively studied. Besides deemed as a bone transcription factor, Runx2 also acts as a metastatic factor that promotes growth and metastasis of BC cells. Studies have reported the significant role of microRNAs (miRNAs) in BC pathogenesis and metastasis by governing...
Source: Current Protein and Peptide Science - November 15, 2020 Category: Biochemistry Authors: Pranavkrishna S, Sanjeev G, Akshaya RL, Rohini M, Selvamurugan N Tags: Curr Protein Pept Sci Source Type: research

Neuropeptidomics: Improvements in Mass Spectrometry Imaging Analysis and Recent Advancements.
Abstract Neuropeptides are an important class of endogenous peptides in the nervous system that regulate physiological functions such as feeding, glucose homeostasis, pain, memory, reproduction, and many others. In order to understand the functional role of neuropeptides in diseases or disorders, studies investigating their dysregulation in terms of changes in abundance and localization must be carried out. Because multiple neuropeptides are believed to play a functional role in each physiological process, techniques capable of globally profiling multiple neuropeptides simultaneously are desired. Mass spectrometry...
Source: Current Protein and Peptide Science - November 15, 2020 Category: Biochemistry Authors: Vu NQ, DeLaney K, Li L Tags: Curr Protein Pept Sci Source Type: research

Current updates in transdermal therapeutic systems and their role in neurological disorders.
Abstract The transdermal therapeutic system presents an important role in the treatment of neuropathic pain. Transdermal drug delivery is considered an ideal therapeutic approach for the management of chronic neurological disorders in the elderly population, It is a simple to use, non-invasive and painless drug delivery system, which provides sustained therapeutic plasma levels of drug for an extended period. Moreover, it bypasses the first-pass metabolism of the active agent, improves bioavailability and reduces undesired adverse effects, which in turn improves patient compliance. Several transdermal delivery sys...
Source: Current Protein and Peptide Science - November 11, 2020 Category: Biochemistry Authors: Yadav N, Mittal A, Ali J, Sahoo J Tags: Curr Protein Pept Sci Source Type: research

Are Hsp90 inhibitors good candidates against Covid-19?
Abstract Drug reposition, or repurposing, has become a promising strategy in therapeutics due to its advantages in several aspects of drug therapy. General drug development is expensive and can take more than 10 years to go through the designing, development, and necessary approval steps. However, established drugs have already overcome these steps and thus a potential candidate may be already available decreasing the risks and costs involved. Viruses invade cells, usually provoking biochemical changes, leading to tissue damage, alteration of normal physiological condition in organisms and can even result in death...
Source: Current Protein and Peptide Science - November 11, 2020 Category: Biochemistry Authors: Ramos CHI, Ayinde KS Tags: Curr Protein Pept Sci Source Type: research

Interaction of flavonoids with serum albumin: A review.
Abstract Flavonoids are plant products abundant in every day diet and claimed to be beneficial for human health. After absorption, flavonoids are transported by the serum albumin (SA), the most abundant carrier blood protein, through formation of flavonoids-SA complex. This review deals with the current state of knowledge on flavonoids-SA complex over the past 10 years, mainly involved multi-spectroscopic techniques and molecular dynamics simulation studies to explore the binding mechanism, thermodynamics and structural aspects of flavonoids binding to SA. Especially, the novel method, capillary electrophoresis, h...
Source: Current Protein and Peptide Science - November 8, 2020 Category: Biochemistry Authors: Xue P, Zhang G, Zhang J, Ren L Tags: Curr Protein Pept Sci Source Type: research

A review of pedal peptide/orcokinin-type neuropeptides.
Abstract Neuropeptides are endogenous active substances that play important roles in a number of physiological processes and are ubiquitous in the nervous tissue in vivo. The gene encoding pedal peptide/orcokinin-type (PP/OK-type) neuropeptide is an important member of the neuropeptide gene family and is ubiquitous in invertebrates of Bilateria; orcokinin (OK) is mainly found in Arthropoda, while pedal peptide (PP) is mainly found in Mollusca. OK and PP are also present in other animals. PP/OK-type neuropeptides are a kind of multifunctional neuropeptide predominantly expressed in the nervous tissue and play impor...
Source: Current Protein and Peptide Science - November 8, 2020 Category: Biochemistry Authors: Wang P, Cui Q, Zhang Y, Wang X, Huang X, Li X, Zhao Q, Lei G, Li B, Wei W Tags: Curr Protein Pept Sci Source Type: research

Application of contemporary neuroproteomic techniques in unravelling neurological disorders.
This article will collectively discuss the use and relevance of neuroproteomics in a range of neurological diseases such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy, and psychiatric disorders. We have also attempted to present the current successes and failures of the neuroproteomics approach on the results obtained from different clinical studies that targeted biomarkers associated with any particular neurological disorder. PMID: 33148155 [PubMed - as supplied by publisher] (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - November 4, 2020 Category: Biochemistry Authors: Khurana M, Rahman SO, Najmi AK, Pottoo FH, Akhtar MS Tags: Curr Protein Pept Sci Source Type: research

Current view on the helicase activity of RNA helicase A and its role in gene expression.
Abstract RNA helicase A (RHA) is a DExH-box helicase that plays regulatory roles in a variety of cellular processes including transcription, translation, RNA splicing, editing, transport, and processing, microRNA genesis and maintenance of genomic stability. It is involved in virus replication, oncogenesis, and innate immune response. RHA can unwind nucleic acid duplex by nucleoside triphosphate hydrolysis. The insight into molecular mechanism of helicase activity is fundamental to understanding the role of RHA in the cell. Herein, we reviewed the current advances on the helicase activity of RHA and its relevance ...
Source: Current Protein and Peptide Science - November 2, 2020 Category: Biochemistry Authors: Pan YQ, Xing L Tags: Curr Protein Pept Sci Source Type: research

Insights into Peptide Mediated Antibiofilm Treatment in Chronic Wound; A Bench to Bedside Approach.
Abstract Chronic wound biofilm infections are a threat to the population with respect to morbidity and mortality. Presence of multidrug resistant bacterial pathogens in chronic wound renders the action of antibiotics and antibiofilm agents difficult. Therefore an alternative therapy is essential for reducing bacterial biofilm burden. In this scenario, the peptide based antibiofilm therapy for chronic wound biofilm management seeks more attention. Synthetic peptide with a broad range of antibiofilm activity against preformed and established biofilms, ability to kill multispecies bacteria within biofilms and combina...
Source: Current Protein and Peptide Science - November 2, 2020 Category: Biochemistry Authors: Radhakrishnan MP, Suryaletha K, Shankar A, Savithri AV, George S, Thomas S Tags: Curr Protein Pept Sci Source Type: research

Plant NHX Antiporters: from function to biotechnological application, with case study.
Abstract Salt stress is one of the major abiotic stresses that negatively affect crops worldwide. Plants have evolved a series of mechanisms to cope with the limitations imposed by salinity. Molecular mechanisms including the upregulation of cation transporters such as the Na+/H+ antiporters, are one of the processes adopted by plants to survive in saline environments. NHX antiporters are involved in salt tolerance, development, cell expansion, growth performance and disease resistance of plants. They are integral membrane proteins belonging to the widely distributed CPA1 sub-group of monovalent cation/H+ antiport...
Source: Current Protein and Peptide Science - November 2, 2020 Category: Biochemistry Authors: Karim R, Bouchra B, Fatima G, Abdelkarim FM, Laila S Tags: Curr Protein Pept Sci Source Type: research

Applications of iTRAQ and TMT labeling techniques to the study of neurodegenerative diseases.
Abstract Neurodegenerative diseases are caused by progressive lesions or loss of specific nerve cells, which endanger human health. However, the mechanism by which neurodegeneration manifests remains unclear. Proteomics can shed light on this question as well as help establish diagnostic standards and discover new drug targets. The power of proteomics for understanding neurodegenerative diseases has increased substantially with the application of iTRAQ and TMT labeling techniques. This review focuses on progress in these labeling techniques and their applications in neurodegeneration research. PMID: 33143625 ...
Source: Current Protein and Peptide Science - November 2, 2020 Category: Biochemistry Authors: Li K, Chen Z, Yang X, Zhang Y Tags: Curr Protein Pept Sci Source Type: research

Zinc oxide nanoparticles help to enhance plant growth and alleviate abiotic stress: A review.
Abstract Abiotic stresses arising from atmosphere change belie plant growth and yield, leading to food reduction. The cultivation of a large number of crops in the contaminated environment is a main concern of environmentalists in the present time. To get food safety, a highly developed nanotechnology is a useful tool for promoting food production and assuring sustainability. Nanotechnology helps to better production in agriculture by promoting the efficiency of inputs and reducing relevant losses. This review examines the research performed in the past to show how zinc oxide nanoparticles (ZnO-NPs) are influencin...
Source: Current Protein and Peptide Science - October 16, 2020 Category: Biochemistry Authors: Faizan M, Yu F, Chen C, Faraz A, Hayat S Tags: Curr Protein Pept Sci Source Type: research

Proteomic analysis of Huntington's Disease.
Abstract Huntington's disease (HD) is a neurodegenerative disease which is genetically inherited through an autosomal dominant gene located on chromosome 4. HD is caused by DNA mutation (generally 37 or more repetition of CAG nucleotides) that leads to an excess glutamine residues stretch. However, the main pathogenesis pathway resulted by polyglutamine expansion in mutant HD is unknown. The characteristics of this disease mostly appear in adults. Patients who suffer from this disease have shown inability to control physical movements, emotional problems, speech disturbance, dementia, loss of thinking ability and ...
Source: Current Protein and Peptide Science - October 6, 2020 Category: Biochemistry Authors: Kumar S, Singh P, Sharma S, Ali J, Baboota S, Pottoo FH Tags: Curr Protein Pept Sci Source Type: research

Molecular Insight into the Crosstalk of UPS Components and Alzheimer's Disease.
Abstract The ubiquitin (Ub)-proteasome system (UPS) targets various cellular proteins for degradation. It has been found that defects in the UPS play a crucial role in the pathogenesis of Alzheimer's disease (AD), as the existence of Ub immunoreactivity in AD-linked neuronal inclusions, including neurofibrillary tangles, is observed in all types of AD cases. Current investigations have shown that components of the UPS can be connected with the early stage of AD, which is characterized by synaptic dysfunction, and to the late phases of the disease, marked by neurodegeneration. Although the significance of UPS in th...
Source: Current Protein and Peptide Science - September 22, 2020 Category: Biochemistry Authors: Al Mamun A, Rahman MM, Zaman S, Munira MS, Uddin MS, Rauf A, Banu N, Ashraf GM Tags: Curr Protein Pept Sci Source Type: research

Drug Repurposing Approaches: Existing Leads For Novel Threats And Drug Targets.
Abstract Drug Repurposing (DR) is an alternative to the traditional drug discovery process. It is cost and time effective, with high returns and low risk process that can tackle the increasing need for interventions for varied diseases and new outbreaks. Repurposing of old drugs for other diseases has gained a wider attention, as there have been several old drugs approved by FDA for new diseases. In the global emergency of COVID19 pandemic, this is one of the strategies implemented in repurposing of old anti-infective, anti-rheumatic and anti-thrombotic drugs. The goal of the current review is to elaborate the pro...
Source: Current Protein and Peptide Science - September 20, 2020 Category: Biochemistry Authors: Usha T, Middha SK, Kukanur AA, Shravani RV, Anupama MN, Harshitha N, Rahamath A, Kukanur SA, Goyal AK Tags: Curr Protein Pept Sci Source Type: research

Mass Spectrometry Techniques: Principles and Practices for Quantitative Proteomics.
Abstract In the current omics-age of research, major developments have been made in technologies that attempt to survey the entire repertoire of genes, transcripts, proteins, and metabolites present within a cell. While genomics has led to a dramatic increase in our understanding of such things as disease morphology and how organisms respond to medications, it is critical to obtain information at the proteome level since proteins carry out most of the functions within the cell. The primary tool for obtaining proteome-wide information on proteins within the cell is mass spectrometry (MS). While it has historically ...
Source: Current Protein and Peptide Science - September 20, 2020 Category: Biochemistry Authors: Rotello RJ, Veenstra TD Tags: Curr Protein Pept Sci Source Type: research

Exploring the Role of Aggregated Proteomes in the Pathogenesis of Alzheimer's Disease.
Abstract Alzheimer's disease (AD) is a progressive brain disorder and one of the most common causes of dementia and death. AD can be of two types; early-onset and late-onset, where late-onset AD occurs sporadically whereas early-onset AD results from a mutation in any of the three genes that include amyloid precursor protein (APP), presenilin 1 (PSEN 1) and presenilin 2 (PSEN 2). Biologically, AD is defined by the presence of the distinct neuropathological profile that consists of the extracellular β-amyloid (Aβ) deposition in the form of diffuse neuritic plaques, intraneuronal neurofibrillary tangles (N...
Source: Current Protein and Peptide Science - September 20, 2020 Category: Biochemistry Authors: Narayanan SE, Sekhar N, Rajamma RG, Marathakam A, Al Mamun A, Uddin MS, Mathew B Tags: Curr Protein Pept Sci Source Type: research

Strategic aspects of NPY-based monoclonal antibodies for diagnosis and treatment of breast cancer.
Abstract Immunotherapy emerges as a treatment strategy for breast cancer marker, diagnosis and treatment. In this review, monoclonal antibodies (mAbs)-based passive and peptide vaccines as active immunotherapy approaches like activation of B-cells and T-cells are studied. Passive immunotherapy is mAbs-based therapy effective against tumor cells acts by targeting HER2, IGF 1R, VEGF, BCSC and immune checkpoints. Neuropeptide Y (NPY) and GPCR are the areas of interest to target BC metastases for on-targeting therapeutic action. Neuropeptide S (NPS) or NPS receptor 1 acts as a biomarker for Neuroendocrine tumors (NET)...
Source: Current Protein and Peptide Science - September 17, 2020 Category: Biochemistry Authors: Desai D, Shende P Tags: Curr Protein Pept Sci Source Type: research

Natural Product as Anti-Cancerous Therapeutic Molecules Targeted towards Topoisomerases.
Abstract Topoisomerases are reported to resolve the topological problem of DNA during several cellular processes such as DNA replication, transcription, recombination, and chromatin remodeling. Two types of topoisomerases (Topo I and II) accomplish their designated tasks by introducing single- or double-strand breaks within the duplex DNA molecule, and thus maintain the proper structural conditions of DNA to release the topological torsions, which is generated by unwinding of DNA to access coded information, in the course of replication, transcription, and other processes. Both the topoisomerases have been looked ...
Source: Current Protein and Peptide Science - September 17, 2020 Category: Biochemistry Authors: Singh S, Pandey VP, Yadav K, Yadav A, Dwivedi UN Tags: Curr Protein Pept Sci Source Type: research

Carbohydrate-Binding Agents: Potential of Repurposing for COVID-19 Therapy.
Abstract With the emergence of the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the whole world is suffering from atypical pneumonia which resulted in more than 559,047 deaths worldwide. In this time of crisis and urgency, the only hope comes from new candidate vaccines and potential antivirals. However, formulating new vaccines and synthesizing new antivirals is a laborious task. Therefore, considering the high infection rate and mortality due to COVID-19, utilization of previous information, and repurposing of existing drugs against valid viral targets has emerged as a novel drug discovery...
Source: Current Protein and Peptide Science - September 17, 2020 Category: Biochemistry Authors: Gupta RK, Apte GR, Lokhande KB, Mishra S, Pal JK Tags: Curr Protein Pept Sci Source Type: research

Development of peptides that inhibit aminoglycoside-modifying enzymes and β-lactamases for control of resistant bacteria.
Development of peptides that inhibit aminoglycoside-modifying enzymes and β-lactamases for control of resistant bacteria. Curr Protein Pept Sci. 2020 Sep 15;: Authors: Costa BO, Cardoso MH, Franco OL Abstract Aminoglycosidesand β-lactams are the most commonly used antimicrobial agents in clinical practice. This occurs because they are capable of acting in the treatment of acute bacterial infections. However, the effectiveness of antibiotics has been constantly threatened due to bacterial pathogens producing resistance enzymes. Among them, the aminoglycosidemodifying enzymes (AMEs) and β...
Source: Current Protein and Peptide Science - September 14, 2020 Category: Biochemistry Authors: Costa BO, Cardoso MH, Franco OL Tags: Curr Protein Pept Sci Source Type: research

ES-MDA: Enhanced Similarity-based MiRNA-Disease Association.
Abstract Accumulating evidences demonstrate that miRNAs can be treated as critical biomarkers in various complex human diseases. Thus, the identifications on potential miRNA-disease associations have become a hotpot for providing better understanding of disease pathology in this field. Recently, with various biological datasets, increasingly computational prediction approaches have been designed to uncover disease-related miRNAs for further experimental validation. To improve the prediction accuracy, several algorithms integrated miRNA similarities of known miRNA-disease associations to enhance the miRNA functiona...
Source: Current Protein and Peptide Science - September 10, 2020 Category: Biochemistry Authors: Jiang GN, Xu L Tags: Curr Protein Pept Sci Source Type: research

Fusion protein targeted antiviral peptides: fragment based drug design (FBDD) guided rational design of dipeptides against SARS-CoV-2.
Abstract Infectious diseases caused by viruses become a serious public health issue in the recent past, including current pandemic situation of COVID-19. Enveloped viruses are most commonly known to cause emerging and recurring infectious diseases. Viral and cell membrane fusion is the major key event in case of enveloped viruses that required for their entry into the cell. Viral fusion proteins are playing important role in fusion process and in infection establishment. Because of this, fusion process targeting antivirals become an interest to fight against viral diseases caused by enveloped virus. Lower respirat...
Source: Current Protein and Peptide Science - September 7, 2020 Category: Biochemistry Authors: Manna S, Baindara P, Mandal SM Tags: Curr Protein Pept Sci Source Type: research

Ligand-Linked Association-Dissociation In Transport Proteins and Hormone Receptors.
Abstract Ligand-linked changes in the aggregation state of biological macromolecules occur and have importance in several physiological processes, e.g., the response of hormone receptors, cooperative ligand binding, and others. The mathematical formalisms that express the thermodynamics governing these processes are complex, as they are required to describe observations made under experimental conditions in which many parameters may be simultaneously varied. The description of the functional behaviour of proteins that present ligand-linked association-dissociation events must accommodate cases where both the bindi...
Source: Current Protein and Peptide Science - August 9, 2020 Category: Biochemistry Authors: Saccoccia F, Bellelli A Tags: Curr Protein Pept Sci Source Type: research

Mass Spectrometric (MS) Analysis of Proteins and Peptides.
Abstract The human genome is sequenced and is comprised of~30,000 genes, making humans just a little bit more complicated than worms or flies. However, complexity of humans is given by proteins that these genes code for, because one gene can produce many proteins mostly through alternative splicing and tissue-dependent expression of particular proteins. In addition, post-translational modifications (PTMs) in proteins greatly increase the number of gene products or protein isoforms. Furthermore, stable and transient interactions between proteins, protein isoforms/proteoforms and PTM-ed proteins (proteinprotein inte...
Source: Current Protein and Peptide Science - July 25, 2020 Category: Biochemistry Authors: Jayathirtha M, Dupree EJ, Manzoor Z, Larose B, Sechrist Z, Neagu AN, Petre BA, Darie CC Tags: Curr Protein Pept Sci Source Type: research

Traceable Peptidic Ligands that Target Ghrelin Receptors.
Abstract Ghrelin is a 28-amino acid octanoylated peptide hormone that is implicated in many physiological and pathophysiological processes. Specific visualization of ghrelin and its cognate receptor using traceable ligands is crucial in elucidating the localization, functions and expression pattern of the peptide's signaling pathway. Here we review 12 representative radio- and fluorescently-labeled peptide-based ligands for in vitro and in vivo imaging studies. In particular, we focus on their structural features, pharmacological properties and applications in further biochemical research. PMID: 32614744 [Pub...
Source: Current Protein and Peptide Science - July 1, 2020 Category: Biochemistry Authors: Liu M, Wade J, Hossain MA Tags: Curr Protein Pept Sci Source Type: research

A Survey of Network Embedding for Drug Analysis and Prediction.
This article offers a comprehensive survey of the primary network embedding methods and their applications in drug analysis and prediction. The network embedding technologies applied in homogeneous network and heterogeneous network are investigated and compared, including matrix decomposition, random walk, and deep learning. Especially, the Graph neural network (GNN) methods in deep learning are highlighted. Further, the applications of network embedding in drug similarity estimation, drug-target interaction prediction, adverse drug reactions prediction, protein function and therapeutic peptides prediction are discussed. S...
Source: Current Protein and Peptide Science - July 1, 2020 Category: Biochemistry Authors: Liu Z, Chen Q, Lan W, Liang J, Chen YP, Chen B Tags: Curr Protein Pept Sci Source Type: research

EHAI: Enhanced Human Microbe-Disease Association Identification.
Abstract Recently, an increasing number of biological and clinical reports have demonstrated that imbalance of microbial community has the ability to play important roles among several complex diseases in the level of human health. Having a good knowledge of discovery potential of microbe-disease relationships, which provides the ability to having better understanding on some issues, including disease pathology, further boosts disease diagnostics and prognostics, has been taken into account. Nevertheless, a few of computational approaches can meet the need of huge scale of microbe-disease association discovery. In...
Source: Current Protein and Peptide Science - July 1, 2020 Category: Biochemistry Authors: Fan R, Dong C, Song H, Xu Y, Shi L, Xu T, Cao M, Jiang T, Song J Tags: Curr Protein Pept Sci Source Type: research

Non-Histone Protein Methylation: Molecular Mechanisms and Physiopathological Relevance.
PMID: 32571200 [PubMed - as supplied by publisher] (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - June 19, 2020 Category: Biochemistry Authors: Salvi M Tags: Curr Protein Pept Sci Source Type: research

An Overview on Stroke: Mechanism, in vivo Experimental Models Thereof and Neuroprotective Agents.
CONCLUSION: The injury mechanism, available encouraging medicaments thereof, and outcomes of natural and modern medicines for ischemia have been summarised. In spite of available therapeutic agents (thrombolytics, calcium channel blockers, NMDA receptor antagonists and antioxidants), there is a need of an ideal drug for stroke. PMID: 32552641 [PubMed - as supplied by publisher] (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - June 16, 2020 Category: Biochemistry Authors: Khan MM, Badruddeen, Mujahid M, Akhtar J, Khan MI, Ahmad U Tags: Curr Protein Pept Sci Source Type: research

Gut barrier proteins mediate liver regulation by the effects of serotonin on the non-alcoholic fatty liver disease.
Abstract Serotonin (5-hydroxytryptamine, 5-HT) has been recognized as a potent pro-inflammatory mediator. Increasing the bioavailability and preventing the formation of 5-HT can reduce the inflammatory response in the body. Moreover, 5-HT is considered as an important central physiologic mediator of intestinal function by regulating intestinal motility, permeability and other functions. The dysfunction of intestinal serotonergic system causes intestinal barrier damage and it further leads to the increase of bacterial endotoxin (LPS) translocation into the liver which contributes to the development of non-alcoholic...
Source: Current Protein and Peptide Science - June 14, 2020 Category: Biochemistry Authors: Zhang K, Li X, Wang X, Zheng H, Tang S, Lu L, Ma X Tags: Curr Protein Pept Sci Source Type: research

Advent of Proteomic Tools For Diagnostic Biomarker Analysis in Alzheimer's Disease.
Abstract Locating remedies for Alzheimer's disease (AD) is been majorly restricted by inefficiency to establish a definitive detection model for early stage diagnosis of pathological events. This current lapse in AD diagnosis also limits the therapeutic efficiency of the drugs, which might have been effective if given at the earlier stages of the disease. The indicated situation directs towards the burgeoned need for an effective biomarker technique that will help in early detection of AD and would be imminently useful to facilitate improved diagnosis and stimulate therapeutic trials. Till date the major biomarker...
Source: Current Protein and Peptide Science - June 14, 2020 Category: Biochemistry Authors: Singh M, Singh SP, Dubey PK, Rachana R, Mani S, Yadav D, Agarwal M, Agarwal S, Agarwal V, Kaur H Tags: Curr Protein Pept Sci Source Type: research

Affinity tags for protein purification.
Abstract The affinity tags are unique proteins/peptides that are attached at the N- or C-terminus of the recombinant proteins. These tags help in protein purification. Additionally, some affinity tags also serve a dual purpose as solubility enhancers for challenging protein targets. By applying a combinatorial approach, carefully chosen affinity tags designed in tandem have proven to be very successful in the purification of single proteins or multi-protein complexes. In this minireview, I discuss the key features of the most commonly used affinity tags. I have classified the affinity tags into two significant cat...
Source: Current Protein and Peptide Science - June 5, 2020 Category: Biochemistry Authors: Mishra V Tags: Curr Protein Pept Sci Source Type: research

Vitamin D-RAAS connection: An Integrative Standpoint into Cardiovascular and Neuroinflammatory Disorders.
, Manucha W Abstract BACKGROUND: The neuroinflammatory process is associated with the pathogenesis of many cardiovascular disorders, particularly with hypertension. In this regard, the deficiency of vitamin D seems to increase the risk of cardiovascular pathologies related to neuroinflammation. Long-term vitamin D lack leads to over-activation of the reninangiotensin-aldosterone system (RAAS), one of the essential mechanisms of blood pressure regulation. PURPOSE OF REVIEW: This review summarizes the latest studies carried out to evaluate the primary mechanisms underlying the neuroprotective effect of vitamin ...
Source: Current Protein and Peptide Science - June 5, 2020 Category: Biochemistry Authors: Giménez VMM, Sanz RL, Marón FJM, Ferder L, Manucha W Tags: Curr Protein Pept Sci Source Type: research

The TRPM7 channel in the nervous and cardiovascular systems.
Abstract Transient receptor potential melastatin 7 (TRPM7), along with the closely related TRPM6, are unique channels that have dual operations: cation permeability and kinase activity. In contrast to the limited tissue distribution of TRPM6, TRPM7 is widely expressed among tissues and is therefore implicated in a variety of cellular functions physiologically and pathophysiologically. The discovery of TRPM7's unique structure imparting dual ion channel and kinase activities shed light onto novel and peculiar biological functions, such as Mg2+ homeostasis, cellular Ca2+ flickering, and even intranuclear transcripti...
Source: Current Protein and Peptide Science - June 4, 2020 Category: Biochemistry Authors: Inoue K, Xiong ZG, Ueki T Tags: Curr Protein Pept Sci Source Type: research

The Advances of the Structure and Function of Indoleamine 2, 3-dioxygenase 1 and Its Inhibitors.
Abstract Indoleamine 2, 3-dioxygenase 1 (IDO1) is the only rate-limiting enzyme outside the liver that catalyzes the oxidation and cracking of indole rings in the tryptophan along the kynurenine pathway (KP). The overactivation of IDO1 is closely related to the pathogenesis of various human immune and neurological diseases. As an important target for the treatment of many human serious diseases including malignant tumors, the development of IDO1 inhibitors is of great practical significance. In this work, the structure and function of IDO1 both are summarized from the aspects of signal pathway, catalytic mechanism...
Source: Current Protein and Peptide Science - May 25, 2020 Category: Biochemistry Authors: Duan HC, Peng LX, Luo Q, Hu YC, Liu XY, Sun X, Liang L, Gan Y, Liu W, Wan H, Shi HB, Zhao G, Hu JP Tags: Curr Protein Pept Sci Source Type: research

Nanotechnologies to Improve the Pharmacological Profile of Therapeutic Peptides.
PMID: 32400322 [PubMed - in process] (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - May 15, 2020 Category: Biochemistry Authors: Casciaro B, Mangoni ML Tags: Curr Protein Pept Sci Source Type: research

Melatonin modulates lactation by regulating prolactin secretion via tuberoinfundibular dopaminergic neurons in Hypothalamus-Pituitary system.
Abstract In-depth studies have identified many hormones important for controlling mammary growth and maintaining lactation. One of these is melatonin, which is synthesized and secreted by the pineal gland to regulate circadian rhythms, improve antioxidant capacity, and enhance immunity. Prolactin is secreted by the pituitary gland and is associated with growth and development of mammary glands as well as initiation and maintenance of lactation. The hypothalamus-pituitary system, the most important endocrine system in the body, regulates prolactin secretion mainly through dopamine released from tuberoinfundibular d...
Source: Current Protein and Peptide Science - May 9, 2020 Category: Biochemistry Authors: Li H, Wei J, Ma F, Shan Q, Gao D, Jin Y, Sun P Tags: Curr Protein Pept Sci Source Type: research

Proteomics in Neurodegenerative Disease.
Abstract Changes in protein structure and function, alteration in protein-protein interaction, and significant difference in protein concentration inside the body could play an important role in indicating the pathological evidence of abnormalities before the development of clinical symptoms and act as a critical detection and diagnostic tool commonly known as biomarkers. Biomarkers play important roles in the diagnosis of various chronic diseases including cancer. Neurodegenerative disorders including Parkinson's, Alzheimer's, Huntington's, prion, and multiple sclerosis are well characterized by neuronal deterior...
Source: Current Protein and Peptide Science - May 9, 2020 Category: Biochemistry Authors: Puranik N, Yadav D, Yadav SK, Chavda VK, Jin JO Tags: Curr Protein Pept Sci Source Type: research