Efficacy and Safety of Esaxerenone in Hypertensive Patients with Diabetes Mellitus Undergoing Treatment with Sodium-Glucose Cotransporter  2 Inhibitors (EAGLE-DH)

CONCLUSION: Esaxerenone effectively lowered BP, was safe, and showed renoprotective effects in hypertensive patients with diabetes mellitus receiving treatment with SGLT2 inhibitors. Esaxerenone and SGLT2 inhibitors did not interfere with either drug's efficacy and may reduce the frequency of serum potassium elevations, suggesting they are a compatible combination.CLINICAL TRIAL REGISTRATION: jRCTs031200273.PMID:37733211 | DOI:10.1007/s12325-023-02633-8

Source: Adv Data - September 21, 2023 Category: Epidemiology Authors: Hirohiko Motoki Yoshito Inobe Toshiki Fukui Arata Iwasaki Shinya Hiramitsu Sekiya Koyama Izuru Masuda Noriyuki Sekimura Kazuya Yamamoto Ai Sato Mitsuhisa Komatsu Takashi Taguchi Kazuhito Shiosakai Kotaro Sugimoto Koichiro Kuwahara Source Type: research