Intestinal MAdCAM-1 imaging as biomarker for prognostic in murine models of multiple sclerosis
CONCLUSION: Altogether, these data unveil a crosstalk between intestinal and central inflammation in EAE and support the use of molecular MRI of intestinal MAdCAM-1 as a new biomarker for prognostic in MS patients.PMID:38604270 | DOI:10.1016/j.bbi.2024.04.006 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 11, 2024 Category: Neurology Authors: Erwan Baudron Sara Martinez de Lizarrondo Maxime Gauberti Barbara Delaunay-Piednoir Antoine P Fournier Denis Vivien Fabian Docagne Isabelle Bardou Source Type: research
Intestinal MAdCAM-1 imaging as biomarker for prognostic in murine models of multiple sclerosis
CONCLUSION: Altogether, these data unveil a crosstalk between intestinal and central inflammation in EAE and support the use of molecular MRI of intestinal MAdCAM-1 as a new biomarker for prognostic in MS patients.PMID:38604270 | DOI:10.1016/j.bbi.2024.04.006 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 11, 2024 Category: Neurology Authors: Erwan Baudron Sara Martinez de Lizarrondo Maxime Gauberti Barbara Delaunay-Piednoir Antoine P Fournier Denis Vivien Fabian Docagne Isabelle Bardou Source Type: research
Cancers, Vol. 16, Pages 1462: The Challenge for a Correct Diagnosis of Refractory Thrombocytopenia: ITP or MDS with Isolated Thrombocytopenia?
nidis
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by isolated thrombocytopenia. It is diagnosed in patients with a platelet count below 100,000 per cubic millimeter in whom other causes of thrombocytopenia have been ruled out, and its diagnosis is generally one of exclusion. Clinical manifestations of patients may vary from asymptomatic disease to mild mucocutaneous or life-threatening bleeding. Glucocorticoids are used as first-line treatment for ITP, while other second-line medications, mainly thrombopoietin-receptor agonists (TPO-RA) and rituximab, are given to patients in whom ITP does not ...
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Aikaterini Kosmidou Eleni Gavriilaki Athanasios Tragiannidis Tags: Review Source Type: research
Shift in perspective: autoimmunity protecting against rheumatoid arthritis
A hallmark of rheumatoid arthritis (RA) is the increased levels of autoantibodies preceding the onset and contributing to the classification of the disease. These autoantibodies, mainly anti-citrullinated protein antibody (ACPA) and rheumatoid factor, have been assumed to be pathogenic and many attempts have been made to link them to the development of bone erosion, pain and arthritis. We and others have recently discovered that most cloned ACPA protect against experimental arthritis in the mouse. In addition, we have identified suppressor B cells in healthy individuals, selected in response to collagen type II, and these ...
Source: Annals of the Rheumatic Diseases - April 11, 2024 Category: Rheumatology Authors: He, Y., Aoun, M., Xu, Z., Holmdahl, R. Tags: ARD Reviews Source Type: research
Proinflammatory phenotype of B10 and B10pro cells elicited by TNF-{alpha} in rheumatoid arthritis
Conclusions
TNF-α provoked the proinflammatory phenotype of B10 and B10pro cells by disturbing SHIP-1 in RA, contributing to the disease development. Reinstating the immunosuppressive property of B10 and B10pro cells might represent novel therapeutic approaches for RA. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - April 11, 2024 Category: Rheumatology Authors: Hu, F., Shi, L., Liu, X., Chen, Y., Zhang, X., Jia, Y., Liu, X., Guo, J., Zhu, H., Liu, H., Xu, L., Li, Y., Wang, P., Fang, X., Xue, J., Xie, Y., Wei, C., Song, J., Zheng, X., Liu, Y.-Y., Li, Y., Ren, L., Xu, D., Lu, L., Qiu, X., Mu, R., He, J., Wang, M., Tags: ARD, Rheumatoid arthritis Source Type: research
Single-cell transcriptome analyses reveal disturbed decidual homoeostasis in obstetric antiphospholipid syndrome
Conclusion
This study provided a comprehensive decidual cell landscape and identified aberrant decidual microenvironment in OAPS, providing some potential therapeutic targets for this disease. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - April 11, 2024 Category: Rheumatology Authors: Lu, C., Gao, R., Qing, P., Zeng, X., Liao, X., Cheng, M., Qin, L., Liu, Y. Tags: ARD, Autoimmunity Source Type: research
Deep immunophenotyping reveals that autoimmune and autoinflammatory disorders are spread along two immunological axes capturing disease inflammation levels and types
Conclusions
We have refined the monodimensional continuum of autoimmune and autoinflammatory diseases as a continuum characterised by both disease inflammation levels and targeted tissues. Such classification should be helpful for defining therapies. Our results call for further investigations into the role of the LAG3+/ICOS+ balance in Tregs and the contribution of ILC3s in autoimmune and autoinflammatory diseases.
Trial registration number
NCT02466217. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - April 11, 2024 Category: Rheumatology Authors: Tchitchek, N., Binvignat, M., Roux, A., Pitoiset, F., Dubois, J., Marguerit, G., Saadoun, D., Cacoub, P., Sellam, J., Berenbaum, F., Hartemann, A., Amouyal, C., Lorenzon, R., Mariotti-Ferrandiz, E., Rosenzwajg, M., Klatzmann, D. Tags: Open access, ARD, Autoimmunity Source Type: research
Characteristics of the oral microbiota in patients with primary Sj ögren’s syndrome
ConclusionsThe oral microbial ecology of patients with pSS is dysregulated, resulting in a decrease in overall diversity.Prevotella andVeillonella may be related to pSS, whileFusobacterium,Actinomyces, andLeptotrichia may be related to dental caries in pSS patients.Key Points•This study revealed differences in the oral microbial composition of patients with pSS compared to healthy controls.•We included a plaque group of pSS patients to identify the microbiota related to pSS and dental caries.•Prevotella and Veillonella may contribute to pSS, and Fusobacterium,Actinomyces, and Leptotrichia are associated with dental c...
Source: Clinical Rheumatology - April 11, 2024 Category: Rheumatology Source Type: research
NELL-1 associated membranous nephropathy linked to skin fairness cream use- insights from an Indian case series
Neural epidermal growth factor-like protein 1 (NELL-1) is an autoantigen associated with both primary and secondary membranous nephropathy (MN) and is described with malignancy, autoimmune diseases, lipoic acid and traditional indigenous medicines (TIM).1-6 (Source: Kidney International)
Source: Kidney International - April 11, 2024 Category: Urology & Nephrology Authors: Ranjit Narayanan, Sajeesh Sivadas, Anila Abraham Kurien Tags: research letter Source Type: research
NELL-1 –associated membranous nephropathy linked to skin fairness cream use: insights from an Indian case series
Neural epidermal growth factor-like protein 1 (NELL-1) is an autoantigen associated with both primary and secondary membranous nephropathy (MN) and is described with malignancy, autoimmune diseases, lipoic acid, and traditional indigenous medicines.1 –6 (Source: Kidney International)
Source: Kidney International - April 11, 2024 Category: Urology & Nephrology Authors: Ranjit Narayanan, Sajeesh Sivadas, Anila Abraham Kurien Tags: Research Letter Source Type: research
Homotherapy for heteropathy: Interleukin-41 and its biological functions
Immunology. 2024 Apr 9. doi: 10.1111/imm.13791. Online ahead of print.ABSTRACTInterleukin-41 (IL-41) is a newly discovered cytokine, named Cometin, Subfatin, meteorin-like transcription (Metrnl), and so forth. It is widely expressed in animals and can exert its biological roles through autocrine and paracrine forms. It has functions such as anti-inflammatory, improving body metabolism, regulating immunity, regulating fat metabolism and participates in the process of autoimmune disease or inflammatory injury. It plays an important role in psoriasis, diabetes, Crohn's disease (CD), osteoarthritis, Kawasaki disease (KD), Grav...
Source: Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Runfeng Shi Meixin He Yongzheng Peng Xu Xia Source Type: research
Anti-aquaporin-4 immunoglobulin G/anti-myelin oligodendrocyte glycoprotein immunoglobulin G double-positive paraneoplastic neurological syndrome in a patient with triple-negative breast cancer
We report a rare case of paraneoplastic neurological syndrome with dual seropositivity of anti-aquaporin-4 and myelin oligodendrocyte glycoprotein antibodies in a 40 year-old woman with metastatic triple-negative breast cancer. She received multiple lines of anti-neoplastic treatment, including immunotherapy with pembrolizumab, as well as cytotoxic chemotherapy. Paraneoplastic meningoencephalomyelitis developed 2 years after diagnosis of breast cancer and 1 year after discontinuation of immunotherapy with pembrolizumab. She first developed longitudinally extending transverse myelitis followed by left optic neuritis and men...
Source: Clinical Breast Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Amna Siddiqui Dylan Ross Ronak H Jani Vikram C Prabhu Shelly Lo Derek A Wainwright Stasia Rouse Tamer Refaat Yirong Zhu Jigisha P Thakkar Source Type: research
Anti-aquaporin-4 immunoglobulin G/anti-myelin oligodendrocyte glycoprotein immunoglobulin G double-positive paraneoplastic neurological syndrome in a patient with triple-negative breast cancer
We report a rare case of paraneoplastic neurological syndrome with dual seropositivity of anti-aquaporin-4 and myelin oligodendrocyte glycoprotein antibodies in a 40 year-old woman with metastatic triple-negative breast cancer. She received multiple lines of anti-neoplastic treatment, including immunotherapy with pembrolizumab, as well as cytotoxic chemotherapy. Paraneoplastic meningoencephalomyelitis developed 2 years after diagnosis of breast cancer and 1 year after discontinuation of immunotherapy with pembrolizumab. She first developed longitudinally extending transverse myelitis followed by left optic neuritis and men...
Source: Clinical Genitourinary Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Amna Siddiqui Dylan Ross Ronak H Jani Vikram C Prabhu Shelly Lo Derek A Wainwright Stasia Rouse Tamer Refaat Yirong Zhu Jigisha P Thakkar Source Type: research
CD177 drives the transendothelial migration of Treg cells enriched in human colorectal cancer
CONCLUSIONS: These results demonstrated that Treg cells with higher CD177 levels exhibited an enhanced activation status and transendothelial migration capacity. Our findings suggest that CD177 may serve as an immunotherapeutic target and that overexpression of CD177 may improve the efficacy of chimeric antigen receptor T (CAR-T) cell therapy.PMID:38596253 | PMC:PMC11003710 | DOI:10.1002/cti2.1506 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Shouyu Ke Yi Lei Yixian Guo Feng Xie Yimeng Yu Haigang Geng Yiqing Zhong Danhua Xu Xu Liu Fengrong Yu Xiang Xia Zizhen Zhang Chunchao Zhu Wei Ling Bin Li Wenyi Zhao Source Type: research
Accelerated atherosclerosis in Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: case report
We describe the case of a 60-year-old patient with a history of hypertension, diabetes mellitus, and chronic kidney disease of unknown etiology, who presented two acute coronary syndromes with only a six-month difference. Rapid progression of coronary involvement was evidenced, along with increased markers of inflammatory response, usual interstitial pneumonia on tomography, and positive anti-myeloperoxidase antibodies (anti-MPO), leading to the diagnosis of microscopic polyangiitis (MPA). In these cases, timely diagnostic suspicion is crucial, as early treatment significantly impacts the course and prognosis of the diseas...
Source: Atherosclerosis - April 10, 2024 Category: Cardiology Authors: Natalia Andrea Uribe Ru íz Mar ía Paulina Villa Alberto Álzate Gutiérrez Clara In és Saldarriaga Giraldo Jos é Gregorio Thorrens Ríos Source Type: research
