Deep immunophenotyping reveals that autoimmune and autoinflammatory disorders are spread along two immunological axes capturing disease inflammation levels and types

Conclusions
We have refined the monodimensional continuum of autoimmune and autoinflammatory diseases as a continuum characterised by both disease inflammation levels and targeted tissues. Such classification should be helpful for defining therapies. Our results call for further investigations into the role of the LAG3+/ICOS+ balance in Tregs and the contribution of ILC3s in autoimmune and autoinflammatory diseases.

Trial registration number
NCT02466217.

Source: Annals of the Rheumatic Diseases - April 11, 2024 Category: Rheumatology Authors: Tchitchek, N., Binvignat, M., Roux, A., Pitoiset, F., Dubois, J., Marguerit, G., Saadoun, D., Cacoub, P., Sellam, J., Berenbaum, F., Hartemann, A., Amouyal, C., Lorenzon, R., Mariotti-Ferrandiz, E., Rosenzwajg, M., Klatzmann, D. Tags: Open access, ARD, Autoimmunity Source Type: research