Proinflammatory phenotype of B10 and B10pro cells elicited by TNF-{alpha} in rheumatoid arthritis

Conclusions
TNF-α provoked the proinflammatory phenotype of B10 and B10pro cells by disturbing SHIP-1 in RA, contributing to the disease development. Reinstating the immunosuppressive property of B10 and B10pro cells might represent novel therapeutic approaches for RA.

Source: Annals of the Rheumatic Diseases - April 11, 2024 Category: Rheumatology Authors: Hu, F., Shi, L., Liu, X., Chen, Y., Zhang, X., Jia, Y., Liu, X., Guo, J., Zhu, H., Liu, H., Xu, L., Li, Y., Wang, P., Fang, X., Xue, J., Xie, Y., Wei, C., Song, J., Zheng, X., Liu, Y.-Y., Li, Y., Ren, L., Xu, D., Lu, L., Qiu, X., Mu, R., He, J., Wang, M., Tags: ARD, Rheumatoid arthritis Source Type: research