Salidroside Ameliorates Ultraviolet-Induced Keratinocyte Injury by Inducing SIRT1-Dependent Autophagy
DISCUSSION: The present study results speculate that SAL suppresses UVB-induced injury and autophagy by enhancing SIRT1 expression.PMID:35941856 | PMC:PMC9356605 | DOI:10.2147/CCID.S367233 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - August 9, 2022 Category: Dermatology Authors: Jin Ke Jie Wang Xing Wu Yuehua Yan Source Type: research
Molecules, Vol. 27, Pages 4455: The Influence of Tyrosol-Enriched Rhodiola sachalinensis Extracts Bioconverted by the Mycelium of Bovista plumbe on Scopolamine-Induced Cognitive, Behavioral, and Physiological Responses in Mice
In conclusion, Bio-RSE protected against Sco-induced cognitive impairment by activating Nrf2/HO-1 signaling and may be developed as a potential beneficial material for AD. (Source: Molecules)
Source: Molecules - July 12, 2022 Category: Chemistry Authors: Mi-Jin Kwon Ju-Woon Lee Kwan-Soo Kim Hao Chen Cheng-Bi Cui Gye Won Lee Young Ho Cho Tags: Article Source Type: research
The Combination of Salidroside and Hedysari Radix Polysaccharide Inhibits Mitochondrial Damage and Apoptosis via the PKC/ERK Pathway
CONCLUSIONS: CSH treatment have protective effects against Aβ 25-35-induced cytotoxicity through decreasing ROS levels, increasing MMP, inhibiting early apoptosis, and regulating PKC/ERK pathway in HT22 cells. CSH may be a potential therapeutic agent for treating or preventing neurodegenerative diseases.PMID:35795284 | PMC:PMC9252633 | DOI:10.1155/2022/9475703 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 7, 2022 Category: Complementary Medicine Authors: Sixia Yang Linshuang Wang Zeping Xie Yi Zeng Qiaowu Xiong Tingting Pei Dongfeng Wei Weidong Cheng Source Type: research
Comparative transcriptome and tissue-specific expression analysis of genes reveal tissue-cultured plants as an alternative source for phenylethanoids and phenylpropanoids in Rhodiola imbricata (Edgew.)
Gene. 2022 Jun 14:146672. doi: 10.1016/j.gene.2022.146672. Online ahead of print.ABSTRACTRhodiola imbricata (Crassulaceae) is a traditional trans-Himalayan endangered medicinal herb with immense therapeutic applications. Over the years, over-exploitation, un-managed harvesting, and lack of captive cultivation procedures led to the huge market gap. Therefore, plant tissue culture and RNA-Seq-based molecular bioprospection of key regulatory genes will aid the understanding of molecular dynamics involved in specialized metabolites (phenylethanoids and phenylpropanoids) biosynthesis and its sustainable production. Hence, compa...
Source: Gene - June 17, 2022 Category: Genetics & Stem Cells Authors: Shiv Rattan Pankaj Kumar Ekjot Kaur Archit Sood Vishal Acharya Ashish R Warghat Source Type: research
Comparative transcriptome and tissue-specific expression analysis of genes reveal tissue-cultured plants as an alternative source for phenylethanoids and phenylpropanoids in Rhodiola imbricata (Edgew.)
Gene. 2022 Jun 14:146672. doi: 10.1016/j.gene.2022.146672. Online ahead of print.ABSTRACTRhodiola imbricata (Crassulaceae) is a traditional trans-Himalayan endangered medicinal herb with immense therapeutic applications. Over the years, over-exploitation, un-managed harvesting, and lack of captive cultivation procedures led to the huge market gap. Therefore, plant tissue culture and RNA-Seq-based molecular bioprospection of key regulatory genes will aid the understanding of molecular dynamics involved in specialized metabolites (phenylethanoids and phenylpropanoids) biosynthesis and its sustainable production. Hence, compa...
Source: Gene - June 17, 2022 Category: Genetics & Stem Cells Authors: Shiv Rattan Pankaj Kumar Ekjot Kaur Archit Sood Vishal Acharya Ashish R Warghat Source Type: research
Molecules, Vol. 27, Pages 3902: The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions & mdash;Encouraging Clinical Evidence
Molecules, Vol. 27, Pages 3902: The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions—Encouraging Clinical Evidence
Molecules doi: 10.3390/molecules27123902
Authors:
Ivanova Stojcheva
Quintela
Rhodiola rosea L. has a long history of use in traditional medicine to stimulate the nervous system, treat stress-induced fatigue and depression, enhance physical performance and work productivity and treat gastrointestinal ailments and impotence. Apart from its well-established traditional use, a significant number of publication...
Source: Molecules - June 17, 2022 Category: Chemistry Authors: Ivanova Stojcheva Quintela Tags: Review Source Type: research
< em > Rhodiola rosea < /em > polysaccharides promote the proliferation of bone marrow haematopoietic progenitor cells and stromal cells in mice with aplastic anaemia
CONCLUSIONS: RRPs helped to promote haematopoietic recovery in mice with aplastic anaemia, facilitating haematopoietic tissue recovery. This study indicated some mechanisms of the haematopoietic regulatory effects of RRPs. Our findings provide a laboratory basis for clinical research on RRPs.PMID:35695011 | PMC:PMC9196840 | DOI:10.1080/13880209.2022.2083187 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - June 13, 2022 Category: Drugs & Pharmacology Authors: Jing Li Yongfeng Chen Source Type: research
< em > Rhodiola rosea < /em > polysaccharides promote the proliferation of bone marrow haematopoietic progenitor cells and stromal cells in mice with aplastic anaemia
CONCLUSIONS: RRPs helped to promote haematopoietic recovery in mice with aplastic anaemia, facilitating haematopoietic tissue recovery. This study indicated some mechanisms of the haematopoietic regulatory effects of RRPs. Our findings provide a laboratory basis for clinical research on RRPs.PMID:35695011 | DOI:10.1080/13880209.2022.2083187 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - June 13, 2022 Category: Drugs & Pharmacology Authors: Jing Li Yongfeng Chen Source Type: research
Salidroside attenuates myocardial ischemia/reperfusion injury via AMPK-induced suppression of endoplasmic reticulum stress and mitochondrial fission
In this study, we established a myocardial ischemia/reperfusion (I/R) rat model. Rat hearts exposed to Sal with or without compound C were then subjected to I/R. Further, H9c2 cardiomyocytes were subjected to simulated ischemia/reperfusion (SIR) by hypoxia-reoxygenation. The rats and cardiomyocytes were pretreated with Sal, followed by Compound C and AMPK-siRNA to block AMPK activity. We found that Sal significantly ameliorated cardiac function, mitigated infarct size and serum content of lactate dehydrogenase and creatine kinase, improved mitochondrial function, and reduced mitochondrial fission and apoptosis. Furthermore...
Source: Toxicology and Applied Pharmacology - June 6, 2022 Category: Toxicology Authors: Xin Tian Ye Huang Xiaofeng Zhang Rong Fang Yi Feng Wanfang Zhang Ling Li Tian Li Source Type: research
Salidroside alleviates cadmium-induced toxicity in mice by restoring the notch/HES-1 and RIP1-driven inflammatory signaling axis
CONCLUSION: SAL is a natural product with good anti-Cd effects, indicating that Rhodiola rosea is promising plant that is worthy of cultivation for health and economic benefits.PMID:35583558 | DOI:10.1007/s00011-022-01580-4 (Source: Cell Research)
Source: Cell Research - May 18, 2022 Category: Cytology Authors: Xing-Mei Shu Yang Hu Xin Fang Jing Wang Xiao-Yan Qin Rongfeng Lan Source Type: research
Salidroside attenuates high altitude hypobaric hypoxia-induced brain injury in mice via inhibiting NF- κB/NLRP3 pathway
Eur J Pharmacol. 2022 May 10:175015. doi: 10.1016/j.ejphar.2022.175015. Online ahead of print.ABSTRACTSalidroside (Sal), an active ingredient from Rhodiola crenulate, has been reported to exert neuroprotection in cerebral injury from hypobaric hypoxia (HH) at high altitude. However, it remains to be understood whether its protective effects are related to inflammation suppression. In the present work, we aimed to reveal the mechanism of Sal attenuating HH-induced brain injury in mice caused by an animal hypobaric and hypoxic chamber. Our results provided that Sal could attenuate HH-evoked pathological injury and oxidative ...
Source: European Journal of Pharmacology - May 13, 2022 Category: Drugs & Pharmacology Authors: Shengnan Jiang Fangfang Fan Lu Yang Ke Chen Zhihao Sun Yi Zhang Nanjia Cairang Xiaobo Wang Xianli Meng Source Type: research
Salidroside Ameliorates Ischemia-Induced Neuronal Injury through AMPK Dependent and Independent Pathways to Maintain Mitochondrial Quality Control
In this study, we employed a mouse middle cerebral artery occlusion (MCAO) and cellular oxygen and glucose deprivation (OGD) models to test the hypothesis that salidroside may restore mitochondrial quality control in neurons by modulating the relevant signaling. The results indicated that salidroside mitigated almost 40% the ischemia-induced brain infarct volumes in mice and the OGD-decreased viability of neurons to ameliorate the mitochondrial functions. Furthermore, salidroside treatment alleviated the OGD- or ischemia-induced imbalance of mitochondrial fission and fusion, mitophagy and promoted mitochondrial biogenesis ...
Source: The American Journal of Chinese Medicine - May 11, 2022 Category: Complementary Medicine Authors: Bin Wen Keru Zhou Caiyin Hu Jiehui Chen Kai Xu Tao Liang Benhong He Ling Chen Juan Chen Source Type: research
Salidroside Ameliorates Ischemia-Induced Neuronal Injury through AMPK Dependent and Independent Pathways to Maintain Mitochondrial Quality Control
In this study, we employed a mouse middle cerebral artery occlusion (MCAO) and cellular oxygen and glucose deprivation (OGD) models to test the hypothesis that salidroside may restore mitochondrial quality control in neurons by modulating the relevant signaling. The results indicated that salidroside mitigated almost 40% the ischemia-induced brain infarct volumes in mice and the OGD-decreased viability of neurons to ameliorate the mitochondrial functions. Furthermore, salidroside treatment alleviated the OGD- or ischemia-induced imbalance of mitochondrial fission and fusion, mitophagy and promoted mitochondrial biogenesis ...
Source: The American Journal of Chinese Medicine - May 11, 2022 Category: Complementary Medicine Authors: Bin Wen Keru Zhou Caiyin Hu Jiehui Chen Kai Xu Tao Liang Benhong He Ling Chen Juan Chen Source Type: research
Salidroside Ameliorates Ischemia-Induced Neuronal Injury through AMPK Dependent and Independent Pathways to Maintain Mitochondrial Quality Control
In this study, we employed a mouse middle cerebral artery occlusion (MCAO) and cellular oxygen and glucose deprivation (OGD) models to test the hypothesis that salidroside may restore mitochondrial quality control in neurons by modulating the relevant signaling. The results indicated that salidroside mitigated almost 40% the ischemia-induced brain infarct volumes in mice and the OGD-decreased viability of neurons to ameliorate the mitochondrial functions. Furthermore, salidroside treatment alleviated the OGD- or ischemia-induced imbalance of mitochondrial fission and fusion, mitophagy and promoted mitochondrial biogenesis ...
Source: The American Journal of Chinese Medicine - May 11, 2022 Category: Complementary Medicine Authors: Bin Wen Keru Zhou Caiyin Hu Jiehui Chen Kai Xu Tao Liang Benhong He Ling Chen Juan Chen Source Type: research
