New Metabolites of Rhodiola rosea. II. Hibiscetin Glycosides
Two new flavonoids (1 and2) were isolated from the extract of flowers ofRhodiola rosea L. [Sedum roseum (L.) Scop., Crassulaceae]. Their structures were established as hibiscetin 3-O-(3 ″-O-malonyl)-β-D-glucopyranoside-8-O- β-D-glucuronopyranoside (rhodirosin G,1) and hibiscetin 3-O- β-D-glucopyranoside-8-O-(2 ″-O-malonyl)-β-D-glucuronopyranoside (rhodirosin H,2) using UV, IR, and NMR spectroscopy and mass spectrometry. Their antiradical activity was investigated. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - April 4, 2023 Category: Chemistry Source Type: research
Genes, Vol. 14, Pages 794: Genetic Diversity in Natural Populations of Rhodiola Species of Different Adaptation Strategies
Ruslan Kalendar
Representatives of the Crassulaceae family’s genus Rhodiola are succulents, making them distinctive in a changing environment. One of the most significant tools for analyzing plant resources, including numerous genetic processes in wild populations, is the analysis of molecular genetic polymorphism. This work aimed to look at the polymorphisms of allelic variations of the superoxide dismutase (SOD) and auxin response factor (ARF) gene families, as well as the genetic diversity of five Rhodiola species, using the retrotransposons-based fingerprinting approach. The multi-locus exon-primed ...
Source: Genes - March 25, 2023 Category: Genetics & Stem Cells Authors: Nina V. Terletskaya Ainur S. Turzhanova Oxana N. Khapilina Moldir Z. Zhumagul Nataliya D. Meduntseva Nataliya O. Kudrina Nazym K. Korbozova Serik A. Kubentayev Ruslan Kalendar Tags: Article Source Type: research
Rhodiola rosea polysaccharides-based nanoparticles loaded with DOX boosts chemo-immunotherapy for triple-negative breast cancer by re-educating tumor-associated macrophages
Int J Biol Macromol. 2023 Mar 21:124110. doi: 10.1016/j.ijbiomac.2023.124110. Online ahead of print.ABSTRACTEfficient encapsulation and tumor targeting ability are the key issues for hydrophobic drugs delivery vectors in cancer therapy. In the current study, Rhodiola rosea polysaccharides (RHPs) serve as an immunoactive vector for drug delivery with tumor-associated macrophages (TAMs) modulating ability and typical structural characteristics. Firstly, Folic acid (FA) and stearic acid (SA) were chemically modified to the backbone of RHPs to obtain the self-assemble and tumor targeting behaviors. Then, the hydrophobic drug (...
Source: International Journal of Biological Macromolecules - March 23, 2023 Category: Biochemistry Authors: Ying-Xia Xiong Nan Li Miao-Miao Han Fan Ye Tian Liu Han-Yi Ye Ting-Ting Zheng Jin-Jia Wu Ying Li Yun Zhang Ying-Hua Zhang Shaohua Lv Zheng-Qi Dong Source Type: research
Comparative analysis of the organelle genomes of three Rhodiola species provide insights into their structural dynamics and sequence divergences
Plant organelle genomes are a valuable resource for evolutionary biology research, yet their genome architectures, evolutionary patterns and environmental adaptations are poorly understood in many lineages. Rhodi... (Source: BMC Plant Biology)
Source: BMC Plant Biology - March 22, 2023 Category: Biology Authors: Xiaolei Yu, Pei Wei, Zhuyifu Chen, Xinzhong Li, Wencai Zhang, Yujiao Yang, Chenlai Liu, Shuqi Zhao, Xiaoyan Li and Xing Liu Tags: Research Source Type: research
Salidroside postconditioning attenuates ferroptosis-mediated lung ischemia-reperfusion injury by activating the Nrf2/SLC7A11 signaling axis
CONCLUSIONS: This study clearly shows that salidroside postconditioning attenuates ferroptosis-mediated lung ischemia-reperfusion injury by activating the Nrf2/SLC7A11 signaling axis.PMID:36907990 | DOI:10.1016/j.intimp.2023.109731 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 13, 2023 Category: Allergy & Immunology Authors: Yun Wang Zhe Chen Jing Luo Jing Zhang A-Ming Sang Zhen-Shun Cheng Xin-Yi Li Source Type: research
Salidroside postconditioning attenuates ferroptosis-mediated lung ischemia-reperfusion injury by activating the Nrf2/SLC7A11 signaling axis
CONCLUSIONS: This study clearly shows that salidroside postconditioning attenuates ferroptosis-mediated lung ischemia-reperfusion injury by activating the Nrf2/SLC7A11 signaling axis.PMID:36907990 | DOI:10.1016/j.intimp.2023.109731 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 13, 2023 Category: Allergy & Immunology Authors: Yun Wang Zhe Chen Jing Luo Jing Zhang A-Ming Sang Zhen-Shun Cheng Xin-Yi Li Source Type: research
Salidroside postconditioning attenuates ferroptosis-mediated lung ischemia-reperfusion injury by activating the Nrf2/SLC7A11 signaling axis
CONCLUSIONS: This study clearly shows that salidroside postconditioning attenuates ferroptosis-mediated lung ischemia-reperfusion injury by activating the Nrf2/SLC7A11 signaling axis.PMID:36907990 | DOI:10.1016/j.intimp.2023.109731 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 13, 2023 Category: Allergy & Immunology Authors: Yun Wang Zhe Chen Jing Luo Jing Zhang A-Ming Sang Zhen-Shun Cheng Xin-Yi Li Source Type: research
Investigating the Effects and Mechanism of Rhodiola Rosea Injection on Cardiac Function in Rats with Chronic Heart Failure
CONCLUSION: The present study offers preliminary evidence supporting the use of Rhodiola rosea injection in the treatment of heart failure and offers a solid foundation for clinical off-label medication use.PMID:36740798 | DOI:10.2174/1386207326666230203145254 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 6, 2023 Category: Chemistry Authors: Xiuqin Li Shaopeng Chen Weihua Shao Suxing Wang Lixia Yao Source Type: research
Investigating the Effects and Mechanism of Rhodiola Rosea Injection on Cardiac Function in Rats with Chronic Heart Failure
CONCLUSION: The present study offers preliminary evidence supporting the use of Rhodiola rosea injection in the treatment of heart failure and offers a solid foundation for clinical off-label medication use.PMID:36740798 | DOI:10.2174/1386207326666230203145254 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 6, 2023 Category: Chemistry Authors: Xiuqin Li Shaopeng Chen Weihua Shao Suxing Wang Lixia Yao Source Type: research
[ASAP] Geraniol-Derived Monoterpenoid Glucosides from < italic toggle="yes" > Rhodiola rosea < /italic > : Resolving Structures by QM-HifSA Methodology
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.2c00836 (Source: Journal of Natural Products)
Source: Journal of Natural Products - February 6, 2023 Category: Biochemistry Authors: Yu Tang, J. Brent Friesen, David C. Lankin, James B. McAlpine, Dejan Nikolic ́, Shao-Nong Chen, and Guido F. Pauli Source Type: research
Molecules, Vol. 28, Pages 1535: Bioactivity Profiles on 15 Different Effect Mechanisms for 15 Golden Root Products via High-Performance Thin-Layer Chromatography, Planar Assays, and High-Resolution Mass Spectrometry
rlock
Planar chromatography has recently been combined with six different effect-directed assays for three golden root (Rhodiola rosea L.) samples. However, the profiles obtained showed an intense tailing, making zone differentiation impossible. The profiling was therefore improved to allow for the detection of individual bioactive compounds, and the range of samples was extended to 15 commercial golden root products. Further effect-directed assays were studied providing information on 15 different effect mechanisms, i.e., (1) tyrosinase, (2) acetylcholinesterase, (3) butyrylcholinesterase, (4) &beta;-glucuroni...
Source: Molecules - February 5, 2023 Category: Chemistry Authors: Hanna Nikolaichuk Irena M. Choma Gertrud E. Morlock Tags: Article Source Type: research
Phytochemical profile and anti-inflammatory activity of a commercially available Rhodiola rosea root extract
This study was aimed at providing a detailed phytochemical characterization of the Rhodiola 5%, a commercially available extract of R. rosea roots, and resulted in the characterization of 18 secondary metabolites, including 13 polyphenols and 6 terpenoids, and in the discovery of the new rhodiosidin (5), the first R. rosea metabolite to show both terpenoid and cinnamoyl moieties. The 5-lipoxygenase inhibiting activity of the main components was characterized and disclosed that rosiridin (6), kenposide A and rosavins are mainly responsible for this activity of the extract.PMID:36716798 | DOI:10.1016/j.fitote.2023.105439 (Source: Fitoterapia)
Source: Fitoterapia - January 30, 2023 Category: Biochemistry Authors: Francesca Masi Giuseppina Chianese Robert K Hofstetter Arianna Lucia Cavallaro Antonella Riva Oliver Werz Orazio Taglialatela-Scafati Source Type: research
Phytochemical profile and anti-inflammatory activity of a commercially available Rhodiola rosea root extract
This study was aimed at providing a detailed phytochemical characterization of the Rhodiola 5%, a commercially available extract of R. rosea roots, and resulted in the characterization of 18 secondary metabolites, including 13 polyphenols and 6 terpenoids, and in the discovery of the new rhodiosidin (5), the first R. rosea metabolite to show both terpenoid and cinnamoyl moieties. The 5-lipoxygenase inhibiting activity of the main components was characterized and disclosed that rosiridin (6), kenposide A and rosavins are mainly responsible for this activity of the extract.PMID:36716798 | DOI:10.1016/j.fitote.2023.105439 (Source: Fitoterapia)
Source: Fitoterapia - January 30, 2023 Category: Biochemistry Authors: Francesca Masi Giuseppina Chianese Robert K Hofstetter Arianna Lucia Cavallaro Antonella Riva Oliver Werz Orazio Taglialatela-Scafati Source Type: research
Phytochemical profile and anti-inflammatory activity of a commercially available Rhodiola rosea root extract
This study was aimed at providing a detailed phytochemical characterization of the Rhodiola 5%, a commercially available extract of R. rosea roots, and resulted in the characterization of 18 secondary metabolites, including 13 polyphenols and 6 terpenoids, and in the discovery of the new rhodiosidin (5), the first R. rosea metabolite to show both terpenoid and cinnamoyl moieties. The 5-lipoxygenase inhibiting activity of the main components was characterized and disclosed that rosiridin (6), kenposide A and rosavins are mainly responsible for this activity of the extract.PMID:36716798 | DOI:10.1016/j.fitote.2023.105439 (Source: Fitoterapia)
Source: Fitoterapia - January 30, 2023 Category: Biochemistry Authors: Francesca Masi Giuseppina Chianese Robert K Hofstetter Arianna Lucia Cavallaro Antonella Riva Oliver Werz Orazio Taglialatela-Scafati Source Type: research
Molecules, Vol. 28, Pages 912: Application of Natural Deep Eutectic Solvents for Extraction of Bioactive Components from Rhodiola rosea (L.)
y Samarov
Rhodiola rosea (L.) is a valuable source of nutrients. Nutrients have adaptogenic, immunostimulating, nootropic, anti-inflammatory and anti-cancer properties. Natural deep eutectic solvents (NADES) consisting of choline chloride and malonic, malic, tartaric or citric acids have been first used to extract biologically active substances from R. rosea. The total content of polyphenols has been determined by the Folin&ndash;Ciocalteu method for all extracts. Antioxidant activity has been determined by the phosphomolybdate method, and antiradical activity has been determined by the 2,2-diphenyl-1-picrylhyd...
Source: Molecules - January 16, 2023 Category: Chemistry Authors: Nikita Tsvetov Oksana Paukshta Nadezhda Fokina Natalia Volodina Artemiy Samarov Tags: Article Source Type: research
