Salidroside orchestrates metabolic reprogramming by regulating the Hif-1 α signalling pathway in acute mountain sickness
CONCLUSIONS: These results suggest that Sal induces metabolic reprogramming by regulating the Hif-1α signalling pathway to activate compensatory responses, which may be the core mechanism underlying the effect of Rhodiola crenulata on the central nervous system.PMID:34739769 | DOI:10.1080/13880209.2021.1992449 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - November 5, 2021 Category: Drugs & Pharmacology Authors: Xiaoning Yan Jie Liu Meixia Zhu Lirong Liu Yijun Chen Yinhuan Zhang Menghan Feng Zhixin Jia Hongbin Xiao Source Type: research
Preclinical Evidence and Possible Mechanisms of Rhodiola rosea L. and Its Components for Ischemic Stroke: A Systematic Review and Meta-Analysis
Conclusion: The findings suggested that RRC can improve ischemia stroke. The possible mechanisms of RRC are largely through antioxidant, anti-apoptosis activities, anti-inflammatory, repressing lipid peroxidation, antigliosis, and alleviating the pathological blood brain barrier damage. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 5, 2021 Category: Drugs & Pharmacology Source Type: research
Salidroside Alleviates Chronic Constriction Injury-Induced Neuropathic Pain and Inhibits of TXNIP/NLRP3 Pathway
This study investigates the time course of activation of spinal NLRP3 inflammasome axis in the development of neuropathic pain and also whether SAL could be an effective treatment for this type of pain by modulating NLRP3 inflammasome. In the chronic constriction injury (CCI) mice model, spinal NLRP3 inflammasome-related proteins and TXNIP, the mediator of NLRP3, were upregulated from the 14th to the 28th day after injury. The TXNIP and NLRP3 inflammasome-related proteins were mainly present in neurons and microglial cells in the spinal dorsal horn after CCI. Intraperitoneal injection of SAL at 200 mg/kg for 14 consecutive...
Source: Neurochemical Research - October 9, 2021 Category: Neuroscience Authors: Tingting Hu Qingyu Sun Yu Gou Yurui Zhang Yumeng Ding Yiran Ma Jing Liu Wen Chen Ting Lan Peipei Wang Qian Li Fei Yang Source Type: research
Salidroside Alleviates Chronic Constriction Injury-Induced Neuropathic Pain and Inhibits of TXNIP/NLRP3 Pathway
This study investigates the time course of activation of spinal NLRP3 inflammasome axis in the development of neuropathic pain and also whether SAL could be an effective treatment for this type of pain by modulating NLRP3 inflammasome. In the chronic constriction injury (CCI) mice model, spinal NLRP3 inflammasome-related proteins and TXNIP, the mediator of NLRP3, were upregulated from the 14th to the 28th day after injury. The TXNIP and NLRP3 inflammasome-related proteins were mainly present in neurons and microglial cells in the spinal dorsal horn after CCI. Intraperitoneal injection of SAL at 200 mg/kg for 14 consecutive...
Source: Neurochemical Research - October 9, 2021 Category: Neuroscience Authors: Tingting Hu Qingyu Sun Yu Gou Yurui Zhang Yumeng Ding Yiran Ma Jing Liu Wen Chen Ting Lan Peipei Wang Qian Li Fei Yang Source Type: research
Salidroside Alleviates Chronic Constriction Injury-Induced Neuropathic Pain and Inhibits of TXNIP/NLRP3 Pathway
This study investigates the time course of activation of spinal NLRP3 inflammasome axis in the development of neuropathic pain and also whether SAL could be an effective treatment for this type of pain by modulating NLRP3 inflammasome. In the chronic constriction injury (CCI) mice model, spinal NLRP3 inflammasome-related proteins and TXNIP, the mediator of NLRP3, were upregulated from the 14th to the 28th day after injury. The TXNIP and NLRP3 inflammasome-related proteins were mainly present in neurons and microglial cells in the spinal dorsal horn after CCI. Intraperitoneal injection of SAL at 200 mg/kg for 14 consecutive...
Source: Neurochemical Research - October 9, 2021 Category: Neuroscience Authors: Tingting Hu Qingyu Sun Yu Gou Yurui Zhang Yumeng Ding Yiran Ma Jing Liu Wen Chen Ting Lan Peipei Wang Qian Li Fei Yang Source Type: research
Salidroside Alleviates Chronic Constriction Injury-Induced Neuropathic Pain and Inhibits of TXNIP/NLRP3 Pathway
This study investigates the time course of activation of spinal NLRP3 inflammasome axis in the development of neuropathic pain and also whether SAL could be an effective treatment for this type of pain by modulating NLRP3 inflammasome. In the chronic constriction injury (CCI) mice model, spinal NLRP3 inflammasome-related proteins and TXNIP, the mediator of NLRP3, were upregulated from the 14th to the 28th day after injury. The TXNIP and NLRP3 inflammasome-related proteins were mainly present in neurons and microglial cells in the spinal dorsal horn after CCI. Intraperitoneal injection of SAL at 200 mg/kg for 14 consecutive...
Source: Neurochemical Research - October 9, 2021 Category: Neuroscience Authors: Tingting Hu Qingyu Sun Yu Gou Yurui Zhang Yumeng Ding Yiran Ma Jing Liu Wen Chen Ting Lan Peipei Wang Qian Li Fei Yang Source Type: research
GSE184840 15-Lipoxygenase-2 Deficiency Induces a Dysfunction in Macrophages that can be Restored by Salidroside
In conclusion, our study shows a newly identified link between 15-LOX-2 deficiency and salidroside in regulating macrophage survival, proliferation, and function. Salidroside may be a promising therapeutic strategy for treating inflammation-related diseases resulting from 15-LO X-2 deficiency. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - October 4, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Salidroside inhibits chronic myeloid leukemia cell proliferation and induces apoptosis by regulating the miR-140-5p/wnt5a/ β-catenin axis
Exp Ther Med. 2021 Nov;22(5):1249. doi: 10.3892/etm.2021.10684. Epub 2021 Sep 2.ABSTRACTSalidroside, an active ingredient of Rhodiola rosea, exhibits antitumor effects in various types of cancer. However, the role of salidroside in chronic myeloid leukemia (CML) has not been elucidated. In the presents study, cell viability was assessed by CCK-8 assay, while apoptosis was detected by flow cytometry. Reverse transcription-quantitative PCR analysis was used to examine the expression levels of miR-140-5p in human CML cell lines. The expression levels of apoptosis and cell cycle-associated proteins and of the wnt5a/β-catenin ...
Source: Experimental and Therapeutic Medicine - September 20, 2021 Category: General Medicine Authors: Danjun Chen Cong Luo Source Type: research
