Salidroside protects against ventilation-induced lung injury by inhibiting the expression of matrix metalloproteinase-9
CONCLUSIONS: Salidroside protected against stretch-induced endothelial barrier function, improving lung injury after ventilation. Thus, salidroside may be a promising therapeutic agent for patients with MV-induced lung injury.PMID:34517742 | PMC:PMC8439245 | DOI:10.1080/13880209.2021.1967409 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 14, 2021 Category: Drugs & Pharmacology Authors: Hui Zhang Wenwen Dong Siyuan Li Yunqian Zhang Zhou Lv Lu Yang Lai Jiang Tao Wu Yan Wang Source Type: research
Salidroside protects against ventilation-induced lung injury by inhibiting the expression of matrix metalloproteinase-9
CONCLUSIONS: Salidroside protected against stretch-induced endothelial barrier function, improving lung injury after ventilation. Thus, salidroside may be a promising therapeutic agent for patients with MV-induced lung injury.PMID:34517742 | DOI:10.1080/13880209.2021.1967409 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 14, 2021 Category: Drugs & Pharmacology Authors: Hui Zhang Wenwen Dong Siyuan Li Yunqian Zhang Zhou Lv Lu Yang Lai Jiang Tao Wu Yan Wang Source Type: research
Salidroside protects against ventilation-induced lung injury by inhibiting the expression of matrix metalloproteinase-9
CONCLUSIONS: Salidroside protected against stretch-induced endothelial barrier function, improving lung injury after ventilation. Thus, salidroside may be a promising therapeutic agent for patients with MV-induced lung injury.PMID:34517742 | PMC:PMC8439245 | DOI:10.1080/13880209.2021.1967409 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 14, 2021 Category: Drugs & Pharmacology Authors: Hui Zhang Wenwen Dong Siyuan Li Yunqian Zhang Zhou Lv Lu Yang Lai Jiang Tao Wu Yan Wang Source Type: research
Polyketone metabolites isolated from Rhodiola tibetica endohytic fungus Alternaria sp. HJT-Y7 and their SARS-CoV-2 virus inhibitory activitives
Bioorg Chem. 2021 Aug 28;116:105309. doi: 10.1016/j.bioorg.2021.105309. Online ahead of print.ABSTRACTSix new polyketone metabolites, compounds (1-6) and seven known polyketone compounds (7-13) were isolated from Rhodiola tibetica endophytic fungus Alternaria sp. The structural elucidation of five new polyketone metabolites were elucidated on the basis of spectroscopic including 2D NMR and HRMS and spectrometric analysis. Inhibition rate evaluation revealed that compounds 1(EC50 = 0.02 mM), 3(EC50 = 0.3 mM), 6(EC50 = 0.07 mM), 8(EC50 = 0.1 mM) and 9(EC50 = 0.04 mM) had inhibitory effect on the SARS-CoV-2 virus.PMID:3447905...
Source: Bioorganic Chemistry - September 3, 2021 Category: Chemistry Authors: Xuan Lu Xiao-Yuan Tang Hai-Xin Wang Wei-Jin Huang Wei-Xing Feng Bao-Min Feng Source Type: research
Salidroside induces apoptosis in human gastric cancer cells via the downregulation of ENO1/PKM2/GLUT1 expression
This study investigated the effects of purified salidroside, an ingredient of Rhodiola rosea, on the proliferation of two human gastric cancer cell lines and further investigating its possible molecular mechanisms. We verified that salidroside exerts a dose-dependent inhibitory effect on the proliferation of SGC-7901 and MKN-45 human gastric cancer cells. Moreover, salidroside can induce cell apoptosis, which was accompanied by an increase in nuclear fragmentation. In addition, salidroside inhibited glycolysis, as evidenced by the reduced expression levels of the glycolysis-related enzymes pyruvate kinase isoenzyme M2 (PKM...
Source: Biological and Pharmaceutical Bulletin - September 2, 2021 Category: Drugs & Pharmacology Authors: Ziying Dai Xuan Zhang Wuyan Li Junxia Tang Tingting Pan Chenru Ma Quanlin Guan Source Type: research
Salidroside induces apoptosis in human gastric cancer cells via the downregulation of ENO1/PKM2/GLUT1 expression
This study investigated the effects of purified salidroside, an ingredient of Rhodiola rosea, on the proliferation of two human gastric cancer cell lines and further investigating its possible molecular mechanisms. We verified that salidroside exerts a dose-dependent inhibitory effect on the proliferation of SGC-7901 and MKN-45 human gastric cancer cells. Moreover, salidroside can induce cell apoptosis, which was accompanied by an increase in nuclear fragmentation. In addition, salidroside inhibited glycolysis, as evidenced by the reduced expression levels of the glycolysis-related enzymes pyruvate kinase isoenzyme M2 (PKM...
Source: Biological and Pharmaceutical Bulletin - September 2, 2021 Category: Drugs & Pharmacology Authors: Ziying Dai Xuan Zhang Wuyan Li Junxia Tang Tingting Pan Chenru Ma Quanlin Guan Source Type: research
Salidroside induces apoptosis in human gastric cancer cells via the downregulation of ENO1/PKM2/GLUT1 expression
This study investigated the effects of purified salidroside, an ingredient of Rhodiola rosea, on the proliferation of two human gastric cancer cell lines and further investigating its possible molecular mechanisms. We verified that salidroside exerts a dose-dependent inhibitory effect on the proliferation of SGC-7901 and MKN-45 human gastric cancer cells. Moreover, salidroside can induce cell apoptosis, which was accompanied by an increase in nuclear fragmentation. In addition, salidroside inhibited glycolysis, as evidenced by the reduced expression levels of the glycolysis-related enzymes pyruvate kinase isoenzyme M2 (PKM...
Source: Biological and Pharmaceutical Bulletin - September 2, 2021 Category: Drugs & Pharmacology Authors: Ziying Dai Xuan Zhang Wuyan Li Junxia Tang Tingting Pan Chenru Ma Quanlin Guan Source Type: research
Salidroside induces apoptosis in human gastric cancer cells via the downregulation of ENO1/PKM2/GLUT1 expression
This study investigated the effects of purified salidroside, an ingredient of Rhodiola rosea, on the proliferation of two human gastric cancer cell lines and further investigating its possible molecular mechanisms. We verified that salidroside exerts a dose-dependent inhibitory effect on the proliferation of SGC-7901 and MKN-45 human gastric cancer cells. Moreover, salidroside can induce cell apoptosis, which was accompanied by an increase in nuclear fragmentation. In addition, salidroside inhibited glycolysis, as evidenced by the reduced expression levels of the glycolysis-related enzymes pyruvate kinase isoenzyme M2 (PKM...
Source: Biological and Pharmaceutical Bulletin - September 2, 2021 Category: Drugs & Pharmacology Authors: Ziying Dai Xuan Zhang Wuyan Li Junxia Tang Tingting Pan Chenru Ma Quanlin Guan Source Type: research
Salidroside induces apoptosis in human gastric cancer cells via the downregulation of ENO1/PKM2/GLUT1 expression
This study investigated the effects of purified salidroside, an ingredient of Rhodiola rosea, on the proliferation of two human gastric cancer cell lines and further investigating its possible molecular mechanisms. We verified that salidroside exerts a dose-dependent inhibitory effect on the proliferation of SGC-7901 and MKN-45 human gastric cancer cells. Moreover, salidroside can induce cell apoptosis, which was accompanied by an increase in nuclear fragmentation. In addition, salidroside inhibited glycolysis, as evidenced by the reduced expression levels of the glycolysis-related enzymes pyruvate kinase isoenzyme M2 (PKM...
Source: Biological and Pharmaceutical Bulletin - September 2, 2021 Category: Drugs & Pharmacology Authors: Ziying Dai Xuan Zhang Wuyan Li Junxia Tang Tingting Pan Chenru Ma Quanlin Guan Source Type: research
Salidroside induces apoptosis in human gastric cancer cells via the downregulation of ENO1/PKM2/GLUT1 expression
This study investigated the effects of purified salidroside, an ingredient of Rhodiola rosea, on the proliferation of two human gastric cancer cell lines and further investigating its possible molecular mechanisms. We verified that salidroside exerts a dose-dependent inhibitory effect on the proliferation of SGC-7901 and MKN-45 human gastric cancer cells. Moreover, salidroside can induce cell apoptosis, which was accompanied by an increase in nuclear fragmentation. In addition, salidroside inhibited glycolysis, as evidenced by the reduced expression levels of the glycolysis-related enzymes pyruvate kinase isoenzyme M2 (PKM...
Source: Biological and Pharmaceutical Bulletin - September 2, 2021 Category: Drugs & Pharmacology Authors: Ziying Dai Xuan Zhang Wuyan Li Junxia Tang Tingting Pan Chenru Ma Quanlin Guan Source Type: research
