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In vitro effects of undifferentiated callus extracts from Plantago major L, Rhodiola rosea L and Silybum marianum L in normal and malignant human skin cells
CONCLUSION: All in all, we have confirmed that undifferentiated callus extracts of S. marianum possess properties such as antioxidant and anti-inflammatory activities in both normal and malignant keratinocytes, and thus could be a promising agent controlling the pro-inflammatory IL-6 production.PMID:37292297 | PMC:PMC10245016 | DOI:10.1016/j.heliyon.2023.e16480 (Source: Cancer Control)
Source: Cancer Control - June 9, 2023 Category: Cancer & Oncology Authors: Anette Gj örloff Wingren Riyam Ziyad Faik Anna Holefors Edina Filecovic Anna Gustafsson Source Type: research

Salidroside ameliorates memory impairment following long-term ethanol intake in rats by modulating the altered intestinal microbiota content and hippocampal gene expression
ConclusionSal improved memory impairment caused by long-term EtOH intake in rats, which may be related to its regulation of gut dysbiosis and hippocampal dysfunction. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - June 9, 2023 Category: Microbiology Source Type: research

Cancers, Vol. 15, Pages 3086: The Potent Anti-Tumor Effects of Rhodiola Drinking Are Associated with the Inhibition of the mTOR Pathway and Modification of Tumor Metabolism in the UPII-Mutant Ha-Ras Model
Conclusions: Our findings highlight the potential of SHR-5 as an anti-aging agent for bladder cancer prevention through reshaping tumor metabolism via the inhibition of the mTOR signaling. Global metabolomics profiling provides a unique and efficient tool for studying the mechanisms of complex herb extracts&rsquo; action. (Source: Cancers)
Source: Cancers - June 7, 2023 Category: Cancer & Oncology Authors: Zhongbo Liu Noriko N Yokoyama Liankun Song Jun Xie Zhina Sadeghi Yi Xi Wu Sarah Yee Xue-Ru Wu Beverly Wang Edward Uchio Xiaolin Zi Tags: Article Source Type: research

Rosavin protects the blood-brain barrier against ischemia/reperfusion-induced cerebral injury by regulating MAPK-mediated MMPs pathway
In conclusion, rosavin protects the BBB against I/R injury possibly by regulating the MAPK pathway. The above results provide a rationale for further exploration of rosavin as a therapeutic candidate for cerebral I/R injury.PMID:37254848 | DOI:10.1111/1440-1681.13781 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - May 31, 2023 Category: Drugs & Pharmacology Authors: Hongyun Zou Lei Li Zhilai Yang Lili Tang Chunhui Wang Source Type: research

Rosavidin protects against PM2.5-induced lung toxicity via inhibition of NLRP3 inflammasome-mediated pyroptosis by activating the PI3K/AKT pathway
This study aimed to investigate the potential protective effect and mechanism of Ro in PM2.5-induced lung toxicity. A lung toxicity rat model was established through trachea drip of PM2.5 suspension after the different dose pretreatment of Ro (50 mg/kg and 100 mg/kg) to evaluate the effect of Ro on PM2.5 caused lung toxicity. The results showed that Ro attenuated the pathological changes, edema, and inflammation response in rats. The PI3K/AKT signaling pathway may be associated with the protective effect of Ro against pulmonary toxicity. Subsequently, we verified the role of PI3K/AKT in the PM2.5 exposure lung tissue. More...
Source: Biochemical Pharmacology - May 27, 2023 Category: Drugs & Pharmacology Authors: Demei Huang Nan Jia Caixia Pei Zherui Shen Sijing Zhao Yilan Wang Yongcan Wu Shihua Shi Shuiqin Li Zhenxing Wang Source Type: research

Salidroside pretreatment alleviates PM 2.5 caused lung injury via inhibition of apoptosis and pyroptosis through regulating NLRP3 Inflammasome
Food Chem Toxicol. 2023 May 24:113858. doi: 10.1016/j.fct.2023.113858. Online ahead of print.ABSTRACTAmbient fine particulate matter (PM2.5) is considered a leading cause of pathogenic particulate matter induced lung injury. And Salidroside (Sal), the major bioactive constituent isolated from Rhodiola rosea L., has been shown to ameliorate lung injury in various conditions. To uncover the possible therapy for PM2.5 related pulmonary disease, we evaluated the protective role of Sal pre-treatment on PM2.5 induced lung injury in mice by utilizing the survival analysis, hematoxylin and eosin (H&E) staining, lung injury sco...
Source: Food and Chemical Toxicology - May 26, 2023 Category: Food Science Authors: Shihua Shi Demei Huang Yongcan Wu Caixia Pei Yilan Wang Zherui Shen Sijing Zhao Nan Jia Xiaomin Wang Bonan Chen Jie Pan Fei Wang Zhenxing Wang Source Type: research