Hormesis determines lifespan
Ageing Res Rev. 2024 Jan 3:102181. doi: 10.1016/j.arr.2023.102181. Online ahead of print.ABSTRACTThis paper addresses how long lifespan can be extended via multiple interventions, such as dietary supplements [e.g., curcumin, resveratrol, sulforaphane, complex phytochemical mixtures (e.g., Moringa, Rhodiola)], pharmaceutical agents (e.g., metformin), caloric restriction, intermittent fasting, exercise and other activities. This evaluation was framed within the context of hormesis, a biphasic dose response with specific quantitative features describing the limits of biological/phenotypic plasticity for integrative biological...
Source: Ageing Research Reviews - January 5, 2024 Category: Genetics & Stem Cells Authors: Edward J Calabrese Marc Nascarella Peter Pressman A Wallace Hayes Gaurav Dhawan Rachna Kapoor Vittorio Calabrese Evgenios Agathokleous Source Type: research
Hormesis determines lifespan
Ageing Res Rev. 2024 Feb;94:102181. doi: 10.1016/j.arr.2023.102181. Epub 2024 Jan 3.ABSTRACTThis paper addresses how long lifespan can be extended via multiple interventions, such as dietary supplements [e.g., curcumin, resveratrol, sulforaphane, complex phytochemical mixtures (e.g., Moringa, Rhodiola)], pharmaceutical agents (e.g., metformin), caloric restriction, intermittent fasting, exercise and other activities. This evaluation was framed within the context of hormesis, a biphasic dose response with specific quantitative features describing the limits of biological/phenotypic plasticity for integrative biological endp...
Source: Ageing Research Reviews - January 5, 2024 Category: Genetics & Stem Cells Authors: Edward J Calabrese Marc Nascarella Peter Pressman A Wallace Hayes Gaurav Dhawan Rachna Kapoor Vittorio Calabrese Evgenios Agathokleous Source Type: research
Mechanism of Rhodiola rosea –Euonymus alatus drug pair against rheumatoid arthritis: Network pharmacology and experimental validation
ConclusionTY can inhibit the PI3K/AKT signaling pathway and regulate the balance between MMPs and TIMP, thus playing a therapeutic role in RA. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - December 26, 2023 Category: Allergy & Immunology Authors: Qiu ‐han Zheng,
Lian‐yun Du,
Ying Zhao,
Zhong Zhang,
Song‐lan Piao,
Ying‐hang Wang,
Zhi Pan Tags: ORIGINAL ARTICLE Source Type: research
Evaluating the effects of surfactant types on the properties and stability of oil-in-water Rhodiola rosea nanoemulsion
In this study, four groups of oil-in-water (O/W) nanoemulsions (NEs) with different ratios of surfactant and co-surfactant, and two oils were formulated as carriers of Rhodiola rosea. The variable optimization was investigated and then indicated as optimization group A (Opt A) with the formula of 10% of transcutol, 16.63% of tween 80, Opt B with 10% of tween 80, 29.87% of span 80, Opt C with 28.42% of transcutol, 30% of labrasol, and Opt D with 30% of transcutol, 30% of tween 80. Labrafac and soybean oil were used as the oil phase. The optimized formula using the response surface method (RSM) by design expert software show...
Source: Colloids and Surfaces - December 17, 2023 Category: Biotechnology Authors: Benni Iskandar Hui-Ching Mei Ta-Wei Liu Hsiu-Mei Lin Ching-Kuo Lee Source Type: research
Evaluating the effects of surfactant types on the properties and stability of oil-in-water Rhodiola rosea nanoemulsion
In this study, four groups of oil-in-water (O/W) nanoemulsions (NEs) with different ratios of surfactant and co-surfactant, and two oils were formulated as carriers of Rhodiola rosea. The variable optimization was investigated and then indicated as optimization group A (Opt A) with the formula of 10% of transcutol, 16.63% of tween 80, Opt B with 10% of tween 80, 29.87% of span 80, Opt C with 28.42% of transcutol, 30% of labrasol, and Opt D with 30% of transcutol, 30% of tween 80. Labrafac and soybean oil were used as the oil phase. The optimized formula using the response surface method (RSM) by design expert software show...
Source: Colloids and Surfaces - December 17, 2023 Category: Biotechnology Authors: Benni Iskandar Hui-Ching Mei Ta-Wei Liu Hsiu-Mei Lin Ching-Kuo Lee Source Type: research
Evaluating the effects of surfactant types on the properties and stability of oil-in-water Rhodiola rosea nanoemulsion
In this study, four groups of oil-in-water (O/W) nanoemulsions (NEs) with different ratios of surfactant and co-surfactant, and two oils were formulated as carriers of Rhodiola rosea. The variable optimization was investigated and then indicated as optimization group A (Opt A) with the formula of 10% of transcutol, 16.63% of tween 80, Opt B with 10% of tween 80, 29.87% of span 80, Opt C with 28.42% of transcutol, 30% of labrasol, and Opt D with 30% of transcutol, 30% of tween 80. Labrafac and soybean oil were used as the oil phase. The optimized formula using the response surface method (RSM) by design expert software show...
Source: Colloids and Surfaces - December 17, 2023 Category: Biotechnology Authors: Benni Iskandar Hui-Ching Mei Ta-Wei Liu Hsiu-Mei Lin Ching-Kuo Lee Source Type: research
Salidroside attenuates myocardial remodeling in DOCA-salt-induced mice by inhibiting the endothelin 1 and PI3K/AKT/NF κB signaling pathways
Eur J Pharmacol. 2023 Dec 2:176236. doi: 10.1016/j.ejphar.2023.176236. Online ahead of print.ABSTRACTMyocardial remodeling, which occurs in the final stage of cardiovascular diseases such as hypertension, can ultimately result in heart failure. However, the pathogenesis of myocardial remodeling remains incompletely understood, and there is currently a lack of safe and effective treatment options. Salidroside, which is extracted from the plant Rhodiola rosea, shows remarkable antioxidant and anti-inflammatory characteristics. The purpose of this investigation was to examine the cardioprotective effect of salidroside on myoc...
Source: European Journal of Pharmacology - December 4, 2023 Category: Drugs & Pharmacology Authors: Qiao Liu Qingman Luo Bin Zhong Kecheng Tang XueLing Chen Shengqian Yang Xiaohui Li Source Type: research
Effect of low-intensity pulsed ultrasound combined with Rhodiola rosea on proliferation and differentiation of osteoblasts
In this study, rat OB was used as the research material and divided into groups A, B, C and D according to different intervention methods after osteogenic culture. Joint Salvia miltiorrhiza LIPUS ever seen from the results of the study promotes the strongest OB proliferation, at the same time, effectively reduces the apoptosis rate of the OB and apoptosis-related proteins expression, and promotes the OCN and ALO protein expression, indicated by LIPUS Salvia miltiorrhiza can effectively promote the osteoblast proliferation, differentiation, in order to promote cartilage repair and bone strengthen provides an effective means...
Source: Cellular and Molecular Biology - November 13, 2023 Category: Molecular Biology Authors: Lanjun Zhang Hang Yuan Yongjun Tong Yu Zhang Yu Sun Yan Li Source Type: research
Effect of low-intensity pulsed ultrasound combined with Rhodiola rosea on proliferation and differentiation of osteoblasts
In this study, rat OB was used as the research material and divided into groups A, B, C and D according to different intervention methods after osteogenic culture. Joint Salvia miltiorrhiza LIPUS ever seen from the results of the study promotes the strongest OB proliferation, at the same time, effectively reduces the apoptosis rate of the OB and apoptosis-related proteins expression, and promotes the OCN and ALO protein expression, indicated by LIPUS Salvia miltiorrhiza can effectively promote the osteoblast proliferation, differentiation, in order to promote cartilage repair and bone strengthen provides an effective means...
Source: Mol Biol Cell - November 13, 2023 Category: Molecular Biology Authors: Lanjun Zhang Hang Yuan Yongjun Tong Yu Zhang Yu Sun Yan Li Source Type: research
Effect of low-intensity pulsed ultrasound combined with Rhodiola rosea on proliferation and differentiation of osteoblasts
In this study, rat OB was used as the research material and divided into groups A, B, C and D according to different intervention methods after osteogenic culture. Joint Salvia miltiorrhiza LIPUS ever seen from the results of the study promotes the strongest OB proliferation, at the same time, effectively reduces the apoptosis rate of the OB and apoptosis-related proteins expression, and promotes the OCN and ALO protein expression, indicated by LIPUS Salvia miltiorrhiza can effectively promote the osteoblast proliferation, differentiation, in order to promote cartilage repair and bone strengthen provides an effective means...
Source: Cellular and Molecular Biology - November 13, 2023 Category: Molecular Biology Authors: Lanjun Zhang Hang Yuan Yongjun Tong Yu Zhang Yu Sun Yan Li Source Type: research
Effect of low-intensity pulsed ultrasound combined with Rhodiola rosea on proliferation and differentiation of osteoblasts
In this study, rat OB was used as the research material and divided into groups A, B, C and D according to different intervention methods after osteogenic culture. Joint Salvia miltiorrhiza LIPUS ever seen from the results of the study promotes the strongest OB proliferation, at the same time, effectively reduces the apoptosis rate of the OB and apoptosis-related proteins expression, and promotes the OCN and ALO protein expression, indicated by LIPUS Salvia miltiorrhiza can effectively promote the osteoblast proliferation, differentiation, in order to promote cartilage repair and bone strengthen provides an effective means...
Source: Mol Biol Cell - November 13, 2023 Category: Molecular Biology Authors: Lanjun Zhang Hang Yuan Yongjun Tong Yu Zhang Yu Sun Yan Li Source Type: research
Effect of low-intensity pulsed ultrasound combined with Rhodiola rosea on proliferation and differentiation of osteoblasts
In this study, rat OB was used as the research material and divided into groups A, B, C and D according to different intervention methods after osteogenic culture. Joint Salvia miltiorrhiza LIPUS ever seen from the results of the study promotes the strongest OB proliferation, at the same time, effectively reduces the apoptosis rate of the OB and apoptosis-related proteins expression, and promotes the OCN and ALO protein expression, indicated by LIPUS Salvia miltiorrhiza can effectively promote the osteoblast proliferation, differentiation, in order to promote cartilage repair and bone strengthen provides an effective means...
Source: Cellular and Molecular Biology - November 13, 2023 Category: Molecular Biology Authors: Lanjun Zhang Hang Yuan Yongjun Tong Yu Zhang Yu Sun Yan Li Source Type: research
