Salidroside protects mice from high-fat diet-induced obesity by modulating the gut microbiota
Int Immunopharmacol. 2023 May 14;120:110278. doi: 10.1016/j.intimp.2023.110278. Online ahead of print.ABSTRACTObesity is a systemic disease with multisystem inflammation associated with gut dysbiosis. Salidroside (SAL) which is a major glycoside extracted from Rhodiola rosea L. has a wide range of pharmacological effects, but the role of gut microbiota in the protective effects of SAL on obesity has not been studied. Herein, we aim to explore whether SAL could ameliorate high-fat diet (HFD)-induced obesity in mice by modulating microbiota. Results showed that oral treatment with SAL alleviated HFD-induced obesity in mice a...
Source: International Immunopharmacology - May 16, 2023 Category: Allergy & Immunology Authors: Jiuxi Liu Jiapei Cai Peng Fan Xue Dong Naisheng Zhang Jiandong Tai Yongguo Cao Source Type: research
Salidroside protects mice from high-fat diet-induced obesity by modulating the gut microbiota
Int Immunopharmacol. 2023 May 14;120:110278. doi: 10.1016/j.intimp.2023.110278. Online ahead of print.ABSTRACTObesity is a systemic disease with multisystem inflammation associated with gut dysbiosis. Salidroside (SAL) which is a major glycoside extracted from Rhodiola rosea L. has a wide range of pharmacological effects, but the role of gut microbiota in the protective effects of SAL on obesity has not been studied. Herein, we aim to explore whether SAL could ameliorate high-fat diet (HFD)-induced obesity in mice by modulating microbiota. Results showed that oral treatment with SAL alleviated HFD-induced obesity in mice a...
Source: International Immunopharmacology - May 16, 2023 Category: Allergy & Immunology Authors: Jiuxi Liu Jiapei Cai Peng Fan Xue Dong Naisheng Zhang Jiandong Tai Yongguo Cao Source Type: research
Rhodiola rosea and Salidroside commonly induce hormesis, with particular focus on longevity and neuroprotection
Chem Biol Interact. 2023 May 9:110540. doi: 10.1016/j.cbi.2023.110540. Online ahead of print.ABSTRACTThe biological effects of Rhodiola rosea extracts and one of its major constituents, Salidroside, were evaluated for their capacity to induce hormesis/hormetic effects. The findings indicate that the Rhodiola rosea extracts and Salidroside commonly induce hormetic dose responses within a broad range of biological models, cell types and across a broad range of endpoints, with particular emphasis on longevity and neuroprotective endpoints. This paper represents the first integrative documentation and assessment of Rhodiola ro...
Source: Chemico-Biological Interactions - May 11, 2023 Category: Molecular Biology Authors: Edward J Calabrese Gaurav Dhawan Rachna Kapoor Evgenios Agathokleous Vittorio Calabrese Source Type: research
Rhodiola rosea and Salidroside commonly induce hormesis, with particular focus on longevity and neuroprotection
Chem Biol Interact. 2023 May 9:110540. doi: 10.1016/j.cbi.2023.110540. Online ahead of print.ABSTRACTThe biological effects of Rhodiola rosea extracts and one of its major constituents, Salidroside, were evaluated for their capacity to induce hormesis/hormetic effects. The findings indicate that the Rhodiola rosea extracts and Salidroside commonly induce hormetic dose responses within a broad range of biological models, cell types and across a broad range of endpoints, with particular emphasis on longevity and neuroprotective endpoints. This paper represents the first integrative documentation and assessment of Rhodiola ro...
Source: Chemico-Biological Interactions - May 11, 2023 Category: Molecular Biology Authors: Edward J Calabrese Gaurav Dhawan Rachna Kapoor Evgenios Agathokleous Vittorio Calabrese Source Type: research
Rhodiola wallichiana var.cholaensis protects against myocardial ischemia-reperfusion injury by attenuating oxidative stress-mediated apoptosis via enhancing Nrf2 signaling
The present study aimed to explore the cardioprotective effects of Rhodiola wallichiana var.cholaensis (RW) against hypoxia/reoxygenation (H/R)-induced H9c2 cell injury and ischemia/reperfusion (I/R)-induced myocardial injury. Following treatment with RW, H9c2 cells were subjected to 4 h of hypoxia/3 h of reoxygenation. MTT assay, LDH assay, and flow cytometry were employed to detect cell viability and changes of ROS and mitochondrial membrane potential. Moreover, after RW treatment, rats underwent 30 min of ischemia, followed by 120 min of reperfusion. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 11, 2023 Category: Cardiology Authors: Tingxu Yan, Xu Li, Xin Wang, Yue Zhang, Bosai He, Ying Jia, Wei Xiao Source Type: research
Tyrosol attenuates lipopolysaccharide ‑induced inflammation in HUVECs to promote vascular health against atherosclerosis challenge
Exp Ther Med. 2023 Apr 6;25(5):240. doi: 10.3892/etm.2023.11939. eCollection 2023 May.ABSTRACTThe role of vascular endothelial cells in acute and chronic vascular inflammatory response has long been recognized. Therefore, persistent vascular inflammation may lead to endothelial dysfunction, thus resulting in the release of pro-inflammatory cytokines and the expression of adhesion molecules, which in turn promote monocyte/macrophage adhesion. Inflammation serves a key role in the development of vascular diseases, such as atherosclerosis. Tyrosol is a natural polyphenolic compound with diverse biological functions, found in ...
Source: Experimental and Therapeutic Medicine - April 28, 2023 Category: General Medicine Authors: Weiwei Zhao Huizhen Wei Jun Lu Wenjun Sha Dusang Sun Ting Pan Tao Lei Source Type: research
Tyrosol attenuates lipopolysaccharide ‑induced inflammation in HUVECs to promote vascular health against atherosclerosis challenge
Exp Ther Med. 2023 Apr 6;25(5):240. doi: 10.3892/etm.2023.11939. eCollection 2023 May.ABSTRACTThe role of vascular endothelial cells in acute and chronic vascular inflammatory response has long been recognized. Therefore, persistent vascular inflammation may lead to endothelial dysfunction, thus resulting in the release of pro-inflammatory cytokines and the expression of adhesion molecules, which in turn promote monocyte/macrophage adhesion. Inflammation serves a key role in the development of vascular diseases, such as atherosclerosis. Tyrosol is a natural polyphenolic compound with diverse biological functions, found in ...
Source: Atherosclerosis - April 28, 2023 Category: Cardiology Authors: Weiwei Zhao Huizhen Wei Jun Lu Wenjun Sha Dusang Sun Ting Pan Tao Lei Source Type: research
Tyrosol attenuates lipopolysaccharide ‑induced inflammation in HUVECs to promote vascular health against atherosclerosis challenge
Exp Ther Med. 2023 Apr 6;25(5):240. doi: 10.3892/etm.2023.11939. eCollection 2023 May.ABSTRACTThe role of vascular endothelial cells in acute and chronic vascular inflammatory response has long been recognized. Therefore, persistent vascular inflammation may lead to endothelial dysfunction, thus resulting in the release of pro-inflammatory cytokines and the expression of adhesion molecules, which in turn promote monocyte/macrophage adhesion. Inflammation serves a key role in the development of vascular diseases, such as atherosclerosis. Tyrosol is a natural polyphenolic compound with diverse biological functions, found in ...
Source: Experimental and Therapeutic Medicine - April 28, 2023 Category: General Medicine Authors: Weiwei Zhao Huizhen Wei Jun Lu Wenjun Sha Dusang Sun Ting Pan Tao Lei Source Type: research
Tyrosol attenuates lipopolysaccharide ‑induced inflammation in HUVECs to promote vascular health against atherosclerosis challenge
Exp Ther Med. 2023 Apr 6;25(5):240. doi: 10.3892/etm.2023.11939. eCollection 2023 May.ABSTRACTThe role of vascular endothelial cells in acute and chronic vascular inflammatory response has long been recognized. Therefore, persistent vascular inflammation may lead to endothelial dysfunction, thus resulting in the release of pro-inflammatory cytokines and the expression of adhesion molecules, which in turn promote monocyte/macrophage adhesion. Inflammation serves a key role in the development of vascular diseases, such as atherosclerosis. Tyrosol is a natural polyphenolic compound with diverse biological functions, found in ...
Source: Atherosclerosis - April 28, 2023 Category: Cardiology Authors: Weiwei Zhao Huizhen Wei Jun Lu Wenjun Sha Dusang Sun Ting Pan Tao Lei Source Type: research
Tyrosol attenuates lipopolysaccharide ‑induced inflammation in HUVECs to promote vascular health against atherosclerosis challenge
Exp Ther Med. 2023 Apr 6;25(5):240. doi: 10.3892/etm.2023.11939. eCollection 2023 May.ABSTRACTThe role of vascular endothelial cells in acute and chronic vascular inflammatory response has long been recognized. Therefore, persistent vascular inflammation may lead to endothelial dysfunction, thus resulting in the release of pro-inflammatory cytokines and the expression of adhesion molecules, which in turn promote monocyte/macrophage adhesion. Inflammation serves a key role in the development of vascular diseases, such as atherosclerosis. Tyrosol is a natural polyphenolic compound with diverse biological functions, found in ...
Source: Experimental and Therapeutic Medicine - April 28, 2023 Category: General Medicine Authors: Weiwei Zhao Huizhen Wei Jun Lu Wenjun Sha Dusang Sun Ting Pan Tao Lei Source Type: research
The ovarian-related effects of polystyrene nanoplastics on human ovarian granulosa cells and female mice
This study aimed to explore the effects of NPs on female reproduction using human ovarian granulosa cells (GCs) and female mice. The accumulation of polystyrene NPs (PS-NPs) in human granulosa-like tumor cells (KGN cells) and the ovaries of female Balb/c mice were evaluated by exposure to fluorescent PS-NPs. Proliferation and apoptosis, reactive oxygen species (ROS), and Hippo signaling pathway-related factors were analyzed in KGN cells. In addition, fertility rate, litter size, ovarian weight and microstructure, follicle development, serum level of anti-Mullerian hormone, and apoptosis in ovaries were examined in female m...
Source: Ecotoxicology and Environmental Safety - April 21, 2023 Category: Environmental Health Authors: Lianjie Zeng Chong Zhou Wenqing Xu Yupei Huang Wencan Wang Zhangqiang Ma Jian Huang Jia Li Liaoliao Hu Yue Xue Tao Luo Liping Zheng Source Type: research
The ovarian-related effects of polystyrene nanoplastics on human ovarian granulosa cells and female mice
This study aimed to explore the effects of NPs on female reproduction using human ovarian granulosa cells (GCs) and female mice. The accumulation of polystyrene NPs (PS-NPs) in human granulosa-like tumor cells (KGN cells) and the ovaries of female Balb/c mice were evaluated by exposure to fluorescent PS-NPs. Proliferation and apoptosis, reactive oxygen species (ROS), and Hippo signaling pathway-related factors were analyzed in KGN cells. In addition, fertility rate, litter size, ovarian weight and microstructure, follicle development, serum level of anti-Mullerian hormone, and apoptosis in ovaries were examined in female m...
Source: Ecotoxicology and Environmental Safety - April 21, 2023 Category: Environmental Health Authors: Lianjie Zeng Chong Zhou Wenqing Xu Yupei Huang Wencan Wang Zhangqiang Ma Jian Huang Jia Li Liaoliao Hu Yue Xue Tao Luo Liping Zheng Source Type: research
Multi-pathway neuroprotective effects of a novel salidroside derivative SHPL-49 against acute cerebral ischemic injury
Eur J Pharmacol. 2023 Apr 12:175716. doi: 10.1016/j.ejphar.2023.175716. Online ahead of print.ABSTRACTSHPL-49 ((2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-(4-methoxyphenyl) butoxy) tetrahydro-2H-pyran-3,4,5-triol) is a novel glycoside derivative obtained from structural modification of salidroside, which is isolated from the medicinal plant Rhodiola rosea L. SHPL-49 was administered to rats with permanent middle cerebral artery occlusion (pMCAO) for 5 days, and it was found that SHPL-49 could alleviate the cerebral infarct volume and reduce the neurological deficit score. Moreover, the effective time window of SHPL-49 in the p...
Source: European Journal of Pharmacology - April 14, 2023 Category: Drugs & Pharmacology Authors: Pei Zhang Jiazhen Xu Qianfei Cui Guoqiang Lin Feiyun Wang Xinyue Ding Suxin You Nina Sang Junchao Tan Wenwen Xu Changsen Zhan Yuying Zhu Jiange Zhang Source Type: research
Multi-pathway neuroprotective effects of a novel salidroside derivative SHPL-49 against acute cerebral ischemic injury
Eur J Pharmacol. 2023 Apr 12:175716. doi: 10.1016/j.ejphar.2023.175716. Online ahead of print.ABSTRACTSHPL-49 ((2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-(4-methoxyphenyl) butoxy) tetrahydro-2H-pyran-3,4,5-triol) is a novel glycoside derivative obtained from structural modification of salidroside, which is isolated from the medicinal plant Rhodiola rosea L. SHPL-49 was administered to rats with permanent middle cerebral artery occlusion (pMCAO) for 5 days, and it was found that SHPL-49 could alleviate the cerebral infarct volume and reduce the neurological deficit score. Moreover, the effective time window of SHPL-49 in the p...
Source: European Journal of Pharmacology - April 14, 2023 Category: Drugs & Pharmacology Authors: Pei Zhang Jiazhen Xu Qianfei Cui Guoqiang Lin Feiyun Wang Xinyue Ding Suxin You Nina Sang Junchao Tan Wenwen Xu Changsen Zhan Yuying Zhu Jiange Zhang Source Type: research
Efficacy and safety of three species of Rhodiola L. in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis
Conclusion: Among the Rhodiola L. genus, this review included R. wallichiana, R. crenulata, and R. kirilowii, which might be safe and effective in COPD. Although this study has several limitations, further RCTs are needed.Systematic Review Registration: [https://www.crd.york.ac.uk/PROSPERO/ display_record.php?RecordID=302881], identifier [CRD42022361890]. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 6, 2023 Category: Drugs & Pharmacology Source Type: research
