Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via P2X7/NF- κB/NLRP3 Signaling Pathway
Depression is a common and serious mental disorder. Data on its pathogenesis remain unclear and the options of drug treatments are limited. Here, we explored the role of pyroptosis, a novel pro-inflammatory programmed cell death process, in depression as well as the anti-depression effects and mechanisms of salidroside (Sal), a bioactive extract from Rhodiola rosea L. We established a corticosterone (CORT)-induced or lipopolysaccharide (LPS)-induced mice in vivo, and CORT, or nigericin (NLRP3 agonist)-induced PC12 cells in vitro. Our findings demonstrated that Sal profoundly mediated CORT or LPS-induced depressive behavior...
Source: Frontiers in Pharmacology - April 12, 2022 Category: Drugs & Pharmacology Source Type: research
Genome-wide Identification and Expression Analysis of RcMYB Genes in Rhodiola crenulata
Modern research has proved that the main medicinal component of Rhodiola crenulata, which has a wide range of medicinal value, is its secondary metabolite salidroside. The MYB transcription factor family is widely involved in biosynthesis of second metabolism and other roles in the stress response in plants, so a genome-wide identification and analysis for this family in R. crenulata is worth conducting. In this research, genome-wide analysis identified 139 MYB genes based on conserved domains in the R. crenulata genome, and 137 genes were used to construct a phylogenetic tree and modified with expression files to reveal e...
Source: Frontiers in Genetics - March 31, 2022 Category: Genetics & Stem Cells Source Type: research
Enhanced Production of Phenylethanoids Mediated Through Synergistic Approach of Precursor Feeding and Light Regime in Cell Suspension Culture of Rhodiola imbricata (Edgew.)
Appl Biochem Biotechnol. 2022 Mar 29. doi: 10.1007/s12010-022-03914-8. Online ahead of print.ABSTRACTPrecursor feeding is a potential strategy for increasing specialized metabolite production in plant cell culture systems. In the present study, cell suspension cultures were developed and subsequently evaluated for precursor feeding investigations. Cell suspension cultures were established in Murashige and Skoog (MS) medium containing 0.5 mg/L thidiazuron (TDZ) + 1 mg/L α-naphthalene acetic acid (NAA). The growth biomass and metabolite pattern were analyzed to identify specific culture days required for prolific biomass pr...
Source: Applied Biochemistry and Biotechnology - March 29, 2022 Category: Biochemistry Authors: Shiv Rattan Anil Kumar Dinesh Kumar Ashish R Warghat Source Type: research
Enhanced Production of Phenylethanoids Mediated Through Synergistic Approach of Precursor Feeding and Light Regime in Cell Suspension Culture of Rhodiola imbricata (Edgew.)
Appl Biochem Biotechnol. 2022 Mar 29. doi: 10.1007/s12010-022-03914-8. Online ahead of print.ABSTRACTPrecursor feeding is a potential strategy for increasing specialized metabolite production in plant cell culture systems. In the present study, cell suspension cultures were developed and subsequently evaluated for precursor feeding investigations. Cell suspension cultures were established in Murashige and Skoog (MS) medium containing 0.5 mg/L thidiazuron (TDZ) + 1 mg/L α-naphthalene acetic acid (NAA). The growth biomass and metabolite pattern were analyzed to identify specific culture days required for prolific biomass pr...
Source: Cell Research - March 29, 2022 Category: Cytology Authors: Shiv Rattan Anil Kumar Dinesh Kumar Ashish R Warghat Source Type: research
Enhanced Production of Phenylethanoids Mediated Through Synergistic Approach of Precursor Feeding and Light Regime in Cell Suspension Culture of Rhodiola imbricata (Edgew.)
Appl Biochem Biotechnol. 2022 Mar 29. doi: 10.1007/s12010-022-03914-8. Online ahead of print.ABSTRACTPrecursor feeding is a potential strategy for increasing specialized metabolite production in plant cell culture systems. In the present study, cell suspension cultures were developed and subsequently evaluated for precursor feeding investigations. Cell suspension cultures were established in Murashige and Skoog (MS) medium containing 0.5 mg/L thidiazuron (TDZ) + 1 mg/L α-naphthalene acetic acid (NAA). The growth biomass and metabolite pattern were analyzed to identify specific culture days required for prolific biomass pr...
Source: Applied Biochemistry and Biotechnology - March 29, 2022 Category: Biochemistry Authors: Shiv Rattan Anil Kumar Dinesh Kumar Ashish R Warghat Source Type: research
Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce
CONCLUSIONS: Based on the current data and clinician input, a range of nutraceuticals and phytoceuticals were given either a supportive recommendation or a provisional recommendation across a range of various psychiatric disorders. However several had only a weak endorsement for potential use; for a few it was not possible to reach a clear recommendation direction, largely due to mixed study findings; while some other agents showed no obvious therapeutic benefit and were clearly not recommended for use. It is the intention of these guidelines to inform psychiatric/medical, and health professional practice globally.PMID:353...
Source: The World Journal of Biological Psychiatry - March 21, 2022 Category: Psychiatry Authors: Jerome Sarris Arun Ravindran Lakshmi N Yatham Wolfgang Marx Julia J Rucklidge Roger S McIntyre Shahin Akhondzadeh Francesco Benedetti Constanza Caneo Holger Cramer Lachlan Cribb Michael de Manincor Olivia Dean Andrea Camaz Deslandes Marlene P Freeman Bang Source Type: research
Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce
CONCLUSIONS: Based on the current data and clinician input, a range of nutraceuticals and phytoceuticals were given either a supportive recommendation or a provisional recommendation across a range of various psychiatric disorders. However several had only a weak endorsement for potential use; for a few it was not possible to reach a clear recommendation direction, largely due to mixed study findings; while some other agents showed no obvious therapeutic benefit and were clearly not recommended for use. It is the intention of these guidelines to inform psychiatric/medical, and health professional practice globally.PMID:353...
Source: The World Journal of Biological Psychiatry - March 21, 2022 Category: Psychiatry Authors: Jerome Sarris Arun Ravindran Lakshmi N Yatham Wolfgang Marx Julia J Rucklidge Roger S McIntyre Shahin Akhondzadeh Francesco Benedetti Constanza Caneo Holger Cramer Lachlan Cribb Michael de Manincor Olivia Dean Andrea Camaz Deslandes Marlene P Freeman Bang Source Type: research
Mania Associated With Rhodiola Rosea: An Adaptogen With Antidepressant Effects
Prim Care Companion CNS Disord. 2022 Mar 17;24(2):21cr02980. doi: 10.4088/PCC.21cr02980.NO ABSTRACTPMID:35303403 | DOI:10.4088/PCC.21cr02980 (Source: The Primary Care Companion for CNS Disorders)
Source: The Primary Care Companion for CNS Disorders - March 18, 2022 Category: Primary Care Authors: Rahat Whig Raphael J Leo Source Type: research
Mania Associated With Rhodiola Rosea: An Adaptogen With Antidepressant Effects
Prim Care Companion CNS Disord. 2022 Mar 17;24(2):21cr02980. doi: 10.4088/PCC.21cr02980.NO ABSTRACTPMID:35303403 | DOI:10.4088/PCC.21cr02980 (Source: Primary Care)
Source: Primary Care - March 18, 2022 Category: Primary Care Authors: Rahat Whig Raphael J Leo Source Type: research
Mania Associated With Rhodiola Rosea: An Adaptogen With Antidepressant Effects
Prim Care Companion CNS Disord. 2022 Mar 17;24(2):21cr02980. doi: 10.4088/PCC.21cr02980.NO ABSTRACTPMID:35303403 | DOI:10.4088/PCC.21cr02980 (Source: The Primary Care Companion for CNS Disorders)
Source: The Primary Care Companion for CNS Disorders - March 18, 2022 Category: Primary Care Authors: Rahat Whig Raphael J Leo Source Type: research
