Molecules, Vol. 27, Pages 7335: Chemical Profiling and Biological Activity of Extracts from Nine Norwegian Medicinal and Aromatic Plants
s Rosnes
There is an increased interest in identifying beneficial compounds of plant origin that can be added to animal diets to improve animal performance and have a health-promoting effect. In the present study, nine herb species of the Norwegian wild flora or which can be cultivated in Norway were selected for phytogenic evaluation (hops, maral root, mint, oregano, purslane, rosemary, roseroot, sweet wormwood, yarrow). Dried herbs were sequentially extracted with dichloromethane (DCM), ethanol (EtOH) and finally water (H2O) by ultrasound-assisted extraction (UAE). The UAE protocol was found to be more rational than ...
Source: Molecules - October 28, 2022 Category: Chemistry Authors: Rune Slimestad Amritha Johny Mette Goul Thomsen Christian Ren è Karlsen Jan Thomas Rosnes Tags: Article Source Type: research
Pharmacological effects of salidroside on central nervous system diseases
Biomed Pharmacother. 2022 Oct 10;156:113746. doi: 10.1016/j.biopha.2022.113746. Online ahead of print.ABSTRACTSalidroside (SAL) is a phenylpropanoid glycoside monomer extracted from Rhodiola at high altitudes. It has been proven to have protective effects on myocardial injury, liver cancer, renal fibrosis, and other organ diseases, as well as play neuroprotective roles in central nervous system (CNS) diseases. Specifically, SAL can inhibit a series of pathological reactions in CNS diseases and improve neurological dysfunction. This review elucidated the pharmacological effects of SAL on inflammation, oxidative stress, apop...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 13, 2022 Category: Drugs & Pharmacology Authors: Meihua Jin Chun Wang Yifeng Xu Zijing Zhang Xueyan Wu Runfa Ye Qinggao Zhang Donghe Han Source Type: research
Pharmacological effects of salidroside on central nervous system diseases
Biomed Pharmacother. 2022 Oct 10;156:113746. doi: 10.1016/j.biopha.2022.113746. Online ahead of print.ABSTRACTSalidroside (SAL) is a phenylpropanoid glycoside monomer extracted from Rhodiola at high altitudes. It has been proven to have protective effects on myocardial injury, liver cancer, renal fibrosis, and other organ diseases, as well as play neuroprotective roles in central nervous system (CNS) diseases. Specifically, SAL can inhibit a series of pathological reactions in CNS diseases and improve neurological dysfunction. This review elucidated the pharmacological effects of SAL on inflammation, oxidative stress, apop...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 13, 2022 Category: Drugs & Pharmacology Authors: Meihua Jin Chun Wang Yifeng Xu Zijing Zhang Xueyan Wu Runfa Ye Qinggao Zhang Donghe Han Source Type: research
Salidroside in the treatment of NAFLD/NASH
In conclusion, although the multiple bioactivities of SDS have been confirmed, the clinical data are inadequate and need to become the focus of attention in the later study.PMID:36210339 | DOI:10.1002/cbdv.202200401 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - October 9, 2022 Category: Biochemistry Authors: Baozhen Qu Xuemao Liu Yanjiao Liang Keke Zheng Chunling Zhang Linlin Lu Source Type: research
Gut microbiota profiling revealed the regulating effects of salidroside on iron metabolism in diabetic mice
ConclusionsSAL could reduce the glucose level and protect against diabetic cardiomyopathy in diabetic mice, which might be mediated by the change in the gut microbiota and the regulation of iron metabolism. The findings suggested that SAL was a promising complementary option for diabetes therapy. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - September 23, 2022 Category: Endocrinology Source Type: research
The Mechanism of Volatile Oil of < em > Rhodiola tangutica < /em > against Hypoxia-Induced Pulmonary Hypertension in Rats Based on RAS Pathway
CONCLUSIONS: HPH rat model as established based on the significant increased mPAP and RVHI. VORA presented a significant antihypoxia function plus an inhibiting effect on PASMC proliferation induced by hypoxia. Moreover, VORA treatment inhibited oxidative stress among PASMCs. With regard to the mechanism, VORA reduced ACE, AngII, and AT1R protein expressions but increased ACE2 and MAS protein expressions. There were 48 constituents in VORA identified by GC-MS.PMID:36110120 | PMC:PMC9470319 | DOI:10.1155/2022/9650650 (Source: Biomed Res)
Source: Biomed Res - September 16, 2022 Category: Research Authors: Xingmei Nan Zhanting Yang Shanshan Su Zhengnan Huang Ke Ma Shengrong Xu E Zhang Dianxiang Lu Zhanqiang Li Source Type: research
The Mechanism of Volatile Oil of < em > Rhodiola tangutica < /em > against Hypoxia-Induced Pulmonary Hypertension in Rats Based on RAS Pathway
CONCLUSIONS: HPH rat model as established based on the significant increased mPAP and RVHI. VORA presented a significant antihypoxia function plus an inhibiting effect on PASMC proliferation induced by hypoxia. Moreover, VORA treatment inhibited oxidative stress among PASMCs. With regard to the mechanism, VORA reduced ACE, AngII, and AT1R protein expressions but increased ACE2 and MAS protein expressions. There were 48 constituents in VORA identified by GC-MS.PMID:36110120 | PMC:PMC9470319 | DOI:10.1155/2022/9650650 (Source: Cell Research)
Source: Cell Research - September 16, 2022 Category: Cytology Authors: Xingmei Nan Zhanting Yang Shanshan Su Zhengnan Huang Ke Ma Shengrong Xu E Zhang Dianxiang Lu Zhanqiang Li Source Type: research
The Mechanism of Volatile Oil of < em > Rhodiola tangutica < /em > against Hypoxia-Induced Pulmonary Hypertension in Rats Based on RAS Pathway
CONCLUSIONS: HPH rat model as established based on the significant increased mPAP and RVHI. VORA presented a significant antihypoxia function plus an inhibiting effect on PASMC proliferation induced by hypoxia. Moreover, VORA treatment inhibited oxidative stress among PASMCs. With regard to the mechanism, VORA reduced ACE, AngII, and AT1R protein expressions but increased ACE2 and MAS protein expressions. There were 48 constituents in VORA identified by GC-MS.PMID:36110120 | PMC:PMC9470319 | DOI:10.1155/2022/9650650 (Source: Biomed Res)
Source: Biomed Res - September 16, 2022 Category: Research Authors: Xingmei Nan Zhanting Yang Shanshan Su Zhengnan Huang Ke Ma Shengrong Xu E Zhang Dianxiang Lu Zhanqiang Li Source Type: research
The Mechanism of Volatile Oil of < em > Rhodiola tangutica < /em > against Hypoxia-Induced Pulmonary Hypertension in Rats Based on RAS Pathway
CONCLUSIONS: HPH rat model as established based on the significant increased mPAP and RVHI. VORA presented a significant antihypoxia function plus an inhibiting effect on PASMC proliferation induced by hypoxia. Moreover, VORA treatment inhibited oxidative stress among PASMCs. With regard to the mechanism, VORA reduced ACE, AngII, and AT1R protein expressions but increased ACE2 and MAS protein expressions. There were 48 constituents in VORA identified by GC-MS.PMID:36110120 | PMC:PMC9470319 | DOI:10.1155/2022/9650650 (Source: Biomed Res)
Source: Biomed Res - September 16, 2022 Category: Research Authors: Xingmei Nan Zhanting Yang Shanshan Su Zhengnan Huang Ke Ma Shengrong Xu E Zhang Dianxiang Lu Zhanqiang Li Source Type: research
The Mechanism of Volatile Oil of < em > Rhodiola tangutica < /em > against Hypoxia-Induced Pulmonary Hypertension in Rats Based on RAS Pathway
CONCLUSIONS: HPH rat model as established based on the significant increased mPAP and RVHI. VORA presented a significant antihypoxia function plus an inhibiting effect on PASMC proliferation induced by hypoxia. Moreover, VORA treatment inhibited oxidative stress among PASMCs. With regard to the mechanism, VORA reduced ACE, AngII, and AT1R protein expressions but increased ACE2 and MAS protein expressions. There were 48 constituents in VORA identified by GC-MS.PMID:36110120 | PMC:PMC9470319 | DOI:10.1155/2022/9650650 (Source: Biomed Res)
Source: Biomed Res - September 16, 2022 Category: Research Authors: Xingmei Nan Zhanting Yang Shanshan Su Zhengnan Huang Ke Ma Shengrong Xu E Zhang Dianxiang Lu Zhanqiang Li Source Type: research
Molecules, Vol. 27, Pages 6058: Traditional Chinese Medicine Rhodiola Sachalinensis Borissova from Baekdu Mountain (RsBBM) for Rheumatoid Arthritis: Therapeutic Effect and Underlying Molecular Mechanisms
Shi
Wenliang Li
The lack of effective rheumatoid arthritis (RA) therapies is a persistent challenge worldwide, prompting researchers to urgently evaluate traditional Chinese medicines (TCMs) as potential clinical RA treatments. The present investigation was conducted to evaluate the therapeutic effects and potential molecular mechanisms of the active components isolated from TCM Rhodiola sachalinensis Borissova from Baekdu Mountain (RsBBM) using an experimental adjuvant arthritis model induced by injection of rats with Freund&rsquo;s complete adjuvant. After induction of the adjuvant arthritis rat model, the ...
Source: Molecules - September 16, 2022 Category: Chemistry Authors: Yinghui Ma Jinbei Zhang Huan Yu Yanfei Zhang Huifeng Zhang Chengyi Hao Lili Zuo Nianqiu Shi Wenliang Li Tags: Article Source Type: research
Protective effect of salidroside on streptozotocin-induced diabetic nephropathy by inhibiting oxidative stress and inflammation in rats via the Akt/GSK-3 β signalling pathway
CONCLUSION: The present study validated the involvement of the Akt/GSK-3β signalling pathway in renal improvement. These findings can form the basis to investigate the protective effect of SAL in DN in clinical trials.PMID:36086879 | PMC:PMC9467606 | DOI:10.1080/13880209.2022.2116055 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 10, 2022 Category: Drugs & Pharmacology Authors: Delong Pei Shengri Tian Yanqiu Bao Jun Zhang Dongyuan Xu Minhu Piao Source Type: research
Protective effect of salidroside on streptozotocin-induced diabetic nephropathy by inhibiting oxidative stress and inflammation in rats via the Akt/GSK-3 β signalling pathway
CONCLUSION: The present study validated the involvement of the Akt/GSK-3β signalling pathway in renal improvement. These findings can form the basis to investigate the protective effect of SAL in DN in clinical trials.PMID:36086879 | DOI:10.1080/13880209.2022.2116055 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 10, 2022 Category: Drugs & Pharmacology Authors: Delong Pei Shengri Tian Yanqiu Bao Jun Zhang Dongyuan Xu Minhu Piao Source Type: research
Molecules, Vol. 27, Pages 5888: Rosiridin Attenuates Scopolamine-Induced Cognitive Impairments in Rats via Inhibition of Oxidative and Nitrative Stress Leaded Caspase-3/9 and TNF- & alpha; Signaling Pathways
Conclusion: A significant behavioral parameter restoration was seen in the rosiridin-treated group, including reduction in latency time during acquisition and retention trial in the Morris water maze test, and percentage of spontaneous alterations in the y-maze test, when compared to the disease control group that received scopolamine; rosiridin also altered the oxidative stress and neuroinflammatory markers, as well as restoring Ach and ChAT activities and normalizing GSH, SOD, MDA, TNF-&alpha;, nitrate, IL-1&beta;, IL-6, IFN-&#42857;, caspases 3 and 9 levels. The results imply that rosiridin limit...
Source: Molecules - September 10, 2022 Category: Chemistry Authors: Muhammad Afzal Sami I. Alzarea Khalid Saad Alharbi Abdulaziz I. Alzarea Sattam Khulaif Alenezi Mohammed Salem Alshammari Ali H. Alquraini Imran Kazmi Tags: Article Source Type: research
Tibetan medicine salidroside improves host anti-mycobacterial response by boosting inflammatory cytokine production in zebrafish
The treatment for tuberculosis (TB), especially multidrug-resistant TB (MDR-TB), has a prolonged cycle which can last up to a year. This is partially due to the lack of effective therapies. The development of novel anti-TB drugs from the perspective of host immune regulation can provide an important supplement for conventional treatment strategies. Salidroside (SAL), a bioactive component from the Tibetan medicine Rhodiola rosea, has been used in the treatment of TB, although its mechanism remains unclear. Here, the bacteriostatic effect of SAL in vivo was first demonstrated using a zebrafish–M. marinum infection model. ...
Source: Frontiers in Pharmacology - August 31, 2022 Category: Drugs & Pharmacology Source Type: research
