The Mechanism of Volatile Oil of < em > Rhodiola tangutica < /em > against Hypoxia-Induced Pulmonary Hypertension in Rats Based on RAS Pathway

CONCLUSIONS: HPH rat model as established based on the significant increased mPAP and RVHI. VORA presented a significant antihypoxia function plus an inhibiting effect on PASMC proliferation induced by hypoxia. Moreover, VORA treatment inhibited oxidative stress among PASMCs. With regard to the mechanism, VORA reduced ACE, AngII, and AT1R protein expressions but increased ACE2 and MAS protein expressions. There were 48 constituents in VORA identified by GC-MS.PMID:36110120 | PMC:PMC9470319 | DOI:10.1155/2022/9650650

Source: Biomed Res - September 16, 2022 Category: Research Authors: Xingmei Nan Zhanting Yang Shanshan Su Zhengnan Huang Ke Ma Shengrong Xu E Zhang Dianxiang Lu Zhanqiang Li Source Type: research