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Salidroside suppresses cell growth and inflammatory response of fibroblast-like synoviocytes via inhibition of phosphoinositol-3 kinase/threonine kinase signaling in rheumatoid arthritis
CONCLUSION: Sal suppressed cell growth and inflammation in RA-FLSs by inactivating PI3K/AKT-signaling pathways.PMID:37851166 | DOI:10.1007/s00393-023-01431-5 (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - October 18, 2023 Category: Rheumatology Authors: Yajing Qin Juan Su Source Type: research

Rosavin regulates bone homeostasis through HDAC1-induced epigenetic regulation of EEF2
Chem Biol Interact. 2023 Sep 7:110696. doi: 10.1016/j.cbi.2023.110696. Online ahead of print.ABSTRACTBioactive constituents from Rhodiola rosea L. show a myriad of pharmacological effects on diverse diseases. Rosavin has been linked to reduced osteoclastogenesis, while its role in regulating osteogenesis remains unclear. The present study investigated whether and how Rosavin alleviates ovariectomy (OVX)-induced osteoporosis (OP) in mice. Rosavin had a therapeutic effect on OP in ovariectomized mice and inhibited osteoclast viability and promoted osteoblast viability. Integrated transcriptome sequencing, GO enrichment analy...
Source: Chemico-Biological Interactions - September 9, 2023 Category: Molecular Biology Authors: Wenhao Zhang Leilei Yu Fang Wang Minjie Chen Hui Li Source Type: research

Genes, Vol. 14, Pages 1729: Salidroside Supplementation Affects In Vitro Maturation and Preimplantation Embryonic Development by Promoting Meiotic Resumption
ang Yongxun Jin Salidroside (Sal) possesses several pharmacological activities, such as antiaging, and anti-inflammatory, antioxidant, anticancer activities, and proliferation-promoting activities, but the effects of Sal on oocytes have rarely been reported. In the present study, we evaluated the beneficial effects of Sal, which is mainly found in the roots of Rhodiola. Porcine cumulus oocyte complexes were cultured in IVM medium supplemented (with 250 &mu;mol/L) with Sal or not supplemented with Sal. The maturation rate in the Sal group increased from 88.34 &plusmn; 4.32% to 94.12 &plusmn; 2....
Source: Genes - August 30, 2023 Category: Genetics & Stem Cells Authors: Shuming Shi Zhaojun Geng Xianfeng Yu Bing Hu Liying Liu Zhichao Chi Linyi Qu Mingjun Zhang Yongxun Jin Tags: Article Source Type: research

 Rhodiola Rosea as an Adaptogen to Enhance Exercise Performance: A Review of the Literature
Br J Nutr. 2023 Aug 29:1-27. doi: 10.1017/S0007114523001988. Online ahead of print.ABSTRACTRhodiola rosea (RR) is a plant whose bioactive components may function as adaptogens, thereby increasing resistance to stress and improving overall resilience. Some of these effects may influence exercise performance and adaptations. Based on studies of rodents, potential mechanisms for the ergogenic effects of RR include modulation of energy substrate stores and use, reductions in fatigue and muscle damage, and altered antioxidant activity. At least 16 investigations in humans have explored the potential ergogenicity of RR. These st...
Source: The British Journal of Nutrition - August 29, 2023 Category: Nutrition Authors: Grant M Tinsley Andrew R Jagim Gregory D M Potter Dan Garner Andrew J Galpin Source Type: research

Adsorption properties of active biochar: Overlooked role of the structure of biomass
In conclusion, the protection of vascular bundle during biochar preparation is important to improve the utilization of biological resources and environmental adsorption.PMID:37598803 | DOI:10.1016/j.biortech.2023.129695 (Source: Bioresource Technology)
Source: Bioresource Technology - August 20, 2023 Category: Biotechnology Authors: Fangke Zhi Wenjing Zhou Jingru Chen Yumeng Meng Xiaohong Hou Jianhua Qu Yudan Zhao Qi Hu Source Type: research

Effect of Rhodiola rosea Rhizome and Punica granatum Fruit Peel on the Metabolic Processes and Physiological Activity of Rats Fed with Excessively Fat Diet
CONCLUSIONS: Body mass of rats fed with golden root (R. rosea) reached 125.8 % of the initial body mass; when fed on pomegranate (P. granatum), it reached 123.9 %; and the control group reached only 111.5 % of the initial body mass. The rhizomes of R. rosea in the diet of male rats during the month of the experiment did not cause significant changes in the relative organ mass, and the pomegranate peel fruits led to a decrease in the thymus relative mass, as well as liver and brain. R. rosea rhizomes in the rats' diet led to an increase in the activity of alkaline phosphatase, and also to a decrease in the concentration of ...
Source: Atherosclerosis - July 17, 2023 Category: Cardiology Authors: Maryna Lieshchova Viktor Brygadyrenko Source Type: research

Salidroside affects the Th17/Treg cell balance in aplastic anemia via the STAT3/HIF-1 α/RORγt pathway
CONCLUSION: Salidroside has potential as a novel AA treatment by correcting the Th17/Treg imbalance through the STAT3/HIF-1α/RORγt pathway.PMID:37439434 | PMC:PMC10348039 | DOI:10.1080/13510002.2023.2225868 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - July 13, 2023 Category: Biochemistry Authors: Zenghui Liu Lixuan Chen Defang Xiong Yu Zhan Jiduo Liu Ling Ouyang Wancheng Chen Ziyuan Lu Tianqi Gao Xiaozhen Li Yanqun Zhou Xuekui Gu Yang Xiao Source Type: research

Salidroside affects the Th17/Treg cell balance in aplastic anemia via the STAT3/HIF-1 α/RORγt pathway
CONCLUSION: Salidroside has potential as a novel AA treatment by correcting the Th17/Treg imbalance through the STAT3/HIF-1α/RORγt pathway.PMID:37439434 | DOI:10.1080/13510002.2023.2225868 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - July 13, 2023 Category: Biochemistry Authors: Zenghui Liu Lixuan Chen Defang Xiong Yu Zhan Jiduo Liu Ling Ouyang Wancheng Chen Ziyuan Lu Tianqi Gao Xiaozhen Li Yanqun Zhou Xuekui Gu Yang Xiao Source Type: research