[Muscle weakness and CK elevation: is it myositis?]
This article presents two cases from this hospital where the diagnosis could be only be determined by muscle biopsy. In the first case the patient presented with muscle weakness, pathological weight loss and a significant increase in CK levels. A muscle biopsy revealed an immune-mediated necrotizing myopathy (IMNM) caused by anti-3-hydroxy-3-methyl-gulatryl-CoA reductase (HMG-CoA reductase) autoantibodies due to the intake of statins. The second patient presented with cramp-like and burning muscle pain and weakness of the extremities without a relevant increase in CK level. Myoadenylate deaminase deficiency was a...
Source: Zeitschrift fur Rheumatologie - May 27, 2020 Category: Rheumatology Authors: Kernder A, Mucke J, Moldovan AS, Albrecht P, Neuen-Jacob E, Schneider M Tags: Z Rheumatol Source Type: research

[Antinuclear antibodies in the diagnostics of rheumatic diseases].
r T Abstract Testing for antinuclear antibodies (ANA) on human epithelial cell lines (HEp-2) using indirect immunofluorescence (IIF) is central for ruling out or for diagnosing connective tissue diseases and other diseases, such as primary biliary cholangitis and autoimmune hepatitis as well as drug-induced ANA. The comprehensive description of 29 different ANA-IIF patterns by the international consensus of ANA patterns (ICAP) facilitates the harmonization of ANA-IIF diagnostics. Positive ANA tests are frequently observed in healthy individuals and a reason for referral to rheumatologists. In these cases...
Source: Zeitschrift fur Rheumatologie - May 26, 2020 Category: Rheumatology Authors: Rose T, Dörner T Tags: Z Rheumatol Source Type: research

[Treatment of Takayasu arteritis].
Abstract Despite advances in the diagnosis and treatment, the mortality rate of Takayasu arteritis (TAK) is still elevated even today. The diagnosis is often made after a long time delay and the course of the disease is characterized by progressive structural vascular lesions. Recently, new recommendations for the management of large vessel vasculitis were published by the European League Against Rheumatism (EULAR). For induction of remission oral glucocorticoids (GC) are administered in an initial daily dose of 40-60 mg. As experience has shown that the cumulative GC demand in TAK is high, GC-sparing treat...
Source: Zeitschrift fur Rheumatologie - May 19, 2020 Category: Rheumatology Authors: Hellmich B Tags: Z Rheumatol Source Type: research

[Long-term complications, monitoring and interventional treatment of large vessel vasculitis].
th M Abstract Giant cell arteritis (GCA) and Takayasu's arteritis (TAK) both belong to the group of large vessel vasculitides and require long-term drug treatment. Glucocorticoids (GC) are the first choice for the treatment of both diseases. For GCA immunosuppressants, such as tocilizumab or methotrexate should be considered in cases of treatment refractory and relapses or if there is a high risk for GC-related adverse events. In TAK patients the use of immunosuppressive agents should be considered for all patients. In the course of the disease, severe disease-associated and treatment-associated complications...
Source: Zeitschrift fur Rheumatologie - May 19, 2020 Category: Rheumatology Authors: Wipfler-Freißmuth E, Dejaco C, Both M Tags: Z Rheumatol Source Type: research

[Pathogenesis of large vessel vasculitides].
Abstract Large vessel vasculitides comprise two distinct entities, giant cell arteritis (GCA) and Takayasu arteritis (TAK). GCA is the most common vasculitis in central Europe, becoming manifested at an age over 50 years. In contrast, the much rarer TAK affects almost exclusively young adults and mostly women. Both vasculitides are granulomatous arteritides affecting mainly the aorta and its major arterial branches. GCA and TAK are associated with different major histocompatibility complex genes. Infections possibly play a role in the initiation of large vessel vasculitides. Activation of dendritic cells...
Source: Zeitschrift fur Rheumatologie - May 19, 2020 Category: Rheumatology Authors: Arnold S, Holl Ulrich K, Lamprecht P Tags: Z Rheumatol Source Type: research

[Rheumatologists are in deep sorrow for Norbert Gschend].
gie, Berlin PMID: 32430567 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - May 19, 2020 Category: Rheumatology Authors: Gaulke R, Vorstände der Deutschen Gesellschaften für Rheumatologie und Orthopädische Rheumatologie, Berlin Tags: Z Rheumatol Source Type: research

[Erratum to: Biologicals and small molecules for rheumatoid arthritis].
l S PMID: 32415317 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - May 15, 2020 Category: Rheumatology Authors: Blüml S Tags: Z Rheumatol Source Type: research

[Cutaneous disorders caused by physical damage mimicking rheumatic diseases].
Abstract The skin is the primary interface between the body and the environment. It is exposed to a variety of external physical factors to which it must respond in a dynamic manner. In the following review such cutaneous reactions to physical damage are discussed under the aspects of rheumatological differential diagnoses. In particular, circumscribed hyperpigmentation and hyperkeratosis, reactive patterns to cold, with or without humidity, and lightning are presented. Most of these disorders do not need extensive laboratory investigations or imaging techniques. Knowledge of such cutaneous disease sympt...
Source: Zeitschrift fur Rheumatologie - May 14, 2020 Category: Rheumatology Authors: Wollina U Tags: Z Rheumatol Source Type: research

[The German Protection Against Infection Act after entry into force of the German Measles Protection Act].
Abstract On 1 March 2020, the amendments to the German Protection Against Infection Act that were introduced by the act to protect against measles and strengthen vaccination prevention (Measles Protection Act) entered into force. The reason for the changes is that the number of individuals with measles has significantly increased in recent years. To protect public health, the Measles Protection Act has implemented regulations requiring that persons in certain institutions must either have adequate protection against measles or have immunity to measles. In this article the current legal situation with regard to hea...
Source: Zeitschrift fur Rheumatologie - May 12, 2020 Category: Rheumatology Authors: Lissel PM Tags: Z Rheumatol Source Type: research

[Treatment of giant cell arteritis: what is in the pipeline?]
This article gives an overview on current treatment studies for GCA. PMID: 32399619 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - May 12, 2020 Category: Rheumatology Authors: Holle JU, Moosig F Tags: Z Rheumatol Source Type: research

[Classification of autoinflammatory diseases based on pathophysiological mechanisms].
Abstract Monogenic autoinflammatory diseases present with systemic inflammation with the involvement of multiple organs. With the help of modern molecular genetic techniques a large number of diseases with previously unknown pathomechanisms have been described in recent years. This knowledge can be utilized to group autoinflammatory diseases according to the signalling pathways involved and thus provide a better understanding of these entities. PMID: 32394046 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - May 11, 2020 Category: Rheumatology Authors: Kallinich T, Hinze C, Wittkowski H Tags: Z Rheumatol Source Type: research

Comparative efficacy and safety of tofacitinib, baricitinib, upadacitinib, and filgotinib in active rheumatoid arthritis refractory to biologic disease-modifying antirheumatic drugs.
CONCLUSION: Tofacitinib, baricitinib, upadacitinib, and filgotinib were effective treatment options for RA patients with an inadequate response to bDMARDs but with different efficacy and safety profiles. PMID: 32367211 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - May 4, 2020 Category: Rheumatology Authors: Lee YH, Song GG Tags: Z Rheumatol Source Type: research

[Autologous hematopoietic stem cell transplantation for autoimmune diseases : Current indications and mode of action, a review on behalf of the EBMT Autoimmune Diseases Working Party (ADWP)].
This article presents the current indications of AHSCT for autoimmune diseases based on the registry data of the European Society of Blood and Marrow Transplantation (EBMT) and discusses the results from mechanistic studies, which provide detailed insights into the mode of action of this treatment. PMID: 32356079 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - April 30, 2020 Category: Rheumatology Authors: Alexander T, Badoglio M, Henes J, Heesen C, Arnold R, Radbruch A, Snowden JA, Hiepe F Tags: Z Rheumatol Source Type: research

[Current guidance of the German Society of Rheumatology for the care of patients with rheumatic diseases during the SARS-CoV-2/Covid  19 pandemic].
[Current guidance of the German Society of Rheumatology for the care of patients with rheumatic diseases during the SARS-CoV-2/Covid 19 pandemic]. Z Rheumatol. 2020 Apr 27;: Authors: Schulze-Koops H, Holle J, Moosig F, Specker C, Aries P, Burmester G, Fiehn C, Hoyer B, Krause A, Leipe J, Lorenz HM, Schneider M, Sewerin P, Voormann A, Wager U, Krüger K, Iking-Konert C, im Auftrag der Kommission Pharmakotherapie und des Vorstandes der Deutschen Gesellschaft für Rheumatologie Abstract In the current SARS-CoV-2 pandemic there are many questions regarding the safe treatment of patients with ...
Source: Zeitschrift fur Rheumatologie - April 27, 2020 Category: Rheumatology Authors: Schulze-Koops H, Holle J, Moosig F, Specker C, Aries P, Burmester G, Fiehn C, Hoyer B, Krause A, Leipe J, Lorenz HM, Schneider M, Sewerin P, Voormann A, Wager U, Krüger K, Iking-Konert C, im Auftrag der Kommission Pharmakotherapie und des Vorstandes der Tags: Z Rheumatol Source Type: research

Circulating interleukin-23 levels in ankylosing spondylitis and their correlation with disease activity : A  meta-analysis.
Circulating interleukin-23 levels in ankylosing spondylitis and their correlation with disease activity : A meta-analysis. Z Rheumatol. 2020 Apr 26;: Authors: Lee YH, Song GG Abstract OBJECTIVE: To systematically investigate the relationship between circulating interleukin-23 (IL‑23) levels and ankylosing spondylitis (AS) and establish a correlation between these hematological indices and AS activity/severity. METHODS: We searched the Medline, Embase, and Cochrane databases; performed a meta-analysis comparing serum/plasma IL‑23 levels in patients with AS to those of controls; ...
Source: Zeitschrift fur Rheumatologie - April 26, 2020 Category: Rheumatology Authors: Lee YH, Song GG Tags: Z Rheumatol Source Type: research

Comparative efficacy and safety of mycophenolate mofetil versus cyclophosphamide in patients with active antineutrophil cytoplasmic antibody-associated vasculitis: a  meta-analysis of randomized trials.
CONCLUSION: MMF was an equally effective alternative treatment to CYC and MMF was comparable to CYC in patients with active AAV in terms of safety, suggesting that MMF can be used as an alternative to CYC for remission induction in AAV. PMID: 32337635 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - April 26, 2020 Category: Rheumatology Authors: Song GG, Lee YH Tags: Z Rheumatol Source Type: research

[Chronic chikungunya arthritis].
This article describes the case of a 48-year-old female traveller returning from Bangladesh who presented with persisting pain and joint swelling due to chikungunya virus infection, which had persisted for months. Typical symptoms are a high fever and musculoskeletal disorders, which can last for months up to years. The chronic inflammatory form is treated similarly to those recommended for other chronic inflammatory joint diseases. Due to the increasing prevalence of the virus and its vectors as well as the unbroken travel activity, an increase in imported cases in Europe and establishment of the pathogen in sou...
Source: Zeitschrift fur Rheumatologie - April 24, 2020 Category: Rheumatology Authors: Trawinski H, Krasselt M, Lübbert C Tags: Z Rheumatol Source Type: research

[Application of image-guided injection for cervical and lumbar syndromes].
Abstract The X‑ray image-guided injection methods are an important tool for the treatment of cervical and lumbar pain syndromes. For the application of these methods it is necessary to have a differentiated consideration of cervical and lumbar pain syndromes. This leads to a decoding of complaints to assignable pain generators, which enables a targeted injection method. Depending on the origin of pain, injections are placed at the nerve root or the joints. Thus, the vicious cycle of pain can be stopped. A correct technical procedure is of enormous importance. Particular attention must be paid...
Source: Zeitschrift fur Rheumatologie - April 24, 2020 Category: Rheumatology Authors: Faber F, Benditz A, Boluki D, Grifka J Tags: Z Rheumatol Source Type: research

[Mesenchymal stem cell treatment in autoimmune diseases].
er G Abstract Mesenchymal stromal or stem cells (MSC) possess strong immunomodulatory properties. Due to their impressive potential to differentiate into various cell types they are capable of inducing mechanisms of tissue repair. Experimental data have demonstrated impaired MSC function in several rheumatic diseases in vitro; however, the relevance of these phenomena for the pathogenesis of rheumatic disorders has not been convincingly demonstrated. Nevertheless, allogeneic MSC transplantation (MSCT), and possibly autologous MSCT as well, could prove to be an interesting instrument for the treatment of autoimmune...
Source: Zeitschrift fur Rheumatologie - April 22, 2020 Category: Rheumatology Authors: Keyßer G Tags: Z Rheumatol Source Type: research

[Autologous hematopoietic stem cell transplantation for systemic sclerosis : Position statement of the stem cell therapy working party of the German Society of Rheumatology].
e F Abstract There have been three randomized controlled trials on autologous hematopoietic stem cell transplantation (AHSCT) in systemic sclerosis (SSc) that demonstrated significant superiority with respect to survival, improvement of cutaneous fibrosis, lung function and quality of life compared to standard treatment; however, these advantages must be carefully weighed against the transplantation-related risks. For this reason, an expert group from the stem cell therapy working party of the German Society for Rheumatology (DGRh) has now developed recommendations for the use of AHSCT in SSc. Based on the high-qu...
Source: Zeitschrift fur Rheumatologie - April 22, 2020 Category: Rheumatology Authors: Alexander T, Henes J, Distler JHW, Schmalzing M, Blank N, Kötter I, Hiepe F Tags: Z Rheumatol Source Type: research

[A  cross sectional study on patients with inflammatory rheumatic diseases in terms of their compliance to their immunsuppressive medication during COVID-19 pandemic].
In this study, patients with inflammatory rheumatic disease were asked in the first weeks of the pandemic on their opinion of their immunomodulating therapy. The result shows that over 90% of the patients followed the recommendation of the rheumatologist to continue the antirheumatic therapy, and only a small percentage of the patients terminated the therapy on their own. This result was independent of the individual anti-rheumatic therapy. Taken together, the results of this study illustrate not only the trustful patient-physician partnership in a threatening situation but also the high impact of state-of-the ar...
Source: Zeitschrift fur Rheumatologie - April 17, 2020 Category: Rheumatology Authors: Schmeiser T, Broll M, Dormann A, Fräbel C, Hermann W, Hudowenz O, Keil F, Müller-Ladner U, Özden F, Pfeiffer U, Saech J, Schwarting A, Stapfer G, Steinchen N, Storck-Müller K, Strunk J, Thiele A, Triantafyllias K, Wassenberg S, Wilden E, Hasseli R Tags: Z Rheumatol Source Type: research

[New treatments for systemic lupus erythematosus].
This article addresses the promising new drugs currently under development for the treatment of SLE. PMID: 32303822 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - April 17, 2020 Category: Rheumatology Authors: Hoyer BF Tags: Z Rheumatol Source Type: research

[Lupus and thrombophilia : Antiphospholipid syndrome].
r T Abstract Even early on thromboembolic events were observed in patients with systemic lupus erythematosus (SLE) until the antiphospholipid syndrome (APS) was described in the 1980s as an independent disorder. The APS is a systemic autoimmune disease often overlapping with SLE in which antiphospholipid autoantibodies, including lupus anticoagulant, can cause a hypercoagulation state, which clinically by definition is manifested as arterial and venous occlusions or pregnancy complications. The pathophysiology has not yet been entirely delineated and the clinical spectrum of associated concomitant manife...
Source: Zeitschrift fur Rheumatologie - April 16, 2020 Category: Rheumatology Authors: Lettau M, Schrezenmeier EV, Specker C, Dörner T Tags: Z Rheumatol Source Type: research

[A  look into the eyes … : … still an important diagnostic criterion].
[A look into the eyes … : … still an important diagnostic criterion]. Z Rheumatol. 2020 Apr 14;: Authors: Fischer F, Strunk J PMID: 32291515 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - April 14, 2020 Category: Rheumatology Authors: Fischer F, Strunk J Tags: Z Rheumatol Source Type: research

Association of HLA-G polymorphisms with systemic lupus erythematosus and correlation between soluble HLA ‑G levels and the disease: a meta-analysis.
Association of HLA-G polymorphisms with systemic lupus erythematosus and correlation between soluble HLA‑G levels and the disease: a meta-analysis. Z Rheumatol. 2020 Apr 09;: Authors: Bae SC, Lee YH Abstract OBJECTIVE: To investigate the association between HLA‑G polymorphisms and systemic lupus erythematosus (SLE) susceptibility as well as the relationship between circulating soluble HLA‑G (sHLA‑G) levels and SLE. METHODS: A meta-analysis was performed to investigate the relationships between HLA‑G 14-bp insertion (I)/deletion (D), +3142 G/C, +3035 T/C, and +300...
Source: Zeitschrift fur Rheumatologie - April 9, 2020 Category: Rheumatology Authors: Bae SC, Lee YH Tags: Z Rheumatol Source Type: research

[Still's disease as biphasic disorder : Current knowledge on pathogenesis and novel treatment approaches].
e C Abstract Still's disease covers a range of disorders from systemic juvenile idiopathic arthritis (SJIA) up to adult onset Still's disease (AOSD). The overlapping clinical features suggest that SJIA and AOSD are different manifestations of a phenotypic continuum in different age stages. Still's disease is clinically characterized by fever, rash, joint involvement, lymphadenopathy and serositis. In this review the more recent pathogenetic model of a biphasic disease course is presented. The initial autoinflammation with predominant dysregulation of innate immunity is the basis of the "window ...
Source: Zeitschrift fur Rheumatologie - April 6, 2020 Category: Rheumatology Authors: Föll D, Wittkowski H, Hinze C Tags: Z Rheumatol Source Type: research

[Autoinflammatory syndromes and AA amyloidosis].
SO Abstract Autoinflammatory syndromes (AIS) are characterized by uniform attacks often with febrile episodes, exanthema, abdominal pain, muscle and joint pain. Patients show markedly elevated levels of the inflammatory serum parameters C‑reactive protein (CRP) and systemic amyloid A (SAA) during an attack. The origin of the family of the patient and the duration of the attacks are helpful to find the appropriate diagnosis. Molecular genetic tests are used to confirm the clinical diagnosis of an AIS. Colchicine can prevent attacks of familial Mediterranean fever but not the other forms of AIS. In refractory cas...
Source: Zeitschrift fur Rheumatologie - April 6, 2020 Category: Rheumatology Authors: Blank N, Schönland SO Tags: Z Rheumatol Source Type: research

[EULAR points to consider: use of big data in rheumatic and musculoskeletal diseases].
PMID: 32248285 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - April 4, 2020 Category: Rheumatology Authors: Kiefer D, Baraliakos X Tags: Z Rheumatol Source Type: research

[Nintedanib in progressive fibrosing interstitial lung diseases].
PMID: 32246191 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - April 3, 2020 Category: Rheumatology Authors: Hadjiski D Tags: Z Rheumatol Source Type: research

[Small molecules and biologicals].
PMID: 32240355 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - April 1, 2020 Category: Rheumatology Authors: Smolen J Tags: Z Rheumatol Source Type: research

Mitteilungen der DGRh.
Authors: PMID: 32240356 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - April 1, 2020 Category: Rheumatology Tags: Z Rheumatol Source Type: research

Mitteilungen der DGRh.
Authors: PMID: 32240357 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - April 1, 2020 Category: Rheumatology Tags: Z Rheumatol Source Type: research

Mitteilungen der DRL.
Authors: PMID: 32240358 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - April 1, 2020 Category: Rheumatology Tags: Z Rheumatol Source Type: research

Safety management in treatment with antimalarials in rheumatology. Interdisciplinary recommendations on the basis of a  systematic literature review.
CONCLUSION: The updated recommendations on AM treatment in rheumatology in particular include a more rigorous measuring of doses, risk stratification in monitoring and defined ophthalmological examination methods to detect a possible retinopathy. PMID: 32236844 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - March 31, 2020 Category: Rheumatology Authors: Fiehn C, Ness T, Weseloh C, Specker C, Hadjiski D, Detert J, Krüger K, DGRh Kommission Pharmakotherapie Tags: Z Rheumatol Source Type: research

[Pregnancy with lupus erythematosus-an update].
Abstract Current research in the field of systemic lupus erythematosus (SLE) and pregnancy focuses on predictors of adverse pregnancy outcomes, the safety and efficacy of hydroxychloroquine (HCQ) in pregnancy and the importance of preconception counselling. In particular, the prospective predictors of pregnancy outcome: biomarkers in antiphospholipid antibody syndrome and SLE (PROMISSE) study adds to the understanding of risk factors for adverse outcomes. There is increasing evidence of the numerous benefits associated with continuing HCQ treatment in pregnancy and for the use of low-dose acetylsalicylic acid in t...
Source: Zeitschrift fur Rheumatologie - March 31, 2020 Category: Rheumatology Authors: Fischer-Betz R, Haase I Tags: Z Rheumatol Source Type: research

[Treat to target in systemic lupus erythematosus].
CONCLUSION: The use of T2T for SLE remains a challenge. With the definitions of the lupus low disease activity states (LLDAS) and the definitions of remission in SLE (DORIS) a big step forward has been taken on the road towards the ideal treatment target; however, many aspects of the "treat" remain unclear. As an example, due to a lack of data there are no explicit strategies for steroid reduction although it is often mandatory to achieve the targets. The T2T also includes much more than only immunosuppressive treatment and antimalarial agents, as disease damage which has already occurred and damag...
Source: Zeitschrift fur Rheumatologie - March 30, 2020 Category: Rheumatology Authors: Mucke J, Düsing C, Chehab G, Schneider M Tags: Z Rheumatol Source Type: research

[Fever in systemic lupus erythematosus: disease exacerbation or infection?]
z F Abstract The differential diagnosis of fever, especially in the context of autoimmune diseases is broad. Accordingly, the spectrum of diagnostic procedures is extensive and the therapeutic consequences are partly contradictory. Fever is basically the manifestation of an increased cell proliferation, such as classically seen in tumors, infections or autoimmune inflammation. Systemic lupus erythematosus (SLE) is one of the most multifaceted rheumatological diseases. Fever is one component of the new classification criteria which help to classify and possibly diagnose SLE. The differential work-up of fever is a s...
Source: Zeitschrift fur Rheumatologie - March 27, 2020 Category: Rheumatology Authors: Lorenz HM, Pieterse L, Rüter T, Lorenz F Tags: Z Rheumatol Source Type: research

[Janus kinase inhibitors : State of the art in clinical use and future perspectives].
r T Abstract BACKGROUND: Cytokines and associated intracellular signal cascades play a major role in the pathogenesis of autoimmune diseases. Janus kinases (JAK) are part of these intracellular signal transduction processes. A relatively new drug group of targeted synthetic disease-modifying antirheumatic drugs (tsDMARD) are JAK inhibitors (JAKi) and are a promising treatment approach for autoimmune diseases. EFFICACY: Hitherto, three JAKis, Tofacitinib, Baricitinib and Upadacitinib, have been approved for treatment of Rheumatoid Arthritis (RA) in the USA, Switzerland and the EU. Filgotinib, an...
Source: Zeitschrift fur Rheumatologie - March 26, 2020 Category: Rheumatology Authors: Alten R, Mischkewitz M, Stefanski AL, Dörner T Tags: Z Rheumatol Source Type: research

[Biologicals and small molecules for systemic lupus erythematosus].
r T Abstract Targeted treatment is a rheumatologist's dream, which, with the advent of biologicals and more recently small molecules, has become true for rheumatoid arthritis and is about to translate into reality for systemic lupus erythematosus (SLE). Belimumab, the first biological approved for SLE, is now also available in a subcutaneous formulation. It is notable that this drug achieved the primary endpoint in four independent trials and demonstrated substantial reduction of organ damage accrual. The B cell depletion with antibodies against CD20 remains clinically relevant and of interest for f...
Source: Zeitschrift fur Rheumatologie - March 23, 2020 Category: Rheumatology Authors: Aringer M, Leuchten N, Dörner T Tags: Z Rheumatol Source Type: research

[Antiphospholipid syndrome : Update on diagnostics and management].
r T Abstract Antiphospholipid syndrome (APS) was first identified in patients with systemic lupus erythematosus (SLE) and frequent occurrence of thromboembolic complications and miscarriages accompanied by detection of anticardiolipin antibodies (aCL). When APS was also later found without an underlying SLE, the so-called primary APS was distinguished from its secondary form with SLE. Even more specific than aCL are the lupus anticoagulant (LA) and antibodies against beta‑2 glycoprotein I (aB2GP I). In recent years, it has become evident that the risk of (further) thromboembolic and obstetric complicat...
Source: Zeitschrift fur Rheumatologie - March 17, 2020 Category: Rheumatology Authors: Specker C, Fischer-Betz R, Dörner T Tags: Z Rheumatol Source Type: research

[Biologicals and small molecules for rheumatoid arthritis].
l S Abstract In recent years tremendous progress has been made in the therapeutic management of rheumatoid arthritis. Rheumatologists now have a large armamentarium of highly efficient drugs with different mechanisms of action at their disposal. These new drugs consist of biologicals (biological disease-modifying antirheumatic drugs, bDMARDs) as well as targeted synthetic DMARDs (tsDMARD). A common feature of these new drugs for treatment of rheumatoid arthritis is that the molecular target of the drug is known, which is not the case for conventional DMARDs. With the help of the new drugs, the therapeutic goa...
Source: Zeitschrift fur Rheumatologie - March 16, 2020 Category: Rheumatology Authors: Blüml S Tags: Z Rheumatol Source Type: research

[Evaluation of a basic educational program for patients with rheumatoid arthritis].
CONCLUSION: The basic training program provides a good foundation to develop further interventions to improve attitudinal and disease parameters. It can serve as a central component for rheumatological healthcare for patients with RA at various levels. PMID: 32179965 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - March 16, 2020 Category: Rheumatology Authors: Gerlich C, Andreica I, Küffner R, Krause D, Lakomek HJ, Reusch A, Braun J Tags: Z Rheumatol Source Type: research

[Evaluation of the trabecular bone score (TBS) in routine clinical care of patients with inflammatory rheumatic and non-inflammatory diseases : Correlation with conventional bone mineral density measurement and prevalence of vertebral fractures].
n J Abstract BACKGROUND: Osteoporosis-related fractures are common in patients with rheumatoid arthritis (RA). Bone mineral density (BMD) measurements using dual-energy x‑ray absorptiometry (DXA) alone has only a limited value for predicting the risk of fractures. The trabecular bone score (TBS) is a surrogate parameter for trabecular microarchitecture of bone and a predictor of fracture risk independent of BMD. AIM: To examine the prevalence of BMD, TBS and osteoporosis-related vertebral fractures (VF) in patients with RA in comparison to controls with non-inflammatory musculoskeletal diseases. ...
Source: Zeitschrift fur Rheumatologie - March 11, 2020 Category: Rheumatology Authors: Buehring B, Thomas J, Wittkämper T, Baraliakos X, Braun J Tags: Z Rheumatol Source Type: research

[The Jena standing stability (JESS) score : Development, standard value generation and clinical applicability of a  score for evaluation of standing stability].
CONCLUSION: The JESS score is a practicable test to verify the standing stereotype. The extension of the norm group by including further study participants will decide on a stabilization or modification of the current results. The testing of further cohorts will show to what extent these items are sensitive to changes caused by training methods and whether the score can also be used to congruently map clinical changes. PMID: 32157383 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - March 10, 2020 Category: Rheumatology Authors: Best N, Nisser M, Loudovici-Krug D Tags: Z Rheumatol Source Type: research

First Asian case of biopsy-confirmed manubriosternal joint involvement in rheumatoid arthritis.
Abstract Rheumatoid arthritis (RA) is an inflammatory polyarthritis that typically affects the small joints but can also involve the manubriosternal joint (MSJ). Although cases of MSJ involvement in RA are rare, such cases present with chest pain, a mass-like lesion, and subluxation. These cases can also be diagnosed incidentally, while patients are asymptomatic. It is important to differentiate RA involving the MSJ from other diseases such as ankylosing spondylitis that can affect the MSJ. Several cases of RA affecting the MSJ have been reported in Western countries, but none have been reported to date in As...
Source: Zeitschrift fur Rheumatologie - March 5, 2020 Category: Rheumatology Authors: Kim Y, Kim GT, Lee SG, Lee HN, Kang J, Ko TY Tags: Z Rheumatol Source Type: research

[Early, timely limited intensive immune-modulatory treatment for achievement of remission state in psoriatic arthritis].
m M PMID: 32130492 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - March 4, 2020 Category: Rheumatology Authors: Köhm M Tags: Z Rheumatol Source Type: research

[The Deutsches Rheuma-Forschungszentrum - and German rheumatology].
gie PMID: 32125508 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - March 1, 2020 Category: Rheumatology Authors: Schulze-Koops H, den Vorstand der Deutschen Gesellschaft für Rheumatologie Tags: Z Rheumatol Source Type: research

Mitteilungen der DGRh.
Authors: PMID: 32125509 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - March 1, 2020 Category: Rheumatology Tags: Z Rheumatol Source Type: research

Mitteilungen der DRL.
Authors: PMID: 32125510 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - March 1, 2020 Category: Rheumatology Tags: Z Rheumatol Source Type: research

[Online ultrasound learning modules in rheumatology : Innovative elective course increases student interest in the discipline of rheumatology].
n D PMID: 32103342 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - February 26, 2020 Category: Rheumatology Authors: Knitza J, Kleyer A, Klüppel M, Krauser M, Wacker J, Schett G, Simon D Tags: Z Rheumatol Source Type: research