Monogenic variants in Laccase domain-containing 1 (LACC1) as the cause of juvenile arthritis
Z Rheumatol. 2023 Nov 3. doi: 10.1007/s00393-023-01442-2. Online ahead of print.ABSTRACTMonogenic mutations in laccase domain-containing 1 (LACC1) are associated with clinical pictures that mimic severe courses of polyarticular or systemic juvenile idiopathic arthritis. The diseases are characterized by an early onset during the first year of life, a familial clustering and a high inflammatory activity. The courses are mostly difficult to influence and often lead to sequelae. In this article four cases from two families are presented in which the homozygous mutation p.T276fs* in LACC1 was detected. The children initially s...
Source: Zeitschrift fur Rheumatologie - November 3, 2023 Category: Rheumatology Authors: Anne-Marie Knieper Anne Sae Lim von Stuckrad Kirsten Minden Carl Christoph Goetzke Tilmann Kallinich Source Type: research
Structured approach for infected prosthesis
CONCLUSION: A structured approach for prosthesis infections oriented to an evidence-based algorithm provides a sufficient possibility of healing. An interdisciplinary approach involving cooperation between orthopedic and infectious disease specialists has proven to be beneficial. Surgical treatment with the aim of reducing the bacterial load by removing the biofilm with subsequent antibiotic treatment is of intrinsic importance.PMID:37851164 | DOI:10.1007/s00393-023-01421-7 (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - October 18, 2023 Category: Rheumatology Authors: Markus Scharf Amadeus Dominik Schraag Marianne Ehrnsperger Joachim Grifka Source Type: research
Gout (ICD 10: M10): a retrospective analysis of the data from the histopathological arthritis register of the DGORh
CONCLUSION: Gout affects different anatomical regions with the first metatarsophalangeal joint being the main localization site. The sensitivity of clinical gout diagnostics was determined at 73.53%. These results emphasize the importance of histopathology in gout diagnostics.PMID:37851165 | DOI:10.1007/s00393-023-01435-1 (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - October 18, 2023 Category: Rheumatology Authors: Fabian Zucchero N öllner Matteo Dufour Nada El Hamrawi Martin Liebisch Andreas Niemeier Veit Krenn Source Type: research
Salidroside suppresses cell growth and inflammatory response of fibroblast-like synoviocytes via inhibition of phosphoinositol-3 kinase/threonine kinase signaling in rheumatoid arthritis
CONCLUSION: Sal suppressed cell growth and inflammation in RA-FLSs by inactivating PI3K/AKT-signaling pathways.PMID:37851166 | DOI:10.1007/s00393-023-01431-5 (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - October 18, 2023 Category: Rheumatology Authors: Yajing Qin Juan Su Source Type: research
Structured approach for infected prosthesis
CONCLUSION: A structured approach for prosthesis infections oriented to an evidence-based algorithm provides a sufficient possibility of healing. An interdisciplinary approach involving cooperation between orthopedic and infectious disease specialists has proven to be beneficial. Surgical treatment with the aim of reducing the bacterial load by removing the biofilm with subsequent antibiotic treatment is of intrinsic importance.PMID:37851164 | DOI:10.1007/s00393-023-01421-7 (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - October 18, 2023 Category: Rheumatology Authors: Markus Scharf Amadeus Dominik Schraag Marianne Ehrnsperger Joachim Grifka Source Type: research
Gout (ICD 10: M10): a retrospective analysis of the data from the histopathological arthritis register of the DGORh
CONCLUSION: Gout affects different anatomical regions with the first metatarsophalangeal joint being the main localization site. The sensitivity of clinical gout diagnostics was determined at 73.53%. These results emphasize the importance of histopathology in gout diagnostics.PMID:37851165 | DOI:10.1007/s00393-023-01435-1 (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - October 18, 2023 Category: Rheumatology Authors: Fabian Zucchero N öllner Matteo Dufour Nada El Hamrawi Martin Liebisch Andreas Niemeier Veit Krenn Source Type: research
Salidroside suppresses cell growth and inflammatory response of fibroblast-like synoviocytes via inhibition of phosphoinositol-3 kinase/threonine kinase signaling in rheumatoid arthritis
CONCLUSION: Sal suppressed cell growth and inflammation in RA-FLSs by inactivating PI3K/AKT-signaling pathways.PMID:37851166 | DOI:10.1007/s00393-023-01431-5 (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - October 18, 2023 Category: Rheumatology Authors: Yajing Qin Juan Su Source Type: research
Structured approach for infected prosthesis
CONCLUSION: A structured approach for prosthesis infections oriented to an evidence-based algorithm provides a sufficient possibility of healing. An interdisciplinary approach involving cooperation between orthopedic and infectious disease specialists has proven to be beneficial. Surgical treatment with the aim of reducing the bacterial load by removing the biofilm with subsequent antibiotic treatment is of intrinsic importance.PMID:37851164 | DOI:10.1007/s00393-023-01421-7 (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - October 18, 2023 Category: Rheumatology Authors: Markus Scharf Amadeus Dominik Schraag Marianne Ehrnsperger Joachim Grifka Source Type: research
Gout (ICD 10: M10): a retrospective analysis of the data from the histopathological arthritis register of the DGORh
CONCLUSION: Gout affects different anatomical regions with the first metatarsophalangeal joint being the main localization site. The sensitivity of clinical gout diagnostics was determined at 73.53%. These results emphasize the importance of histopathology in gout diagnostics.PMID:37851165 | DOI:10.1007/s00393-023-01435-1 (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - October 18, 2023 Category: Rheumatology Authors: Fabian Zucchero N öllner Matteo Dufour Nada El Hamrawi Martin Liebisch Andreas Niemeier Veit Krenn Source Type: research
Salidroside suppresses cell growth and inflammatory response of fibroblast-like synoviocytes via inhibition of phosphoinositol-3 kinase/threonine kinase signaling in rheumatoid arthritis
CONCLUSION: Sal suppressed cell growth and inflammation in RA-FLSs by inactivating PI3K/AKT-signaling pathways.PMID:37851166 | DOI:10.1007/s00393-023-01431-5 (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - October 18, 2023 Category: Rheumatology Authors: Yajing Qin Juan Su Source Type: research
Structured approach for infected prosthesis
CONCLUSION: A structured approach for prosthesis infections oriented to an evidence-based algorithm provides a sufficient possibility of healing. An interdisciplinary approach involving cooperation between orthopedic and infectious disease specialists has proven to be beneficial. Surgical treatment with the aim of reducing the bacterial load by removing the biofilm with subsequent antibiotic treatment is of intrinsic importance.PMID:37851164 | DOI:10.1007/s00393-023-01421-7 (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - October 18, 2023 Category: Rheumatology Authors: Markus Scharf Amadeus Dominik Schraag Marianne Ehrnsperger Joachim Grifka Source Type: research
Gout (ICD 10: M10): a retrospective analysis of the data from the histopathological arthritis register of the DGORh
CONCLUSION: Gout affects different anatomical regions with the first metatarsophalangeal joint being the main localization site. The sensitivity of clinical gout diagnostics was determined at 73.53%. These results emphasize the importance of histopathology in gout diagnostics.PMID:37851165 | DOI:10.1007/s00393-023-01435-1 (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - October 18, 2023 Category: Rheumatology Authors: Fabian Zucchero N öllner Matteo Dufour Nada El Hamrawi Martin Liebisch Andreas Niemeier Veit Krenn Source Type: research
Salidroside suppresses cell growth and inflammatory response of fibroblast-like synoviocytes via inhibition of phosphoinositol-3 kinase/threonine kinase signaling in rheumatoid arthritis
CONCLUSION: Sal suppressed cell growth and inflammation in RA-FLSs by inactivating PI3K/AKT-signaling pathways.PMID:37851166 | DOI:10.1007/s00393-023-01431-5 (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - October 18, 2023 Category: Rheumatology Authors: Yajing Qin Juan Su Source Type: research
Structured approach for infected prosthesis
CONCLUSION: A structured approach for prosthesis infections oriented to an evidence-based algorithm provides a sufficient possibility of healing. An interdisciplinary approach involving cooperation between orthopedic and infectious disease specialists has proven to be beneficial. Surgical treatment with the aim of reducing the bacterial load by removing the biofilm with subsequent antibiotic treatment is of intrinsic importance.PMID:37851164 | DOI:10.1007/s00393-023-01421-7 (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - October 18, 2023 Category: Rheumatology Authors: Markus Scharf Amadeus Dominik Schraag Marianne Ehrnsperger Joachim Grifka Source Type: research
Gout (ICD 10: M10): a retrospective analysis of the data from the histopathological arthritis register of the DGORh
CONCLUSION: Gout affects different anatomical regions with the first metatarsophalangeal joint being the main localization site. The sensitivity of clinical gout diagnostics was determined at 73.53%. These results emphasize the importance of histopathology in gout diagnostics.PMID:37851165 | DOI:10.1007/s00393-023-01435-1 (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - October 18, 2023 Category: Rheumatology Authors: Fabian Zucchero N öllner Matteo Dufour Nada El Hamrawi Martin Liebisch Andreas Niemeier Veit Krenn Source Type: research
