Total glycosides of Rhodiola rosea L. attenuate LPS-induced acute lung injury by inhibiting TLR4/NF- κB pathway
In this study, we identified the effect and mechanism of RTG on ALI through LPS-induced ALI mice. After RTG treatment, the pathological structure of lung tissue in ALI mice induced by LPS was significantly improved, and the infiltration of inflammatory cells was reduced. In addition, RTG reduced the production of IL-6, IL-1β, and TNF-α in the serum of ALI mice and reduced the content or activity of MPO, T-SOD, GSH, and MDA in lung tissue. RNAseq analysis showed that RTG ameliorated LPS-induced ALI through anti-inflammatory, reduced immune response, and anti-apoptotic activities. The western blotting analysis confirmed th...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 1, 2023 Category: Drugs & Pharmacology Authors: Xuehai Jia Ke Zhang Shushu Feng Yuyao Li Dahong Yao Qiaohui Liu Dong Liu Xin Li Jian Huang Hangyu Wang Jinhui Wang Source Type: research
Total glycosides of Rhodiola rosea L. attenuate LPS-induced acute lung injury by inhibiting TLR4/NF- κB pathway
In this study, we identified the effect and mechanism of RTG on ALI through LPS-induced ALI mice. After RTG treatment, the pathological structure of lung tissue in ALI mice induced by LPS was significantly improved, and the infiltration of inflammatory cells was reduced. In addition, RTG reduced the production of IL-6, IL-1β, and TNF-α in the serum of ALI mice and reduced the content or activity of MPO, T-SOD, GSH, and MDA in lung tissue. RNAseq analysis showed that RTG ameliorated LPS-induced ALI through anti-inflammatory, reduced immune response, and anti-apoptotic activities. The western blotting analysis confirmed th...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 1, 2023 Category: Drugs & Pharmacology Authors: Xuehai Jia Ke Zhang Shushu Feng Yuyao Li Dahong Yao Qiaohui Liu Dong Liu Xin Li Jian Huang Hangyu Wang Jinhui Wang Source Type: research
Combination of chloroquine diphosphate and salidroside induces human liver cell apoptosis via regulation of mitochondrial dysfunction and autophagy
Mol Med Rep. 2023 Feb;27(2):37. doi: 10.3892/mmr.2022.12924. Epub 2022 Dec 29.ABSTRACTHepatocellular carcinoma (HCC) is the leading cause of cancer‑associated death in the world. Chemotherapy remains the primary treatment method for HCC. Despite advances in chemotherapy and modalities, recurrence and resistance limit therapeutic success. Salidroside (Sal), a bioactive component extracted from the rhizome of Rhodiola rosea L, exhibits a spectrum of biological activities including antitumor effects. In the present study, it was demonstrated that Sal could induce apoptosis and autophagy of 97H cells by using CCK‑8 assay, ...
Source: Molecular Medicine Reports - December 29, 2022 Category: Molecular Biology Authors: Bing Jiang Longfei Feng Tao Yang Wenjing Guo Yangyang Li Tao Wang Chengguang Liu Haixiang Su Source Type: research
Combination of chloroquine diphosphate and salidroside induces human liver cell apoptosis via regulation of mitochondrial dysfunction and autophagy
Mol Med Rep. 2023 Feb;27(2):37. doi: 10.3892/mmr.2022.12924. Epub 2022 Dec 29.ABSTRACTHepatocellular carcinoma (HCC) is the leading cause of cancer‑associated death in the world. Chemotherapy remains the primary treatment method for HCC. Despite advances in chemotherapy and modalities, recurrence and resistance limit therapeutic success. Salidroside (Sal), a bioactive component extracted from the rhizome of Rhodiola rosea L, exhibits a spectrum of biological activities including antitumor effects. In the present study, it was demonstrated that Sal could induce apoptosis and autophagy of 97H cells by using CCK‑8 assay, ...
Source: Molecular Medicine - December 29, 2022 Category: Molecular Biology Authors: Bing Jiang Longfei Feng Tao Yang Wenjing Guo Yangyang Li Tao Wang Chengguang Liu Haixiang Su Source Type: research
Combination of chloroquine diphosphate and salidroside induces human liver cell apoptosis via regulation of mitochondrial dysfunction and autophagy
Mol Med Rep. 2023 Feb;27(2):37. doi: 10.3892/mmr.2022.12924. Epub 2022 Dec 29.ABSTRACTHepatocellular carcinoma (HCC) is the leading cause of cancer‑associated death in the world. Chemotherapy remains the primary treatment method for HCC. Despite advances in chemotherapy and modalities, recurrence and resistance limit therapeutic success. Salidroside (Sal), a bioactive component extracted from the rhizome of Rhodiola rosea L, exhibits a spectrum of biological activities including antitumor effects. In the present study, it was demonstrated that Sal could induce apoptosis and autophagy of 97H cells by using CCK‑8 assay, ...
Source: Molecular Medicine Reports - December 29, 2022 Category: Molecular Biology Authors: Bing Jiang Longfei Feng Tao Yang Wenjing Guo Yangyang Li Tao Wang Chengguang Liu Haixiang Su Source Type: research
Combination of chloroquine diphosphate and salidroside induces human liver cell apoptosis via regulation of mitochondrial dysfunction and autophagy
Mol Med Rep. 2023 Feb;27(2):37. doi: 10.3892/mmr.2022.12924. Epub 2022 Dec 29.ABSTRACTHepatocellular carcinoma (HCC) is the leading cause of cancer‑associated death in the world. Chemotherapy remains the primary treatment method for HCC. Despite advances in chemotherapy and modalities, recurrence and resistance limit therapeutic success. Salidroside (Sal), a bioactive component extracted from the rhizome of Rhodiola rosea L, exhibits a spectrum of biological activities including antitumor effects. In the present study, it was demonstrated that Sal could induce apoptosis and autophagy of 97H cells by using CCK‑8 assay, ...
Source: Molecular Medicine - December 29, 2022 Category: Molecular Biology Authors: Bing Jiang Longfei Feng Tao Yang Wenjing Guo Yangyang Li Tao Wang Chengguang Liu Haixiang Su Source Type: research
Combination of chloroquine diphosphate and salidroside induces human liver cell apoptosis via regulation of mitochondrial dysfunction and autophagy
Mol Med Rep. 2023 Feb;27(2):37. doi: 10.3892/mmr.2022.12924. Epub 2022 Dec 29.ABSTRACTHepatocellular carcinoma (HCC) is the leading cause of cancer‑associated death in the world. Chemotherapy remains the primary treatment method for HCC. Despite advances in chemotherapy and modalities, recurrence and resistance limit therapeutic success. Salidroside (Sal), a bioactive component extracted from the rhizome of Rhodiola rosea L, exhibits a spectrum of biological activities including antitumor effects. In the present study, it was demonstrated that Sal could induce apoptosis and autophagy of 97H cells by using CCK‑8 assay, ...
Source: Molecular Medicine Reports - December 29, 2022 Category: Molecular Biology Authors: Bing Jiang Longfei Feng Tao Yang Wenjing Guo Yangyang Li Tao Wang Chengguang Liu Haixiang Su Source Type: research
Biological and pharmacological properties of myrtenol: a review
Curr Pharm Des. 2022 Dec 22. doi: 10.2174/1381612829666221222121041. Online ahead of print.ABSTRACTMyrtenol (C10H16O) is a volatile compound belonging to the terpenoid family of monocyclic monoterpenes. It is one of the essential oils constituents of several aromatic plants, including the genera Myrtus, Tanacetum, Artemisia, Hyssopus, and Rhodiola. The oxidation of α-pinene can produce it. Several reports demonstrated the pharmacological properties of myrtenol, including its antioxidant, antibacterial, antifungal, antidiabetic, anxiolytic, and gastroprotective activities. In this review, we discussed and highlighted in de...
Source: Current Pharmaceutical Design - December 25, 2022 Category: Drugs & Pharmacology Authors: Hanae Naceiri Mrabti Imane Jaouadi Ikrame Zeouk Rokia Ghchime Naoual El Mniyi Nasreddine El Omari Abdelaali Balahbib Samiah H Al-Mijalli Emad M Abdallah Mohamed El-Shazly Gokhan Zengin Abdelhakim Bouyahya Source Type: research
Biological and pharmacological properties of myrtenol: a review
Curr Pharm Des. 2022 Dec 22. doi: 10.2174/1381612829666221222121041. Online ahead of print.ABSTRACTMyrtenol (C10H16O) is a volatile compound belonging to the terpenoid family of monocyclic monoterpenes. It is one of the essential oils constituents of several aromatic plants, including the genera Myrtus, Tanacetum, Artemisia, Hyssopus, and Rhodiola. The oxidation of α-pinene can produce it. Several reports demonstrated the pharmacological properties of myrtenol, including its antioxidant, antibacterial, antifungal, antidiabetic, anxiolytic, and gastroprotective activities. In this review, we discussed and highlighted in de...
Source: Current Pharmaceutical Design - December 25, 2022 Category: Drugs & Pharmacology Authors: Hanae Naceiri Mrabti Imane Jaouadi Ikrame Zeouk Rokia Ghchime Naoual El Mniyi Nasreddine El Omari Abdelaali Balahbib Samiah H Al-Mijalli Emad M Abdallah Mohamed El-Shazly Gokhan Zengin Abdelhakim Bouyahya Source Type: research
Biological and pharmacological properties of myrtenol: a review
Curr Pharm Des. 2022 Dec 22. doi: 10.2174/1381612829666221222121041. Online ahead of print.ABSTRACTMyrtenol (C10H16O) is a volatile compound belonging to the terpenoid family of monocyclic monoterpenes. It is one of the essential oils constituents of several aromatic plants, including the genera Myrtus, Tanacetum, Artemisia, Hyssopus, and Rhodiola. The oxidation of α-pinene can produce it. Several reports demonstrated the pharmacological properties of myrtenol, including its antioxidant, antibacterial, antifungal, antidiabetic, anxiolytic, and gastroprotective activities. In this review, we discussed and highlighted in de...
Source: Current Pharmaceutical Design - December 25, 2022 Category: Drugs & Pharmacology Authors: Hanae Naceiri Mrabti Imane Jaouadi Ikrame Zeouk Rokia Ghchime Naoual El Mniyi Nasreddine El Omari Abdelaali Balahbib Samiah H Al-Mijalli Emad M Abdallah Mohamed El-Shazly Gokhan Zengin Abdelhakim Bouyahya Source Type: research
Biological and pharmacological properties of myrtenol: a review
Curr Pharm Des. 2022 Dec 22. doi: 10.2174/1381612829666221222121041. Online ahead of print.ABSTRACTMyrtenol (C10H16O) is a volatile compound belonging to the terpenoid family of monocyclic monoterpenes. It is one of the essential oils constituents of several aromatic plants, including the genera Myrtus, Tanacetum, Artemisia, Hyssopus, and Rhodiola. The oxidation of α-pinene can produce it. Several reports demonstrated the pharmacological properties of myrtenol, including its antioxidant, antibacterial, antifungal, antidiabetic, anxiolytic, and gastroprotective activities. In this review, we discussed and highlighted in de...
Source: Current Pharmaceutical Design - December 25, 2022 Category: Drugs & Pharmacology Authors: Hanae Naceiri Mrabti Imane Jaouadi Ikrame Zeouk Rokia Ghchime Naoual El Mniyi Nasreddine El Omari Abdelaali Balahbib Samiah H Al-Mijalli Emad M Abdallah Mohamed El-Shazly Gokhan Zengin Abdelhakim Bouyahya Source Type: research
Biological and pharmacological properties of myrtenol: a review
Curr Pharm Des. 2022 Dec 22. doi: 10.2174/1381612829666221222121041. Online ahead of print.ABSTRACTMyrtenol (C10H16O) is a volatile compound belonging to the terpenoid family of monocyclic monoterpenes. It is one of the essential oils constituents of several aromatic plants, including the genera Myrtus, Tanacetum, Artemisia, Hyssopus, and Rhodiola. The oxidation of α-pinene can produce it. Several reports demonstrated the pharmacological properties of myrtenol, including its antioxidant, antibacterial, antifungal, antidiabetic, anxiolytic, and gastroprotective activities. In this review, we discussed and highlighted in de...
Source: Current Pharmaceutical Design - December 25, 2022 Category: Drugs & Pharmacology Authors: Hanae Naceiri Mrabti Imane Jaouadi Ikrame Zeouk Rokia Ghchime Naoual El Mniyi Nasreddine El Omari Abdelaali Balahbib Samiah H Al-Mijalli Emad M Abdallah Mohamed El-Shazly Gokhan Zengin Abdelhakim Bouyahya Source Type: research
