Viruses, Vol. 16, Pages 170: Molecular Amplification and Cell Culturing Efficiency for Enteroviruses & rsquo; Detection in Cerebrospinal Fluids of Algerian Patients Suffering from Meningitis
Viruses, Vol. 16, Pages 170: Molecular Amplification and Cell Culturing Efficiency for Enteroviruses’ Detection in Cerebrospinal Fluids of Algerian Patients Suffering from Meningitis
Viruses doi: 10.3390/v16020170
Authors:
Abdelwahab Rai
Zohra Ammi
Dahbia Leila Anes-Boulahbal
Aymen Amin Assadi
Abdeltif Amrane
Oussama Baaloudj
Lotfi Mouni
Enteroviruses (EVs) represent a major cause of viral meningitis, being responsible for nearly 1 billion infections each year worldwide. Several techniques were developed to obtain better diagnostic results of EV infections. Herein, we evaluated the efficiency ...
Source: Viruses - January 23, 2024 Category: Virology Authors: Abdelwahab Rai Zohra Ammi Dahbia Leila Anes-Boulahbal Aymen Amin Assadi Abdeltif Amrane Oussama Baaloudj Lotfi Mouni Tags: Article Source Type: research
Divergent HLA variations and heterogeneous expression but recurrent HLA loss-of- heterozygosity and common HLA-B and TAP transcriptional silencing across advanced pediatric solid cancers
The human leukocyte antigen (HLA) system is a major factor controlling cancer immunosurveillance and response to immunotherapy, yet its status in pediatric cancers remains fragmentary. We determined high-confidence HLA genotypes in 576 children, adolescents and young adults with recurrent/refractory solid tumors from the MOSCATO-01 and MAPPYACTS trials, using normal and tumor whole exome and RNA sequencing data and benchmarked algorithms. There was no evidence for narrowed HLA allelic diversity but discordant homozygosity and allele frequencies across tumor types and subtypes, such as in embryonal and alveolar rhabdomyosar...
Source: Frontiers in Immunology - January 22, 2024 Category: Allergy & Immunology Source Type: research
Oral rhabdomyosarcoma, a rare malignant tumor mimicking an endodontic-periodontal lesion in an adult patient: a case report
According to previous research, 2.8% of lesions clinically identified as endodontic pathosis were ultimately diagnosed as non-endodontic periapical lesions via histopathology, and 3.7% of these non-endodontic ... (Source: BMC Oral Health)
Source: BMC Oral Health - January 16, 2024 Category: Dentistry Authors: Fang-Yu Zheng, Juan-You Qiu, Kuo-Han Liao and Nan-Chin Lin Tags: Case Report Source Type: research
Cancers, Vol. 16, Pages 373: Trap-Door Thoracotomy and Clamshell Thoracotomy as Surgical Approaches for Neuroblastoma and Other Thoracic Tumors in Children
In conclusion, surgical resection of solid tumors of the cervicothoracic junction in children can be performed safely and successfully with trap-door thoracotomy and with clamshell thoracotomy for posterior mediastinal or bilateral dorsal thoracic tumors. (Source: Cancers)
Source: Cancers - January 15, 2024 Category: Cancer & Oncology Authors: Benjamin F. B. Mayer Matthias C. Schunn Cristian Urla J ürgen F. Schäfer Frank Fideler Felix Neunhoeffer Martin U. Schuhmann Steven W. Warmann J örg Fuchs Tags: Article Source Type: research
Mandibular rhabdomyosarcoma with TFCP2 rearrangement and osteogenic differentiation: a case misdiagnosed as fibrous dysplasia or low-grade central osteosarcoma
Rhabdomyosarcoma with TFCP2-related fusions (TFCP2-RMS) is a rare entity, commonly affects young adults, with a predilection for skeletal involvement. We herein report a 40-year-old female patient with TFCP2-RMS who was misdiagnosed as fibrous dysplasia or low-grade central osteosarcoma of the mandible by referring institutions. Histologically, the tumor showed dominant spindle cells and focal epithelioid cells with marked immature wove bone formation. Immunophenotypically, in addition to the characteristic expression of myogenic markers, ALK, and cytokeratins, tumor cells also unusually expressed osteogenic markers, such ...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - January 10, 2024 Category: ENT & OMF Authors: Fu Chen, Junjia Wang, Yanan Sun, Jiali Zhang Source Type: research
The Role of FDG- PET/CT in Detecting Bone Marrow Involvement in Childhood Solid Tumors
CONCLUSION: PET/CT has a high sensitivity and specificity for the assessing marrow involvement in pediatric solid tumors. We believe that PET/CT imaging should be performed as the first step in diagnostic staging, and BMB may not be necessary in every patient, only in patients with suspicious PET/CT results for bone marrow involvement. Additionally, for a more precise determination of bone marrow involvement, it is reasonable to perform BMB from FDG-retaining areas, using PET/CT as a guide tool.PMID:38190995 | DOI:10.1055/a-2224-9441 (Source: Nuklearmedizin)
Source: Nuklearmedizin - January 8, 2024 Category: Radiology Authors: Esra Arslanta ş Ali Ay çiçek Burcu Esen Akkas Tuba Nur Tahtakesen G üçer Sultan Okur Acar Ayse Özkan Karagenc Sibel Akp ınar Tekgündüz Cengiz Bayram Source Type: research
The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma
Oncogene. 2024 Jan 4. doi: 10.1038/s41388-023-02911-3. Online ahead of print.ABSTRACTRhabdomyosarcoma tumor cells resemble differentiating skeletal muscle cells, which unlike normal muscle cells, fail to undergo terminal differentiation, underlying their proliferative and metastatic properties. We identify the corepressor TLE3 as a key regulator of rhabdomyosarcoma tumorigenesis by inhibiting the Wnt-pathway. Loss of TLE3 function leads to Wnt-pathway activation, reduced proliferation, decreased migration, and enhanced differentiation in rhabdomyosarcoma cells. Muscle-specific TLE3-knockout results in enhanced expression o...
Source: Cell Research - January 4, 2024 Category: Cytology Authors: Bhargab Kalita Subhashni Sahu Anushree Bharadwaj Lakshmikanthan Panneerselvam Gerard Martinez-Cebrian Megha Agarwal Sam J Mathew Source Type: research
The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma
Oncogene, Published online: 04 January 2024; doi:10.1038/s41388-023-02911-3The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma (Source: Oncogene)
Source: Oncogene - January 4, 2024 Category: Cancer & Oncology Authors: Bhargab Kalita Subhashni Sahu Anushree Bharadwaj Lakshmikanthan Panneerselvam Gerard Martinez-Cebrian Megha Agarwal Sam J. Mathew Source Type: research
GSE219199 KDM3B inhibitors disrupt PAX3-FOXO1 oncogenic activity in fusion positive rhabdomyosarcoma.
Contributors : Yong Y Kim ; Javed Khan ; Xinyu Wen ; Hsien-Chao ChouSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensFusion-positive alveolar rhabdomyosarcoma (FP-RMS) is an aggressive pediatric sarcoma driven primarily by the PAX3-FOXO1 fusion oncogene, for which therapies targeting PAX3-FOXO1 are lacking. We screened 62,643 compounds using an engineered cell line that monitors PAX3-FOXO1 transcriptional activity identifying a hitherto uncharacterized compound, PFI-63. RNA-seq, ATAC-seq, and docking analyses...
Source: GEO: Gene Expression Omnibus - December 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Other Homo sapiens Source Type: research
Surgery for adult head and neck rhabdomyosarcoma: A retrospective report from one institution
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - December 29, 2023 Category: Allergy & Immunology Authors: Tian Wang,
Jie Wang,
Tianci Tang,
Qiang Li,
Yi Li,
Xinmao Song Tags: RESEARCH NOTE Source Type: research
Embryonal rhabdomyosarcoma of the uterine cervix
Med Ultrason. 2023 Dec 27;25(4):475-476. doi: 10.11152/mu-4309.ABSTRACTPMID:38150685 | DOI:10.11152/mu-4309 (Source: Medical Ultrasonography)
Source: Medical Ultrasonography - December 27, 2023 Category: Radiology Authors: Qianyu Qin Zhen Yu Ying Tang Source Type: research
