Rhabdomyosarcoma Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Embryonal rhabdomyosarcoma of the testis in a young male: A rare case report
Asian J Surg. 2023 Dec 3:S1015-9584(23)01864-X. doi: 10.1016/j.asjsur.2023.11.084. Online ahead of print.NO ABSTRACTPMID:38049349 | DOI:10.1016/j.asjsur.2023.11.084 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - December 4, 2023 Category: Surgery Authors: Jun Zou Peiyue Luo Tao Chen Biao Qian Source Type: research

GSE215393 Dynamic interplay of BRD4 isoforms in embryonal rhabdomyosarcoma
In this study, we show that long and short isoform of the epigenetic regulator BRD4 is overexpressed in ERMS patient-derived cell lines and patient tumour specimens. Functionally, knockdown of long isoform of BRD4 reduced proliferation and promotes differentiation. Knockdown of the short isoform on the other hand promotes migration and invasion. The functional observations were confirmed in vitro and in vivo. Through RNA Sequencing analysis, we identified Myostatin (MSTN) and Integrins (ITGs) as important downstream target of long and short isoform of BRD4 respectively. We thus conclude from this study that long isoform fu...
Source: GEO: Gene Expression Omnibus - December 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

P130 Treatment rationale in the management of Osteo-Radio-Necrosis (ORN) of the midface – what are the anatomical considerations and treatment options?
We present the case of a 25 year old who was diagnosed with a Ewing ’s like sarcoma of the right zygoma that was initially managed as an embryonal rhabdomyosarcoma with surgery, chemotherapy and radiotherapy in 2011. He was also diagnosed with sarcoma of the T12 vertebrae in 2017, deemed as late bony metastases, treated with proton beam therapy in 2018. (Source: The British Journal of Oral and Maxillofacial Surgery)
Source: The British Journal of Oral and Maxillofacial Surgery - December 1, 2023 Category: ENT & OMF Authors: Mo Bajalan, Mo Bajalan, Bhavin Visavadia Source Type: research

Rapid liposomal formulation for nucleolin targeting to rhabdomyosarcoma cells
Eur J Pharm Biopharm. 2023 Nov 27:S0939-6411(23)00309-0. doi: 10.1016/j.ejpb.2023.11.020. Online ahead of print.ABSTRACTRhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma. More effective and less toxic therapies are urgently needed for high-risk patients. Peptide-guided targeted drug delivery can increase the therapeutic index of encapsulated drugs and improve patients' well-being. To apply this strategy to RMS, we identified the peptide F3 in a screening for peptides binding to RMS cells surface. F3 binds to nucleolin, which is present on the surface of RMS cells and is abundantly expressed at the mRN...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 29, 2023 Category: Drugs & Pharmacology Authors: Dzhangar Dzhumashev Stenija Anton-Joseph Victoria J Morel Andrea Timpanaro Gregor Bordon Caroline Piccand Simone Aleandri Paola Luciani Jochen R össler Michele Bernasconi Source Type: research

Insight into the design of FGFR4 selective inhibitors in cancer therapy: Prospects and challenges
Eur J Med Chem. 2023 Nov 13;263:115947. doi: 10.1016/j.ejmech.2023.115947. Online ahead of print.ABSTRACTRecently, FGFR4 has become a hot target for the treatment of cancer owing to its important role in cellular physiological processes. FGFR4 has been validated to be closely related to the occurrence of cancers, such as hepatocellular carcinoma, rhabdomyosarcoma, breast cancer and colorectal cancer. Hence, the development of FGFR4 small-molecule inhibitors is essential to further understanding the functions of FGFR4 in cancer and the treatment of FGFR4-dependent diseases. Given the particular structures of FGFR1-4, the de...
Source: European Journal of Medicinal Chemistry - November 17, 2023 Category: Chemistry Authors: Xiaolu Chen Yajiao Huang Ban Chen Huihui Liu Yuepiao Cai Yuanrong Yang Source Type: research

Emerging mesenchymal tumour types and biases in the era of ubiquitous sequencing
New tumour types are being described at increasing frequency, and most new tumour types are now identified via retrospective review of next-generation sequencing data. This contrasts with the traditional, morphology-based method of identifying new tumour types, and while the sequencing-based approach has accelerated progress in the field, it has also introduced novel and under-recognised biases. Here, we discuss tumour types identified based on morphology, including superficial CD34-positive fibroblastic tumour, pseudoendocrine sarcoma and cutaneous clear cell tumour with melanocytic differentiation and ACTIN::MITF fusion....
Source: Journal of Clinical Pathology - November 17, 2023 Category: Pathology Authors: Towery, E. A., Papke, D. J. Tags: Editor's choice Review Source Type: research

GC-MS profiling and evaluation of acute oral toxicity, anti-tumour, antimicrobial and antioxidant activities of Croton socotranus Balf.f. aerial parts: in-vitro , in-vivo and in-silico studies
Nat Prod Res. 2023 Nov 16:1-10. doi: 10.1080/14786419.2023.2280820. Online ahead of print.ABSTRACTCroton socotranus Balf.f. shrub is widely used traditionally in Asia as an anti-infective. The study was conducted for metabolite profiling, oral acute toxicity and antioxidant studies, antimicrobial activity and anticancer effect against human hepatoma (HepG2), breast cancer (MCF-7) and rhabdomyosarcoma (RD) cells. Gas chromatography-mass spectrometry analysis revealed the presence of 39 compounds, predominantly comprising fatty acids (57.76%), sesquiterpenes (24.56%) and triterpenes (9.54%). The n-hexane fraction exhibited p...
Source: Natural Product Research - November 16, 2023 Category: Biochemistry Authors: Ibrahim Ali Al-Hakami Amina El-Shaibany Hassan Al-Mahbashi Ahmed S Abdelkhalek Mahmoud M Elaasser Ali E Raslan Source Type: research

Robotic retroperitoneal lymph node dissection for paratesticular rhabdomyosarcoma in adolescents: a case series
We present an analysis of RA-RPLND for boys with paratesticular RMS. We queried our ins titution’s prospectively collected database of pediatric robotic cases for patients undergoing RA-RPLND post-radical orchiectomy for paratesticular mass, confirmed by pathology as RMS. Demographic, surgical, follow-up, and oncological outcomes were evaluated between 2017 and 2023. Five patients un derwent RA-RPLND for paratesticular RMS. The median age was 16.1 years (15–17), with median OR time of 456 min (357–508). No conversions to open occurred. Inpatient median total opioid use was 1.8 (0.4–2.7) morphine equivalent/kg. Th...
Source: Journal of Robotic Surgery - November 16, 2023 Category: Surgery Source Type: research

The RRAS2 pathogenic variant (c.67G > T; p. Gly23Cys) produces Noonan syndrome with embryonal rhabdomyosarcoma
ConclusionsOur investigations suggested that the heterozygous missense ofRRAS2 may be a potential causal variant in a rare cause of Noonan syndrome, expanding our understanding of the causally relevant mutations for this disorder. (Source: Molecular Genetics & Genomic Medicine)
Source: Molecular Genetics & Genomic Medicine - November 10, 2023 Category: Genetics & Stem Cells Authors: Lan Zeng, Jin Wang, Hui Zhu, Yu Huang, Yi Deng, Ping Wei, Jing Nie, Bei Tang, Ai Chen, Shuyao Zhu Tags: ORIGINAL ARTICLE Source Type: research

The RRAS2 pathogenic variant (c.67G & gt;T; p. Gly23Cys) produces Noonan syndrome with embryonal rhabdomyosarcoma
CONCLUSIONS: Our investigations suggested that the heterozygous missense of RRAS2 may be a potential causal variant in a rare cause of Noonan syndrome, expanding our understanding of the causally relevant mutations for this disorder.PMID:37942564 | DOI:10.1002/mgg3.2313 (Source: Molecular Medicine)
Source: Molecular Medicine - November 9, 2023 Category: Molecular Biology Authors: Lan Zeng Jin Wang Hui Zhu Yu Huang Yi Deng Ping Wei Jing Nie Bei Tang Ai Chen Shuyao Zhu Source Type: research

Intractable Ventricular Tachycardia Prior to an Overt Cardiac Tumor Mass of Metastatic Cardiac Rhabdomyosarcoma (Spindle-cell Type)
Intern Med. 2023 Nov 6. doi: 10.2169/internalmedicine.2568-23. Online ahead of print.ABSTRACTWe herein report a 37-year-old man who experienced recurrence of metastatic cardiac rhabdomyosarcoma along with intractable ventricular tachycardia (VT) 7 years after resection of rhabdomyosarcoma in his right elbow. At 36 years old, he developed VT unresponsive to radiofrequency catheter ablation (RFCA). Initially, the cardiac tumor was not detected, but it gradually grew in size at the RFCA site. A surgical biopsy confirmed the diagnosis of metastatic cardiac rhabdomyosarcoma. Despite radiation therapy, cardiac tumor progression ...
Source: Internal Medicine - November 5, 2023 Category: Internal Medicine Authors: Yosuke Terui Hideaki Suzuki Akio Chikata Yuichi Hanaki Yuki Komatsu Hideki Ota Fumiyoshi Fujishima Rei Umezawa Kota Ouchi Haruka Sato Taijyu Satoh Saori Miyamichi-Yamamoto Nobuhiro Yaoita Hideka Hayashi Kotaro Nochioka Hiroyuki Takahama Akihiko Nogami Yos Source Type: research