GSE242690 Piperacetazine directly binds to the PAX3::FOXO1 fusion protein and inhibits its transcriptional activity
Contributors : Jun S Wei ; Xinyu Wen ; Javed KhanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe tumor-specific chromosomal translocation product, PAX3::FOXO1, is an aberrant fusion protein that plays a key role for oncogenesis in the alveolar subtype of rhabdomyosarcoma (RMS). PAX3::FOXO1 represents a validated molecular target for alveolar RMS and successful inhibition of its oncogenic activity is likely to have significant clinical applications. Even though several PAX3::FOXO1 function-based screening studies have been successfully completed, a directly binding small molecule...
Source: GEO: Gene Expression Omnibus - September 12, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
In-utero Diagnosis of Prostatic Embryonal Rhabdomyosarcoma
This report demonstrates the first reported case of this phenomenon and its subsequent workup, diagnosis, and treatment. (Source: Urology)
Source: Urology - September 9, 2023 Category: Urology & Nephrology Authors: Emily Schiller, Parth Joshi, Alexander El-Ali, William Brenseke, Margret S. Magid, Leonard Wexler, Jordan Gitlin Source Type: research
Quantitative diffusion-weighted MRI response assessment in rhabdomyosarcoma: an international retrospective study on behalf of the European paediatric Soft tissue sarcoma Study Group Imaging Committee
ConclusionA significant change in the 5th percentile and the mean ADC after chemotherapy was observed. Strong heterogeneity was identified in DW-MRI acquisition protocols between centers and in individual patients.Graphical Abstract (Source: Pediatric Radiology)
Source: Pediatric Radiology - September 8, 2023 Category: Radiology Source Type: research
Clinical features and outcomes of infantile soft-tissue sarcoma: A multicenter retrospective study in Beijing
CONCLUSIONS: Infant-onset soft-tissue sarcoma is heterogeneous. The primary location of the abdominal or pelvic cavity of RMS and EWS was at a later stage and had a poorer prognosis. Multimodal therapy resulted in successful disease control for the majority of patients. Standardization of treatment protocols will facilitate care for such challenging conditions.PMID:37675711 | DOI:10.4103/jcrt.jcrt_1950_22 (Source: Cancer Control)
Source: Cancer Control - September 7, 2023 Category: Cancer & Oncology Authors: Shuai Zhu Na Xu Tian Zhi Yangxu Gao Dixiao Zhong Weiling Zhang Mei Jin Qing Sun Yao Xie Xiaolun Zhang Long Li Shengcai Wang Huanmin Wang Rong Liu Weihong Zhao Dongsheng Huang Xin Ni Xiaoli Ma Source Type: research
Intraosseous Spindle Cell Rhabdomyosarcoma with < em > MEIS1 < /em > :: < em > NCOA2 < /em > Fusion - Case Report with Substantial Clinical Follow-up and Review of the Literature
We report here a new case of the very rare intraosseous SSRMS with MEIS1::NCOA2 gene fusion and include the detailed treatment course and 52 months of clinical follow-up. SSRMS with MEIS1::NCOA2 gene fusion appears biologically distinct from other intraosseous SSRMS, following a course characterized by local recurrence with rare reports of metastasis to date.PMID:37668330 | DOI:10.1080/07357907.2023.2255668 (Source: Cancer Investigation)
Source: Cancer Investigation - September 5, 2023 Category: Cancer & Oncology Authors: Benjamin F Smith Yee-Cheen Doung Brooke Beckett Christopher L Corless Lara E Davis Jessica L Davis Source Type: research
