Cardiac tumours
Cardiac tumours are most often secondaries from malignancies of breast, lung or malignant melanoma. Primary tumours of the heart are most often benign, of which about half are myxomas. Malignant primary tumours of the heart contribute to about a quarter of the primary cardiac tumours. The commonest primary malignant tumour of the heart would be a sarcoma [1]. Cardiac tumours may present with cardiovascular or constitutional symptoms. Sometimes they are incidentally detected on echocardiography or other imaging modalities.
Left atrial myxoma on echocardiogram
Computed tomography and magnetic resonance imaging can give addi...
Source: Cardiophile MD - August 25, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Back to School: Top Tips for Undergraduates Eyeing Careers in Biomedical Sciences
Finding a career path in
biomedical research can be challenging for many young people, especially when
they have no footsteps to follow. We asked three recent college graduates who
are pursuing advanced degrees in biomedical sciences to give us their best
advice for undergrads.
Tip 1: Talk with mentors and peers, and explore opportunities.
One of the most challenging things for incoming undergraduates is simply to find out about biomedical research opportunities. By talking to professors and peers, students can find ways to explore and develop their interests in biomedical research.
Credit: Mariajose Franco.
Ma...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - September 11, 2019 Category: Research Authors: Matt Mills Tags: Being a Scientist Profiles Training Source Type: blogs
Shai ’s Story
Shai’s Story is about a mother who fought with her daughter, Shai, through Shai’s battle with rhabdomyosarcoma, a tumorous cancer which developed in her pelvis while she was still in utero. It was diagnosed almost a year after her birth leaving Shai with little option for treatment. Shai’s mother, Frances, spent many months at a time in hospitals with Shai for chemotherapy treatment that was both saving her child’s life and killing her.
While treatment helped Shai with one cancer, leaving her family excited for her recovery, it also caused another cancer to develop while she was in remission. Shai had three organs ...
Source: Cord Blood News - January 9, 2019 Category: Perinatology & Neonatology Authors: Maze Cord Blood Tags: babies Cord Blood parents stem cells Source Type: blogs
New Nanopackaging for Chemo Agents for Targeted Killing of Tumors
We report for the first time on a nano-drug delivery system based on glucosylated polymeric nanomicelles to actively target the second-generation tyrosine kinase inhibitor dasatinib to glucose-avid pediatric sarcomas by the intravenous route. After a comprehensive physicochemical characterization that confirmed the substantially lower critical micellar concentration and the higher encapsulation capacity of the glucosylated amphiphilic nanocarrier with respect to the pristine counterpart, we showed a 9-fold decrease of the half maximal inhibitory concentration of dasatinib in a rhabdomyosarcoma cell line, Rh30, i...
Source: Medgadget - June 4, 2018 Category: Medical Devices Authors: Editors Tags: Nanomedicine Oncology Source Type: blogs
MR-HIFU and ThermoDox to Treat Recurrent Childhood Tumors: Interview with AeRang Kim, Principal Investigator
Children’s National Health System and the Celsion Corporation (Lawrenceville, NJ) have recently announced a Phase I clinical trial in the US to determine a safe and tolerable dose of ThermoDox in conjunction with non-invasive magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU). The trial is aimed on young adults and children with recurring solid tumors.
ThermoDox technology consists of liposomes loaded with doxorubicin, a conventional chemotherapeutic drug. Liposomes are small lipid structures which can be used to encapsulate and deliver drugs through the bloodstream. While liposomal doxorubicin formu...
Source: Medgadget - December 6, 2016 Category: Medical Equipment Authors: Conn Hastings Tags: Exclusive Nanomedicine Oncology Source Type: blogs
Orbital rhabdomyosarcoma
with cross striations and rhabdomyoblasts. Arrow points to eosinophilic strap cell with cross striations. Rhabdomyosarcoma is the most common malignant orbital tumor of childhood.(Adapted from Eye Pathology: An Atlas and Text [2nd edition] by Ralph C. Eagle) (Source: neuropathology blog)
Source: neuropathology blog - May 26, 2016 Category: Radiology Tags: neoplasms Source Type: blogs
Aneuploidy and Carcinogenesis
In June, 2014, my book, entitled Rare Diseases and Orphan Drugs: Keys to Understanding and Treating the Common Diseases was published by Elsevier. The book builds the argument that our best chance of curing the common diseases will come from studying and curing the rare diseases. The book has an extensive glossary, that explains the meaning and relevance of medical terms appearing throughout the chapters. The glossary can be read as a stand-along document. Here is an example of one term, "aneuploidy", excerpted from the glossary.Aneuploidy - The presence of an abnormal number of chromosomes (for the species) in a cell...
Source: Specified Life - July 15, 2014 Category: Pathologists Tags: aneuploidy cancer types carcinogenesis common cancers common disease cytogenetics glossary orphan disease orphan drugs rare cancers rare disease tumor biology tumor types types of cancer Source Type: blogs
The Power of Social Media
In the past, I've discussed the financial challenges facing those of us who conduct research on rare diseases and the important role private foundations play in facilitating our work. What I haven't mentioned before is the role social media can play in linking researchers with foundations.
As some of you may know, I'm on Twitter. Well... sort of. I've been on Twitter recently about as much as I've been posting on my blog.
But through Twitter, I found the Rally Foundation. Honestly, I'm not sure I would have found them otherwise. I'm sure glad I did, though. They're a fabulous organizat...
Source: Doctor David's Blog - March 14, 2013 Category: Oncologists Tags: Being a Pediatric Oncologist Philanthropy Announcements Source Type: blogs
Sarcoma – Signs, Histology, and Treatment
Pathophysiology of Soft Tissue Sarcoma
1) sarcomas of the soft tissue are a family of neoplasms affecting the soft tissue of the body Causes 2) previous radiation 3) HIV 4) genetic predisposition such as L-Fraumeni syndrome 5) asbestosis 6) congenital immunodeficiences 7) dioxin exposure 8) Herpes virus
Signs and Symptoms
1) most common presentation is an enlarging mass 2) pain 3) neuralgia and neurologic deficits, if the tumor encases a nerve structure 4) metastases are usually via the blood system and most commonly go to the lungs
Characteristic Test Findings
Radiology – mass on MRI
Histology/Gross Pathology
1) m...
Source: Inside Surgery - January 27, 2013 Category: Surgeons Authors: Editor Tags: Oncology angiosarcoma leimyosarcoma malignant fibrous histiocytosis p53 Schwannoma tumor suppressor Source Type: blogs
Minimal Reporting Guidelines for the Treatment of Cancer Patients
Minimal Reporting Guidelines for the Treatment of Cancer Patients As laboratory physicians, our contribution to patient care is knowledge: this is the starting point from which all informed therapeutic intervention proceeds. How that knowledge is obtained and communicated is the art and science of our profession. These minimal diagnostic guidelines are designed to be used as an aid, not a constraint, in that process. The guidelines are presented in a specific format out of necessity, but any format that effectively communicates the necessary information in a given patho...
Source: Oncopathology - September 5, 2011 Category: Cancer & Oncology Source Type: blogs
