CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models
CONCLUSIONS: CD276- and CD276/FGFR4-directed CAR Ts showed effective RMS cell killing in vitro and eradication of CD276high RMS tumors in vivo. CD276low tumors escaped the therapy highlighting a correlation between antigen density and effectiveness. FGFR4-CAR Ts showed specific killing in vitro but could only delay RMS growth in vivo. Our results demonstrate that combined expression of CD276-CAR with other CAR does not reduce its benefit. Introducing immunotherapy with CD276-CAR Ts in RMS seems to be feasible and promising, although CAR constructs design and target combinations have to be further improved to eradicate tumo...
Source: Cell Research - November 4, 2023 Category: Cytology Authors: Andrea Timpanaro Caroline Piccand Dzhangar Dzhumashev Stenija Anton-Joseph Andrea Robbi Janine Moser Jochen R össler Michele Bernasconi Source Type: research
CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood, whose prognosis is still poor especially for metastatic, high-grade, and relapsed RMS. New treatments are urgently needed, especially... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - November 4, 2023 Category: Cancer & Oncology Authors: Andrea Timpanaro, Caroline Piccand, Dzhangar Dzhumashev, Stenija Anton-Joseph, Andrea Robbi, Janine Moser, Jochen R össler and Michele Bernasconi Tags: Research Source Type: research
Receptor tyrosine kinase gene expression profiling of orbital rhabdomyosarcoma unveils MET as a potential biomarker and therapeutic target
AbstractReceptor tyrosine kinases (RTKs) serve as molecular targets for the development of novel personalized therapies in many malignancies. In the present study, expression pattern of receptor tyrosine kinases and its clinical significance in orbital RMS has been explored. Eighteen patients with histopathologically confirmed orbital RMS formed part of this study. Comprehensive q-PCR gene expression profiles of 19 RTKs were generated in the cases and controls. The patients were followed up for 59.53 ± 20.93 years. Clustering and statistical analysis tools were applied to identify the significant combination of RTKs...
Source: Human Cell - November 2, 2023 Category: Cytology Source Type: research
Cancers, Vol. 15, Pages 5269: Rhabdomyosarcoma: Current Therapy, Challenges, and Future Approaches to Treatment Strategies
Marek J. Łos
Benjamin Lindsey
Nilufer Cakir
Atefeh Zarepour
Kiavash Hushmandi
Ali Fallah
Bahattin Koc
Arezoo Khosravi
Mazaher Ahmadi
Susan Logue
Gorka Orive
Stevan Pecic
Joseph W. Gordon
Saeid Ghavami
Rhabdomyosarcoma is a rare cancer arising in skeletal muscle that typically impacts children and young adults. It is a worldwide challenge in child health as treatment outcomes for metastatic and recurrent disease still pose a major concern for both basic and clinical scientists. The treatment strategies for rhabdomyosarcoma include multi-agent chemotherapies after surgical resection with or w...
Source: Cancers - November 2, 2023 Category: Cancer & Oncology Authors: Ali Zarrabi David Perrin Mahboubeh Kavoosi Micah Sommer Serap Sezen Parvaneh Mehrbod Bhavya Bhushan Filip Machaj Jakub Rosik Philip Kawalec Saba Afifi Seyed Mohammadreza Bolandi Peiman Koleini Mohsen Taheri Tayyebeh Madrakian Marek J. Łos Benjamin Lindse Tags: Review Source Type: research
Diversity of small round cell sarcoma in soft tissues around bone among Indian patients
Bioinformation. 2023 Aug 31;19(8):871-875. doi: 10.6026/97320630019871. eCollection 2023.ABSTRACTRound cell tumors are a group of malignant tumors which shows overlapping microscopic features of small round monotonous cells with hyper-chromatic nucleus. It mostly occurs in children, adolescent, and young adults. The ancillary technique to confirm the differential diagnosis of round cells sarcoma is immuno-histo chemistry (IHC). Therefore, it is of interest to document the diversity of small round cell sarcoma in soft tissues around bones among Indian patients using IHC. A total of 334 cases among Indians were studied. Amon...
Source: Bioinformation - November 1, 2023 Category: Bioinformatics Authors: Rani Singh Guddi Kumari Bharti Anuja Mishra Dinesh Kumar Sinha Debaditya Haldar Shabana Azad Source Type: research
Diversity of small round cell sarcoma in soft tissues around bone among Indian patients
Bioinformation. 2023 Aug 31;19(8):871-875. doi: 10.6026/97320630019871. eCollection 2023.ABSTRACTRound cell tumors are a group of malignant tumors which shows overlapping microscopic features of small round monotonous cells with hyper-chromatic nucleus. It mostly occurs in children, adolescent, and young adults. The ancillary technique to confirm the differential diagnosis of round cells sarcoma is immuno-histo chemistry (IHC). Therefore, it is of interest to document the diversity of small round cell sarcoma in soft tissues around bones among Indian patients using IHC. A total of 334 cases among Indians were studied. Amon...
Source: Bioinformation - November 1, 2023 Category: Bioinformatics Authors: Rani Singh Guddi Kumari Bharti Anuja Mishra Dinesh Kumar Sinha Debaditya Haldar Shabana Azad Source Type: research
Diversity of small round cell sarcoma in soft tissues around bone among Indian patients
Bioinformation. 2023 Aug 31;19(8):871-875. doi: 10.6026/97320630019871. eCollection 2023.ABSTRACTRound cell tumors are a group of malignant tumors which shows overlapping microscopic features of small round monotonous cells with hyper-chromatic nucleus. It mostly occurs in children, adolescent, and young adults. The ancillary technique to confirm the differential diagnosis of round cells sarcoma is immuno-histo chemistry (IHC). Therefore, it is of interest to document the diversity of small round cell sarcoma in soft tissues around bones among Indian patients using IHC. A total of 334 cases among Indians were studied. Amon...
Source: Bioinformation - November 1, 2023 Category: Bioinformatics Authors: Rani Singh Guddi Kumari Bharti Anuja Mishra Dinesh Kumar Sinha Debaditya Haldar Shabana Azad Source Type: research
Diversity of small round cell sarcoma in soft tissues around bone among Indian patients
Bioinformation. 2023 Aug 31;19(8):871-875. doi: 10.6026/97320630019871. eCollection 2023.ABSTRACTRound cell tumors are a group of malignant tumors which shows overlapping microscopic features of small round monotonous cells with hyper-chromatic nucleus. It mostly occurs in children, adolescent, and young adults. The ancillary technique to confirm the differential diagnosis of round cells sarcoma is immuno-histo chemistry (IHC). Therefore, it is of interest to document the diversity of small round cell sarcoma in soft tissues around bones among Indian patients using IHC. A total of 334 cases among Indians were studied. Amon...
Source: Bioinformation - November 1, 2023 Category: Bioinformatics Authors: Rani Singh Guddi Kumari Bharti Anuja Mishra Dinesh Kumar Sinha Debaditya Haldar Shabana Azad Source Type: research
Diversity of small round cell sarcoma in soft tissues around bone among Indian patients
Bioinformation. 2023 Aug 31;19(8):871-875. doi: 10.6026/97320630019871. eCollection 2023.ABSTRACTRound cell tumors are a group of malignant tumors which shows overlapping microscopic features of small round monotonous cells with hyper-chromatic nucleus. It mostly occurs in children, adolescent, and young adults. The ancillary technique to confirm the differential diagnosis of round cells sarcoma is immuno-histo chemistry (IHC). Therefore, it is of interest to document the diversity of small round cell sarcoma in soft tissues around bones among Indian patients using IHC. A total of 334 cases among Indians were studied. Amon...
Source: Bioinformation - November 1, 2023 Category: Bioinformatics Authors: Rani Singh Guddi Kumari Bharti Anuja Mishra Dinesh Kumar Sinha Debaditya Haldar Shabana Azad Source Type: research
Survival outcomes including salvage therapy of adult head and neck para-meningeal rhabdomyosarcoma: a multicenter retrospective study from Japan
Rhabdomyosarcoma is the most common soft tissue sarcoma in children, but rare in adults. Para-meningeal rhabdomyosarcoma in head and neck (PM-HNRMS) is less applicable for surgery due to the anatomic reason. P... (Source: BMC Cancer)
Source: BMC Cancer - October 31, 2023 Category: Cancer & Oncology Authors: Kenji Tsuchihashi, Mamoru Ito, Shuji Arita, Hitoshi Kusaba, Wataru Kusano, Takashi Matsumura, Takafumi Kitazono, Shohei Ueno, Ryosuke Taguchi, Tomoyasu Yoshihiro, Yasuhiro Doi, Kohei Arimizu, Hirofumi Ohmura, Tatsuhiro Kajitani, Kenta Nio, Michitaka Nakan Tags: Research Source Type: research
9525 Pelvic Rhabdomyosarcoma in an Adolescent Presenting with Bilateral Adnexal Masses Treated with Minimally Invasive Surgical Resection
To review a unique presentation of acute abdomen with bilateral pelvic rhabdomyosarcomas, initially thought to be endometriosis, in an adolescent. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 27, 2023 Category: OBGYN Authors: V Kim, E Sulger, HI Park Source Type: research
A SNAI2/CTCF Interaction is Required for < em > NOTCH1 < /em > Expression in Rhabdomyosarcoma
Mol Cell Biol. 2023 Oct 26:1-19. doi: 10.1080/10985549.2023.2256640. Online ahead of print.ABSTRACTRhabdomyosarcoma (RMS) is a pediatric malignancy of the muscle with characteristics of cells blocked in differentiation. NOTCH1 is an oncogene that promotes self-renewal and blocks differentiation in the fusion negative-RMS sub-type. However, how NOTCH1 expression is transcriptionally maintained in tumors is unknown. Analyses of SNAI2 and CTCF chromatin binding and HiC analyses revealed a conserved SNAI2/CTCF overlapping peak downstream of the NOTCH1 locus marking a sub-topologically associating domain (TAD) boundary. Deletio...
Source: Mol Biol Cell - October 26, 2023 Category: Molecular Biology Authors: Prethish Sreenivas Long Wang Meng Wang Anil Challa Paulomi Modi Nicole Rae Hensch Berkley Gryder Hsien-Chao Chou Xiang R Zhao Benjamin Sunkel Rodrigo Moreno-Campos Javed Khan Benjamin Z Stanton Myron S Ignatius Source Type: research
