Cancers, Vol. 15, Pages 5269: Rhabdomyosarcoma: Current Therapy, Challenges, and Future Approaches to Treatment Strategies
Cancers, Vol. 15, Pages 5269: Rhabdomyosarcoma: Current Therapy, Challenges, and Future Approaches to Treatment Strategies
Cancers doi: 10.3390/cancers15215269
Authors:
Ali Zarrabi
David Perrin
Mahboubeh Kavoosi
Micah Sommer
Serap Sezen
Parvaneh Mehrbod
Bhavya Bhushan
Filip Machaj
Jakub Rosik
Philip Kawalec
Saba Afifi
Seyed Mohammadreza Bolandi
Peiman Koleini
Mohsen Taheri
Tayyebeh Madrakian
Marek J. Łos
Benjamin Lindsey
Nilufer Cakir
Atefeh Zarepour
Kiavash Hushmandi
Ali Fallah
Bahattin Koc
Arezoo Khosravi
Mazaher Ahmadi
Susan Logue
Gorka Orive
Stevan Pecic
Joseph W. Gordon
Saeid Ghavami
Rhabdomyosarcoma is a rare cancer arising in skeletal muscle that typically impacts children and young adults. It is a worldwide challenge in child health as treatment outcomes for metastatic and recurrent disease still pose a major concern for both basic and clinical scientists. The treatment strategies for rhabdomyosarcoma include multi-agent chemotherapies after surgical resection with or without ionization radiotherapy. In this comprehensive review, we first provide a detailed clinical understanding of rhabdomyosarcoma including its classification and subtypes, diagnosis, and treatment strategies. Later, we focus on chemotherapy strategies for this childhood sarcoma and discuss the impact of three mechanisms that are involved in the chemotherapy response including apoptosis, macro-autophagy, and the unfolded protein respons...
Source: Cancers - Category: Cancer & Oncology Authors: Ali Zarrabi David Perrin Mahboubeh Kavoosi Micah Sommer Serap Sezen Parvaneh Mehrbod Bhavya Bhushan Filip Machaj Jakub Rosik Philip Kawalec Saba Afifi Seyed Mohammadreza Bolandi Peiman Koleini Mohsen Taheri Tayyebeh Madrakian Marek J. Łos Benjamin Lindse Tags: Review Source Type: research
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