Cancers, Vol. 16, Pages 853: Statin-Sensitive Akt1/Src/Caveolin-1 Signaling Enhances Oxidative Stress Resistance in Rhabdomyosarcoma
o Sampaolesi Stefano Gastaldello Matteo Cassandri Francesco Marampon Alessandro Fanzani Identifying the molecular mechanisms underlying radioresistance is a priority for the treatment of RMS, a myogenic tumor accounting for approximately 50% of all pediatric soft tissue sarcomas. We found that irradiation (IR) transiently increased phosphorylation of Akt1, Src, and Cav1 in human RD and RH30 lines. Synthetic inhibition of Akt1 and Src phosphorylation increased ROS levels in all RMS lines, promoting cellular radiosensitization. Accordingly, the elevated activation of the Akt1/Src/Cav1 pathway, as detected in two ...
Source: Cancers - February 20, 2024 Category: Cancer & Oncology Authors: Silvia Codenotti Leonardo Sandrini Delia Mandracchia Luisa Lorenzi Giovanni Corsetti Maura Poli Michela Asperti Valentina Salvi Daniela Bosisio Eugenio Monti Stefania Mitola Luca Triggiani Michele Guescini Enrico Pozzo Maurilio Sampaolesi Stefano Gastalde Tags: Article Source Type: research

Evaluation of clinical and imaging features for differentiating rhabdomyosarcoma from neuroblastoma in pediatric soft tissue
ConclusionThe clinical and imaging features-based nomogram has potential for helping radiologists distinguish between pediatric soft tissue RMS and NB patients preoperatively, and reduce unnecessary interventions. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - February 9, 2024 Category: Cancer & Oncology Source Type: research

GSE240722 CD73 contributes to the pathogenesis of Fusion-Negative Rhabdomyosarcoma through the purinergic signaling pathway
Contributors : Lei Guo ; Lin Xu ; Akansha M Shah ; Victor A Lopez ; Vincent S Tagliabracci ; Kenian Chen ; Lin Xu ; Rhonda Bassel-Duby ; Eric N Olson ; Ning LiuSeries Type : Expression profiling by high throughput sequencingOrganism :We performed RNA-seq to evaluated the transcriptional changes of CD73 knockdown in RD cells, a Fusion Negative Rhabdomyosarcoma cell line. We used a Dox-inducible shRNA targetting the 3'UTR of CD73 to knockdown this gene. Cells with No-Dox were used as control. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - February 7, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research

Contemporary preclinical mouse models for pediatric rhabdomyosarcoma: from bedside to bench to bedside
ConclusionsThis up-to-date review highlights the need for mouse models with dissemination phenotypes and cell lines from primary untreated tumors. Furthermore, efforts should be directed towards underexplored areas such as surgery, radiotherapy, and biomarkers. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - February 2, 2024 Category: Cancer & Oncology Source Type: research

High-dose chemotherapy for Ewing Sarcoma and Rhabdomyosarcoma: a systematic review by the Australia and New Zealand Sarcoma Association clinical practice guidelines working party
Ewing sarcoma (ES) and rhabdomyosarcoma (RMS) are small round blue cell tumours that occur in children, adolescents and young adults (AYA) [1 –3]. In ES, the EWSR1-FLI1 fusion is identified in 85% of cases [1,4]. Small round cell sarcomas of bone and soft tissue where EWSR1-FLI1 fusion is not identified were previously collated with ES and termed the Ewing sarcoma family of tumours (ESFT) [1]. Molecular profiling has revealed fusions in cluding EWSR1–non-ETS fusions, CIC-rearrangements, and BCOR alterations by which these tumours are now classified and understood to confer different natural histories and treatment sens...
Source: Cancer Treatment Reviews - February 1, 2024 Category: Cancer & Oncology Authors: Ashika Ramamurthy, Elizabeth A Connolly, Jasmine Mar, Jeremy Lewin, Vivek A Bhadri, Marianne B Phillips, Mark Winstanley, Lisa M Orme, Peter Grimison, Joanna Connor, Smaro Lazarakis, Angela M Hong, Natacha Omer, Julie Cayrol Source Type: research

Application of hysteroscopy and vaginoscopy in follow up of young patients with genital tract rhabdomyosarcoma
Objective: Does operative hysteroscopy and vaginoscopy can be applied in detection of relapse and as a follow up of young patients with RMS of genital tract. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 1, 2024 Category: OBGYN Authors: Patrycja Gumu ła, Katarzyna Sachadel, Ewa Filipp, Anna Raciborska, Tadeusz Issat Source Type: research

Case report of 13-year old girl with rms of the uterus- gynecological intervention and oncolfertility procedure
Introduction: This is a case report of a 13 year old girl diagnosed with rhabdomyosarcoma embryonale of the uterus. After the initial chemotherapy there was an abnormal tissue left in the anterior wall of the uterus in MRI report. The patient was qualified for two step diagnostic approach to detectany residual neoplasia. First was operative hysteroscopy and the second was diagnostic laparoscopy combined with oncofertility procedure. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 1, 2024 Category: OBGYN Authors: Katarzyna Sachadel, Patrycja Gumu ła, Aleksandra Januszaniec, Anna Raciborska, Monika Bekesińska-Figatowska Source Type: research

Ocular and Orbital Tumors in Childhood
Pediatric tumors of the eye and orbit can be benign or malignant as well as congenital or acquired and are usually distinctively different than those seen in adults.1 Although most of these neoplasms are benign (e.g. dermoid cyst, chalazion or molluscum), their location near and within a vital organ can result in serious dermatologic and ophthalmologic sequelae. Lesions discussed include vascular lesions, retinoblastomas (the most common primary pediatric intraocular malignancy), rhabdomyosarcoma (the most common primary pediatric orbital malignancy), Langerhans cell histiocytosis, and metastatic lesions to the orbit (neur...
Source: Clinics in Dermatology - January 30, 2024 Category: Dermatology Authors: Kathryn Bentivegna, Nicholas J. Saba, Roman Shinder, Jane M. Grant-Kels Source Type: research

When the second comes first – rhabdomyosarcoma preceding heritable retinoblastoma– a case report
Retinoblastoma (rb) is the most frequent intraocular tumor, accounting for 3% of all childhood cancers. Heritable rb survivors are germline carriers for an RB1 mutation and have a lifelong risk to develop non-... (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - January 30, 2024 Category: Opthalmology Authors: Devjyoti Tripathy, Alexandre Moulin, Jacques Bijon, Carole Gengler, Maja Beck-Popovic, Francis L. Munier and Christina Stathopoulos Tags: Case Report Source Type: research

Resection of a Large Growing Mediastinal Germ Cell Tumor Using a Multidisciplinary Approach
Curr Oncol. 2023 Dec 21;31(1):42-49. doi: 10.3390/curroncol31010003.ABSTRACTMediastinal germ cell tumors (GCTs) are rare. Post-chemotherapy residual masses in patients with a nonseminomatous GCT require resection. A patient with a large mediastinal GCT involving the left subclavian artery, superior vena cava (SVC) and hilum of the right lung is presented. Despite a biochemical response to chemotherapy, the tumor enlarged on serial imaging. With guidance from medical oncology, a multidisciplinary surgical team, including cardiac anesthesia, cardiac surgery and thoracic surgery resected the tumor with a staged reconstruction...
Source: Current Oncology - January 26, 2024 Category: Cancer & Oncology Authors: Alison Greene Lori Wood Philip Champion Mathieu Castonguay Matthias Scheffler Catherine Deshaies Jeremy Wood Daniel French Source Type: research

Viruses, Vol. 16, Pages 170: Molecular Amplification and Cell Culturing Efficiency for Enteroviruses & rsquo; Detection in Cerebrospinal Fluids of Algerian Patients Suffering from Meningitis
Viruses, Vol. 16, Pages 170: Molecular Amplification and Cell Culturing Efficiency for Enteroviruses’ Detection in Cerebrospinal Fluids of Algerian Patients Suffering from Meningitis Viruses doi: 10.3390/v16020170 Authors: Abdelwahab Rai Zohra Ammi Dahbia Leila Anes-Boulahbal Aymen Amin Assadi Abdeltif Amrane Oussama Baaloudj Lotfi Mouni Enteroviruses (EVs) represent a major cause of viral meningitis, being responsible for nearly 1 billion infections each year worldwide. Several techniques were developed to obtain better diagnostic results of EV infections. Herein, we evaluated the efficiency ...
Source: Viruses - January 23, 2024 Category: Virology Authors: Abdelwahab Rai Zohra Ammi Dahbia Leila Anes-Boulahbal Aymen Amin Assadi Abdeltif Amrane Oussama Baaloudj Lotfi Mouni Tags: Article Source Type: research

Divergent HLA variations and heterogeneous expression but recurrent HLA loss-of- heterozygosity and common HLA-B and TAP transcriptional silencing across advanced pediatric solid cancers
The human leukocyte antigen (HLA) system is a major factor controlling cancer immunosurveillance and response to immunotherapy, yet its status in pediatric cancers remains fragmentary. We determined high-confidence HLA genotypes in 576 children, adolescents and young adults with recurrent/refractory solid tumors from the MOSCATO-01 and MAPPYACTS trials, using normal and tumor whole exome and RNA sequencing data and benchmarked algorithms. There was no evidence for narrowed HLA allelic diversity but discordant homozygosity and allele frequencies across tumor types and subtypes, such as in embryonal and alveolar rhabdomyosar...
Source: Frontiers in Immunology - January 22, 2024 Category: Allergy & Immunology Source Type: research