Potential of radiolabelled PSMA PET/CT or PET/MRI diagnostic procedures in gliomas/glioblastomas.
CONCLUSION: Radiolabelled PSMA imaging seems to be useful in analyzing glioma/glioblastoma. Further studies enrolling a wider population are needed to clarify the real clinical and diagnostic role of radiolabelled PSMA in this setting and its possible position in the diagnostic flow-chart. PMID: 31625482 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - October 20, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

The Screening of Renoprotective Agents by 99mTc-DMSA: A Review of Preclinical Studies.
CONCLUSION: In this review, the recent findings about the renoprotective agents were evaluated and screened with respect to the use of 99mTc-DMSA , which is preclinically and clinically used for animal cases and cancer patients under the treatment by radiotherapy and chemotherapy. PMID: 31612808 [PubMed - in process] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - October 17, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Clinical and prognostic value of 18F-FDG-PET/CT in the restaging process of recurrent cutaneous melanoma.
Authors: Albano D, Familiari D, Fornito MC, Scalisi S, Laudicella R, Galia M, Grassedonio E, Ruggeri A, Ganduscio G, Messina M, Spada M, Midiri M, Alongi P Abstract OBJECTIVE: The aim of this retrospective multicenter study was to evaluate the clinical and prognostic impact of 18F-FDG-PET/CT in the restaging process of cutaneous melanoma (CM) after surgery in patients with suspected distant recurrent disease or suspected metastatic progression disease. MATERIALS AND METHODS: 74 patients surgically treated for CM underwent 18F-FDG-PET/CT for suspicious of distant recurrent disease or suspected metastatic progres...
Source: Current Radiopharmaceuticals - October 11, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

A preliminary study for quantitative assessment with HFUS (High Frequency ultrasound) of nodular skin melanoma Breslow thickness in adults before surgery: Interdisciplinary team experience.
CONCLUSIONS: If further studies are needed to support its widespread clinical use, we believe that, in expert hands and with a interdisciplinary team, HFUS are already capable to reliably calculate a Breslow index in the large majority of patients with cutaneous melanoma. PMID: 31589132 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - October 8, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Analysis of Unusual Adverse Effects after Radium-223 Dichloride Administration.
CONCLUSIONS: The management of adverse effects after radiopharmaceuticals administration as in case of lymphedema onset, is extremely simple. These data confirms the safety of Radium-223 treatment. PMID: 31560295 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - September 30, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Oxidant and Antioxidant Effects of Gentisic Acid in a 177Lu-Labelled Methionine-containing Minigastrin Analogue.
CONCLUSION: The selective oxidation of the methionine residue could be induced by the H2O2 produced in the reaction between gentisic acid and free radicals of water, during the protection of the radiolabelled peptide from the attack of these harmful species. Therefore, the addition of methionine becomes necessary to effectively decrease this selective oxidation in the methionine-containing peptide. PMID: 31526356 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - September 20, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Preparation and biological evaluation of 67Gallium- labeled Iranian Hemiscorpius lepturus scorpion venom.
CONCLUSION: The results have largely shown the direct clinical effects on the studied tissues during the 72-hour period and antivenom administration can strongly alleviate the toxicity effects as early as 72 hours in the management of the patients. PMID: 31456528 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - August 29, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Molecular Imaging and Theranostics in Pancreatic Neuroendocrine Tumours: From a Luminous Present to an Even Brighter Future.
Authors: Paola M, Mansi L Abstract PMID: 31362647 [PubMed - in process] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - August 2, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Toward the discovery and development of PSMA targeted inhibitors for nuclear medicine applications.
CONCLUSION: PSMA represents for researchers the most attractive target for the detection and treatment of patients affected by PCa using nuclear medicine modalities. [99mTc]MIP-1404 is considered the tracer of choice for SPECT imaging and [68Ga]PSMA-11 is the leading diagnostic for PET imaging by general consensus. [18F]DCFPyL and [18F]PSMA-1007 are clearly the emerging PET PSMA candidates for their great potential for a widespread commercial distribution. After paving the way with new imaging tools, academic and industrial R&Ds are now focusing on the development of PSMA inhibitors labeled with alpha or beta minus emi...
Source: Current Radiopharmaceuticals - August 2, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Comparison of 99mTc Injected Activity with Prescribed Activity in Four Types of Nuclear Medicine Exams.
CONCLUSION: This uncertainty in activity exists due to time delay between the injection preparation time and administration time to patients as well as due to residual radionuclide that is not injected into patients and remains in syringe. PMID: 31258094 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - July 3, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

68Ga/64Cu PSMA bio-distribution in prostate cancer patients: potential pitfalls for different tracers.
CONCLUSION: The knowledge of difference in bio-distribution between two tracers may help in interpretation of PET data. Diagnostic pitfalls can be documented, due to the possibility of PSMA uptake in inflammation. Our results are preliminary to future studies comparing diagnostic accuracies of 68Ga-PSMA and 64Cu-PSMA. PMID: 31113354 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - May 23, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

PET/MRI in Neuroendocrine Tumours: Blessings and Curses.
Authors: Picchio M, De Cobelli F, Mapelli P PMID: 30947647 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 7, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Pre-feasibility Study for Establishing Radioisotope and Radiopharmaceutical Production Facilities in Developing Countries.
CONCLUSION: This work clearly shows that access to life-saving radioisotopes and the geographical distribution of corresponding infrastructure is highly unbalanced. Technology transfer is important as it not only immediate benefits patients, but also provide. PMID: 30924426 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - March 31, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Preface.
Authors: Mansi L, Kitson SL Abstract PMID: 30854945 [PubMed - in process] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - March 13, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Synthesis of Deuterium Labeled 5, 5-Dimethyl-3-( α, α, α-trifluoro-4-nitro-m-tolyl) Hydantoin.
CONCLUSION: We successfully synthesized [2H6]-nilutamide and [2H6]-dimethylhydantoin with good isotopic purity, measured to be of adequate quality for use as internal standards in bio-analytical studies. A brief mechanistic study of Bucherer-Bergs hydantoin reaction was carried and the reason for possible H/D exchange was explained. PMID: 30854946 [PubMed - in process] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - March 13, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

State of the art and recent developments of radiopharmaceuticals for pancreatic neuroendocrine tumors imaging.
CONCLUSION: This paper shows an overview of the RPs used so far in the imaging of pNETs with insight on potential new radiopharmaceuticals currently under clinical evaluation. PMID: 30843499 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - March 8, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Gamma emitters in pancreatic endocrine tumors imaging in the PET era: is there a clinical space for 99mTc-peptides?
CONCLUSION: In our opinion, Tektrotyd© could already find its applicative dimension in the daily practice of NETs, either pancreatic or not, at least in centers without a PET/CT or a 68Ga generator. Because of a wider availability, a lower cost, and a longer decay respect to peptides labeled with 68Ga, it could be also proposed , in a theranostic context, for a dosimetry evaluation of patients undergoing Peptide Receptor Radionuclide Therapy (PRRT), and for non-oncologic indications of radiolabelled SSA. In this direction, and for a more rigorous cost/effective evaluation , more precisely individuating its clinical ro...
Source: Current Radiopharmaceuticals - March 6, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Evaluation of the radioprotective effects of melatonin against ionizing radiation-induced muscle tissue injury.
Authors: Shabeeb D, Keshavarz M, Shirazi A, Hassanzadeh G, Hadian MR, Nowrouzi A, Najafi M, Musa AE Abstract BACKGROUND: Radiotherapy (RT) is a treatment method for cancer using ionizing radiation (IR). The interaction between IR with tissues produces free radicals that cause biological damages.As the largest organ in the human body, the skeletal muscles may be affected by detrimental effects of ionizing radiation. To eliminatethese side effects, we used melatonin, a major product secreted by the pineal gland in mammals, as a radioprotective agent. MATERIALS AND METHODS: For this study, a total of sixty male Wi...
Source: Current Radiopharmaceuticals - February 28, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Imaging of Pancreatic-Neuroendocrine Tumours: an Outline of Conventional Radiological Techniques.
CONCLUSION: Pancreatic neuroendocrine tumours are a unique collection of neoplasms that have markedly disparate clinical features but similar imaging characteristics. Most p-NETs are small and well-defined with homogenous enhancement following contrast administration, although larger and less well-differentiated tumours can demonstrate areas of necrosis and cystic architecture with heterogeneous enhancement characteristics. Prognosis is generally favourable for these tumours with various treatment options available. However, conventional radiological techniques will remain the foundation for the initial diagnosis and stagi...
Source: Current Radiopharmaceuticals - February 17, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

New 99mTc Radiotracers for Myocardial Perfusion Imaging by SPECT.
CONCLUSION: 99mTc-3SPboroximine is an excellent example of perfusion radiotracers, the heart uptake of which is largely relies on the regional blood flow. It is possible to use 99mTc-3SPboroximine for detection of perfusion defect(s), accurate quantification and determination of regional blood flow rate. Development of such a 99mTc radiotracer is of great clinical benefit for accurate diagnosis of CAD and assessing risk of future hard events (e.g. heart attack and sudden death) in cardiac patients. PMID: 30727939 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - February 10, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Physiopathological premises to Nuclear Medicine Imaging of pancreatic neuroendocrine tumours.
CONCLUSIONS: Although agonists usually provide efficient internalization, also somatostatin antagonists (SS-ANTs) could be used for imaging and therapy. Peptide receptor radionuclide therapy (PRRT) represents the most successful option for targeted therapy. The theranostic model based on SSTR doesn't work in insulinoma, in which different radiotracers such as F-18 FluoroDOPA or tracers for the glucagon-like peptide-1 receptor have to be preferred. PMID: 30727940 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - February 10, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Peptide receptor radionuclide therapy for pancreatic neuroendocrine tumours.
CONCLUSIONS: PRRT is well tolerated and effective treatment option for non-operable and/or metastatic pNETs. Side effects are usually mild and reversible. Larger randomized controlled trails need to be done to compare PRRT with other treatment modalities and to provide more detailed guidelines regarding patient selections, the choice of PRRT, follow up and response assessment to maximum potential benefit. PMID: 30714538 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - February 5, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Feasibility and evaluation of automated methods for radiolabeling of radiopharmaceutical kits with gallium-68.
CONCLUSION: The present study reports for the first time both the feasibility of using a [68Ga]-radiopharmaceutical kit with a synthesizer and the limits for the development of a fully automated process. PMID: 30636620 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - January 16, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

O ‑(2‑[18F]‑fluoroethyl)-L‑tyrosine (FET) in neurooncology: A review of experimental results.
CONCLUSION: This article summarizes the knowledge on the uptake behavior of FET, which has been collected in more than 30 experimental studies during the last two decades and discusses the role of these results in the clinical context. PMID: 30636621 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - January 16, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Comparison between 18f-Dopa and 18f-Fet Pet/Ct in Patients with Suspicious Recurrent High Grade Glioma: A Literature Review and our Experience.
CONCLUSIONS: 18F-DOPA and 18F-FET PET/CT have a similar diagnostic accuracy in patients with recurrent HGG. However, 18F-DOPA PET/CT could be affected by inflammation conditions (false positive) that can alter the final results. Large comparative trials are warranted in order to better understand the utility of 18F-DOPA or 18F-FET PET/CT in patients with HGG. PMID: 30644351 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - January 16, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

[18F]Amylovis as a Potential PET Probe for β-Amyloid Plaque: Synthesis, in Silico, in Vitro and in Vivo Evaluations.
CONCLUSION: The in silico, in vitro and in vivo results justify that [18F]Amylovis should be studied as a promissory PET imaging agent to detect the presence of Aβ senile plaques. PMID: 30605068 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - January 5, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

[68Ga]-Dota Peptide Pet/Ct In Neuroendocrine Tumors: Main Clinical Applications.
CONCLUSION: This review offers the systems of classification and grading of NENs and summarizes the more useful recommendations based on data recently published for the management of patients with NENs, with special focus on the role of imaging modalities based on SST targeting with PET / CT radiotracers. PMID: 30539709 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - December 13, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

Biochemical and histopathological evaluation of the radioprotective effects of melatonin against Gamma ray-induced skin damage in rats.
Authors: Shabeeb D, Najafi M, Musa AE, Keshavarz M, Shirazi A, Hassanzadeh G, Hadian MR, Samandari H Abstract BACKGROUND: Radiotherapy is one of the treatment methods for cancers using ionizing radiations. About 70% of cancer patients undergo radiotherapy. Radiation effect on the skin is one of the main complications of radiotherapy and dose limiting factor. To ameliorate this complication, we used melatonin as a radioprotective agent due to its antioxidant and anti-inflammatory effects, free radical scavenging, improving overall survival after irradiation as well as minimizing the degree of DNA damage and frequenc...
Source: Current Radiopharmaceuticals - November 23, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

Utility Of Molecular Imaging With 2-Deoxy-2-[Fluorine-18] Fluoro-D-Glucose Positron Emission Tomography (18f-Fdg Pet) For Small Cell Lung Cancer (Sclc): A Radiation Oncology Perspective.
CONCLUSION: PET provides useful functional information as a non-invasive molecular imaging modality and may be exploited to improve management of patients with SCLC. Incorporation of PET/CT in staging of patients with SCLC may aid in optimal treatment allocation for an improved therapeutic ratio. From a radiation oncology perspective, combination of functional and anatomical data provided by integrated PET/CT improves discrimination between atelectasis and tumor, and assists in designation of RT portals with its high accuracy to detect intrathoracic tumor and nodal disease. Utility of molecular imaging for SCLC should be f...
Source: Current Radiopharmaceuticals - November 23, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

The Evolving Clinical Role of Actinium-225 and Bismuth-213 for Targeted Alpha Therapy (TAT) - Production, Radiopharmaceutical Development and Clinical Applications.
Authors: Radchenko V, Schaffer P, Knapp FFR Abstract PMID: 30378473 [PubMed - in process] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - November 2, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

Synthesis of [18F]FAZA using Nosyl and Iodo Precursors for Nucleophilic Radiofluorination.
Authors: Sun W, Falzon C, Naimi E, Akbari A, Wiebe LI, Tandon M, Kumar P Abstract BACKGROUND: 1-α-D-(5-Deoxy-5-[18F]fluoroarabinofuranosyl)-2-nitroimidazole ([18F]FAZA) is manufactured by nucleophilic radiofluorination of 1-α-D-(2',3'-di-O-acetyl-5'-O-toluenesulfonylarabinofuranosyl)-2-nitroimidazole (DiAcTosAZA) and alkaline deprotection to afford [18F]FAZA. High yields (>60%) under optimized conditions frequently revert to low yields (
Source: Current Radiopharmaceuticals - October 20, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

Determination of gamma camera's calibration factors for quantitation of diagnostic radionuclides in simultaneous scattering and attenuation correction.
CONCLUSION: The presented procedure may help to determine the absorbed dose in target and likewise to optimize treatment planning. PMID: 30215339 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - September 16, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

Dosimetry and toxicity studies of the novel sulfonamide derivative of Sulforhodamine 101([18F]SRF101) at a preclinical level.
Authors: Kreimerman I, Mora-Ramirez E, Reyes AL, Bardies M, Savio E, Engler H Abstract Background The SR101 N-(3-[18F]Fluoropropyl) sulfonamide ([18F]SRF101) is a Sulforhodamine 101 derivative that was previously synthesised by our group. The fluorescent dye SR101 has been reported as a marker of astroglia in the neocortex of rodents in vivo. Objective The aim of this study was to perform a toxicological evaluation of [18F]SRF101 and to estimate human radiation dosimetry based on preclinical studies. Methods Radiation dosimetry studies were conducted based on biokinetic data obtained from a mouse model. A single-do...
Source: Current Radiopharmaceuticals - September 4, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

Evaluating the radioprotective effect of curcumin on rat's heart tissues.
CONCLUSION: Curcumin could reduce radiation-induced heart injury markers in rats. PMID: 30173659 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - September 4, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

Choline-PET/CT in the differential diagnosis between cystic glioblastoma and intraparenchymal hemorrhage.
CONCLUSION: in this case report FCH PET/CT represented the final diagnostic technique to confirm the suspicious of a cystic GBM. Our case demonstrated the potential role of 18F-FCH PET/CT for discrimination of higher proliferation area over intraparenchymal hemorrage, supporting the potential use of this imaging biomarker in surgical or radiosurgical approach. Obviously, further prospective studies are needed to confirm this role and to exactly define possible routinely applications. PMID: 30117406 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - August 18, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

Stability study of [18F]fludeoxyglucose and [18F]fluorocholine in different medical devices for intravenous administration.
In conclusion, these radiopharmaceuticals repackaged in plastic medical devices retained their quality after dispensing and prolonged storage. PMID: 29972107 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - July 5, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

Final outcome of 223Ra-therapy and the role of 18F-fluoride-PET in response evaluation in metastatic castration resistant prostate cancer -a single institution experience.
CONCLUSIONS: From these results we conclude that interim imaging does not help in assessing the final outcome of 223Ra therapy. The survival benefit of 223Ra therapy alone is more than a year in a high risk group of advanced prostate cancer. PMID: 29956640 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - July 1, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

In Vivo Evaluation of [225Ac]Ac-DOTAZOL for α-Therapy of Bone Metastases.
Conclusion [225Ac]Ac-DOTAZOL repeats the well-known pharmacology of DOTAZOL derivatives in preclinical evaluations. It thus may be considered for translational application together with strategies to reduce renal toxicity. PMID: 29866026 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - June 7, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

Clinical Studies with Bismuth-213 and Actinium-225 for Hematologic Malignancies.
Authors: Jurcic JG Abstract Because α-particles have a shorter range and a higher linear energy transfer compared to β-particles, targeted α-particle therapy offers the potential for more efficient tumor cell killing while sparing surrounding normal cells. To date, clinical studies of α-particle therapy for acute myeloid leukemia (AML) have focused on targeting the cell surface antigen CD33 using the humanized monoclonal antibody lintuzumab. An initial phase I study showed the safety feasibility, and anti-leukemic effects of bismuth-213 (213Bi)-labeled lintuzumab. Subsequently, 213Bi-lintuzum...
Source: Current Radiopharmaceuticals - May 30, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

PET evaluation of late cerebral effect in advanced radiation therapy techniques for cranial base tumors.
CONCLUSION: The present study support the safety of advanced radiation therapy techniques. 18F-FDG-PET, using SPM and semi-quantitative methods, might be a valuable tool to evaluate the cerebral radiotoxicity in patients treated for brain neoplasms. PMID: 29804540 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - May 30, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

Radioprotective effect of cerium oxide nanoparticles against genotoxicity induced by ionizing radiation on human lymphocytes.
CONCLUSION: This result provides a new potential indication of CNPs for protection of normal cells during radiation therapy in treatment of cancer or unwanted radiation exposure. PMID: 29804541 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - May 30, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

Development and Evaluation of Liquid and Solid Lipid Based Drug Delivery Systems Containing Technetium-99m-Radiolabeled Alendronate Sodium.
CONCLUSION: As a conclusion, spray dried formulations could be a promising drug delivery system for enhancing the permeability of ALD. Furthermore, this study is a good example of the use of radiolabeled compounds in drug development. PMID: 29807525 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - May 30, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

NorthStar Perspectives for Actinium-225 Production at Commercial Scale.
This article will discuss those efforts and results to date. PMID: 29766832 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - May 20, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

Automated Synthesis of 68Ga-DOTA-TOC: Methodological Aspects and Suitable Technical Solutions for a Cationic Purification System.
We reported the Ga-68 DOTATOC production by automated cassette-based theranostic synthesizer system used in combination with a disposable GMP grade cassette system for cationic purification. The synthesizer is integrated with the 68Ge/68Ga generator systems and it allows to perform elution, eluate purification and radiolabeling in about 38 minutes. We have performed between January 2016 and January 2017 over 100 [68Ga]Ga-DOTA-TOC preparation and of these only three have failed. The average synthesis yield of radiopharmaceutical production was 54.4 ± 2.3 % and the average radiochemical purity was 96.94 ± 0.74 ...
Source: Current Radiopharmaceuticals - May 12, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

An overview of targeted alpha therapy with 225Actinium and 213Bismuth.
Authors: Morgenstern A, Apostolidis C, Kratochwil C, Sathekge M, Krolicki L, Bruchertseifer F Abstract Recent reports of the remarkable therapeutic efficacy of 225Ac-labeled PSMA-617 for therapy of metastatic castration-resistant prostate cancer have underlined the clinical potential of targeted alpha therapy. This review describes methods for the production of 225Ac and its daughter nuclide 213Bi and summarizes the current clinical experience with both alpha emitters with particular focus on recent studies of targeted alpha therapy of bladder cancer, brain tumors, neuroendocrine tumors and prostate cancer. PMI...
Source: Current Radiopharmaceuticals - May 9, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

Dosimetry and Radiobiology of Alpha-Particle Emitting Radionuclides.
Authors: Sgouros G, Hobbs R, Josefsson A Abstract Radiopharmaceutical therapy is a cancer treatment modality by which radiation is delivered directly to targeted tumor cells or to their microenvironment. This makes it possible to deliver highly potent alpha-particle radiation. The short-range and highly potent nature of alpha-particles requires a dosimetry methodology that considers microscale distributions of the alpha-emitting agent. The high energy deposition density along an alpha-particle track causes a spectrum of DNA lesions. The majority of these are irreparable DNA double-stranded breaks. Accordingly the b...
Source: Current Radiopharmaceuticals - April 28, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

In vivo evaluation of free and chelated accelerator-produced Actinium-225 - radiation dosimetry and toxicity results.
CONCLUSIONS: Our biodistribution/dosimetry/toxicity study of accelerator-produced 225Ac demonstrated the patterns very similar to 229Th-derived 225Ac. We conclude that accelerator-produced 225Ac is suitable for the developmental work of targeted radionuclide therapy. PMID: 29683101 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 25, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

Motion management in PET/CT: technological solutions.
CONCLUSION: Different techniques can be chosen for motion management in PET/CT imaging demonstrating benefits in terms of image quality, quantification and lesion detectability. PMID: 29676240 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 22, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

The Production of Ac-225.
Authors: Engle JW Abstract The radionuclide 225Ac and its daughter 213Bi are among the most interesting alpha emitters being evaluated for incorporation into targeted therapeutic vectors. Global supply of 225Ac is presently insufficient to meet anticipated clinical demand, but the deficiency has been targeted by many research and development efforts, privately and publicly funded. From more than a decade of these endeavors, no single production technology has emerged as a complete solution. In the foreseeable future, global supply of 225Ac will continue to be sourced from a patchwork of production methods and labor...
Source: Current Radiopharmaceuticals - April 20, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research

Ga-68 Nanoparticles and Ultra-small Nanoparticle: Next Generation of PET Radiopharmaceuticals?
CONCLUSION: The results are preliminary and the data must be supported by animal biodistribution assay. PMID: 29667558 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 19, 2018 Category: Radiology Tags: Curr Radiopharm Source Type: research