Media Fill Test for validation of non-radioactive kit for radiopharmaceutical preparations
CONCLUSIONS: The modification proposed shows several advantages: reduction of the costs of the media fill tests, the possibility to manage these without referring to external services, and decreased injuries for technicians who perform the tests.PMID:33655880 | DOI:10.2174/1874471014666210303152908 (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - March 3, 2021 Category: Radiology Authors: Sara Vincenti Teresa Scotognella Stefania Bruno Marco Mariani Federica Boninti Andrea Cambieri Gianfranco Damiani Patrizia Laurenti Alessandro Giordano Source Type: research

Automated Radiosynthesis and Molecular Docking Studies of Coumarin-Triazole Hybrid with fluorine-18: A feasibility study.
CONCLUSION: we reported feasibility study for labeling coumarin-triazole hybrid with fluorine-18 through aromatic nucleophilic fluorination reaction (SNAr). PMID: 33511934 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - January 31, 2021 Category: Radiology Tags: Curr Radiopharm Source Type: research

Head and Neck Cancer Treatments from Chemotherapy to Magnetic Systems: Perspectives and Challenges.
CONCLUSION: The analysis shows that there is still much room for expanding research, especially for alternative therapies since most of the studies still focus on conventional treatments and on the quest to overcome their side effects. The scientific community needs to keep looking for more effective therapies generating fewer side effects for the patient. Currently, the so-called alternative therapies are being used in combination with the conventional ones, but the association of these new therapies shows great potential, in other types of cancer, to improve the treatment efficacy. PMID: 33511961 [PubMed - as supplie...
Source: Current Radiopharmaceuticals - January 31, 2021 Category: Radiology Tags: Curr Radiopharm Source Type: research

The Radiosensitizing Effect of Olanzapine as an Antipsychotic Medication in Glioblastoma Cell.
CONCLUSION: The present study demonstrates that OLA has radiosensitizing effect on cell death induced by IR in glioma cells. PMID: 33494694 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - January 28, 2021 Category: Radiology Tags: Curr Radiopharm Source Type: research

Investigation of radiolabeling efficacy by enhancement of the chemical form of no carrier added 177Lu isolated by electro amalgamation process.
CONCLUSION: This new separation setup consisting of two steps allows using 177Lu of such a favorable quality for labeling studies. PMID: 33480353 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - January 24, 2021 Category: Radiology Tags: Curr Radiopharm Source Type: research

Mayapuri Radiological Catastrophe: Good Practices and the Lessons Learnt.
CONCLUSION: The present article attempts to intensify pragmatic approaches to proactively avert and thwart 'orphan source' incidents like the Mayapuri radiological incident so that threat to the society is minimal, and putting in place enhanced medical preparedness measures for the management of radiation casualties caused by ignorance, negligence, incompetence, accident, or malicious intention. PMID: 33461479 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - January 21, 2021 Category: Radiology Tags: Curr Radiopharm Source Type: research

Meitner-Auger Electron Emitters for Targeted Radionuclide Therapy: Mercury-197m/g and Antimony-119.
Authors: Randhawa P, Olson AP, Chen S, Gower-Fry KL, Hoehr C, Engle JW, Ramogida CF, Radchenko V Abstract Targeted Radionuclide Therapies (TRTs) based on Auger emitting radionuclides have the potential to deliver extremely selective therapeutic payloads on the cellular level. However, to fully exploit this potential, suitable radionuclides need to be applied in combination with appropriate delivery systems. In this review, we summarize the state-of-the-art in production, purification, chelation and applications of two promising candidates for Targeted Auger Therapy, namely antimony-119 (119Sb) and mercury-197 (197H...
Source: Current Radiopharmaceuticals - January 14, 2021 Category: Radiology Tags: Curr Radiopharm Source Type: research

Accelerator Production of Scandium Radioisotopes: Sc-43, Sc-44, and Sc- 47.
Authors: Chernysheva M, Loveless SC, Brossard T, Becker K, Cingoranelli S, Aluicio-Sarduy E, Song J, Ellison P, Nolen J, Rotsch DA, Lapi SE, Engle JW Abstract Scandium radioisotopes are increasingly considered viable radiolabels for targeted molecular imaging (Sc-43, Sc-44) and therapy (Sc-47). Significant technological advances have increased the quantity and quality of available radioscandium in the past decade, motivated in part by the chemical similarity of scandium to therapeutic radionuclides like Lu-177. The production and radiochemical isolation techniques applied to scandium radioisotopes are reviewed, foc...
Source: Current Radiopharmaceuticals - January 14, 2021 Category: Radiology Tags: Curr Radiopharm Source Type: research

90Y-DOTA-nimotuzumab: Synthesis of a Promising β⁻ radiopharmaceutical.
CONCLUSIONS: The optimized conditions for a mild and easy preparation of 90Y-DOTA-nimotuzumab joined to a promising stability under physiological conditions suggest to propose this radioimmunoconjugate as a potential diagnostic radiopharmaceutical for β- radio-guided surgery. PMID: 33397277 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - January 7, 2021 Category: Radiology Tags: Curr Radiopharm Source Type: research

A review of accelerator-produced Ga-68 with solid targets.
Authors: Becker KV, Chernysheva M, Barnhart TE, Gagnon K, Engle JW Abstract Ga-68 is a positron-emitting nuclide that has recently achieved clinical acceptance as the diagnostic radionuclide in PET tracers used for theranostic studies of Lu-177 labeled therapeutic drugs due to the ease of access provided by Ge-68/Ga-68 generators. An alternative method of production currently being explored uses accelerators to form Ga-68 directly. This review of Ga-68 production strategies discusses available accelerator targetry at a range of beam energies and intensities, the many radiochemical separation techniques available to...
Source: Current Radiopharmaceuticals - December 29, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Theranostic radiopharmaceuticals targeting cancer-associated fibroblasts.
Authors: Zhuravlev F Abstract The tumor microenvironment is a dynamic ecosystem where malignant cells interact with the stromal cells sustaining and promoting tumor growth and metastasis. Cancer-associated fibroblasts (CAFs) are the major component of tumor stroma. CAFs control key tumorigenic activities by participating in immune evasion and suppression, extracellular matrix remodeling, neo-angiogenesis, and drug resistance. Therefore, targeting CAFs emerges as an attractive anti-cancer strategy. This review summarized recent advancements in targeting CAFs with diagnostic and therapeutic radiopharmaceuticals using...
Source: Current Radiopharmaceuticals - December 29, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

New Therapies to Modulate Post-infarction Inflammatory Alterations in the Myocardium: State of the art and Forthcoming Applications.
Authors: Clerc OF, Haaf P, Buechel RR, Gaemperli O, Zellweger MJ Abstract Acute myocardial infarction (AMI) is a major cause of morbidity and mortality worldwide. AMI causes a necrosis of cardiac cells and triggers a complex inflammatory response, affecting infarct size, cardiac function and clinical outcomes. This inflammatory response can be divided into 3 phases: 1) the pro-inflammatory phase, in which the release of damage-associated molecular patterns from necrotic cells triggers the secretion of pro-inflammatory mediators and attracts immune cells to clean the debris, further damaging viable myocardium, 2) th...
Source: Current Radiopharmaceuticals - December 12, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

The Imaging of Lung Cancer: A Complete Vision.
Authors: Mansi L, Evangelista L PMID: 33272169 [PubMed - in process] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - December 5, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Development of 186/188Re-Chitosan as an Effective Therapeutic Agent for Rheumatoid Arthritis.
CONCLUSION: According to the results, there is a possibility of labeling rhenium with chitosan in very high radiochemical purity. Regarding the high retention of these radiopharmaceuticals in joints with no leakage to surrounding organs, 186/188Re-chitosan can be applied as new radiosynovectomy drugs for rheumatoid arthritis treatment. PMID: 33272191 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - December 5, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

An exposition of 11C and 18F radiotracers synthesis for PET IMAGING.
Authors: Saxena P, Mahmood T, Dixit M, Gambhir S, Ahsan F Abstract The development of new radiolabeled Positron emission tomography tracers has been extensively utilized to access the increasing diversity in research process and to facilitate the development in research methodology, clinical usage of drug discovery and patient care. Recent advances in radiochemistry as well as latest techniques in automated radiosynthesizer have encouraged and challenge the radiochemist to produce the routinely developed radiotracers. Various radionuclides like 18F, 11C, 15O, 13N 99mTc, 131I, 124I and 64Cu are used for incorporatin...
Source: Current Radiopharmaceuticals - December 4, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Calcium Carbonate Microparticles as Carriers of 224Ra: Impact of Specific Activity in Mice with Intraperitoneal Ovarian Cancer.
CONCLUSION: Radium-224-labeled CaCO3 microparticles present a promising therapy against cancer dissemination in body cavities. PMID: 33261548 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - December 4, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

GMP automated purification of copper-61 produced in cyclotron liquid targets: methodological aspects.
CONCLUSION: The described purification process allows for the production of a highly radionuclidically and chemically pure, GMP compliant copper-61 solution, ready to be used for the development of copper-61 based radiopharmaceuticals for routine clinical use. PMID: 33183218 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - November 17, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Analytical GC-FID Method for the Determination of Organic Solvents in Radiopharmaceutical.
Authors: Hassan H, Othman MF, Zakaria ZA, Saad FFA, Abdul Razak HR Abstract BACKGROUND: Organic solvents play an indispensable role in most of the radiopharmaceutical production stages. It is almost impossible to remove them entirely in the final formulation of the product. OBJECTIVE: In this presented work, an analytical method by gas chromatography coupled with flame ionization detection (GC-FID) has been developed to determine organic solvents in radiopharmaceutical samples. The effect of injection hold time, temperature variation in the injection port, and the column temperature on the analysis time and res...
Source: Current Radiopharmaceuticals - October 30, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Nuclear Imaging Post-infarction Inflammation in Ischemic Cardiac Diseases - New Radiotracers for potential Clinical Applications.
Authors: Krenning BJ, der Heiden KV, Duncker DJ, de Jong M, Bernsen MR Abstract Acute myocardial infarction is one of the leading causes of death in the western world. Despite major improvements in myocardial reperfusion with sophisticated percutaneous coronary intervention technologies and new antithrombotic agents, there is still no effective therapy for preventing post-infarction myocardial injury and remodeling. Death of cardiomyocytes following ischemia results in "danger signals" that elicit an inflammatory reaction to remove cell debris and to form scar tissue. Optimal healing of the damaged myocar...
Source: Current Radiopharmaceuticals - October 15, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Production of Copper Radionuclides in Compact Medical Cyclotrons using Solid Targets.
Authors: Avila-Rodriguez MA, Valdovinos HF Abstract BACKGROUND: Over the last several years there has been a growing interest in the use of radiopharmaceuticals labeled with metallic radionuclides, especially isotopes of copper (Cu). Cu has a unique set of radionuclides with potential application not only for diagnostic imaging but also for applications in targeted radionuclide therapy. OBJECTIVE: To review the methods and routes used for the production of Cu radionuclides in compact medical cyclotrons (Ep
Source: Current Radiopharmaceuticals - September 30, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Challenges in the correct assessment of a case of aggressive thyroid carcinoma with synchronous breast cancer, case report and review of the literature: essential role of radiopharmaceuticals.
CONCLUSION: The case illustrates the challenges in correct assessment of oncologic patients, despite the advances in medical imaging and technologies and underlines the essential role of nuclear medicine procedures in the diagnostic and therapy protocols. PMID: 32988358 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - September 30, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

IAEA activities on 67Cu, 186Re, 47Sc Theranostic radionuclides and Radiopharmaceuticals.
Authors: Jalilian AR, Gizawy MA, Alliot C, Takacs S, Chakarborty S, Rovais MRA, Pupillo G, Nagatsu K, Park JH, Khandaker MU, Mikolajczak R, Bilewicz A, Okarvi S, Gagnon K, Al Rayyes AH, Lapi SE, Starovoitova V, Korde A, Jr JAO Abstract Despite interesting properties, the use of 67Cu, 186Re and 47Sc theranostic radionuclides in preclinical studies and clinical trials is curtailed by their limited availability due to a lack of widely established production methods. An IAEA Coordinated Research Project (CRP) was initiated to identify important technical issues related to the production and quality control of these eme...
Source: Current Radiopharmaceuticals - September 30, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

A Rapid and Specific HPLC Method to Determine Chemical and Radiochemical Purity of [68Ga] Ga-DOTA-Pentixafor (PET) Tracer: Development and Validation.
Authors: Migliari S, Sammartano A, Scarlattei M, Baldari G, Silva C, Ruffini L Abstract BACKGROUND: Due to its overexpression in a variety of tumor types, the chemokine receptor 4 (CXCR4) represents a highly relevant diagnostic and therapeutic target in nuclear oncology. Recently, [68Ga]Ga-DOTA-Pentixafor has emerged as an excellent imaging agent for positron emission tomography (PET) of CXCR4 expression in vivo. Preparation conditions may influence the quality and in vivo behaviour of this tracer and no standard procedure for the quality controls (QCs) is available. OBJECTIVE: The developed analytical test met...
Source: Current Radiopharmaceuticals - September 30, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Evaluation of Left Ventricular Volumes and Ejection Fraction From Gated Myocardial Perfusion SPECT Processed with "Myovation Evolution": Comparison of three Automated Software Packages Using Cardiac Magnetic Resonance as Reference.
CONCLUSION: All reconstruction methods sistematically understimate EDV and ESV, with higher underestimation applying only the RR. No significant differences were observed between 4DM -RR and 4DM-FBP, for each parameter, when 4DM package was used. PMID: 32933466 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - September 17, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Direct incorporation of [ 18F] into aliphatic systems: A promising Mncatalysed labelling technique for PET imaging.
CONCLUSION: The method features mild conditions (60 °C) and promises to constitute a valuable approach to labelling of biomolecules and drug substances. PMID: 32895047 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - September 10, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Theranostics of Metastatic Prostate Cancer Applying 64Cu/18F/68Ga PSMA PET-CT and 177Lu Radiopharmaceuticals.
Authors: Mirzaei S, Mohammed F, Zandieh S Abstract The successful use of theranostic twins in neuroendocrine tumors (NET) was the pioneering approach to radionuclide therapy in other tumor types. 64Cu/18F PSMA for molecular imaging with PET-CT and peptide radioligand therapy (PRLT) with 177Lu labeled PSMA inhibitors are the next theranostic twins in nuclear medicine. 68Ga/ 64Cu/18F PSMA PET-CT detects metastatic prostate cancer with high diagnostic sensitivity and specificity and can be used to select patients for PRLT and evaluate therapy response. Radionuclide therapy with 177Lu-PSMA inhibitors has been shown to ...
Source: Current Radiopharmaceuticals - September 10, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Cyclotron Production of PET Radiometals in Liquid Targets: Aspects and Prospects.
Authors: Pandey MK, DeGrado TR Abstract Present review describes the methodological aspects and prospects of production of Positron Emission Tomography (PET) radiometals in a liquid target using low-medium energy medical cyclotrons. The main objective of this review is to delineate and discuss the critical factors involved in the liquid target production of radiometals including type of salt solution, solution composition, beam energy, beam current, effect of irradiation duration (length of irradiation) and challenges posed by in-target chemistry in relation with irradiation parameters. We also summarize the optima...
Source: Current Radiopharmaceuticals - September 3, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Administered Pediatric Radiopharmaceutical doses at a Tertiary Hospital in South Africa: A comparison with Corresponding Activities Based North American Consensus Guidelines and the Administration of Radioactive Substances Advisory Committee Guidelines.
CONCLUSION: NAC guidelines are recommended for dosing pediatric patients at SATH. These guidelines will certainly reduce pediatric doses which are currently high. PMID: 32798379 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - August 18, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Impact of Tracer Retention Levels on Visual Analysis of Cerebral [18f]- Florbetaben pet Images.
Authors: Giovacchini G, Giovannini E, Borsò E, Lazzeri P, Duce V, Ferrando O, Foppiano F, Ciarmiello A Abstract BACKGROUND: To compare visual and semi-quantitative analysis of brain [18F]Florbetaben PET images in Mild Cognitive Impairment (MCI) patients and relate this finding to the degree of ß-amyloid burden. METHODS: A sample of 71 amnestic MCI patients (age 74 ± 7.3 years, Mini Mental State Examination 24.2 ± 5.3) underwent cerebral [18F]Florbetaben PET/CT. Images were visually scored as positive or negative independently by three certified readers blinded to clinical and neuropsy...
Source: Current Radiopharmaceuticals - July 31, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Extremity Exposure with 99mTc - labelled Radiopharmaceuticals in Diagnostic Nuclear Medicine.
CONCLUSION: The extremity exposures were below the annual limit (500 mSv). However, the use of syringe shields could still reduce the finger doses further. PMID: 32720609 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - July 30, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Diagnostic Value of the Early Heart-to-Mediastinum Count Ratio in Cardiac 123I-mIBG imaging for Parkinson's Disease.
CONCLUSIONS: The He/Me Ratio is almost as accurate as the widely used delayed 123I-mIBG imaging, reducing the burden of delayed imaging but preserving the diagnostic accuracy of the method. Moreover the differential diagnosis in Parkinson's disease can be made in just 2025 minutes against the 4 hours currently needed, lowering costs of the healthcare system and improving patients compliance. PMID: 32720610 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - July 30, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Gonioprobe, an innovative Gamma-probe to guide parathyroid radio-guided surgery: first clinical experiences with Navigator and Lock-on-target functions.
CONCLUSION: The intraoperative use of the innovative Gonioprobe along with the nerve monitoring system allowed an accurate and safe removal of parathyroid adenomas and offered a significant advantage by reducing surgical time and postoperative complications, as well as hospitalization and costs. PMID: 32693772 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - July 24, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

PET and SPECT Imaging in the SARS-CoV-2 Pandemic.
Authors: Evangelista L, Alongi P, Schillaci O PMID: 32571201 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - June 25, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Single Photon Emission Tomography in the Diagnostic Assessment of Cardiac and Vascular Infectious Diseases.
CONCLUSION: SPECT techniques with radiolabeled leucocytes scintigraphy has a high diagnostic performance in the evaluation of patients with suspected cardiac or vascular infection. It is able to confirm or reject the presence of infection when results of anatomic imaging or culture remain inconclusive. Its diagnostic performance is not compromised by sterile inflammation occurring in the early post-operative period or in response to implanted prosthetic materials. PMID: 32564768 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - June 24, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Artificial Neural Networks in Cardiovascular Diseases and its Potential for Clinical Application in Molecular Imaging.
CONCLUSION: Myocardial implementation of Artificial Intelligence algorithms in nuclear cardiology can improve and facilitate the diagnostic and predictive process, and global patient care. Building large databases containing clinical and image data is a first but essential step to create and train automated diagnostic/prognostic models able to help the clinicians to make unbiased and faster decisions for precision healthcare. PMID: 32564769 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - June 24, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

The role of molecular imaging in the assessment of cardiac amyloidosis: state-of-the-art.
CONCLUSION: Molecular imaging represent a sensitive tool for early assessment of both amyloid burden and cardiac innervation, to differentiate between subtypes and to monitor disease burden, disease progression, and potential response to therapy. PMID: 32525789 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - June 12, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

The effects of spacer on radiochemical and biological properties of new radiolabeled bombesin(7-14) derivative.
CONCLUSIONS: The introduction of spacer sequence between chelator and BBN(7-14) led to improved bidistribution. Analogue with tri-Gly spacer is the more promising radiopeptide for targeting GRP receptor than Ser conjugate. Therefore, these analogs can be considered as a candidate for the identification of bombesin-positive tumors. PMID: 32497000 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - June 5, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Novel PET tracers in the management of cardiac sarcoidosis.
Authors: Miceli A, Raffa S, Donegani MI, Cossu V, Morbelli S, Marini C, Sambuceti G, Bauckneht M Abstract Sarcoidosis is a systemic inflammatory disease of unknown etiology, pathologically characterized by non-caseating granulomas involving several organs and tissues. This pathological process can eventually affect the heart during his course leading to fibrosis associated with systolic dysfunction, conduction disturbance, and even sudden cardiac death. Due to this prognostic impact, diagnosis is crucial to optimize clinical management. The low sensitivity of endomyocardial biopsy and its invasive nature prevents i...
Source: Current Radiopharmaceuticals - June 4, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Lung Cancer And Radiological Imaging.
CONCLUSION: Radiological imaging is essential for the management of patients affected by lung cancer. PMID: 32445458 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - May 25, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Analysis of Cell Fraction of 99mTc-HMPAO Radiolabeled Leukocytes.
CONCLUSION: Although the numbers of RBCs and PLTs were highly increased after sedimentation, their individual cellular activity was lower than that of WBCs. 99mTc-HMPAO was more selective to WBCs than RBCs or PLTs. In conclusion, a higher number of WBCs were radiolabeled compared with RBCs and PLTs. PMID: 32386504 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - May 12, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

In situ Generated 212Pb-PSMA Ligand in a 224Ra-Solution for Dual Targeting of Prostate Cancer Sclerotic Stroma and PSMA-positive Cells.
CONCLUSION: A fast method for the labelling of PSMA ligands with 212Pb in the 224Ra/212Pb-solution was developed. Thus, further in vivo studies with dual tumour targeting by alpha-particles are warranted. PMID: 32389119 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - May 12, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Experimental Breast Cancer Models: Preclinical Imaging Perspective.
CONCLUSION: The development of animal models for breast cancer research has been the last century. Imaging methods used in breast cancer are used for tumor localization, quantification of tumor mass, imaging of genes and proteins, evaluation of tumor microenvironment, evaluation of tumor cell proliferation and metabolism and treatment response evaluation. Since human breast cancer is a heterogeneous group of diseases in terms of genetics and phenotype; it is not possible for a single model to adequately address all aspects of breast cancer biology. Considering that each model has advantages and disadvantages compared to ea...
Source: Current Radiopharmaceuticals - May 11, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Emerging molecular targets for imaging of atherosclerotic plaque using positron emission tomography.
CONCLUSION: 18F-sodium fluoride PET, CXCR4-targeted PET and amyloid-β-targeted PET may be used to obtain molecular information on different aspects of plaque biology. Further work is required to improve technical aspects of these imaging techniques and to elucidate their ability to predict adverse cardiac events prospectively. PMID: 32368992 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - May 6, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Polymer Coated Iron Nanoparticles: Radiolabeling & In Vitro Studies.
CONCLUSION: 99mTc labeled SPION-PLGA nanoparticles loaded with GEM may overcome some of the obstacles in anti-cancer drug delivery because of their appropriate size, non-toxic, and supermagnetic characteristics. PMID: 32351192 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - May 2, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Animal Models for the Evaluation of Theranostic Radiopharmaceuticals.
CONCLUSION: To achieve successful results in rapidly accelerating personalized treatment research of today, the first step is to conduct appropriate preclinical studies. PMID: 32334507 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 28, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

The role of 18FDG PET/CT in the assessment of endocarditis, myocarditis and pericarditis.
CONCLUSION: Compared with conventional methods, molecular imaging has the advantage to noninvasively and directly trace the inflammatory process, and to early identify the presence and the extent of intra-cardiac and extra-cardiac involvement, to enable quantification of disease activity, guide therapeutic interventions, and monitor treatment success. PMID: 32321415 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 25, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Physiological Animal Imaging with 68Ga-Citrate.
In this study, by applying the 68Ge/68Ga generator product, a simple technique for the synthesis and quality control of 68Ga-citrate was introduced and was followed by preliminary animal studies. The synthesis of 68Ga-citrate was performed with a cationic method using the Scintomics automated synthesis system (Scintomics GmbH GRP module 4V). Since the standard procedure for quality control (QC) was not available, the definition of chemical and radiochemical purity of 68Ga-citrate was carried out according to the ICH Q2(R1) guideline. The standard QC tests were analysed with Scintomics 8100 radio-HPLC system equipped with a...
Source: Current Radiopharmaceuticals - April 23, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Thymoquinone Glucuronide Conjugated Magnetic Nanoparticle for Bimodal Imaging and Treatment of Cancer as a Novel Theranostic Platform.
CONCLUSION: Our findings suggest that TQGMNP in solid, semi-solid and liquid formulations can be developed using different radiolabeling nuclides for applications in multimodality imaging (SPECT and MRI). By altering the characteristics of radionuclides, TQGMNP may ultimately be used not only for diagnosis but also treatment of various cancers as an in vitro diagnostic kit for the diagnosis of beta glucuronidase-rich cancers. PMID: 32282311 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 15, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Radioiodination of Pimonidazole as a Novel Theranostic Hypoxia Probe.
CONCLUSION: In the current study, radioiodination potential of PIM with 131I, as a potential theranostic hypoxia agent was investigated. Further experimental studies should be performed for developing a novel hypoxia probe including theranostics approaches. PMID: 32228432 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 2, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

123I-FP-CIT Brain SPECT Findings in Succinic Semialdehyde Dehydrogenase (SSADH) Deficiency.
CONCLUSIONS: The findings obtained by means of the 123I-DaTScan brain SPECT may give rise to new concerns on pathophysiological aspects of the SSADH deficiency disorder that has never been investigated before, such as the nigrostriatal dopaminergic system functionality, encouraging further investigation. PMID: 32209047 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - March 27, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research