Impact of Tracer Retention Levels on Visual Analysis of Cerebral [18f]- Florbetaben pet Images.
Authors: Giovacchini G, Giovannini E, Borsò E, Lazzeri P, Duce V, Ferrando O, Foppiano F, Ciarmiello A Abstract BACKGROUND: To compare visual and semi-quantitative analysis of brain [18F]Florbetaben PET images in Mild Cognitive Impairment (MCI) patients and relate this finding to the degree of ß-amyloid burden. METHODS: A sample of 71 amnestic MCI patients (age 74 ± 7.3 years, Mini Mental State Examination 24.2 ± 5.3) underwent cerebral [18F]Florbetaben PET/CT. Images were visually scored as positive or negative independently by three certified readers blinded to clinical and neuropsy...
Source: Current Radiopharmaceuticals - July 31, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Extremity Exposure with 99mTc - labelled Radiopharmaceuticals in Diagnostic Nuclear Medicine.
CONCLUSION: The extremity exposures were below the annual limit (500 mSv). However, the use of syringe shields could still reduce the finger doses further. PMID: 32720609 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - July 30, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Diagnostic Value of the Early Heart-to-Mediastinum Count Ratio in Cardiac 123I-mIBG imaging for Parkinson's Disease.
CONCLUSIONS: The He/Me Ratio is almost as accurate as the widely used delayed 123I-mIBG imaging, reducing the burden of delayed imaging but preserving the diagnostic accuracy of the method. Moreover the differential diagnosis in Parkinson's disease can be made in just 2025 minutes against the 4 hours currently needed, lowering costs of the healthcare system and improving patients compliance. PMID: 32720610 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - July 30, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Gonioprobe, an innovative Gamma-probe to guide parathyroid radio-guided surgery: first clinical experiences with Navigator and Lock-on-target functions.
CONCLUSION: The intraoperative use of the innovative Gonioprobe along with the nerve monitoring system allowed an accurate and safe removal of parathyroid adenomas and offered a significant advantage by reducing surgical time and postoperative complications, as well as hospitalization and costs. PMID: 32693772 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - July 24, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

PET and SPECT Imaging in the SARS-CoV-2 Pandemic.
Authors: Evangelista L, Alongi P, Schillaci O PMID: 32571201 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - June 25, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Single Photon Emission Tomography in the Diagnostic Assessment of Cardiac and Vascular Infectious Diseases.
CONCLUSION: SPECT techniques with radiolabeled leucocytes scintigraphy has a high diagnostic performance in the evaluation of patients with suspected cardiac or vascular infection. It is able to confirm or reject the presence of infection when results of anatomic imaging or culture remain inconclusive. Its diagnostic performance is not compromised by sterile inflammation occurring in the early post-operative period or in response to implanted prosthetic materials. PMID: 32564768 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - June 24, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Artificial Neural Networks in Cardiovascular Diseases and its Potential for Clinical Application in Molecular Imaging.
CONCLUSION: Myocardial implementation of Artificial Intelligence algorithms in nuclear cardiology can improve and facilitate the diagnostic and predictive process, and global patient care. Building large databases containing clinical and image data is a first but essential step to create and train automated diagnostic/prognostic models able to help the clinicians to make unbiased and faster decisions for precision healthcare. PMID: 32564769 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - June 24, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

The role of molecular imaging in the assessment of cardiac amyloidosis: state-of-the-art.
CONCLUSION: Molecular imaging represent a sensitive tool for early assessment of both amyloid burden and cardiac innervation, to differentiate between subtypes and to monitor disease burden, disease progression, and potential response to therapy. PMID: 32525789 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - June 13, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

The effects of spacer on radiochemical and biological properties of new radiolabeled bombesin(7-14) derivative.
CONCLUSIONS: The introduction of spacer sequence between chelator and BBN(7-14) led to improved bidistribution. Analogue with tri-Gly spacer is the more promising radiopeptide for targeting GRP receptor than Ser conjugate. Therefore, these analogs can be considered as a candidate for the identification of bombesin-positive tumors. PMID: 32497000 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - June 5, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Novel PET tracers in the management of cardiac sarcoidosis.
Authors: Miceli A, Raffa S, Donegani MI, Cossu V, Morbelli S, Marini C, Sambuceti G, Bauckneht M Abstract Sarcoidosis is a systemic inflammatory disease of unknown etiology, pathologically characterized by non-caseating granulomas involving several organs and tissues. This pathological process can eventually affect the heart during his course leading to fibrosis associated with systolic dysfunction, conduction disturbance, and even sudden cardiac death. Due to this prognostic impact, diagnosis is crucial to optimize clinical management. The low sensitivity of endomyocardial biopsy and its invasive nature prevents i...
Source: Current Radiopharmaceuticals - June 4, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Lung Cancer And Radiological Imaging.
CONCLUSION: Radiological imaging is essential for the management of patients affected by lung cancer. PMID: 32445458 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - May 25, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Analysis of Cell Fraction of 99mTc-HMPAO Radiolabeled Leukocytes.
CONCLUSION: Although the numbers of RBCs and PLTs were highly increased after sedimentation, their individual cellular activity was lower than that of WBCs. 99mTc-HMPAO was more selective to WBCs than RBCs or PLTs. In conclusion, a higher number of WBCs were radiolabeled compared with RBCs and PLTs. PMID: 32386504 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - May 12, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

In situ Generated 212Pb-PSMA Ligand in a 224Ra-Solution for Dual Targeting of Prostate Cancer Sclerotic Stroma and PSMA-positive Cells.
CONCLUSION: A fast method for the labelling of PSMA ligands with 212Pb in the 224Ra/212Pb-solution was developed. Thus, further in vivo studies with dual tumour targeting by alpha-particles are warranted. PMID: 32389119 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - May 12, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Experimental Breast Cancer Models: Preclinical Imaging Perspective.
CONCLUSION: The development of animal models for breast cancer research has been the last century. Imaging methods used in breast cancer are used for tumor localization, quantification of tumor mass, imaging of genes and proteins, evaluation of tumor microenvironment, evaluation of tumor cell proliferation and metabolism and treatment response evaluation. Since human breast cancer is a heterogeneous group of diseases in terms of genetics and phenotype; it is not possible for a single model to adequately address all aspects of breast cancer biology. Considering that each model has advantages and disadvantages compared to ea...
Source: Current Radiopharmaceuticals - May 11, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Emerging molecular targets for imaging of atherosclerotic plaque using positron emission tomography.
CONCLUSION: 18F-sodium fluoride PET, CXCR4-targeted PET and amyloid-β-targeted PET may be used to obtain molecular information on different aspects of plaque biology. Further work is required to improve technical aspects of these imaging techniques and to elucidate their ability to predict adverse cardiac events prospectively. PMID: 32368992 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - May 6, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Polymer Coated Iron Nanoparticles: Radiolabeling & In Vitro Studies.
CONCLUSION: 99mTc labeled SPION-PLGA nanoparticles loaded with GEM may overcome some of the obstacles in anti-cancer drug delivery because of their appropriate size, non-toxic, and supermagnetic characteristics. PMID: 32351192 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - May 2, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Animal Models for the Evaluation of Theranostic Radiopharmaceuticals.
CONCLUSION: To achieve successful results in rapidly accelerating personalized treatment research of today, the first step is to conduct appropriate preclinical studies. PMID: 32334507 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 28, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

The role of 18FDG PET/CT in the assessment of endocarditis, myocarditis and pericarditis.
CONCLUSION: Compared with conventional methods, molecular imaging has the advantage to noninvasively and directly trace the inflammatory process, and to early identify the presence and the extent of intra-cardiac and extra-cardiac involvement, to enable quantification of disease activity, guide therapeutic interventions, and monitor treatment success. PMID: 32321415 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 25, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Physiological Animal Imaging with 68Ga-Citrate.
In this study, by applying the 68Ge/68Ga generator product, a simple technique for the synthesis and quality control of 68Ga-citrate was introduced and was followed by preliminary animal studies. The synthesis of 68Ga-citrate was performed with a cationic method using the Scintomics automated synthesis system (Scintomics GmbH GRP module 4V). Since the standard procedure for quality control (QC) was not available, the definition of chemical and radiochemical purity of 68Ga-citrate was carried out according to the ICH Q2(R1) guideline. The standard QC tests were analysed with Scintomics 8100 radio-HPLC system equipped with a...
Source: Current Radiopharmaceuticals - April 23, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Thymoquinone Glucuronide Conjugated Magnetic Nanoparticle for Bimodal Imaging and Treatment of Cancer as a Novel Theranostic Platform.
CONCLUSION: Our findings suggest that TQGMNP in solid, semi-solid and liquid formulations can be developed using different radiolabeling nuclides for applications in multimodality imaging (SPECT and MRI). By altering the characteristics of radionuclides, TQGMNP may ultimately be used not only for diagnosis but also treatment of various cancers as an in vitro diagnostic kit for the diagnosis of beta glucuronidase-rich cancers. PMID: 32282311 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 15, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Radioiodination of Pimonidazole as a Novel Theranostic Hypoxia Probe.
CONCLUSION: In the current study, radioiodination potential of PIM with 131I, as a potential theranostic hypoxia agent was investigated. Further experimental studies should be performed for developing a novel hypoxia probe including theranostics approaches. PMID: 32228432 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 2, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

123I-FP-CIT Brain SPECT Findings in Succinic Semialdehyde Dehydrogenase (SSADH) Deficiency.
CONCLUSIONS: The findings obtained by means of the 123I-DaTScan brain SPECT may give rise to new concerns on pathophysiological aspects of the SSADH deficiency disorder that has never been investigated before, such as the nigrostriatal dopaminergic system functionality, encouraging further investigation. PMID: 32209047 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - March 27, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Imaging in Melanoma Management: What's New Under the Sun?
Authors: Alongi P, Argenziano G, Mansi L PMID: 32183658 [PubMed - in process] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - March 20, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Respiratory Gating and the performance of PET/CT in pulmonary lesions.
CONCLUSION: New technologies able to track motion of organs lesion directly from raw PET data, can reduce or definitively solve problems (i.e.: extended acquisition time, radiation exposure) currently limiting the use of gated PET/CT in clinical routine. PMID: 32183685 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - March 20, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

The multicenter ITALIAN trial assess the performance of FDG-PET/CT related to pre-test cancer risk in patients with solitary pulmonary nodules and introduces a segmental thoracic diagnostic strategy.
CONCLUSION: In patients with SPN, the pre-test likelihood of malignancy stratification allows to better define PET clinical setting and its diagnostic power. In subjects with low-intermediate pre-test likelihood of malignancy, s-PET/CT might be planned in advance. The adoption of this segmental strategy could reduce radiation exposure, scan-time, and might allow individually targeted protocols. PMID: 32186274 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - March 20, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Radiotherapy planning and Molecular Imaging in Lung Cancer.
Authors: Filice A, Casali M, Ciammella P, Galaverni M, Fioroni F, Lotti C, Versari A Abstract The goal of the radiotherapy (RT) planning process is to select and delineate target volumes with the best accuracy on the basis of all the available diagnostic information and the knowledge of the physiology of the disease. The recommendation of the International Atomic Energy Agency (IAEA) expert panel, is that an appropriately timed and technically adequate 2-[18F]fluoro-2-deoxy-d-glucose/Positron Emission Tomography-Computer Tomography (18F-FDG-PET/CT) imaging is an essential component in the radiotherapy treatment pla...
Source: Current Radiopharmaceuticals - March 20, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Usefulness of 5 minutes 123I-mIBG scan in Parkinson's Disease and Heart Failure.
CONCLUSION: Our results indicate the potential role of immediate (5 min) or early (15 min) acquisition in replacement of standardized 240 minutes acquisition in PD patients, but this result is not confirmed in HF patients, in which the acquisition at 240 min is confirmed as the most affordable timing for image interpretation, emphasizing the different pathophysiology that underlies these two pathologies. PMID: 31985388 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - January 29, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

99mTc-EDDA/HYNIC-TOC is a new opportunity in Neuroendocrine Tumors of the Lung (and in other malignant and benign pulmonary diseases) .
Authors: Briganti V, Cuccurullo V, Berti V, Di Stasio GD, Linguanti F, Mungai F, Mansi L Abstract Neuroendocrine tumors (NETs) consist of a relatively rare spectrum of malignancies that can arise from neuroendocrine cells; lung NETs (L-NETs) represent about 25% of primary lung neoplasm and 10% of all carcinoid tumors. Diagnostic algorithm usually takes into consideration chest X-ray, contrast-enhanced CT and MRI. Nuclear medicine plays a crucial role in the detection and correct assessment of neoplastic functional status as it provides in vivo metabolic data related to the over-expression of Somatostatin Receptors ...
Source: Current Radiopharmaceuticals - December 31, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

18F-FDG PET/CT in restaging and evaluation of response to therapy in lung cancer: state of art.
CONCLUSION: 18F-FDG parameters appear to be promising factors for evaluating treatment response and for detecting recurrences, although larger prospective trials are needed to confirm these evidences and to determine optimal cut-off values. PMID: 31886757 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - December 31, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Review: Alternative and New Radiopharmaceutical Agents for Lung Cancer.
CONCLUSION: To date the employment of most of the described tracers is limited to the experimental field, however, research development may offer innovative opportunities to improve LC staging, characterization, stratification and response assessment in an era of increased personalized therapy. PMID: 31868150 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - December 24, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

FDG PET/CT in staging of lung cancer.
CONCLUSION: PET/CT with FDG should be included in the diagnostic work-up of patients with lung cancer, because it provides information useful for an appropriate therapy. PMID: 31868151 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - December 24, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

PET/CT And The Response To Immunotherapy In Lung Cancer.
CONCLUSIONS: The utility of FDG PET/CT for patients with lung cancer undergoing immunotherapies, is still preliminary and not well addresses. New agents for PET are promising, but large clinical trials are mandatory. PMID: 31858908 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - December 21, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Evidence-based data about prevalence and risk of malignancy of thyroid incidentalomas detected by different PET radiopharmaceuticals.
CONCLUSION: Evidence-based data demonstrated that thyroid incidentalomas detected by different PET radiopharmaceuticals are not infrequent and their risk of malignancy is not negligible, in particular if focal pattern is evident at PET, thus requiring further clinical and instrumental evaluation. PMID: 31830891 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - December 14, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Clinical Value of PET/CT in staging melanoma and potential new radiotracers.
CONCLUSION: PET/CT plays an important role in the staging workup of patients affected by melanoma. New radiopharmaceuticals and hybrid PET/ceCT could improve the potential of this diagnostic tool in this field. PMID: 31749438 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - November 23, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Malignant cutaneous melanoma:updates inPET imaging.
CONCLUSION: Recently introduced digital PET detector technology in PET/CT and PET/MRI yields higher intrinsic system sensitivity compared with the latest generation analog technology, enabling the detection of very small lesions with potential impact on disease outcome. PMID: 31749439 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - November 23, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Role of PET/CT in the era of immune checkpoint inhibitors: state of art.
CONCLUSION: Although the role of 18F-FDG PET/CT in malignant melanoma has been widely validated for detecting distant metastases and recurrences, evidences in course of ICI are still scarce and larger multicenter clinical trials are needed. PMID: 31749440 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - November 23, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Sentinel Node Identification in melanoma: current clinical impact, new emerging SPECT radiotracers and technological advancements. An update of the last decade.
CONCLUSIONS: This review examined the predictive and prognostic factors of lymphoscintigraphy for metastatic involvement of SLN, the currently available and emerging radiotracers and the evidence of the additional value of SPECT/CT over PL for the identification of SLN in patients with melanoma. Finally, the review discussed the most recent technical advances in the field. PMID: 31749441 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - November 23, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Ileal melanoma, a rare cause of small bowel obstruction: report of a case, and short literature review.
Conclusion: Primary small bowel MM appears to be an extremely rare entity which, however, clinicians should be more aware of, in order to plan better a correct strategy of early diagnosis and appropriate treatment. PMID: 31749442 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - November 23, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Potential of radiolabelled PSMA PET/CT or PET/MRI diagnostic procedures in gliomas/glioblastomas.
CONCLUSION: Radiolabelled PSMA imaging seems to be useful in analyzing glioma/glioblastoma. Further studies enrolling a wider population are needed to clarify the real clinical and diagnostic role of radiolabelled PSMA in this setting and its possible position in the diagnostic flow-chart. PMID: 31625482 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - October 20, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

The Screening of Renoprotective Agents by 99mTc-DMSA: A Review of Preclinical Studies.
CONCLUSION: In this review, the recent findings about the renoprotective agents were evaluated and screened with respect to the use of 99mTc-DMSA , which is preclinically and clinically used for animal cases and cancer patients under the treatment by radiotherapy and chemotherapy. PMID: 31612808 [PubMed - in process] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - October 17, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Clinical and prognostic value of 18F-FDG-PET/CT in the restaging process of recurrent cutaneous melanoma.
Authors: Albano D, Familiari D, Fornito MC, Scalisi S, Laudicella R, Galia M, Grassedonio E, Ruggeri A, Ganduscio G, Messina M, Spada M, Midiri M, Alongi P Abstract OBJECTIVE: The aim of this retrospective multicenter study was to evaluate the clinical and prognostic impact of 18F-FDG-PET/CT in the restaging process of cutaneous melanoma (CM) after surgery in patients with suspected distant recurrent disease or suspected metastatic progression disease. MATERIALS AND METHODS: 74 patients surgically treated for CM underwent 18F-FDG-PET/CT for suspicious of distant recurrent disease or suspected metastatic progres...
Source: Current Radiopharmaceuticals - October 11, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

A preliminary study for quantitative assessment with HFUS (High Frequency ultrasound) of nodular skin melanoma Breslow thickness in adults before surgery: Interdisciplinary team experience.
CONCLUSIONS: If further studies are needed to support its widespread clinical use, we believe that, in expert hands and with a interdisciplinary team, HFUS are already capable to reliably calculate a Breslow index in the large majority of patients with cutaneous melanoma. PMID: 31589132 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - October 8, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Analysis of Unusual Adverse Effects after Radium-223 Dichloride Administration.
CONCLUSIONS: The management of adverse effects after radiopharmaceuticals administration as in case of lymphedema onset, is extremely simple. These data confirms the safety of Radium-223 treatment. PMID: 31560295 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - September 30, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Oxidant and Antioxidant Effects of Gentisic Acid in a 177Lu-Labelled Methionine-containing Minigastrin Analogue.
CONCLUSION: The selective oxidation of the methionine residue could be induced by the H2O2 produced in the reaction between gentisic acid and free radicals of water, during the protection of the radiolabelled peptide from the attack of these harmful species. Therefore, the addition of methionine becomes necessary to effectively decrease this selective oxidation in the methionine-containing peptide. PMID: 31526356 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - September 20, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Preparation and biological evaluation of 67Gallium- labeled Iranian Hemiscorpius lepturus scorpion venom.
CONCLUSION: The results have largely shown the direct clinical effects on the studied tissues during the 72-hour period and antivenom administration can strongly alleviate the toxicity effects as early as 72 hours in the management of the patients. PMID: 31456528 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - August 29, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Molecular Imaging and Theranostics in Pancreatic Neuroendocrine Tumours: From a Luminous Present to an Even Brighter Future.
Authors: Paola M, Mansi L Abstract PMID: 31362647 [PubMed - in process] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - August 2, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Toward the discovery and development of PSMA targeted inhibitors for nuclear medicine applications.
CONCLUSION: PSMA represents for researchers the most attractive target for the detection and treatment of patients affected by PCa using nuclear medicine modalities. [99mTc]MIP-1404 is considered the tracer of choice for SPECT imaging and [68Ga]PSMA-11 is the leading diagnostic for PET imaging by general consensus. [18F]DCFPyL and [18F]PSMA-1007 are clearly the emerging PET PSMA candidates for their great potential for a widespread commercial distribution. After paving the way with new imaging tools, academic and industrial R&Ds are now focusing on the development of PSMA inhibitors labeled with alpha or beta minus emi...
Source: Current Radiopharmaceuticals - August 2, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

Comparison of 99mTc Injected Activity with Prescribed Activity in Four Types of Nuclear Medicine Exams.
CONCLUSION: This uncertainty in activity exists due to time delay between the injection preparation time and administration time to patients as well as due to residual radionuclide that is not injected into patients and remains in syringe. PMID: 31258094 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - July 3, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

68Ga/64Cu PSMA bio-distribution in prostate cancer patients: potential pitfalls for different tracers.
CONCLUSION: The knowledge of difference in bio-distribution between two tracers may help in interpretation of PET data. Diagnostic pitfalls can be documented, due to the possibility of PSMA uptake in inflammation. Our results are preliminary to future studies comparing diagnostic accuracies of 68Ga-PSMA and 64Cu-PSMA. PMID: 31113354 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - May 23, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research

PET/MRI in Neuroendocrine Tumours: Blessings and Curses.
Authors: Picchio M, De Cobelli F, Mapelli P PMID: 30947647 [PubMed - as supplied by publisher] (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 7, 2019 Category: Radiology Tags: Curr Radiopharm Source Type: research