Formulation and In-vivo Characterization of 177Lu-tin-colloid as a Radiosynovectomy Agent
CONCLUSION: 177Lu-tin-colloid was successfully prepared under optimized reaction conditions with high binding efficiency and radiochemical purity. The radiolabeled colloid was found to be stable in-vitro both in PBS and synovial fluid at room temperature. Serial PCET/CT images revealed that the activity was completely retained within the synovial cavity, with no activity leakage out of the joint until 48 hours after the injection. With the support of the results from further clinical studies, it may be possible for the formulation to enter clinical use.PMID:37937551 | DOI:10.2174/0118744710252994231024064842 (Source: Curre...
Source: Current Radiopharmaceuticals - November 8, 2023 Category: Radiology Authors: Guldem Mercanoglu Goksel Alc ın Yusuf Ozturkmen Tevfik Cermik Source Type: research
Astatine-211 Radiopharmaceuticals; Status, Trends, and the Future
Curr Radiopharm. 2023 Nov 3. doi: 10.2174/0118744710262325231025075638. Online ahead of print.ABSTRACTThe low range of alpha particles provides an opportunity to better target cancer cells theoretically leading to the introduction of interesting alpha emitter radiopharmaceuticals including 225Ac, 212Pb, etc. The combination of high energy and short range of alpha emitters differentiates targeted radiotherapy from other methods and reduces unwanted cytotoxicity of the cells around the tumoral tissue. Among interesting alpha emitters candidates for targeted therapy, 211At, one of the radioisotopes with the best optimal decay...
Source: Current Radiopharmaceuticals - November 8, 2023 Category: Radiology Authors: Mobina Rabiei Mahboobeh Asadib Hassan Yousefnia Source Type: research
Design of a New < sup > 99m < /sup > Tc-radiolabeled Cyclo-peptide as Promising Molecular Imaging Agent of CXCR < sub > 4 < /sub > Receptor: Molecular Docking, Synthesis, Radiolabeling, and Biological Evaluation
CONCLUSION: Therefore, the findings indicate this designed radioligand could be used as a potential SPECT imaging agent in highly proliferated CXCR4 receptor tumors.PMID:37921191 | DOI:10.2174/0118744710249305231017073022 (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - November 3, 2023 Category: Radiology Authors: Leila Hassanzadeh Mostafa Erfani Safura Jokar Marjan Shriatpanahi Source Type: research
Protective Effects of Alpha-lipoic Acid, Resveratrol, and Apigenin against Oxidative Damages, Histopathological Changes, and Mortality Induced by Lung Irradiation in Rats
CONCLUSION: APG and RVT could prevent tissue damage induced by radiation effects in rat lung tissues. Hence, APG, LA, and RVT could provide a novel preventive action with their potential antioxidant anti-inflammatory properties, as well as their great safety characteristic.PMID:37909433 | DOI:10.2174/0118744710244357231018070313 (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - November 1, 2023 Category: Radiology Authors: Nasrin Seyedpour Elahe Motevaseli Shahram Taeb Azin Nowrouzi Fatemeh Mirzaei Mina Bahri Hamid Reza Dehghan-Manshadi Mohsen Zhale Khodabakhsh Rashidi Rasool Azmoonfar Rasoul Yahyapour Masoud Najafi Source Type: research
The Anti-hypoxia Potentials of Trans-sodium Crocetinate in Hypoxiarelated Diseases: A Review
Curr Radiopharm. 2023 Oct 24. doi: 10.2174/0118744710268127231020083505. Online ahead of print.ABSTRACTCrocetin is a kind of apocarotenoid carboxylic acid extracted from saffron (Crocus sativus L.), which is effective in upregulating tissue oxygenation. However, crocetin is difficult to solubilize. It was shown that the trans isomer of crocetin is effective in improving oxygen diffusivity, while its cis isomer appears not to be. Hence, the isolated trans isomer of crocetin or trans-sodium crocetinate (TSC) can be used instead of crocetin. It is shown that TSC can upregulate hypoxic tissue oxygenation and be effective in tr...
Source: Current Radiopharmaceuticals - October 25, 2023 Category: Radiology Authors: Natalia S Klunko Harun Achmad Tamara Muayad Abdullah Sami Mohammed Indranil Saha Khulood Saadoon Salim Rasha Fadhel Obaid Rosario Mireya Romero-Parra Shaker Shanawa Al-Hasnawi Wissam Hamid Al-Janabi Bagher Farhood Source Type: research
Radioactive Iodine in Differentiated Carcinoma of Thyroid: An Overview
Curr Radiopharm. 2023 Oct 24. doi: 10.2174/0118744710249684231013072013. Online ahead of print.ABSTRACTThyroid cancer is the fifth most prevalent cancer in women and the fastest-growing malignancy. Although surgery is still the basis of treatment, internal radiation therapy [Brachytherapy] with radioactive iodine-131, which functions by releasing beta particles with low tissue penetration and causing DNA damage, is also a potential option. The three basic aims of RAI therapy in well-differentiated thyroid tumors are ablation of the remnant, adjuvant therapy, and disease management. Radioactive iodine dose is selected in on...
Source: Current Radiopharmaceuticals - October 25, 2023 Category: Radiology Authors: Namit Kant Singh Balaji Ramamourthy Neemu Hage Sushmitha Nagaraju Krishna Medha Kappagantu Source Type: research
The Anti-hypoxia Potentials of Trans-sodium Crocetinate in Hypoxiarelated Diseases: A Review
Curr Radiopharm. 2023 Oct 24. doi: 10.2174/0118744710268127231020083505. Online ahead of print.ABSTRACTCrocetin is a kind of apocarotenoid carboxylic acid extracted from saffron (Crocus sativus L.), which is effective in upregulating tissue oxygenation. However, crocetin is difficult to solubilize. It was shown that the trans isomer of crocetin is effective in improving oxygen diffusivity, while its cis isomer appears not to be. Hence, the isolated trans isomer of crocetin or trans-sodium crocetinate (TSC) can be used instead of crocetin. It is shown that TSC can upregulate hypoxic tissue oxygenation and be effective in tr...
Source: Current Radiopharmaceuticals - October 25, 2023 Category: Radiology Authors: Natalia S Klunko Harun Achmad Tamara Muayad Abdullah Sami Mohammed Indranil Saha Khulood Saadoon Salim Rasha Fadhel Obaid Rosario Mireya Romero-Parra Shaker Shanawa Al-Hasnawi Wissam Hamid Al-Janabi Bagher Farhood Source Type: research
Radioactive Iodine in Differentiated Carcinoma of Thyroid: An Overview
Curr Radiopharm. 2023 Oct 24. doi: 10.2174/0118744710249684231013072013. Online ahead of print.ABSTRACTThyroid cancer is the fifth most prevalent cancer in women and the fastest-growing malignancy. Although surgery is still the basis of treatment, internal radiation therapy [Brachytherapy] with radioactive iodine-131, which functions by releasing beta particles with low tissue penetration and causing DNA damage, is also a potential option. The three basic aims of RAI therapy in well-differentiated thyroid tumors are ablation of the remnant, adjuvant therapy, and disease management. Radioactive iodine dose is selected in on...
Source: Current Radiopharmaceuticals - October 25, 2023 Category: Radiology Authors: Namit Kant Singh Balaji Ramamourthy Neemu Hage Sushmitha Nagaraju Krishna Medha Kappagantu Source Type: research
The Anti-hypoxia Potentials of Trans-sodium Crocetinate in Hypoxiarelated Diseases: A Review
Curr Radiopharm. 2023 Oct 24. doi: 10.2174/0118744710268127231020083505. Online ahead of print.ABSTRACTCrocetin is a kind of apocarotenoid carboxylic acid extracted from saffron (Crocus sativus L.), which is effective in upregulating tissue oxygenation. However, crocetin is difficult to solubilize. It was shown that the trans isomer of crocetin is effective in improving oxygen diffusivity, while its cis isomer appears not to be. Hence, the isolated trans isomer of crocetin or trans-sodium crocetinate (TSC) can be used instead of crocetin. It is shown that TSC can upregulate hypoxic tissue oxygenation and be effective in tr...
Source: Current Radiopharmaceuticals - October 25, 2023 Category: Radiology Authors: Natalia S Klunko Harun Achmad Tamara Muayad Abdullah Sami Mohammed Indranil Saha Khulood Saadoon Salim Rasha Fadhel Obaid Rosario Mireya Romero-Parra Shaker Shanawa Al-Hasnawi Wissam Hamid Al-Janabi Bagher Farhood Source Type: research
Radioactive Iodine in Differentiated Carcinoma of Thyroid: An Overview
Curr Radiopharm. 2023 Oct 24. doi: 10.2174/0118744710249684231013072013. Online ahead of print.ABSTRACTThyroid cancer is the fifth most prevalent cancer in women and the fastest-growing malignancy. Although surgery is still the basis of treatment, internal radiation therapy [Brachytherapy] with radioactive iodine-131, which functions by releasing beta particles with low tissue penetration and causing DNA damage, is also a potential option. The three basic aims of RAI therapy in well-differentiated thyroid tumors are ablation of the remnant, adjuvant therapy, and disease management. Radioactive iodine dose is selected in on...
Source: Current Radiopharmaceuticals - October 25, 2023 Category: Radiology Authors: Namit Kant Singh Balaji Ramamourthy Neemu Hage Sushmitha Nagaraju Krishna Medha Kappagantu Source Type: research
The Anti-hypoxia Potentials of Trans-sodium Crocetinate in Hypoxiarelated Diseases: A Review
Curr Radiopharm. 2023 Oct 24. doi: 10.2174/0118744710268127231020083505. Online ahead of print.ABSTRACTCrocetin is a kind of apocarotenoid carboxylic acid extracted from saffron (Crocus sativus L.), which is effective in upregulating tissue oxygenation. However, crocetin is difficult to solubilize. It was shown that the trans isomer of crocetin is effective in improving oxygen diffusivity, while its cis isomer appears not to be. Hence, the isolated trans isomer of crocetin or trans-sodium crocetinate (TSC) can be used instead of crocetin. It is shown that TSC can upregulate hypoxic tissue oxygenation and be effective in tr...
Source: Current Radiopharmaceuticals - October 25, 2023 Category: Radiology Authors: Natalia S Klunko Harun Achmad Tamara Muayad Abdullah Sami Mohammed Indranil Saha Khulood Saadoon Salim Rasha Fadhel Obaid Rosario Mireya Romero-Parra Shaker Shanawa Al-Hasnawi Wissam Hamid Al-Janabi Bagher Farhood Source Type: research
